GREMLIN Database
Q7LY02 - Uncharacterized protein
UniProt: Q7LY02 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (219)
Sequences: 318 (249)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_G85_M5.7141.00
59_L141_A3.6681.00
70_A138_I3.6621.00
163_A215_D3.6541.00
32_V37_L3.6321.00
170_G173_I3.5581.00
157_L214_F3.3200.99
29_P62_G3.2560.99
173_I176_L3.1550.99
101_I125_V3.0130.99
139_I144_M2.8750.98
170_G176_L2.8710.98
157_L225_A2.8080.98
224_L229_Y2.6880.97
59_L142_D2.4070.94
73_F77_R2.2250.92
42_E99_S2.2040.91
38_R95_H2.1310.90
43_E220_G2.0840.89
16_L106_V2.0760.88
116_V128_I2.0620.88
158_F204_I1.9990.86
132_V138_I1.9850.86
149_A154_A1.9670.85
15_V145_S1.9240.84
18_L23_I1.8950.83
103_A127_L1.8330.81
59_L145_S1.8210.81
138_I194_T1.7360.77
166_I170_G1.6930.75
70_A104_I1.6900.75
166_I172_V1.6850.75
60_H141_A1.6700.74
22_L216_G1.6500.73
204_I211_A1.6360.73
58_L71_S1.6340.73
141_A145_S1.6310.73
15_V142_D1.6010.71
172_V204_I1.5860.70
23_I88_L1.5630.69
26_K131_D1.5550.69
17_K20_G1.5480.68
145_S156_L1.5480.68
85_M135_D1.5370.68
118_S122_K1.5140.67
178_G182_V1.5020.66
62_G142_D1.4880.65
16_L37_L1.4710.64
24_T31_C1.4580.64
146_I203_K1.4530.63
44_I94_K1.3910.60
81_T85_M1.3760.59
142_D145_S1.3530.58
41_S205_F1.3170.56
59_L128_I1.3160.56
214_F225_A1.3080.55
34_L91_I1.2960.54
160_I201_I1.2660.53
24_T88_L1.2470.51
28_V31_C1.2450.51
41_S96_L1.2340.51
32_V91_I1.2280.50
16_L157_L1.2200.50
37_L91_I1.2150.50
159_A216_G1.2090.49
163_A166_I1.2060.49
62_G84_A1.2030.49
143_D203_K1.2020.49
66_G130_G1.2000.49
43_E221_N1.1800.47
29_P84_A1.1790.47
159_A211_A1.1700.47
16_L214_F1.1680.47
160_I213_I1.1590.46
15_V141_A1.1500.46
96_L101_I1.1470.45
31_C174_S1.1370.45
116_V222_I1.1360.45
106_V119_A1.1150.44
201_I213_I1.1070.43
30_R84_A1.1030.43
70_A85_M1.1020.43
70_A135_D1.0850.42
172_V175_E1.0820.42
226_L229_Y1.0810.42
85_M142_D1.0800.42
39_R43_E1.0640.41
16_L101_I1.0630.41
160_I197_I1.0600.40
77_R135_D1.0580.40
29_P68_Y1.0550.40
58_L213_I1.0510.40
70_A132_V1.0510.40
58_L73_F1.0360.39
15_V102_K1.0230.38
15_V148_I1.0160.38
225_A228_G1.0150.38
18_L138_I1.0120.38
62_G69_E1.0080.37
70_A215_D0.9970.37
85_M141_A0.9890.36
216_G221_N0.9860.36
77_R81_T0.9860.36
94_K187_Q0.9860.36
231_I235_V0.9840.36
21_S82_S0.9800.36
177_R180_D0.9790.36
66_G85_M0.9780.36
179_I186_M0.9740.36
172_V211_A0.9720.35
82_S225_A0.9580.35
93_A100_G0.9530.34
45_R231_I0.9520.34
221_N235_V0.9500.34
198_L202_K0.9440.34
155_R210_N0.9430.34
206_E226_L0.9390.34
85_M216_G0.9380.34
35_E150_K0.9310.33
15_V120_L0.9280.33
113_F135_D0.9280.33
41_S95_H0.9250.33
30_R87_E0.9200.33
137_S235_V0.9120.32
29_P85_M0.9120.32
199_S204_I0.9080.32
19_G24_T0.9010.32
20_G24_T0.9010.32
210_N213_I0.8980.32
57_I162_K0.8970.32
119_A134_F0.8940.31
140_S194_T0.8920.31
47_F226_L0.8900.31
62_G129_Y0.8890.31
64_S196_G0.8820.31
24_T64_S0.8810.31
18_L37_L0.8780.31
172_V176_L0.8720.30
169_G172_V0.8700.30
64_S141_A0.8640.30
127_L134_F0.8630.30
143_D211_A0.8600.30
93_A127_L0.8580.30
75_D81_T0.8490.29
43_E215_D0.8460.29
215_D218_K0.8450.29
159_A221_N0.8420.29
33_K181_E0.8390.29
81_T135_D0.8370.29
57_I206_E0.8350.28
45_R49_N0.8310.28
156_L210_N0.8260.28
107_P125_V0.8200.28
81_T84_A0.8180.28
96_L103_A0.8170.28
60_H89_N0.8120.27
140_S193_I0.8080.27
36_V62_G0.8080.27
116_V171_G0.8030.27
96_L107_P0.8010.27
77_R208_N0.7990.27
98_K103_A0.7970.27
160_I167_G0.7970.27
171_G189_N0.7940.26
85_M138_I0.7920.26
180_D208_N0.7890.26
139_I224_L0.7820.26
117_L148_I0.7810.26
59_L229_Y0.7800.26
78_I134_F0.7780.26
37_L158_F0.7740.26
123_D138_I0.7710.25
81_T129_Y0.7710.25
35_E234_L0.7650.25
60_H140_S0.7650.25
132_V194_T0.7650.25
86_Q129_Y0.7640.25
17_K24_T0.7600.25
211_A216_G0.7580.25
109_K167_G0.7560.25
62_G68_Y0.7540.25
165_I226_L0.7540.25
33_K93_A0.7530.25
131_D141_A0.7520.25
15_V59_L0.7490.24
23_I185_L0.7460.24
145_S158_F0.7440.24
39_R44_I0.7420.24
220_G225_A0.7410.24
98_K177_R0.7400.24
16_L149_A0.7390.24
82_S106_V0.7360.24
170_G175_E0.7330.24
33_K75_D0.7280.24
15_V144_M0.7270.24
117_L120_L0.7260.23
108_G179_I0.7250.23
44_I154_A0.7240.23
169_G176_L0.7170.23
148_I188_T0.7170.23
133_K143_D0.7140.23
154_A165_I0.7140.23
121_E147_D0.7120.23
60_H70_A0.7120.23
45_R105_S0.7120.23
31_C92_V0.7070.23
128_I141_A0.7060.23
18_L29_P0.7050.23
15_V57_I0.7020.22
145_S154_A0.6970.22
73_F116_V0.6960.22
75_D199_S0.6950.22
69_E138_I0.6920.22
161_D215_D0.6900.22
86_Q138_I0.6840.22
96_L127_L0.6820.22
118_S185_L0.6810.22
15_V154_A0.6770.21
104_I133_K0.6770.21
68_Y84_A0.6760.21
150_K206_E0.6740.21
24_T191_Y0.6730.21
139_I202_K0.6720.21
99_S201_I0.6700.21
80_R83_E0.6700.21
158_F194_T0.6650.21
17_K21_S0.6620.21
57_I181_E0.6610.21
143_D199_S0.6540.21
85_M214_F0.6470.20
59_L209_L0.6440.20
25_C103_A0.6440.20
68_Y129_Y0.6440.20
20_G26_K0.6390.20
19_G26_K0.6390.20
70_A77_R0.6330.20
15_V128_I0.6310.20
22_L141_A0.6290.20
37_L198_L0.6250.19
48_V107_P0.6230.19
102_K124_L0.6210.19
135_D143_D0.6200.19
110_F224_L0.6150.19
45_R114_D0.6140.19
60_H66_G0.6120.19
95_H118_S0.6120.19
60_H131_D0.6100.19
33_K174_S0.6070.19
221_N224_L0.6050.19
82_S145_S0.5990.18
72_I212_L0.5990.18
56_I165_I0.5860.18
177_R181_E0.5840.18
58_L125_V0.5830.18
123_D126_P0.5820.18
28_V199_S0.5810.18
21_S208_N0.5800.18
131_D138_I0.5730.18
22_L77_R0.5690.17
58_L212_L0.5690.17
71_S147_D0.5680.17
43_E228_G0.5670.17
144_M149_A0.5630.17
37_L92_V0.5620.17
108_G197_I0.5620.17
197_I232_G0.5610.17
25_C98_K0.5610.17
114_D182_V0.5580.17
65_F196_G0.5570.17
55_K121_E0.5560.17
26_K67_H0.5550.17
39_R78_I0.5540.17
58_L104_I0.5500.17
155_R204_I0.5500.17
215_D221_N0.5490.17
77_R85_M0.5480.17
13_Y94_K0.5480.17
96_L199_S0.5480.17
96_L182_V0.5460.17
197_I211_A0.5450.17
154_A180_D0.5440.17
129_Y176_L0.5440.17
66_G215_D0.5420.17
81_T141_A0.5420.17
65_F201_I0.5410.16
166_I171_G0.5410.16
193_I196_G0.5400.16
24_T107_P0.5360.16
81_T128_I0.5360.16
17_K26_K0.5350.16
90_Y142_D0.5350.16
163_A172_V0.5350.16
75_D141_A0.5310.16
22_L234_L0.5300.16
30_R68_Y0.5290.16
73_F197_I0.5280.16
154_A159_A0.5210.16
115_A222_I0.5200.16
159_A214_F0.5200.16
64_S193_I0.5200.16
158_F213_I0.5190.16
68_Y85_M0.5160.16
56_I229_Y0.5150.16
33_K178_G0.5140.16
82_S156_L0.5120.16
157_L193_I0.5120.16
85_M232_G0.5120.16
56_I154_A0.5120.16
30_R58_L0.5120.16
62_G162_K0.5120.16
70_A89_N0.5110.16
132_V212_L0.5110.16
159_A190_Y0.5100.15
76_N80_R0.5100.15
150_K174_S0.5090.15
32_V85_M0.5080.15
120_L126_P0.5070.15
89_N105_S0.5070.15
177_R222_I0.5060.15
134_F153_N0.5060.15
101_I175_E0.5040.15
14_R56_I0.5030.15
60_H88_L0.5030.15
155_R166_I0.5030.15
85_M144_M0.5020.15
27_D41_S0.5020.15
144_M160_I0.5020.15
59_L204_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll9A 2 0.8755 100 0.523 Contact Map
3ll5A 2 0.8797 100 0.523 Contact Map
3k4oA 2 0.9419 100 0.526 Contact Map
3d40A 2 0.8714 100 0.574 Contact Map
1gs5A 2 0.8963 100 0.596 Contact Map
4ndoB 3 0.9295 100 0.598 Contact Map
4ndoA 3 0.917 100 0.599 Contact Map
3wwnA 2 0.8257 100 0.605 Contact Map
2j5vA 2 0.805 100 0.606 Contact Map
4a7wA 2 0.8714 100 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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