GREMLIN Database
Q7LXZ3 - Uncharacterized protein
UniProt: Q7LXZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (352)
Sequences: 277 (242)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_F37_W4.8081.00
152_F205_I3.7760.99
160_N197_K3.5560.99
33_F36_F3.3570.98
170_L177_G3.0520.97
30_V35_S2.8700.95
89_I207_L2.7680.94
253_I256_I2.6770.93
145_S329_L2.6210.93
86_A197_K2.5660.92
84_K193_N2.5590.92
71_P158_T2.5480.91
93_L330_A2.5350.91
251_D283_H2.5220.91
176_P196_L2.4960.91
374_F377_A2.4610.90
142_I325_V2.4400.90
175_F328_S2.3910.89
168_G179_F2.3680.88
187_F199_I2.2780.86
125_I129_T2.1890.84
248_H251_D2.1880.83
203_I334_A2.0540.79
367_Q374_F1.9940.77
236_V245_A1.9580.76
54_V132_I1.9500.75
47_L61_W1.9270.75
36_F40_I1.9200.74
166_N181_E1.9150.74
66_R74_S1.9080.74
30_V34_L1.9020.74
138_I142_I1.8980.73
147_A293_V1.8640.72
183_D208_V1.8510.71
86_A160_N1.8480.71
177_G328_S1.8030.69
195_K348_E1.7890.69
62_R181_E1.7880.69
34_L37_W1.7870.69
175_F324_I1.7790.68
201_A336_P1.7670.68
70_F164_V1.7460.67
259_Y270_L1.7390.67
208_V297_N1.7380.66
167_G180_V1.7230.66
257_N372_L1.7090.65
258_G294_N1.6970.65
283_H295_I1.6890.64
170_L175_F1.6870.64
348_E351_K1.6470.62
278_T281_L1.6400.62
204_V326_N1.6200.61
70_F146_V1.6130.60
165_K183_D1.6050.60
88_P207_L1.6030.60
163_K186_D1.5960.60
240_T247_L1.5940.59
86_A205_I1.5920.59
195_K327_F1.5880.59
69_W148_I1.5820.59
74_S366_L1.5780.59
241_P330_A1.5650.58
105_I209_L1.5620.58
86_A152_F1.5600.58
165_K181_E1.5560.58
324_I328_S1.5550.58
146_V175_F1.5380.57
104_I140_L1.5240.56
156_S267_L1.5080.55
211_L252_I1.4960.55
283_H288_L1.4790.54
144_V281_L1.4760.53
207_L327_F1.4630.53
216_L319_F1.4570.52
29_A40_I1.4530.52
302_V309_P1.4520.52
154_A176_P1.4470.52
83_E156_S1.4380.51
49_K260_R1.4370.51
181_E339_I1.4330.51
126_P343_G1.4270.51
290_N294_N1.4210.51
82_Y86_A1.4180.50
160_N196_L1.4080.50
63_K67_E1.3960.49
109_L261_L1.3960.49
30_V43_F1.3920.49
200_A345_L1.3890.49
339_I343_G1.3830.49
302_V305_T1.3820.49
86_A187_F1.3790.48
138_I328_S1.3770.48
300_L304_V1.3720.48
246_S334_A1.3680.48
96_A375_I1.3470.47
101_I340_T1.3440.47
48_E233_I1.3320.46
139_L318_F1.3240.46
84_K197_K1.3230.46
29_A32_L1.3190.45
346_L374_F1.3160.45
335_A340_T1.3140.45
285_N291_V1.3060.45
233_I256_I1.3040.45
127_G230_G1.2860.44
256_I360_E1.2860.44
181_E343_G1.2600.42
367_Q370_F1.2510.42
357_S380_L1.2470.42
203_I345_L1.2470.42
332_F338_I1.2460.42
85_I91_F1.2440.41
37_W40_I1.2410.41
154_A166_N1.2270.41
150_E202_G1.2240.40
149_H153_H1.2240.40
150_E333_N1.2240.40
149_H202_G1.2240.40
202_G333_N1.2240.40
150_E153_H1.2240.40
149_H333_N1.2240.40
153_H202_G1.2240.40
153_H333_N1.2240.40
305_T309_P1.2160.40
60_L321_W1.2140.40
129_T334_A1.2120.40
281_L284_P1.2100.40
142_I168_G1.2100.40
295_I298_H1.2100.40
160_N194_A1.2050.40
170_L326_N1.2010.39
117_P140_L1.1970.39
32_L37_W1.1960.39
221_P224_P1.1950.39
129_T246_S1.1880.39
301_G305_T1.1780.38
131_S134_Q1.1730.38
236_V261_L1.1700.38
130_I158_T1.1690.38
278_T282_K1.1590.37
72_K76_S1.1580.37
134_Q330_A1.1510.37
281_L286_G1.1430.36
279_I285_N1.1430.36
38_L42_V1.1380.36
133_S175_F1.1330.36
52_L208_V1.1330.36
182_P343_G1.1280.36
261_L270_L1.1260.36
31_A92_L1.1250.36
27_Y33_F1.1230.36
292_S295_I1.1170.35
129_T270_L1.1130.35
88_P369_L1.1110.35
160_N176_P1.1070.35
187_F198_I1.1000.34
62_R321_W1.0980.34
140_L212_I1.0970.34
165_K321_W1.0960.34
75_R362_I1.0960.34
35_S42_V1.0960.34
111_I114_N1.0940.34
73_F85_I1.0880.34
288_L291_V1.0860.34
185_D287_S1.0770.33
28_L33_F1.0700.33
216_L252_I1.0690.33
177_G340_T1.0610.33
374_F381_S1.0580.32
202_G342_G1.0570.32
333_N341_D1.0570.32
333_N342_G1.0570.32
149_H342_G1.0570.32
202_G341_D1.0570.32
149_H341_D1.0570.32
153_H341_D1.0570.32
153_H342_G1.0570.32
150_E342_G1.0570.32
150_E341_D1.0570.32
278_T290_N1.0540.32
278_T283_H1.0430.32
33_F40_I1.0350.31
171_L319_F1.0330.31
74_S251_D1.0220.31
124_I250_G1.0160.31
198_I285_N1.0130.30
176_P240_T1.0130.30
184_E301_G1.0120.30
322_L348_E1.0090.30
140_L260_R1.0080.30
90_G334_A1.0060.30
63_K66_R1.0060.30
47_L51_N1.0040.30
138_I330_A1.0040.30
280_T315_I1.0020.30
199_I258_G0.9900.29
149_H206_N0.9890.29
150_E206_N0.9890.29
153_H206_N0.9890.29
206_N333_N0.9890.29
202_G206_N0.9890.29
209_L215_P0.9870.29
75_R276_T0.9860.29
62_R331_V0.9850.29
70_F261_L0.9760.29
130_I345_L0.9740.29
87_L256_I0.9720.29
132_I274_Y0.9700.29
62_R166_N0.9660.28
63_K339_I0.9640.28
240_T312_I0.9630.28
326_N339_I0.9580.28
34_L39_I0.9570.28
327_F331_V0.9550.28
101_I143_G0.9510.28
48_E169_V0.9510.28
34_L43_F0.9500.28
151_I374_F0.9470.28
205_I321_W0.9450.28
205_I267_L0.9420.27
141_A145_S0.9340.27
378_I381_S0.9340.27
90_G133_S0.9330.27
67_E326_N0.9310.27
85_I238_N0.9290.27
165_K184_E0.9270.27
82_Y200_A0.9210.27
324_I332_F0.9180.26
38_L95_I0.9160.26
373_I382_N0.9150.26
141_A154_A0.9150.26
82_Y205_I0.9140.26
146_V161_N0.9050.26
138_I334_A0.9040.26
61_W137_Y0.9010.26
30_V39_I0.8980.26
258_G321_W0.8970.26
141_A209_L0.8960.26
279_I373_I0.8930.25
283_H286_G0.8900.25
145_S154_A0.8880.25
101_I197_K0.8870.25
259_Y337_L0.8830.25
279_I286_G0.8830.25
160_N201_A0.8790.25
102_L353_M0.8790.25
131_S250_G0.8750.25
294_N298_H0.8750.25
205_I326_N0.8730.25
142_I205_I0.8680.24
146_V233_I0.8670.24
170_L329_L0.8640.24
63_K69_W0.8630.24
210_A334_A0.8600.24
210_A246_S0.8600.24
146_V170_L0.8570.24
72_K252_I0.8570.24
54_V280_T0.8540.24
170_L327_F0.8540.24
174_I315_I0.8520.24
279_I293_V0.8520.24
280_T302_V0.8510.24
159_S330_A0.8450.24
67_E158_T0.8440.24
31_A212_I0.8430.24
176_P328_S0.8410.23
154_A320_T0.8410.23
117_P302_V0.8400.23
209_L324_I0.8350.23
76_S238_N0.8330.23
161_N256_I0.8320.23
29_A43_F0.8280.23
218_F257_N0.8210.23
122_K338_I0.8200.23
206_N341_D0.8190.23
206_N342_G0.8190.23
31_A72_K0.8170.23
181_E301_G0.8170.23
54_V192_S0.8160.23
219_E350_L0.8160.23
67_E205_I0.8140.22
116_T135_L0.8140.22
152_F187_F0.8120.22
96_A145_S0.8100.22
92_L128_V0.8060.22
87_L250_G0.8050.22
81_A139_L0.8030.22
133_S181_E0.8020.22
42_V161_N0.8020.22
198_I220_L0.8020.22
123_P200_A0.8010.22
300_L309_P0.7990.22
230_G263_T0.7960.22
110_T116_T0.7940.22
83_E321_W0.7920.22
78_G271_L0.7910.22
212_I239_N0.7890.22
152_F321_W0.7840.21
66_R326_N0.7840.21
160_N340_T0.7830.21
350_L362_I0.7830.21
96_A261_L0.7820.21
146_V266_Q0.7810.21
156_S345_L0.7810.21
181_E327_F0.7800.21
30_V33_F0.7790.21
328_S337_L0.7770.21
242_A321_W0.7760.21
146_V323_F0.7740.21
94_M239_N0.7700.21
180_V339_I0.7690.21
239_N362_I0.7670.21
128_V163_K0.7640.21
93_L337_L0.7620.21
129_T139_L0.7620.21
239_N243_A0.7620.21
28_L315_I0.7590.21
112_K349_L0.7590.21
63_K334_A0.7580.20
131_S142_I0.7570.20
172_L199_I0.7560.20
152_F204_V0.7520.20
82_Y156_S0.7500.20
243_A356_E0.7440.20
65_S269_E0.7380.20
173_G197_K0.7380.20
91_F345_L0.7370.20
133_S176_P0.7350.20
294_N315_I0.7350.20
291_V376_F0.7330.20
168_G181_E0.7280.19
82_Y204_V0.7280.19
162_V198_I0.7270.19
325_V330_A0.7270.19
92_L95_I0.7240.19
249_T369_L0.7230.19
78_G144_V0.7170.19
34_L38_L0.7160.19
175_F191_T0.7130.19
221_P251_D0.7110.19
157_A251_D0.7100.19
191_T263_T0.7090.19
61_W122_K0.7080.19
137_Y207_L0.7050.19
37_W41_Y0.7040.19
161_N315_I0.7010.19
290_N298_H0.6990.19
246_S346_L0.6920.18
239_N252_I0.6890.18
139_L328_S0.6890.18
28_L39_I0.6880.18
368_S372_L0.6880.18
249_T299_F0.6870.18
297_N378_I0.6850.18
179_F336_P0.6850.18
59_I126_P0.6840.18
61_W94_M0.6810.18
78_G91_F0.6790.18
328_S340_T0.6790.18
57_F131_S0.6770.18
270_L285_N0.6760.18
200_A284_P0.6760.18
333_N336_P0.6720.18
71_P203_I0.6720.18
149_H336_P0.6720.18
150_E336_P0.6720.18
153_H336_P0.6720.18
202_G336_P0.6720.18
146_V177_G0.6710.18
170_L340_T0.6670.18
76_S208_V0.6650.18
148_I329_L0.6650.18
69_W315_I0.6620.17
52_L256_I0.6610.17
79_Y142_I0.6590.17
143_G198_I0.6590.17
101_I199_I0.6570.17
231_I248_H0.6540.17
291_V294_N0.6540.17
222_Y226_A0.6530.17
218_F362_I0.6530.17
29_A33_F0.6530.17
142_I195_K0.6520.17
128_V318_F0.6510.17
282_K285_N0.6500.17
126_P206_N0.6450.17
275_S368_S0.6440.17
129_T167_G0.6440.17
166_N343_G0.6420.17
210_A350_L0.6410.17
162_V186_D0.6390.17
217_S370_F0.6380.17
38_L44_R0.6360.17
142_I247_L0.6350.17
72_K239_N0.6350.17
125_I381_S0.6340.17
169_V338_I0.6340.17
42_V89_I0.6310.17
41_Y105_I0.6310.17
187_F367_Q0.6300.16
231_I237_L0.6280.16
102_L219_E0.6270.16
205_I242_A0.6260.16
301_G321_W0.6260.16
373_I381_S0.6260.16
198_I352_R0.6250.16
70_F151_I0.6230.16
125_I327_F0.6160.16
139_L171_L0.6160.16
83_E175_F0.6150.16
220_L228_S0.6130.16
165_K339_I0.6110.16
363_S376_F0.6110.16
123_P377_A0.6100.16
72_K358_N0.6090.16
157_A176_P0.6080.16
28_L34_L0.6060.16
27_Y35_S0.6030.16
86_A196_L0.6000.16
67_E154_A0.5990.16
90_G203_I0.5990.16
180_V346_L0.5980.16
94_M354_L0.5980.16
209_L351_K0.5980.16
97_G129_T0.5980.16
235_G272_Y0.5970.16
35_S38_L0.5960.16
208_V325_V0.5960.16
191_T256_I0.5950.16
152_F326_N0.5950.16
83_E200_A0.5920.15
368_S377_A0.5900.15
62_R335_A0.5890.15
148_I322_L0.5880.15
233_I249_T0.5870.15
265_S281_L0.5860.15
246_S259_Y0.5850.15
67_E204_V0.5840.15
51_N61_W0.5830.15
75_R272_Y0.5830.15
152_F182_P0.5820.15
35_S157_A0.5800.15
136_P213_A0.5770.15
212_I323_F0.5770.15
112_K208_V0.5750.15
271_L304_V0.5740.15
127_G147_A0.5740.15
31_A39_I0.5720.15
85_I382_N0.5710.15
144_V213_A0.5700.15
151_I208_V0.5690.15
172_L197_K0.5690.15
179_F195_K0.5690.15
73_F79_Y0.5670.15
91_F332_F0.5670.15
32_L39_I0.5650.15
175_F203_I0.5640.15
27_Y30_V0.5640.15
196_L203_I0.5630.15
61_W164_V0.5610.15
164_V218_F0.5610.15
178_A329_L0.5600.15
82_Y152_F0.5600.15
223_L226_A0.5590.15
91_F95_I0.5580.15
293_V296_P0.5580.15
121_L205_I0.5570.15
204_V370_F0.5560.14
255_S258_G0.5540.14
175_F332_F0.5540.14
83_E203_I0.5530.14
92_L253_I0.5520.14
45_R49_K0.5520.14
318_F322_L0.5510.14
167_G175_F0.5480.14
29_A36_F0.5480.14
216_L238_N0.5480.14
171_L217_S0.5480.14
80_R185_D0.5480.14
122_K125_I0.5440.14
203_I329_L0.5440.14
179_F250_G0.5410.14
227_L330_A0.5410.14
205_I329_L0.5400.14
208_V253_I0.5390.14
43_F46_R0.5390.14
87_L164_V0.5380.14
166_N326_N0.5380.14
357_S372_L0.5380.14
96_A329_L0.5370.14
200_A204_V0.5370.14
114_N256_I0.5360.14
43_F86_A0.5360.14
301_G309_P0.5360.14
59_I128_V0.5340.14
286_G298_H0.5340.14
91_F233_I0.5340.14
298_H304_V0.5340.14
190_S360_E0.5330.14
29_A119_I0.5330.14
377_A381_S0.5300.14
59_I144_V0.5290.14
372_L379_F0.5290.14
125_I141_A0.5270.14
53_T100_T0.5240.14
175_F321_W0.5240.14
151_I192_S0.5240.14
175_F198_I0.5230.14
32_L109_L0.5230.14
218_F269_E0.5220.14
152_F267_L0.5220.14
255_S273_N0.5220.14
63_K340_T0.5200.14
261_L362_I0.5180.14
181_E210_A0.5180.14
92_L302_V0.5170.14
212_I325_V0.5160.13
70_F380_L0.5150.13
124_I136_P0.5140.13
209_L352_R0.5120.13
280_T290_N0.5110.13
28_L35_S0.5080.13
217_S319_F0.5080.13
50_Y182_P0.5050.13
299_F304_V0.5050.13
155_L169_V0.5050.13
88_P97_G0.5030.13
38_L357_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.487 99.8 0.821 Contact Map
2vz5A 1 0.2668 99.1 0.883 Contact Map
1v5lA 1 0.2591 99.1 0.885 Contact Map
3i18A 1 0.2228 98.9 0.895 Contact Map
2kl1A 1 0.1995 98.8 0.898 Contact Map
2hgaA 1 0.2461 98.7 0.9 Contact Map
1v5qA 1 0.3005 98.7 0.9 Contact Map
2kjpA 1 0.2098 98.7 0.9 Contact Map
2i4sA 1 0.2642 98.7 0.901 Contact Map
2zpmA 2 0.1865 98.7 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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