GREMLIN Database
Q7LXZ6 - Uncharacterized protein
UniProt: Q7LXZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (314)
Sequences: 187 (137)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_K135_D4.3860.98
81_A110_F3.8920.96
99_I134_L3.4820.93
159_D187_K3.4620.93
306_S310_V3.2890.91
17_P87_D3.1650.89
222_F242_Y2.9320.85
161_G188_F2.9120.85
20_C23_C2.7930.82
54_N106_F2.7160.80
203_N206_S2.6050.77
309_I313_L2.6010.77
309_I312_D2.5740.76
42_Y209_F2.5680.76
171_K227_D2.4740.73
87_D329_E2.4640.73
34_T91_E2.4550.73
133_G185_N2.4310.72
146_Y269_E2.4090.71
126_M131_N2.4070.71
17_P242_Y2.3390.69
221_S248_K2.3140.68
38_D117_T2.2360.65
75_R229_L2.1770.63
74_Y105_E2.1750.63
137_M186_V2.1690.63
79_L126_M2.0420.58
139_F150_V1.9640.55
30_V113_H1.9300.53
169_N241_H1.9230.53
68_D101_E1.9120.53
113_H192_N1.8950.52
59_N76_M1.8770.51
43_Y225_A1.8690.51
160_I168_P1.8460.50
123_D155_K1.8410.50
45_P80_G1.8370.50
126_M130_V1.7800.47
35_G204_L1.7540.46
17_P139_F1.7530.46
211_A217_G1.7350.46
191_L284_T1.7250.45
140_H192_N1.7170.45
74_Y187_K1.7140.45
17_P153_A1.7110.45
113_H140_H1.6780.43
164_L174_I1.6680.43
317_Y321_I1.6630.43
164_L191_L1.6430.42
87_D90_L1.6420.42
98_I216_T1.6350.42
291_L294_F1.6210.41
126_M218_V1.6100.41
139_F153_A1.6070.40
257_F330_H1.6000.40
30_V140_H1.5870.40
79_L111_H1.5750.39
19_G28_K1.5680.39
126_M156_Y1.5430.38
30_V256_R1.5430.38
129_L185_N1.5390.38
118_G153_A1.5170.37
28_K113_H1.5070.37
193_E208_G1.5050.37
30_V192_N1.5000.36
82_G217_G1.4950.36
45_P195_E1.4950.36
140_H256_R1.4940.36
127_R218_V1.4930.36
34_T84_T1.4720.35
100_E128_E1.4640.35
174_I197_N1.4530.35
139_F146_Y1.4500.35
113_H195_E1.4450.34
95_V255_T1.4440.34
63_V69_V1.4200.33
68_D259_R1.4160.33
83_I164_L1.4030.33
150_V166_A1.4020.33
300_S315_N1.3950.33
121_V126_M1.3820.32
175_V227_D1.3680.32
138_R190_N1.3670.32
115_Y138_R1.3670.32
115_Y190_N1.3670.32
19_G188_F1.3660.32
14_G240_V1.3520.31
19_G80_G1.3440.31
162_L181_A1.3400.31
313_L326_I1.3380.31
31_L80_G1.3370.31
65_N207_K1.3330.30
150_V196_L1.3270.30
23_C26_G1.3250.30
20_C26_G1.3250.30
17_P90_L1.3200.30
96_I289_P1.3160.30
77_K101_E1.3160.30
83_I99_I1.3040.29
113_H188_F1.2980.29
225_A327_V1.2810.29
171_K175_V1.2790.29
42_Y261_I1.2680.28
188_F192_N1.2630.28
89_I150_V1.2560.28
140_H195_E1.2500.28
113_H256_R1.2450.27
31_L58_A1.2430.27
310_V313_L1.2340.27
30_V195_E1.2310.27
57_F249_D1.2290.27
162_L244_S1.2270.27
311_G317_Y1.2130.26
147_L172_D1.2090.26
192_N195_E1.2070.26
19_G23_C1.1990.26
306_S324_I1.1990.26
97_E122_N1.1970.26
113_H161_G1.1890.26
33_I146_Y1.1830.26
226_L242_Y1.1800.25
21_E27_G1.1730.25
53_K67_M1.1730.25
192_N256_R1.1670.25
153_A160_I1.1640.25
162_L209_F1.1630.25
47_S58_A1.1560.25
181_A208_G1.1540.25
69_V197_N1.1520.25
191_L282_V1.1510.25
161_G192_N1.1510.25
126_M152_V1.1310.24
77_K263_Y1.1190.24
172_D268_Y1.1170.24
196_L250_L1.1130.23
19_G35_G1.1100.23
80_G195_E1.1090.23
105_E296_E1.1070.23
118_G232_F1.1060.23
304_S314_L1.0940.23
162_L222_F1.0910.23
52_G166_A1.0770.22
237_K271_Y1.0660.22
51_F280_A1.0660.22
140_H188_F1.0650.22
28_K161_G1.0570.22
129_L133_G1.0470.22
316_D323_E1.0440.22
188_F256_R1.0350.21
76_M260_I1.0350.21
137_M254_R1.0300.21
81_A99_I1.0220.21
229_L240_V1.0180.21
68_D167_I1.0180.21
147_L162_L1.0160.21
99_I133_G1.0160.21
130_V152_V1.0150.21
324_I330_H1.0140.21
95_V112_I1.0090.21
29_L56_I1.0080.21
54_N265_S1.0080.21
111_H159_D1.0050.20
19_G161_G1.0040.20
170_E191_L1.0040.20
132_A183_E0.9970.20
82_G253_T0.9960.20
134_L242_Y0.9930.20
166_A194_L0.9870.20
72_E111_H0.9830.20
102_L112_I0.9770.20
111_H132_A0.9760.20
93_G288_I0.9740.20
247_Y257_F0.9700.20
46_V199_R0.9700.20
154_L247_Y0.9600.19
60_E195_E0.9580.19
139_F191_L0.9550.19
33_I305_I0.9540.19
133_G221_S0.9540.19
21_E150_V0.9470.19
96_I123_D0.9460.19
29_L33_I0.9450.19
110_F244_S0.9260.18
83_I95_V0.9230.18
134_L196_L0.9200.18
35_G45_P0.9190.18
46_V113_H0.9180.18
118_G139_F0.9170.18
140_H161_G0.9170.18
30_V249_D0.9110.18
35_G256_R0.9060.18
93_G123_D0.9060.18
195_E254_R0.9030.18
14_G87_D0.9020.18
46_V192_N0.9010.18
229_L327_V0.9010.18
240_V258_F0.9000.18
110_F220_G0.8980.18
255_T325_Y0.8970.18
89_I152_V0.8860.18
43_Y161_G0.8840.17
167_I209_F0.8840.17
42_Y133_G0.8830.17
112_I238_I0.8820.17
191_L196_L0.8820.17
323_E326_I0.8820.17
207_K230_K0.8820.17
324_I327_V0.8770.17
26_G32_F0.8760.17
30_V188_F0.8750.17
27_G112_I0.8700.17
134_L164_L0.8630.17
72_E140_H0.8600.17
30_V161_G0.8600.17
131_N145_L0.8590.17
72_E256_R0.8590.17
71_Y189_V0.8510.17
43_Y80_G0.8510.17
30_V84_T0.8480.17
40_N52_G0.8480.17
50_R62_E0.8450.17
35_G192_N0.8420.17
84_T113_H0.8420.17
87_D120_Y0.8270.16
171_K228_V0.8250.16
81_A121_V0.8180.16
53_K194_L0.8140.16
45_P275_A0.8120.16
197_N247_Y0.8110.16
100_E150_V0.8100.16
134_L167_I0.8070.16
35_G161_G0.8060.16
81_A102_L0.8030.16
49_D164_L0.8010.16
228_V326_I0.7990.16
228_V325_Y0.7940.15
279_R307_P0.7890.15
50_R59_N0.7880.15
100_E264_S0.7870.15
60_E256_R0.7800.15
209_F262_K0.7740.15
27_G279_R0.7700.15
84_T254_R0.7700.15
242_Y270_E0.7680.15
93_G146_Y0.7630.15
52_G208_G0.7620.15
24_R95_V0.7620.15
247_Y258_F0.7610.15
301_D314_L0.7610.15
17_P281_I0.7580.15
302_E309_I0.7560.15
205_N285_K0.7540.15
35_G275_A0.7530.15
130_V219_E0.7530.15
294_F298_T0.7530.15
81_A269_E0.7510.15
35_G80_G0.7480.15
304_S310_V0.7470.15
89_I93_G0.7470.15
145_L201_Y0.7460.14
98_I189_V0.7460.14
67_M227_D0.7440.14
59_N256_R0.7410.14
38_D151_K0.7410.14
131_N185_N0.7370.14
137_M148_N0.7370.14
195_E256_R0.7370.14
35_G113_H0.7360.14
285_K326_I0.7350.14
126_M231_K0.7340.14
34_T195_E0.7340.14
132_A196_L0.7330.14
80_G275_A0.7330.14
33_I291_L0.7290.14
29_L101_E0.7230.14
261_I280_A0.7210.14
123_D209_F0.7190.14
35_G195_E0.7120.14
17_P118_G0.7120.14
247_Y284_T0.7110.14
305_I314_L0.7100.14
34_T254_R0.7100.14
88_P221_S0.7090.14
269_E277_V0.7090.14
209_F274_E0.7040.14
29_L58_A0.7030.14
89_I156_Y0.7030.14
35_G198_S0.6950.14
84_T220_G0.6950.14
57_F223_E0.6920.13
28_K195_E0.6920.13
314_L327_V0.6900.13
78_A81_A0.6890.13
110_F269_E0.6880.13
177_L268_Y0.6850.13
68_D303_Y0.6830.13
34_T282_V0.6800.13
172_D266_K0.6750.13
45_P140_H0.6730.13
114_L167_I0.6720.13
35_G188_F0.6710.13
196_L216_T0.6690.13
28_K192_N0.6670.13
241_H251_V0.6670.13
95_V306_S0.6670.13
100_E183_E0.6660.13
141_P276_T0.6650.13
30_V45_P0.6640.13
50_R256_R0.6620.13
259_R276_T0.6610.13
302_E313_L0.6610.13
97_E218_V0.6610.13
60_E249_D0.6600.13
117_T120_Y0.6600.13
107_G279_R0.6590.13
301_D321_I0.6570.13
54_N102_L0.6570.13
78_A113_H0.6550.13
37_C163_E0.6550.13
37_C165_P0.6550.13
37_C243_C0.6550.13
41_C136_E0.6550.13
41_C163_E0.6550.13
41_C85_G0.6550.13
136_E163_E0.6550.13
136_E165_P0.6550.13
136_E243_C0.6550.13
86_G165_P0.6550.13
41_C86_G0.6550.13
41_C165_P0.6550.13
41_C243_C0.6550.13
37_C136_E0.6550.13
37_C86_G0.6550.13
86_G163_E0.6550.13
86_G243_C0.6550.13
165_P243_C0.6550.13
163_E243_C0.6550.13
86_G136_E0.6550.13
85_G243_C0.6550.13
85_G165_P0.6550.13
85_G163_E0.6550.13
37_C41_C0.6550.13
37_C85_G0.6550.13
85_G136_E0.6550.13
146_Y247_Y0.6530.13
214_G246_I0.6510.13
192_N245_S0.6510.13
126_M153_A0.6500.13
113_H276_T0.6500.13
290_I295_G0.6500.13
130_V158_I0.6490.13
301_D304_S0.6480.13
148_N205_N0.6470.13
46_V188_F0.6470.13
134_L158_I0.6430.13
66_S193_E0.6430.13
121_V149_A0.6420.13
301_D315_N0.6410.13
304_S327_V0.6400.13
30_V60_E0.6390.12
46_V140_H0.6390.12
284_T322_N0.6380.12
300_S329_E0.6330.12
145_L151_K0.6310.12
226_L282_V0.6290.12
103_K106_F0.6290.12
32_F289_P0.6260.12
82_G195_E0.6260.12
69_V257_F0.6260.12
305_I326_I0.6240.12
127_R303_Y0.6220.12
100_E176_R0.6210.12
192_N257_F0.6200.12
148_N207_K0.6180.12
167_I186_V0.6180.12
132_A221_S0.6140.12
304_S308_S0.6130.12
46_V280_A0.6120.12
51_F98_I0.6110.12
97_E137_M0.6110.12
121_V166_A0.6090.12
207_K227_D0.6040.12
168_P187_K0.6000.12
305_I323_E0.5990.12
139_F324_I0.5980.12
271_Y303_Y0.5970.12
99_I112_I0.5960.12
39_D114_L0.5960.12
159_D186_V0.5940.12
68_D230_K0.5940.12
89_I121_V0.5920.12
146_Y257_F0.5910.12
35_G103_K0.5880.12
45_P113_H0.5880.12
77_K133_G0.5860.12
66_S97_E0.5830.12
161_G256_R0.5830.12
171_K288_I0.5820.12
45_P249_D0.5790.11
297_S302_E0.5740.11
307_P310_V0.5720.11
152_V242_Y0.5710.11
130_V173_K0.5690.11
304_S321_I0.5680.11
87_D153_A0.5680.11
27_G259_R0.5670.11
28_K60_E0.5670.11
73_A312_D0.5660.11
130_V157_D0.5610.11
120_Y126_M0.5610.11
149_A152_V0.5600.11
292_E312_D0.5600.11
304_S312_D0.5600.11
17_P239_T0.5590.11
78_A249_D0.5580.11
63_V101_E0.5570.11
80_G272_T0.5560.11
33_I92_I0.5510.11
65_N98_I0.5470.11
29_L276_T0.5460.11
137_M258_F0.5460.11
166_A174_I0.5430.11
121_V156_Y0.5430.11
314_L326_I0.5420.11
89_I114_L0.5410.11
67_M71_Y0.5360.11
198_S251_V0.5340.11
301_D309_I0.5340.11
206_S326_I0.5320.11
71_Y124_D0.5300.11
28_K188_F0.5280.11
30_V80_G0.5260.11
44_C136_E0.5260.11
44_C86_G0.5260.11
44_C165_P0.5260.11
44_C85_G0.5260.11
44_C243_C0.5260.11
44_C163_E0.5260.11
41_C44_C0.5260.11
37_C44_C0.5260.11
287_E295_G0.5230.11
196_L221_S0.5220.11
104_N144_E0.5210.11
121_V142_V0.5200.11
197_N253_T0.5190.11
293_N309_I0.5190.11
57_F141_P0.5180.11
193_E274_E0.5170.10
210_H217_G0.5170.10
113_H257_F0.5170.10
127_R224_T0.5160.10
224_T291_L0.5140.10
229_L264_S0.5140.10
75_R151_K0.5130.10
36_E306_S0.5130.10
70_I181_A0.5110.10
84_T135_D0.5100.10
61_T72_E0.5090.10
305_I327_V0.5080.10
43_Y255_T0.5060.10
17_P137_M0.5050.10
77_K217_G0.5050.10
18_K118_G0.5050.10
168_P207_K0.5040.10
104_N303_Y0.5030.10
28_K140_H0.5020.10
302_E326_I0.5020.10
92_I198_S0.5020.10
62_E183_E0.5020.10
60_E113_H0.5000.10
30_V43_Y0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8fA 1 0.6343 99.8 0.849 Contact Map
2yx0A 1 0.6743 99.7 0.862 Contact Map
1tv8A 2 0.8086 99.7 0.865 Contact Map
2a5hA 4 0.8057 99.7 0.866 Contact Map
4k36A 1 0.7171 99.7 0.872 Contact Map
4u0oB 1 0.6514 99.6 0.875 Contact Map
2z2uA 1 0.6143 99.6 0.876 Contact Map
3iixA 1 0.7657 99.6 0.876 Contact Map
1oltA 1 0.9286 99.5 0.882 Contact Map
3rfaA 1 0.68 99.5 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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