GREMLIN Database
Q7LXY9 - Esterase, tropinesterase related protein
UniProt: Q7LXY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (227)
Sequences: 50573 (41398)
Seq/√Len: 2747.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_V88_K4.7911.00
32_R52_D4.2361.00
16_V224_S3.6091.00
54_R80_Y3.2471.00
219_N222_L3.1721.00
185_T209_D3.0051.00
206_K226_I2.9011.00
66_V87_E2.8661.00
93_G187_D2.8441.00
92_I223_L2.7711.00
64_K87_E2.7371.00
208_I226_I2.5771.00
80_Y84_Y2.3371.00
57_L65_P2.3011.00
185_T207_T2.2301.00
74_S94_A2.2221.00
54_R84_Y2.1841.00
211_Y219_N2.1381.00
23_D228_K2.0971.00
54_R58_V2.0791.00
19_K224_S2.0321.00
79_D83_K1.9841.00
67_L77_A1.9801.00
197_K203_V1.8881.00
51_N83_K1.8131.00
180_L206_K1.8041.00
179_T200_M1.7971.00
24_N66_V1.7851.00
29_Y53_L1.7691.00
192_N207_T1.7691.00
77_A89_L1.7661.00
66_V90_V1.7651.00
81_A89_L1.7351.00
195_V199_N1.6941.00
47_E83_K1.6931.00
31_L76_I1.6811.00
53_L80_Y1.6681.00
50_S79_D1.6611.00
8_G12_S1.6561.00
80_Y86_I1.6381.00
17_I28_A1.5921.00
226_I229_N1.5621.00
27_V56_L1.5601.00
4_H34_H1.5161.00
4_H31_L1.5121.00
90_V227_I1.4961.00
222_L226_I1.4791.00
10_Y36_R1.4781.00
171_E174_G1.4601.00
225_E229_N1.4571.00
3_I31_L1.4531.00
19_K228_K1.4501.00
19_K22_L1.4351.00
200_M203_V1.4241.00
70_H216_N1.4221.00
7_A34_H1.4161.00
3_I53_L1.4141.00
45_N48_D1.4131.00
90_V180_L1.4081.00
10_Y30_D1.3961.00
91_L94_A1.3911.00
56_L60_L1.3801.00
78_I91_L1.3141.00
208_I211_Y1.2971.00
222_L225_E1.2941.00
173_M199_N1.2911.00
82_L171_E1.2681.00
12_S216_N1.2581.00
79_D82_L1.2561.00
2_L68_I1.2561.00
62_I65_P1.2541.00
3_I77_A1.2211.00
183_Y207_T1.2181.00
183_Y205_I1.2041.00
29_Y56_L1.2021.00
65_P86_I1.1961.00
182_V208_I1.1951.00
7_A71_S1.1931.00
19_K221_L1.1881.00
208_I222_L1.1801.00
71_S213_H1.1671.00
68_I227_I1.1631.00
197_K205_I1.1561.00
2_L26_V1.1551.00
68_I92_I1.1481.00
21_S26_V1.1461.00
10_Y28_A1.1231.00
88_K178_K1.1221.00
194_N198_N1.1051.00
211_Y218_E1.1021.00
27_V60_L1.0911.00
195_V198_N1.0881.00
180_L204_E1.0731.00
104_Y111_A1.0571.00
70_H214_F1.0561.00
204_E226_I1.0441.00
57_L62_I1.0411.00
54_R83_K1.0351.00
104_Y108_V1.0301.00
185_T210_G1.0301.00
182_V226_I1.0291.00
212_G218_E1.0291.00
183_Y192_N1.0241.00
50_S76_I1.0221.00
221_L225_E1.0181.00
30_D35_G1.0141.00
5_H71_S1.0121.00
15_F18_P1.0011.00
223_L227_I1.0011.00
194_N197_K0.9971.00
14_K28_A0.9961.00
158_A161_G0.9931.00
31_L72_I0.9911.00
10_Y29_Y0.9901.00
92_I215_L0.9861.00
69_G77_A0.9851.00
57_L80_Y0.9751.00
92_I216_N0.9711.00
105_E109_R0.9701.00
47_E79_D0.9661.00
115_G118_A0.9641.00
137_Y141_N0.9551.00
18_P21_S0.9531.00
208_I219_N0.9531.00
81_A86_I0.9431.00
146_V149_E0.9391.00
43_P48_D0.9361.00
206_K229_N0.9121.00
194_N205_I0.9101.00
79_D171_E0.9101.00
106_K110_I0.9081.00
142_S146_V0.9051.00
126_H130_T0.9021.00
141_N144_L0.8971.00
109_R112_V0.8961.00
93_G215_L0.8911.00
159_V162_L0.8841.00
206_K222_L0.8811.00
104_Y107_Y0.8751.00
17_I26_V0.8751.00
55_R59_Q0.8691.00
89_L179_T0.8671.00
107_Y111_A0.8651.00
107_Y110_I0.8651.00
176_N201_K0.8641.00
16_V19_K0.8631.00
181_I203_V0.8621.00
141_N145_E0.8591.00
160_E164_K0.8541.00
54_R57_L0.8511.00
93_G183_Y0.8501.00
51_N55_R0.8441.00
106_K109_R0.8441.00
49_H72_I0.8441.00
58_V84_Y0.8441.00
61_G64_K0.8431.00
27_V62_I0.8431.00
146_V150_T0.8431.00
114_F118_A0.8411.00
11_K14_K0.8381.00
115_G120_A0.8351.00
108_V111_A0.8351.00
118_A122_Y0.8341.00
153_I157_N0.8331.00
50_S80_Y0.8301.00
144_L148_E0.8281.00
24_N228_K0.8271.00
67_L80_Y0.8251.00
50_S83_K0.8211.00
25_T62_I0.8201.00
194_N207_T0.8201.00
168_Y171_E0.8151.00
211_Y215_L0.8131.00
151_T154_G0.8111.00
220_P224_S0.8101.00
18_P22_L0.8091.00
140_W144_L0.8021.00
3_I67_L0.8001.00
102_E106_K0.7901.00
101_S105_E0.7891.00
51_N54_R0.7881.00
48_D51_N0.7881.00
3_I29_Y0.7881.00
155_Y158_A0.7831.00
17_I21_S0.7771.00
70_H93_G0.7761.00
161_G165_A0.7721.00
142_S145_E0.7711.00
137_Y140_W0.7691.00
30_D36_R0.7681.00
82_L174_G0.7661.00
81_A177_A0.7661.00
93_G184_G0.7631.00
132_T135_S0.7591.00
55_R58_V0.7571.00
156_K160_E0.7561.00
16_V223_L0.7551.00
67_L86_I0.7521.00
145_E148_E0.7521.00
103_V107_Y0.7501.00
114_F119_L0.7491.00
69_G74_S0.7451.00
143_L147_Y0.7431.00
31_L49_H0.7431.00
130_T133_L0.7361.00
86_I177_A0.7321.00
75_L95_L0.7311.00
157_N160_E0.7301.00
182_V223_L0.7281.00
224_S228_K0.7221.00
186_Y210_G0.7191.00
157_N161_G0.7171.00
103_V106_K0.7151.00
81_A175_I0.7141.00
127_K130_T0.7131.00
131_E135_S0.7111.00
210_G219_N0.7101.00
139_A142_S0.7071.00
22_L228_K0.7041.00
78_I96_Y0.7001.00
23_D26_V0.6991.00
131_E134_A0.6961.00
6_L72_I0.6891.00
68_I90_V0.6871.00
16_V20_L0.6821.00
118_A121_E0.6811.00
185_T192_N0.6801.00
117_R121_E0.6781.00
47_E51_N0.6761.00
143_L146_V0.6731.00
107_Y112_V0.6721.00
124_R128_E0.6691.00
133_L136_N0.6671.00
2_L20_L0.6621.00
140_W143_L0.6601.00
108_V112_V0.6591.00
69_G73_G0.6581.00
32_R49_H0.6581.00
105_E112_V0.6551.00
187_D213_H0.6541.00
65_P87_E0.6541.00
13_W16_V0.6541.00
184_G215_L0.6541.00
162_L165_A0.6491.00
125_F129_F0.6481.00
70_H92_I0.6451.00
169_S195_V0.6451.00
161_G164_K0.6451.00
31_L34_H0.6431.00
14_K18_P0.6341.00
50_S54_R0.6311.00
181_I205_I0.6291.00
128_E131_E0.6221.00
117_R122_Y0.6201.00
102_E105_E0.6201.00
169_S199_N0.6191.00
158_A162_L0.6171.00
91_L181_I0.6141.00
83_K171_E0.6121.00
167_D171_E0.6121.00
215_L223_L0.6101.00
103_V111_A0.6091.00
13_W17_I0.6081.00
46_I79_D0.6021.00
183_Y190_I0.6001.00
4_H29_Y0.5991.00
7_A72_I0.5971.00
20_L227_I0.5951.00
225_E228_K0.5951.00
136_N139_A0.5941.00
49_H52_D0.5931.00
159_V163_L0.5931.00
65_P80_Y0.5911.00
139_A143_L0.5901.00
119_L122_Y0.5891.00
116_M120_A0.5881.00
12_S70_H0.5881.00
31_L53_L0.5841.00
115_G122_Y0.5841.00
154_G157_N0.5821.00
128_E132_T0.5811.00
56_L59_Q0.5781.00
6_L34_H0.5731.00
176_N202_N0.5721.00
153_I156_K0.5701.00
170_D173_M0.5701.00
160_E163_L0.5691.00
224_S229_N0.5661.00
127_K131_E0.5641.00
87_E90_V0.5621.00
49_H76_I0.5621.00
114_F117_R0.5611.00
116_M122_Y0.5581.00
113_N116_M0.5551.00
105_E111_A0.5531.00
152_P155_Y0.5531.00
204_E229_N0.5521.00
181_I200_M0.5521.00
216_N223_L0.5501.00
12_S217_F0.5491.00
88_K180_L0.5491.00
71_S214_F0.5481.00
167_D170_D0.5471.00
51_N84_Y0.5461.00
78_I94_A0.5461.00
15_F220_P0.5451.00
117_R120_A0.5431.00
2_L13_W0.5421.00
175_I179_T0.5401.00
46_I76_I0.5351.00
32_R40_P0.5351.00
10_Y17_I0.5321.00
114_F120_A0.5301.00
209_D222_L0.5291.00
147_Y150_T0.5291.00
138_Q142_S0.5281.00
89_L177_A0.5261.00
9_S34_H0.5251.00
104_Y109_R0.5251.00
92_I182_V0.5251.00
181_I197_K0.5241.00
106_K111_A0.5241.00
138_Q141_N0.5241.00
126_H131_E0.5231.00
116_M121_E0.5191.00
13_W68_I0.5191.00
8_G217_F0.5181.00
175_I200_M0.5181.00
4_H13_W0.5171.00
125_F128_E0.5121.00
158_A163_L0.5121.00
97_R100_S0.5111.00
72_I76_I0.5111.00
115_G121_E0.5101.00
33_G44_Y0.5081.00
90_V182_V0.5081.00
79_D168_Y0.5081.00
8_G214_F0.5051.00
2_L28_A0.5031.00
48_D52_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3om8A 4 0.987 100 0.161 Contact Map
1ehyA 1 0.974 100 0.17 Contact Map
2xuaA 2 0.987 100 0.171 Contact Map
4inzA 1 1 100 0.174 Contact Map
3oosA 1 0.987 100 0.18 Contact Map
1womA 1 0.9913 100 0.185 Contact Map
3bf7A 1 0.974 100 0.187 Contact Map
2xmzA 1 1 100 0.198 Contact Map
2pujA 4 1 100 0.208 Contact Map
4psuA 1 0.9784 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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