GREMLIN Database
Q7LXZ1 - Uncharacterized protein
UniProt: Q7LXZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (367)
Sequences: 1502 (1065)
Seq/√Len: 55.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E83_K4.0011.00
236_I292_I3.8661.00
32_R267_D3.5721.00
165_L216_M3.5631.00
21_I84_L3.5091.00
377_E381_I3.4261.00
113_D117_M3.3691.00
88_L91_I3.3151.00
24_M128_F3.2441.00
376_P381_I3.2351.00
28_Q31_R3.2321.00
64_L159_V3.1931.00
188_I198_V3.0981.00
294_N299_R2.9241.00
62_T83_K2.7821.00
120_S140_I2.7511.00
25_P124_N2.7091.00
265_Y282_S2.6411.00
31_R51_F2.5981.00
94_F100_L2.5761.00
239_T287_Y2.5451.00
7_E45_G2.5341.00
61_T82_L2.5261.00
183_R223_H2.5091.00
66_E79_S2.4841.00
39_A226_I2.3621.00
290_Q294_N2.3231.00
216_M221_Y2.2641.00
376_P380_T2.2501.00
61_T86_A2.2171.00
332_Q335_R2.2001.00
8_I170_R2.1791.00
60_L159_V2.1271.00
281_S297_D2.1251.00
276_Y296_L2.0791.00
4_V44_P2.0421.00
377_E382_R1.9681.00
183_R298_R1.9681.00
4_V14_L1.9531.00
198_V206_L1.9441.00
57_T159_V1.9431.00
293_R299_R1.9341.00
229_Y300_G1.9281.00
93_Q112_K1.9221.00
235_E238_R1.9061.00
82_L149_M1.9001.00
126_R130_D1.8981.00
332_Q339_Y1.8761.00
325_V328_L1.8660.99
10_A182_Y1.8470.99
78_E146_N1.8410.99
90_D160_D1.7460.99
96_F272_F1.7460.99
88_L119_I1.7450.99
18_E58_F1.7350.99
89_H160_D1.7230.99
232_M300_G1.7100.99
93_Q111_N1.7100.99
118_I264_S1.6660.99
140_I143_L1.6360.99
58_F83_K1.6330.99
239_T285_P1.6310.99
223_H298_R1.6210.99
41_L229_Y1.6090.98
162_M179_I1.6020.98
137_S141_E1.5970.98
378_T381_I1.5920.98
61_T152_I1.5850.98
376_P382_R1.5780.98
117_M121_K1.5780.98
326_D329_E1.5690.98
82_L153_V1.5640.98
158_D161_R1.5470.98
20_K131_N1.5300.98
232_M301_P1.5270.98
377_E380_T1.5230.98
5_Y11_Y1.5210.98
289_K293_R1.5100.98
216_M220_V1.5090.98
89_H111_N1.4900.97
26_E121_K1.4880.97
23_D31_R1.4820.97
335_R339_Y1.4800.97
202_G205_S1.4750.97
146_N149_M1.4720.97
7_E170_R1.4710.97
239_T243_C1.4710.97
9_H166_V1.4630.97
343_E346_K1.4420.97
329_E332_Q1.4380.97
51_F183_R1.4290.97
22_I27_F1.4260.97
89_H93_Q1.4260.97
64_L188_I1.4250.97
112_K115_R1.4020.96
248_I283_N1.3990.96
376_P379_L1.3940.96
116_Y144_N1.3890.96
379_L382_R1.3890.96
166_V181_L1.3890.96
172_T220_V1.3670.96
3_K11_Y1.3550.95
176_L214_L1.3550.95
32_R297_D1.3490.95
98_H160_D1.3480.95
91_I125_F1.3470.95
75_T146_N1.3320.95
322_K326_D1.3190.95
21_I47_T1.3140.95
47_T52_S1.2960.94
150_S153_V1.2940.94
135_D138_K1.2900.94
379_L383_R1.2880.94
77_E138_K1.2860.94
332_Q337_S1.2760.94
40_Y49_T1.2710.94
2_K19_A1.2650.93
298_R302_K1.2480.93
112_K160_D1.2420.93
89_H112_K1.2360.93
236_I275_L1.2330.93
133_S136_Y1.2330.93
357_S363_N1.2290.92
187_T202_G1.2240.92
262_S265_Y1.2170.92
111_N160_D1.2150.92
28_Q51_F1.2120.92
325_V330_R1.2080.92
59_Y63_I1.2060.92
51_F223_H1.2010.92
161_R210_F1.1800.91
57_T86_A1.1770.91
378_T382_R1.1760.91
91_I119_I1.1750.91
337_S340_P1.1750.91
288_L291_K1.1720.91
240_I280_Y1.1690.90
61_T159_V1.1620.90
109_L114_L1.1620.90
67_K185_L1.1580.90
39_A43_Y1.1520.90
259_Y262_S1.1500.90
294_N301_P1.1460.90
155_S162_M1.1390.89
370_T378_T1.1330.89
165_L212_S1.1320.89
98_H111_N1.1150.88
21_I88_L1.1090.88
93_Q160_D1.1060.88
335_R338_I1.1030.88
125_F128_F1.0980.87
14_L19_A1.0940.87
38_L230_E1.0860.87
112_K164_Y1.0860.87
200_D357_S1.0840.87
174_V177_G1.0840.87
50_R53_H1.0750.86
363_N368_K1.0700.86
98_H112_K1.0700.86
111_N115_R1.0680.86
363_N367_Y1.0580.85
270_W276_Y1.0560.85
162_M166_V1.0560.85
325_V331_N1.0550.85
93_Q98_H1.0500.85
63_I182_Y1.0490.85
23_D28_Q1.0480.85
44_P47_T1.0440.85
14_L22_I1.0340.84
348_L351_D1.0290.84
349_N367_Y1.0290.84
28_Q96_F1.0200.83
63_I66_E1.0200.83
334_P339_Y1.0200.83
18_E84_L1.0180.83
6_D9_H1.0170.83
327_R330_R1.0170.83
5_Y43_Y1.0150.83
217_Y222_Y1.0130.83
101_E207_E1.0120.83
69_R75_T1.0100.83
97_S161_R1.0100.83
36_T39_A1.0060.82
227_I340_P1.0040.82
15_D18_E1.0020.82
14_L18_E1.0020.82
195_E354_N1.0010.82
293_R297_D1.0000.82
176_L216_M0.9970.82
198_V202_G0.9930.82
50_R56_G0.9920.81
315_K318_D0.9900.81
89_H98_H0.9830.81
68_F148_M0.9800.81
345_I349_N0.9760.80
44_P48_H0.9730.80
37_S97_S0.9730.80
31_R41_L0.9710.80
285_P288_L0.9630.80
228_G232_M0.9560.79
55_L246_S0.9520.79
365_I371_L0.9510.79
136_Y140_I0.9490.79
232_M291_K0.9470.78
343_E349_N0.9440.78
328_L332_Q0.9420.78
59_Y62_T0.9400.78
380_T383_R0.9380.78
62_T139_I0.9310.77
35_Q48_H0.9250.77
342_E348_L0.9240.77
7_E171_H0.9230.77
139_I149_M0.9210.76
90_D111_N0.9200.76
68_F95_P0.9170.76
110_S113_D0.9130.76
130_D135_D0.9070.75
53_H56_G0.9060.75
94_F266_W0.9050.75
236_I291_K0.8960.74
357_S361_E0.8950.74
52_S183_R0.8940.74
3_K15_D0.8920.74
171_H226_I0.8880.74
19_A23_D0.8850.73
166_V170_R0.8850.73
243_C285_P0.8830.73
90_D98_H0.8810.73
165_L220_V0.8780.73
91_I115_R0.8770.73
81_Y139_I0.8760.73
69_R79_S0.8690.72
73_I190_Y0.8680.72
99_S230_E0.8640.72
332_Q336_S0.8610.71
99_S226_I0.8560.71
174_V216_M0.8540.71
346_K349_N0.8500.70
372_I375_I0.8420.70
23_D223_H0.8390.69
239_T288_L0.8340.69
92_G97_S0.8310.69
23_D298_R0.8310.69
94_F263_I0.8310.69
183_R225_T0.8270.68
75_T78_E0.8240.68
154_N158_D0.8240.68
28_Q223_H0.8200.68
285_P291_K0.8160.67
342_E346_K0.8160.67
38_L233_L0.8140.67
21_I125_F0.8140.67
159_V184_L0.8100.67
48_H168_D0.8100.67
320_K323_E0.8080.67
370_T373_N0.8070.66
177_G216_M0.8040.66
236_I295_F0.8040.66
37_S158_D0.8020.66
67_K181_L0.8020.66
369_S373_N0.8010.66
177_G207_E0.8000.66
163_D167_R0.8000.66
239_T242_D0.7990.66
225_T298_R0.7940.65
84_L129_F0.7940.65
261_S284_S0.7940.65
40_Y226_I0.7930.65
226_I230_E0.7880.65
342_E347_I0.7870.64
189_F197_V0.7860.64
45_G171_H0.7860.64
46_A172_T0.7850.64
280_Y285_P0.7840.64
37_S99_S0.7830.64
42_V114_L0.7800.64
54_S83_K0.7790.64
333_I338_I0.7760.63
148_M151_S0.7760.63
140_I144_N0.7760.63
98_H164_Y0.7760.63
336_S339_Y0.7750.63
101_E211_I0.7740.63
3_K13_E0.7730.63
37_S40_Y0.7700.63
344_K347_I0.7660.62
325_V329_E0.7630.62
211_I215_H0.7620.62
159_V222_Y0.7600.62
161_R213_R0.7580.62
345_I348_L0.7510.61
53_H90_D0.7490.61
135_D143_L0.7470.60
284_S289_K0.7460.60
204_Y219_A0.7430.60
76_D182_Y0.7420.60
42_V225_T0.7420.60
324_I339_Y0.7410.60
42_V52_S0.7400.60
373_N379_L0.7350.59
263_I266_W0.7350.59
165_L169_S0.7350.59
114_L263_I0.7350.59
5_Y214_L0.7340.59
37_S226_I0.7330.59
90_D93_Q0.7310.59
237_F266_W0.7280.58
120_S153_V0.7270.58
93_Q164_Y0.7240.58
312_N316_G0.7240.58
358_K361_E0.7240.58
342_E345_I0.7210.58
367_Y373_N0.7150.57
333_I337_S0.7150.57
7_E11_Y0.7140.57
25_P261_S0.7130.57
214_L218_Q0.7130.57
327_R331_N0.7130.57
37_S230_E0.7130.57
236_I240_I0.7110.57
197_V383_R0.7110.57
26_E86_A0.7100.57
27_F88_L0.7090.56
24_M27_F0.7090.56
67_K186_D0.7080.56
281_S296_L0.7080.56
8_I12_I0.7040.56
332_Q341_I0.7010.56
113_D144_N0.6970.55
96_F271_V0.6960.55
329_E334_P0.6950.55
90_D112_K0.6950.55
68_F71_L0.6950.55
17_R20_K0.6940.55
14_L58_F0.6920.55
97_S230_E0.6910.55
175_Q178_N0.6890.54
149_M153_V0.6880.54
65_G83_K0.6870.54
333_I340_P0.6870.54
314_M318_D0.6840.54
36_T46_A0.6820.54
209_F224_K0.6820.54
152_I288_L0.6780.53
204_Y218_Q0.6780.53
25_P297_D0.6770.53
65_G69_R0.6710.52
245_D323_E0.6710.52
212_S216_M0.6700.52
359_N377_E0.6700.52
95_P272_F0.6690.52
91_I373_N0.6680.52
15_D83_K0.6660.52
318_D323_E0.6650.52
38_L162_M0.6630.51
49_T86_A0.6630.51
334_P340_P0.6610.51
148_M190_Y0.6610.51
207_E216_M0.6600.51
44_P52_S0.6590.51
5_Y226_I0.6590.51
337_S350_K0.6580.51
7_E222_Y0.6570.51
20_K23_D0.6520.50
101_E158_D0.6520.50
79_S83_K0.6510.50
36_T221_Y0.6500.50
365_I369_S0.6500.50
43_Y220_V0.6480.50
31_R223_H0.6450.50
54_S129_F0.6430.49
4_V22_I0.6410.49
290_Q331_N0.6380.49
326_D331_N0.6370.49
309_S315_K0.6350.48
125_F129_F0.6350.48
10_A78_E0.6330.48
123_P129_F0.6320.48
94_F221_Y0.6310.48
349_N352_K0.6300.48
6_D173_G0.6290.48
97_S164_Y0.6270.48
83_K86_A0.6270.48
220_V298_R0.6230.47
344_K351_D0.6230.47
183_R187_T0.6230.47
118_I260_D0.6200.47
287_Y290_Q0.6170.47
378_T383_R0.6150.46
97_S213_R0.6140.46
158_D164_Y0.6140.46
174_V212_S0.6140.46
224_K303_V0.6130.46
346_K351_D0.6100.46
8_I45_G0.6100.46
24_M124_N0.6090.46
212_S224_K0.6080.46
130_D323_E0.6080.46
290_Q330_R0.6060.45
74_I149_M0.6060.45
55_L206_L0.6050.45
42_V183_R0.6040.45
319_I323_E0.6040.45
185_L216_M0.6040.45
51_F298_R0.6030.45
21_I136_Y0.6030.45
4_V12_I0.6020.45
208_N215_H0.6010.45
4_V8_I0.6000.45
53_H89_H0.6000.45
315_K321_I0.6000.45
237_F272_F0.5980.44
270_W273_M0.5980.44
351_D357_S0.5960.44
370_T374_H0.5950.44
154_N180_D0.5950.44
316_G322_K0.5940.44
13_E186_D0.5940.44
118_I263_I0.5920.44
100_L272_F0.5920.44
60_L181_L0.5910.44
153_V183_R0.5890.44
53_H160_D0.5890.44
44_P183_R0.5880.43
86_A124_N0.5870.43
16_D80_T0.5860.43
112_K154_N0.5850.43
120_S137_S0.5850.43
238_R293_R0.5840.43
295_F298_R0.5840.43
52_S171_H0.5840.43
202_G207_E0.5840.43
157_V209_F0.5840.43
81_Y138_K0.5830.43
27_F271_V0.5830.43
354_N359_N0.5830.43
43_Y223_H0.5820.43
36_T172_T0.5810.43
157_V179_I0.5790.42
337_S344_K0.5790.42
228_G301_P0.5770.42
172_T216_M0.5770.42
9_H31_R0.5750.42
343_E347_I0.5750.42
343_E356_I0.5730.42
44_P49_T0.5730.42
243_C284_S0.5720.42
321_I331_N0.5710.42
209_F263_I0.5690.41
326_D330_R0.5680.41
40_Y47_T0.5680.41
337_S356_I0.5660.41
58_F65_G0.5660.41
350_K354_N0.5660.41
74_I78_E0.5660.41
91_I367_Y0.5650.41
41_L300_G0.5640.41
316_G320_K0.5630.41
30_L35_Q0.5620.41
317_G324_I0.5620.41
139_I143_L0.5610.41
111_N164_Y0.5610.41
35_Q50_R0.5600.40
177_G202_G0.5600.40
5_Y169_S0.5590.40
259_Y301_P0.5590.40
9_H180_D0.5590.40
182_Y206_L0.5570.40
209_F288_L0.5560.40
357_S360_N0.5560.40
57_T225_T0.5560.40
42_V203_I0.5540.40
370_T375_I0.5520.40
346_K350_K0.5500.39
161_R217_Y0.5500.39
373_N376_P0.5500.39
27_F91_I0.5500.39
34_K236_I0.5490.39
14_L27_F0.5470.39
103_L118_I0.5470.39
303_V383_R0.5460.39
162_M186_D0.5440.39
222_Y227_I0.5430.39
36_T301_P0.5430.39
139_I145_G0.5430.39
168_D221_Y0.5420.39
154_N164_Y0.5400.38
130_D134_I0.5400.38
12_I15_D0.5390.38
64_L152_I0.5390.38
162_M209_F0.5390.38
306_E383_R0.5380.38
323_E329_E0.5380.38
313_E318_D0.5370.38
81_Y135_D0.5370.38
82_L139_I0.5360.38
73_I194_N0.5360.38
211_I371_L0.5350.38
342_E351_D0.5340.38
347_I355_I0.5330.38
2_K101_E0.5330.38
61_T65_G0.5320.38
366_R374_H0.5310.37
215_H219_A0.5300.37
100_L152_I0.5290.37
127_E131_N0.5290.37
59_Y316_G0.5290.37
33_I115_R0.5280.37
64_L185_L0.5280.37
76_D261_S0.5270.37
315_K320_K0.5250.37
78_E141_E0.5240.37
58_F62_T0.5240.37
23_D51_F0.5230.37
234_R296_L0.5220.37
11_Y199_Q0.5220.37
74_I230_E0.5210.36
304_V309_S0.5210.36
199_Q268_D0.5210.36
293_R319_I0.5200.36
49_T91_I0.5190.36
361_E367_Y0.5180.36
157_V198_V0.5180.36
314_M321_I0.5180.36
328_L331_N0.5170.36
369_S374_H0.5170.36
97_S267_D0.5160.36
184_L206_L0.5160.36
350_K355_I0.5160.36
245_D265_Y0.5160.36
55_L127_E0.5150.36
77_E81_Y0.5150.36
349_N354_N0.5110.35
218_Q267_D0.5110.35
161_R209_F0.5100.35
26_E118_I0.5100.35
365_I374_H0.5090.35
332_Q338_I0.5090.35
236_I288_L0.5090.35
343_E350_K0.5090.35
44_P224_K0.5060.35
120_S141_E0.5060.35
320_K327_R0.5040.35
179_I210_F0.5030.35
195_E362_M0.5020.35
269_E272_F0.5010.35
11_Y17_R0.5010.35
116_Y143_L0.5010.35
118_I259_Y0.5010.35
22_I31_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lrlA 4 0.985 100 0.255 Contact Map
4mz7A 4 0.99 100 0.283 Contact Map
2hekA 4 0.8997 100 0.305 Contact Map
2q14A 4 0.9474 100 0.313 Contact Map
2pgsA 4 0.6667 100 0.732 Contact Map
3bg2A 4 0.6742 100 0.733 Contact Map
2dqbA 4 0.6767 100 0.744 Contact Map
4x9eA 4 0.7469 100 0.751 Contact Map
3gw7A 2 0.4812 98.5 0.91 Contact Map
2pq7A 2 0.411 98.5 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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