GREMLIN Database
Q7LY05 - Uncharacterized protein
UniProt: Q7LY05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (154)
Sequences: 196 (167)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_G82_T4.9401.00
83_P93_Y4.4131.00
43_L110_A3.4520.99
22_A60_L3.2260.98
24_G28_R2.8480.96
23_G28_R2.8480.96
137_Y141_T2.7770.95
45_S72_F2.7490.95
70_T81_P2.4830.91
32_F69_F2.2320.86
86_S89_N2.2310.86
106_P109_I2.1360.83
22_A28_R2.0640.81
36_L106_P2.0030.79
34_P107_V1.9840.78
95_V152_T1.9660.78
140_V154_I1.9440.77
91_V95_V1.9170.76
36_L169_Y1.7860.71
30_T169_Y1.7680.70
48_F99_G1.7590.69
83_P140_V1.7520.69
103_L116_I1.7170.67
38_V43_L1.7110.67
23_G26_G1.6740.65
21_L24_G1.6720.65
41_K49_D1.6570.65
32_F67_P1.5630.60
88_E137_Y1.4660.55
29_I137_Y1.4360.53
128_M141_T1.4150.52
80_F85_I1.3890.51
38_V99_G1.3880.51
21_L28_R1.3720.50
124_C129_C1.3670.50
63_N69_F1.3530.49
151_Y169_Y1.3330.48
51_V58_V1.3220.47
105_L112_I1.3100.46
112_I117_I1.3030.46
22_A117_I1.3000.46
66_H128_M1.2990.46
107_V114_N1.2890.45
59_Y62_I1.2840.45
42_P110_A1.2660.44
114_N168_D1.2650.44
106_P141_T1.2540.44
48_F103_L1.2450.43
103_L166_W1.2310.42
31_L66_H1.2290.42
69_F128_M1.2240.42
62_I103_L1.2010.41
55_S166_W1.1990.41
61_G94_V1.1970.41
44_I60_L1.1910.40
55_S62_I1.1820.40
128_M134_Y1.1820.40
129_C143_W1.1720.39
92_K95_V1.1720.39
87_Y101_P1.1420.38
157_K163_I1.1380.38
113_N116_I1.1370.38
51_V111_F1.1340.37
40_G163_I1.1250.37
44_I142_Y1.1100.36
55_S76_I1.1050.36
143_W158_E1.1030.36
48_F143_W1.0840.35
46_W130_T1.0830.35
60_L143_W1.0710.34
128_M137_Y1.0700.34
63_N91_V1.0670.34
130_T172_A1.0530.33
48_F170_I1.0480.33
27_K83_P1.0470.33
29_I65_S1.0470.33
31_L98_L1.0290.32
30_T130_T1.0150.32
37_V59_Y1.0020.31
130_T166_W0.9800.30
128_M131_L0.9740.30
91_V172_A0.9630.29
41_K78_K0.9590.29
86_S117_I0.9530.29
101_P168_D0.9460.29
94_V98_L0.9440.28
41_K126_V0.9430.28
77_F140_V0.9370.28
60_L111_F0.9300.28
88_E134_Y0.9190.27
38_V42_P0.9150.27
50_A110_A0.9140.27
69_F141_T0.9070.27
90_D108_D0.9040.27
106_P143_W0.9040.27
109_I137_Y0.9030.27
80_F89_N0.8990.27
70_T73_K0.8880.26
66_H161_Y0.8870.26
47_A110_A0.8830.26
55_S131_L0.8690.25
149_S163_I0.8650.25
37_V167_E0.8590.25
88_E141_T0.8570.25
77_F161_Y0.8540.25
63_N84_D0.8410.24
38_V65_S0.8390.24
48_F163_I0.8300.24
41_K136_S0.8180.23
66_H107_V0.8160.23
63_N133_S0.8110.23
140_V147_N0.8080.23
111_F131_L0.8070.23
103_L121_I0.8030.23
43_L163_I0.8020.23
38_V47_A0.7990.23
44_I163_I0.7880.22
138_L157_K0.7820.22
113_N147_N0.7800.22
47_A159_K0.7720.22
141_T153_D0.7710.22
26_G168_D0.7690.22
23_G33_K0.7670.21
24_G33_K0.7670.21
39_C117_I0.7620.21
51_V121_I0.7600.21
136_S164_N0.7580.21
52_N167_E0.7530.21
69_F159_K0.7520.21
38_V92_K0.7450.21
31_L152_T0.7410.21
25_R167_E0.7410.21
98_L102_I0.7400.21
31_L94_V0.7310.20
68_L153_D0.7310.20
125_A128_M0.7280.20
47_A109_I0.7260.20
48_F116_I0.7260.20
46_W56_D0.7210.20
63_N160_L0.7190.20
41_K46_W0.7170.20
120_L124_C0.7120.20
107_V123_R0.7080.19
33_K108_D0.7070.19
33_K90_D0.7070.19
124_C141_T0.7020.19
47_A82_T0.6950.19
154_I161_Y0.6800.19
49_D140_V0.6790.18
90_D139_G0.6710.18
108_D139_G0.6710.18
26_G138_L0.6690.18
76_I140_V0.6620.18
62_I172_A0.6580.18
37_V166_W0.6560.18
113_N158_E0.6550.18
120_L173_N0.6500.18
122_E173_N0.6480.18
46_W117_I0.6460.17
50_A145_G0.6450.17
124_C152_T0.6340.17
70_T94_V0.6330.17
125_A134_Y0.6330.17
41_K82_T0.6290.17
61_G105_L0.6290.17
95_V155_E0.6270.17
161_Y171_K0.6260.17
110_A160_L0.6240.17
154_I160_L0.6200.17
58_V113_N0.6170.17
64_Q113_N0.6170.17
36_L171_K0.6160.17
27_K150_N0.6140.16
44_I61_G0.6130.16
132_K165_T0.6100.16
27_K161_Y0.6090.16
29_I101_P0.6090.16
68_L146_L0.6040.16
28_R33_K0.6030.16
118_N121_I0.6020.16
88_E161_Y0.5930.16
117_I150_N0.5920.16
48_F77_F0.5910.16
120_L166_W0.5840.16
68_L98_L0.5770.15
58_V154_I0.5760.15
99_G135_G0.5760.15
77_F145_G0.5740.15
109_I142_Y0.5740.15
127_D131_L0.5720.15
26_G34_P0.5710.15
88_E91_V0.5700.15
104_V114_N0.5680.15
137_Y142_Y0.5630.15
32_F63_N0.5630.15
51_V55_S0.5630.15
77_F150_N0.5600.15
128_M143_W0.5600.15
56_D140_V0.5590.15
80_F121_I0.5580.15
25_R78_K0.5550.15
103_L131_L0.5520.15
154_I162_N0.5490.15
106_P172_A0.5440.15
30_T71_I0.5440.15
29_I106_P0.5410.14
140_V157_K0.5380.14
73_K101_P0.5370.14
21_L26_G0.5300.14
95_V145_G0.5280.14
46_W145_G0.5270.14
38_V172_A0.5260.14
133_S174_K0.5240.14
40_G107_V0.5220.14
51_V91_V0.5200.14
134_Y159_K0.5190.14
21_L58_V0.5170.14
62_I125_A0.5170.14
70_T103_L0.5170.14
30_T124_C0.5130.14
27_K164_N0.5130.14
22_A46_W0.5110.14
69_F160_L0.5080.14
48_F53_K0.5080.14
113_N122_E0.5060.14
134_Y141_T0.5010.13
58_V174_K0.5010.13
88_E109_I0.5000.13
87_Y108_D0.5000.13
87_Y90_D0.5000.13
75_S122_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rsbA 1 0.8547 99.9 0.62 Contact Map
2wawA 1 0.9274 99.9 0.661 Contact Map
3ngwA 2 0.8883 99.9 0.67 Contact Map
2weeA 1 0.9106 99.9 0.675 Contact Map
1vpaA 2 0.933 99.9 0.683 Contact Map
2e8bA 1 0.8827 99.9 0.684 Contact Map
1e5kA 1 0.8771 99.9 0.685 Contact Map
3d5nA 2 0.8492 99.8 0.686 Contact Map
1i52A 2 0.9218 99.8 0.691 Contact Map
1vgwA 2 0.8939 99.8 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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