GREMLIN Database
Q7LY04 - Uncharacterized protein
UniProt: Q7LY04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (221)
Sequences: 171 (148)
Seq/√Len: 10.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_K202_N3.9820.99
109_L113_L3.9750.99
59_S187_Y3.6740.98
202_N205_R3.6380.98
141_I201_L3.2650.95
144_S158_M3.1140.94
62_S68_V3.0970.94
196_I200_L2.9760.92
148_S156_V2.9100.91
65_F109_L2.7530.89
199_D224_D2.7050.88
119_S187_Y2.6510.87
49_I231_I2.5530.85
206_I215_I2.5400.84
71_E102_N2.4450.82
45_R200_L2.3210.78
84_V88_G2.2050.75
59_S122_L2.0920.71
187_Y227_F2.0630.69
59_S202_N2.0400.69
44_N183_P2.0020.67
10_F158_M1.9570.65
119_S122_L1.9080.63
140_V194_T1.8760.62
107_V112_A1.8510.61
81_E93_I1.8260.60
32_G212_P1.7900.58
67_L196_I1.7800.57
62_S190_S1.7720.57
199_D230_G1.7530.56
72_V103_T1.7210.55
112_A202_N1.6900.53
118_V202_N1.6550.52
164_S228_V1.6420.51
67_L124_Y1.5780.48
79_I204_R1.5320.46
118_V165_I1.4980.45
112_A205_R1.4980.45
224_D230_G1.4970.45
109_L121_F1.4900.44
32_G37_L1.4620.43
46_D113_L1.4490.42
123_M133_F1.4460.42
190_S220_M1.4440.42
220_M233_S1.4250.41
59_S119_S1.4190.41
137_I148_S1.4010.40
41_V62_S1.4000.40
116_L165_I1.3970.40
205_R208_N1.3960.40
34_F229_S1.3920.40
220_M230_G1.3890.40
145_K204_R1.3850.40
222_T234_V1.3810.39
69_L113_L1.3550.38
143_V166_F1.3430.38
44_N47_I1.3330.37
41_V68_V1.3300.37
21_L105_I1.3260.37
15_R19_Y1.3010.36
187_Y212_P1.2940.36
203_L237_S1.2780.35
122_L227_F1.2660.35
37_L235_F1.2460.34
171_S182_I1.2360.33
69_L156_V1.2360.33
73_K102_N1.2310.33
105_I215_I1.2240.33
60_L87_F1.2220.33
57_F139_V1.2210.33
145_K205_R1.2170.33
17_L165_I1.2130.32
14_F105_I1.1950.32
147_F162_I1.1810.31
134_I201_L1.1750.31
40_I171_S1.1720.31
114_I194_T1.1690.31
148_S158_M1.1630.30
225_G230_G1.1510.30
159_H163_P1.1390.29
14_F18_L1.1370.29
158_M163_P1.1350.29
156_V199_D1.1330.29
18_L48_A1.1280.29
40_I188_I1.1230.29
187_Y191_V1.1230.29
91_I112_A1.1170.29
74_K103_T1.1150.29
41_V45_R1.0990.28
134_I138_I1.0880.28
38_F187_Y1.0770.27
25_I60_L1.0750.27
40_I236_I1.0740.27
12_G29_I1.0680.27
217_I228_V1.0670.27
91_I95_R1.0630.27
38_F227_F1.0600.27
28_L174_L1.0530.26
199_D220_M1.0470.26
109_L134_I1.0400.26
216_S224_D1.0320.26
122_L187_Y1.0220.25
116_L189_G1.0210.25
113_L173_V1.0100.25
24_L152_R1.0090.25
216_S230_G1.0050.25
108_N155_G1.0040.25
212_P227_F1.0020.25
67_L125_E0.9890.24
19_Y131_V0.9870.24
154_V166_F0.9870.24
17_L26_M0.9830.24
16_S21_L0.9810.24
105_I133_F0.9730.24
21_L139_V0.9680.23
156_V224_D0.9620.23
167_S233_S0.9570.23
196_I226_I0.9570.23
220_M224_D0.9390.22
87_F185_S0.9390.22
138_I188_I0.9370.22
40_I68_V0.9360.22
44_N48_A0.9350.22
171_S191_V0.9320.22
138_I233_S0.9310.22
63_S199_D0.9230.22
148_S175_F0.9230.22
79_I113_L0.9160.22
18_L147_F0.9030.21
180_I188_I0.8980.21
20_F131_V0.8970.21
107_V139_V0.8970.21
26_M124_Y0.8950.21
156_V190_S0.8910.21
65_F121_F0.8900.21
107_V113_L0.8890.21
18_L228_V0.8870.21
71_E189_G0.8850.21
112_A145_K0.8790.21
198_A224_D0.8770.21
164_S225_G0.8730.20
139_V158_M0.8680.20
37_L62_S0.8650.20
46_D69_L0.8590.20
76_A204_R0.8560.20
74_K184_L0.8540.20
104_L165_I0.8520.20
75_E226_I0.8500.20
37_L40_I0.8460.20
11_R143_V0.8400.19
198_A217_I0.8400.19
148_S163_P0.8340.19
27_A56_S0.8320.19
216_S225_G0.8270.19
46_D237_S0.8260.19
156_V200_L0.8250.19
217_I220_M0.8250.19
22_L33_Y0.8240.19
61_F142_I0.8230.19
116_L148_S0.8170.19
151_I157_I0.8130.19
154_V157_I0.8100.19
63_S191_V0.8080.19
18_L202_N0.8070.19
13_L135_I0.8060.19
10_F231_I0.8040.18
212_P215_I0.8020.18
106_A161_I0.8020.18
188_I193_G0.8000.18
164_S199_D0.8000.18
22_L166_F0.7990.18
48_A132_Y0.7980.18
196_I230_G0.7930.18
117_G167_S0.7910.18
89_F126_L0.7910.18
23_G58_L0.7870.18
139_V172_Y0.7850.18
33_Y191_V0.7850.18
23_G222_T0.7840.18
134_I208_N0.7830.18
22_L183_P0.7810.18
37_L68_V0.7800.18
56_S122_L0.7790.18
140_V143_V0.7780.18
102_N142_I0.7750.18
21_L120_L0.7710.18
38_F191_V0.7710.18
93_I170_S0.7600.17
51_I163_P0.7600.17
49_I131_V0.7590.17
216_S236_I0.7560.17
66_N216_S0.7530.17
74_K210_A0.7510.17
123_M231_I0.7490.17
93_I142_I0.7480.17
160_P191_V0.7410.17
187_Y194_T0.7370.17
44_N161_I0.7370.17
167_S232_I0.7350.17
18_L200_L0.7330.17
109_L139_V0.7330.17
151_I206_I0.7290.16
107_V216_S0.7290.16
25_I82_D0.7270.16
31_A56_S0.7230.16
150_V209_E0.7210.16
43_I69_L0.7200.16
8_S188_I0.7180.16
139_V170_S0.7150.16
220_M236_I0.7150.16
67_L232_I0.7150.16
112_A227_F0.7150.16
187_Y236_I0.7120.16
119_S227_F0.7030.16
171_S211_R0.7000.16
34_F37_L0.6990.16
21_L121_F0.6980.16
117_G135_I0.6980.16
27_A113_L0.6970.16
150_V191_V0.6970.16
203_L217_I0.6940.16
187_Y202_N0.6910.16
186_A190_S0.6900.16
77_I104_L0.6880.15
164_S224_D0.6880.15
148_S202_N0.6860.15
150_V211_R0.6860.15
10_F144_S0.6850.15
96_I145_K0.6850.15
63_S198_A0.6840.15
216_S220_M0.6790.15
199_D225_G0.6780.15
209_E212_P0.6760.15
19_Y22_L0.6750.15
50_I139_V0.6720.15
36_Q226_I0.6710.15
119_S194_T0.6700.15
218_G221_G0.6690.15
140_V170_S0.6670.15
61_F120_L0.6600.15
133_F137_I0.6600.15
60_L212_P0.6590.15
69_L120_L0.6550.15
105_I142_I0.6540.15
228_V232_I0.6510.15
15_R104_L0.6440.14
87_F173_V0.6430.14
96_I173_V0.6420.14
163_P236_I0.6410.14
227_F234_V0.6390.14
75_E207_I0.6350.14
21_L137_I0.6330.14
120_L208_N0.6320.14
171_S175_F0.6320.14
135_I138_I0.6310.14
103_T223_F0.6310.14
17_L28_L0.6290.14
121_F172_Y0.6290.14
23_G27_A0.6200.14
26_M123_M0.6190.14
27_A185_S0.6180.14
10_F137_I0.6170.14
167_S191_V0.6160.14
13_L162_I0.6160.14
164_S187_Y0.6160.14
26_M231_I0.6150.14
24_L114_I0.6140.14
32_G60_L0.6130.14
84_V90_P0.6080.14
222_T236_I0.6050.14
157_I202_N0.6040.14
164_S230_G0.6030.14
68_V190_S0.6020.14
26_M117_G0.6010.14
164_S167_S0.6010.14
35_S49_I0.5980.13
131_V232_I0.5970.13
67_L148_S0.5970.13
159_H231_I0.5960.13
199_D217_I0.5940.13
131_V168_V0.5930.13
123_M126_L0.5910.13
123_M160_P0.5890.13
33_Y93_I0.5880.13
15_R21_L0.5860.13
191_V211_R0.5830.13
190_S233_S0.5820.13
61_F192_L0.5810.13
79_I211_R0.5800.13
65_F102_N0.5800.13
42_G194_T0.5790.13
58_L122_L0.5740.13
156_V195_L0.5700.13
86_F157_I0.5660.13
144_S194_T0.5630.13
66_N224_D0.5600.13
59_S227_F0.5600.13
89_F92_F0.5570.13
126_L144_S0.5530.13
36_Q169_I0.5510.12
120_L192_L0.5480.12
36_Q176_Y0.5450.12
148_S182_I0.5430.12
67_L228_V0.5420.12
32_G227_F0.5410.12
33_Y208_N0.5410.12
144_S233_S0.5400.12
114_I211_R0.5390.12
79_I208_N0.5330.12
202_N224_D0.5310.12
12_G180_I0.5300.12
91_I163_P0.5300.12
164_S189_G0.5300.12
14_F122_L0.5290.12
88_G112_A0.5290.12
144_S166_F0.5280.12
19_Y173_V0.5260.12
18_L50_I0.5250.12
66_N217_I0.5250.12
95_R135_I0.5230.12
66_N199_D0.5230.12
63_S224_D0.5190.12
51_I173_V0.5170.12
32_G231_I0.5170.12
56_S68_V0.5130.12
19_Y76_A0.5100.12
18_L30_S0.5100.12
44_N142_I0.5090.12
105_I144_S0.5080.12
96_I175_F0.5080.12
163_P166_F0.5030.12
156_V214_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j5pB 3 0.2922 2.6 0.974 Contact Map
3ffvA 1 0.2469 2.4 0.975 Contact Map
1rq8A 1 0.1975 1.9 0.976 Contact Map
3ar4A 1 0.3086 1.7 0.977 Contact Map
3ixzA 1 0.3374 1.6 0.977 Contact Map
2kncB 1 0.1564 1.4 0.978 Contact Map
4j7cI 2 0.358 1.4 0.978 Contact Map
4czbA 2 0.8848 1.3 0.978 Contact Map
1ckkB 1 0.0412 1.1 0.979 Contact Map
4ezcA 3 0.3498 1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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