GREMLIN Database
Q7LY06 - Hydrogenase expression/formation protein (HypE)
UniProt: Q7LY06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (281)
Sequences: 13579 (8847)
Seq/√Len: 527.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_K303_I3.3931.00
252_S306_E3.3111.00
252_S308_K3.2021.00
166_E309_R2.7611.00
254_N257_K2.5861.00
290_T293_K2.5591.00
168_M226_V2.5571.00
115_A118_S2.4941.00
288_S294_I2.4891.00
171_V303_I2.4641.00
169_K306_E2.4531.00
77_S115_A2.3901.00
77_S122_E2.3661.00
170_V287_V2.3361.00
244_A251_V2.3261.00
249_Y307_I2.2881.00
171_V301_A2.1891.00
240_M251_V2.1151.00
121_S125_N2.1001.00
171_V295_L2.0911.00
250_T308_K2.0791.00
66_I96_A2.0631.00
240_M253_I2.0581.00
292_E296_E2.0501.00
77_S118_S2.0391.00
291_P295_L1.9721.00
170_V251_V1.9311.00
169_K291_P1.9241.00
166_E249_Y1.9141.00
250_T310_G1.9121.00
87_A151_A1.8571.00
224_Y290_T1.8471.00
243_V287_V1.8311.00
122_E125_N1.8081.00
76_K145_D1.8031.00
293_K296_E1.7431.00
291_P303_I1.7361.00
99_R154_V1.7351.00
81_F123_A1.7311.00
295_L301_A1.7041.00
171_V288_S1.6781.00
57_V66_I1.6691.00
303_I306_E1.6521.00
63_K154_V1.6291.00
62_D156_N1.6271.00
252_S316_I1.6241.00
122_E126_L1.6131.00
252_S314_L1.6091.00
178_I186_K1.5961.00
33_I37_I1.5891.00
205_A208_F1.5711.00
226_V287_V1.5561.00
68_H151_A1.5461.00
207_E210_K1.5361.00
164_V227_A1.5351.00
222_L297_R1.5331.00
251_V307_I1.5111.00
91_I151_A1.5081.00
78_D81_F1.5041.00
208_F211_D1.4981.00
227_A243_V1.4981.00
103_S120_I1.4861.00
293_K297_R1.4631.00
165_K226_V1.4601.00
279_I282_G1.4591.00
118_S122_E1.4571.00
105_I113_L1.4451.00
207_E211_D1.4351.00
55_A94_K1.4161.00
91_I96_A1.4091.00
164_V307_I1.3951.00
102_N133_G1.3941.00
206_K209_K1.3911.00
48_C64_Y1.3831.00
171_V291_P1.3811.00
292_E295_L1.3791.00
159_L228_M1.3671.00
204_K211_D1.3621.00
231_A285_I1.3491.00
56_A132_V1.3491.00
228_M284_F1.3441.00
288_S291_P1.3411.00
93_M228_M1.3361.00
178_I261_R1.3131.00
84_I120_I1.3091.00
78_D119_A1.3031.00
123_A126_L1.2991.00
164_V287_V1.2981.00
228_M286_A1.2941.00
276_L281_S1.2891.00
208_F212_I1.2841.00
32_P36_F1.2761.00
294_I298_I1.2751.00
310_G314_L1.2691.00
205_A209_K1.2641.00
295_L303_I1.2601.00
254_N306_E1.2571.00
175_S178_I1.2561.00
107_L113_L1.2561.00
295_L299_S1.2501.00
71_P76_K1.2491.00
198_S201_I1.2481.00
155_S158_F1.2411.00
170_V285_I1.2411.00
231_A239_A1.2351.00
168_M307_I1.2341.00
169_K288_S1.2331.00
67_V102_N1.2321.00
69_S150_T1.2281.00
81_F126_L1.2151.00
106_L139_S1.2101.00
250_T311_D1.2041.00
34_N37_I1.1971.00
240_M285_I1.1911.00
287_V307_I1.1841.00
71_P74_E1.1721.00
204_K208_F1.1661.00
275_P279_I1.1621.00
171_V294_I1.1621.00
206_K210_K1.1591.00
250_T313_V1.1581.00
160_S163_N1.1521.00
83_S147_I1.1511.00
176_P179_E1.1501.00
64_Y158_F1.1491.00
124_C131_V1.1481.00
197_I200_E1.1351.00
88_C151_A1.1341.00
102_N150_T1.1301.00
85_A123_A1.1301.00
67_V152_I1.1231.00
160_S164_V1.1191.00
101_V151_A1.1141.00
163_N226_V1.1121.00
69_S104_I1.1111.00
37_I40_L1.1081.00
55_A66_I1.1071.00
88_C129_C1.1041.00
68_H91_I1.1031.00
100_W132_V1.0671.00
64_Y155_S1.0631.00
164_V243_V1.0491.00
229_H242_E1.0491.00
111_S115_A1.0481.00
97_Q221_I1.0431.00
139_S146_I1.0411.00
298_I301_A1.0361.00
57_V158_F1.0361.00
71_P144_Q1.0341.00
218_A222_L1.0341.00
45_C48_C1.0241.00
84_I101_V1.0241.00
277_R280_S1.0171.00
66_I91_I1.0101.00
127_I214_V1.0091.00
260_L265_K1.0031.00
31_V35_K0.9971.00
84_I124_C0.9971.00
196_G199_R0.9971.00
296_E299_S0.9961.00
204_K207_E0.9901.00
73_T205_A0.9771.00
218_A221_I0.9721.00
236_I285_I0.9711.00
60_A154_V0.9701.00
168_M287_V0.9681.00
259_V302_Y0.9641.00
222_L293_K0.9541.00
107_L116_T0.9471.00
81_F122_E0.9401.00
227_A287_V0.9391.00
173_V217_K0.9371.00
100_W152_I0.9291.00
201_I204_K0.9271.00
81_F85_A0.9261.00
202_I205_A0.9171.00
82_L281_S0.9171.00
53_E94_K0.9161.00
166_E169_K0.9151.00
104_I148_I0.9011.00
80_G116_T0.8991.00
240_M244_A0.8971.00
39_N125_N0.8961.00
113_L138_V0.8951.00
101_V149_T0.8901.00
164_V247_S0.8831.00
75_A78_D0.8791.00
157_K223_D0.8711.00
157_K221_I0.8661.00
67_V150_T0.8641.00
277_R282_G0.8621.00
54_D229_H0.8601.00
96_A155_S0.8601.00
46_L49_P0.8521.00
294_I297_R0.8521.00
100_W130_K0.8511.00
30_K33_I0.8481.00
206_K211_D0.8441.00
97_Q128_G0.8441.00
274_D277_R0.8441.00
32_P35_K0.8441.00
199_R202_I0.8431.00
80_G119_A0.8421.00
41_P44_D0.8411.00
274_D278_L0.8371.00
76_K112_H0.8361.00
170_V307_I0.8361.00
120_I149_T0.8361.00
212_I215_Q0.8301.00
199_R203_E0.8281.00
167_G306_E0.8261.00
239_A285_I0.8261.00
200_E203_E0.8251.00
220_S223_D0.8231.00
268_T275_P0.8201.00
265_K269_K0.8181.00
33_I36_F0.8161.00
210_K213_V0.8161.00
116_T120_I0.8141.00
244_A307_I0.8131.00
166_E308_K0.8131.00
275_P280_S0.8071.00
278_L282_G0.8061.00
59_E64_Y0.8031.00
73_T76_K0.7981.00
277_R281_S0.7921.00
286_A294_I0.7901.00
179_E280_S0.7901.00
124_C129_C0.7881.00
80_G120_I0.7871.00
71_P75_A0.7821.00
275_P278_L0.7791.00
229_H285_I0.7761.00
38_Y41_P0.7731.00
254_N316_I0.7721.00
59_E62_D0.7681.00
274_D280_S0.7681.00
252_S255_L0.7651.00
83_S149_T0.7641.00
84_I88_C0.7641.00
72_I75_A0.7551.00
173_V284_F0.7521.00
278_L281_S0.7511.00
57_V94_K0.7501.00
313_V316_I0.7491.00
216_P220_S0.7431.00
310_G313_V0.7391.00
53_E161_Y0.7381.00
71_P82_L0.7381.00
223_D297_R0.7351.00
203_E206_K0.7351.00
259_V265_K0.7321.00
34_N38_Y0.7311.00
292_E303_I0.7301.00
174_G300_E0.7301.00
186_K189_D0.7301.00
250_T312_P0.7261.00
97_Q154_V0.7221.00
274_D279_I0.7201.00
197_I203_E0.7191.00
204_K209_K0.7181.00
184_L187_D0.7171.00
88_C123_A0.7161.00
161_Y164_V0.7161.00
266_I269_K0.7151.00
66_I155_S0.7131.00
244_A313_V0.7131.00
276_L279_I0.7121.00
236_I240_M0.7101.00
219_L294_I0.7101.00
116_T147_I0.7091.00
58_L100_W0.7081.00
159_L163_N0.7051.00
159_L225_V0.7051.00
231_A236_I0.7041.00
105_I147_I0.7041.00
106_L137_E0.7011.00
40_L43_G0.7011.00
202_I208_F0.7001.00
159_L220_S0.6971.00
101_V120_I0.6951.00
114_N118_S0.6931.00
173_V286_A0.6931.00
238_Q277_R0.6921.00
44_D59_E0.6911.00
57_V64_Y0.6911.00
292_E299_S0.6911.00
185_A189_D0.6881.00
101_V124_C0.6831.00
280_S283_S0.6791.00
34_N40_L0.6771.00
216_P219_L0.6751.00
248_G310_G0.6711.00
69_S102_N0.6661.00
77_S119_A0.6641.00
291_P294_I0.6631.00
88_C127_I0.6621.00
69_S148_I0.6621.00
175_S179_E0.6611.00
217_K221_I0.6611.00
219_L223_D0.6581.00
37_I41_P0.6581.00
224_Y293_K0.6491.00
33_I40_L0.6451.00
35_K38_Y0.6441.00
209_K212_I0.6441.00
93_M284_F0.6421.00
244_A247_S0.6401.00
109_D138_V0.6401.00
79_S116_T0.6381.00
224_Y297_R0.6371.00
36_F39_N0.6371.00
35_K39_N0.6351.00
230_D242_E0.6351.00
231_A283_S0.6311.00
212_I216_P0.6221.00
174_G302_Y0.6221.00
172_L259_V0.6221.00
173_V298_I0.6211.00
54_D230_D0.6201.00
67_V100_W0.6171.00
275_P281_S0.6161.00
255_L276_L0.6151.00
49_P160_S0.6141.00
209_K213_V0.6141.00
196_G201_I0.6131.00
257_K302_Y0.6131.00
120_I147_I0.6131.00
165_K168_M0.6121.00
276_L280_S0.6121.00
106_L146_I0.6101.00
164_V226_V0.6091.00
174_G179_E0.6081.00
205_A211_D0.6081.00
35_K40_L0.6081.00
101_V131_V0.6071.00
42_I58_L0.6051.00
197_I202_I0.6031.00
61_K156_N0.5991.00
118_S121_S0.5991.00
217_K220_S0.5981.00
60_A63_K0.5971.00
169_K289_N0.5971.00
84_I123_A0.5961.00
64_Y156_N0.5961.00
37_I43_G0.5951.00
44_D58_L0.5920.99
161_Y246_A0.5910.99
112_H116_T0.5910.99
238_Q242_E0.5900.99
215_Q218_A0.5850.99
196_G200_E0.5840.99
163_N170_V0.5830.99
68_H87_A0.5820.99
266_I270_A0.5820.99
262_R265_K0.5810.99
30_K34_N0.5790.99
158_F161_Y0.5780.99
224_Y294_I0.5780.99
78_D210_K0.5770.99
72_I76_K0.5760.99
140_D144_Q0.5740.99
170_V174_G0.5720.99
172_L176_P0.5720.99
204_K210_K0.5710.99
31_V34_N0.5680.99
164_V249_Y0.5680.99
171_V286_A0.5660.99
202_I207_E0.5660.99
110_I113_L0.5650.99
221_I224_Y0.5650.99
87_A149_T0.5630.99
32_P40_L0.5580.99
185_A188_Y0.5580.99
197_I201_I0.5570.99
112_H115_A0.5560.99
32_P37_I0.5540.99
223_D294_I0.5530.99
202_I210_K0.5520.99
295_L298_I0.5510.99
274_D281_S0.5490.99
90_D230_D0.5490.99
244_A250_T0.5460.99
203_E207_E0.5440.99
162_K246_A0.5430.99
111_S114_N0.5410.99
275_P282_G0.5410.99
55_A68_H0.5410.99
64_Y67_V0.5390.99
103_S117_I0.5390.99
211_D215_Q0.5390.99
75_A206_K0.5380.99
249_Y309_R0.5360.99
170_V243_V0.5360.99
30_K37_I0.5340.99
181_T233_E0.5330.99
182_W185_A0.5290.99
198_S202_I0.5290.99
180_G183_I0.5290.99
183_I187_D0.5250.99
126_L214_V0.5240.99
175_S300_E0.5240.99
207_E212_I0.5240.99
276_L282_G0.5230.99
238_Q241_L0.5230.99
112_H143_K0.5220.99
36_F40_L0.5220.99
32_P39_N0.5210.99
220_S224_Y0.5210.99
48_C59_E0.5170.99
205_A212_I0.5170.99
120_I131_V0.5160.99
170_V253_I0.5160.99
239_A242_E0.5120.99
179_E182_W0.5100.98
259_V300_E0.5100.98
63_K67_V0.5090.98
139_S144_Q0.5070.98
241_L313_V0.5060.98
158_F163_N0.5050.98
39_N114_N0.5020.98
178_I183_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fd5A 2 0.9038 100 0.335 Contact Map
3viuA 1 0.9096 100 0.348 Contact Map
3wjpA 2 0.9038 100 0.354 Contact Map
1vk3A 1 0.9009 100 0.359 Contact Map
4lgyA 1 0.93 100 0.366 Contact Map
2zodA 2 0.8251 100 0.368 Contact Map
2z1uA 2 0.8863 100 0.369 Contact Map
2rb9A 2 0.8659 100 0.372 Contact Map
3vtiC 2 0.8222 100 0.384 Contact Map
3u0oA 2 0.8484 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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