Q7LXY9 - SULSO - GREMLIN Contacts

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Q7LXY9 - Esterase, tropinesterase related protein

UniProt:	Q7LXY9	Sequences: MLIHHLAGSYKSWKFVIPKLSLDNTVVAYDLRGHGRSSTPNSPYNIEDHSNDLRRLLVQLGIEKPVLIGHSIGSLIAIDYALKYPIEKLVLIGALYRAPSSEVYEKYVRIAVNFGMRALAEYRRFHKEFTETLASNYQAWNSLLEVYEETTPIGYKNAVEGLLKAKDYSDELMGINAKTLIVYGTYDGLIVNLNVFKNNMKNVEIKTIDGYGHFLNFENPLLLSEIIKNFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (227)
Sequences:	50573 (41398)
Seq/√Len:	2747.7

ECOLI - YBFF RUTD MHPC BIOH PLDB MENH YCJY YFHR
BACSU - YUGF YDJP YISY RSBQ YBFK YFHM NAP YVAM MENH YCGS YRAK YBDG PLBAC EST YBAC YCLE YQJL YQKD CAH
HALSA - Q9HPT9 Q9HRJ0 Q9HHP4
SULSO - Q7LXY9 PIP Q97WG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_V	88_K	4.791	1.00
32_R	52_D	4.236	1.00
16_V	224_S	3.609	1.00
54_R	80_Y	3.247	1.00
219_N	222_L	3.172	1.00
185_T	209_D	3.005	1.00
206_K	226_I	2.901	1.00
66_V	87_E	2.866	1.00
93_G	187_D	2.844	1.00
92_I	223_L	2.771	1.00
64_K	87_E	2.737	1.00
208_I	226_I	2.577	1.00
80_Y	84_Y	2.337	1.00
57_L	65_P	2.301	1.00
185_T	207_T	2.230	1.00
74_S	94_A	2.222	1.00
54_R	84_Y	2.184	1.00
211_Y	219_N	2.138	1.00
23_D	228_K	2.097	1.00
54_R	58_V	2.079	1.00
19_K	224_S	2.032	1.00
79_D	83_K	1.984	1.00
67_L	77_A	1.980	1.00
197_K	203_V	1.888	1.00
51_N	83_K	1.813	1.00
180_L	206_K	1.804	1.00
179_T	200_M	1.797	1.00
24_N	66_V	1.785	1.00
29_Y	53_L	1.769	1.00
192_N	207_T	1.769	1.00
77_A	89_L	1.766	1.00
66_V	90_V	1.765	1.00
81_A	89_L	1.735	1.00
195_V	199_N	1.694	1.00
47_E	83_K	1.693	1.00
31_L	76_I	1.681	1.00
53_L	80_Y	1.668	1.00
50_S	79_D	1.661	1.00
8_G	12_S	1.656	1.00
80_Y	86_I	1.638	1.00
17_I	28_A	1.592	1.00
226_I	229_N	1.562	1.00
27_V	56_L	1.560	1.00
4_H	34_H	1.516	1.00
4_H	31_L	1.512	1.00
90_V	227_I	1.496	1.00
222_L	226_I	1.479	1.00
10_Y	36_R	1.478	1.00
171_E	174_G	1.460	1.00
225_E	229_N	1.457	1.00
3_I	31_L	1.453	1.00
19_K	228_K	1.450	1.00
19_K	22_L	1.435	1.00
200_M	203_V	1.424	1.00
70_H	216_N	1.422	1.00
7_A	34_H	1.416	1.00
3_I	53_L	1.414	1.00
45_N	48_D	1.413	1.00
90_V	180_L	1.408	1.00
10_Y	30_D	1.396	1.00
91_L	94_A	1.391	1.00
56_L	60_L	1.380	1.00
78_I	91_L	1.314	1.00
208_I	211_Y	1.297	1.00
222_L	225_E	1.294	1.00
173_M	199_N	1.291	1.00
82_L	171_E	1.268	1.00
12_S	216_N	1.258	1.00
79_D	82_L	1.256	1.00
2_L	68_I	1.256	1.00
62_I	65_P	1.254	1.00
3_I	77_A	1.221	1.00
183_Y	207_T	1.218	1.00
183_Y	205_I	1.204	1.00
29_Y	56_L	1.202	1.00
65_P	86_I	1.196	1.00
182_V	208_I	1.195	1.00
7_A	71_S	1.193	1.00
19_K	221_L	1.188	1.00
208_I	222_L	1.180	1.00
71_S	213_H	1.167	1.00
68_I	227_I	1.163	1.00
197_K	205_I	1.156	1.00
2_L	26_V	1.155	1.00
68_I	92_I	1.148	1.00
21_S	26_V	1.146	1.00
10_Y	28_A	1.123	1.00
88_K	178_K	1.122	1.00
194_N	198_N	1.105	1.00
211_Y	218_E	1.102	1.00
27_V	60_L	1.091	1.00
195_V	198_N	1.088	1.00
180_L	204_E	1.073	1.00
104_Y	111_A	1.057	1.00
70_H	214_F	1.056	1.00
204_E	226_I	1.044	1.00
57_L	62_I	1.041	1.00
54_R	83_K	1.035	1.00
104_Y	108_V	1.030	1.00
185_T	210_G	1.030	1.00
182_V	226_I	1.029	1.00
212_G	218_E	1.029	1.00
183_Y	192_N	1.024	1.00
50_S	76_I	1.022	1.00
221_L	225_E	1.018	1.00
30_D	35_G	1.014	1.00
5_H	71_S	1.012	1.00
15_F	18_P	1.001	1.00
223_L	227_I	1.001	1.00
194_N	197_K	0.997	1.00
14_K	28_A	0.996	1.00
158_A	161_G	0.993	1.00
31_L	72_I	0.991	1.00
10_Y	29_Y	0.990	1.00
92_I	215_L	0.986	1.00
69_G	77_A	0.985	1.00
57_L	80_Y	0.975	1.00
92_I	216_N	0.971	1.00
105_E	109_R	0.970	1.00
47_E	79_D	0.966	1.00
115_G	118_A	0.964	1.00
137_Y	141_N	0.955	1.00
18_P	21_S	0.953	1.00
208_I	219_N	0.953	1.00
81_A	86_I	0.943	1.00
146_V	149_E	0.939	1.00
43_P	48_D	0.936	1.00
206_K	229_N	0.912	1.00
194_N	205_I	0.910	1.00
79_D	171_E	0.910	1.00
106_K	110_I	0.908	1.00
142_S	146_V	0.905	1.00
126_H	130_T	0.902	1.00
141_N	144_L	0.897	1.00
109_R	112_V	0.896	1.00
93_G	215_L	0.891	1.00
159_V	162_L	0.884	1.00
206_K	222_L	0.881	1.00
104_Y	107_Y	0.875	1.00
17_I	26_V	0.875	1.00
55_R	59_Q	0.869	1.00
89_L	179_T	0.867	1.00
107_Y	111_A	0.865	1.00
107_Y	110_I	0.865	1.00
176_N	201_K	0.864	1.00
16_V	19_K	0.863	1.00
181_I	203_V	0.862	1.00
141_N	145_E	0.859	1.00
160_E	164_K	0.854	1.00
54_R	57_L	0.851	1.00
93_G	183_Y	0.850	1.00
51_N	55_R	0.844	1.00
106_K	109_R	0.844	1.00
49_H	72_I	0.844	1.00
58_V	84_Y	0.844	1.00
61_G	64_K	0.843	1.00
27_V	62_I	0.843	1.00
146_V	150_T	0.843	1.00
114_F	118_A	0.841	1.00
11_K	14_K	0.838	1.00
115_G	120_A	0.835	1.00
108_V	111_A	0.835	1.00
118_A	122_Y	0.834	1.00
153_I	157_N	0.833	1.00
50_S	80_Y	0.830	1.00
144_L	148_E	0.828	1.00
24_N	228_K	0.827	1.00
67_L	80_Y	0.825	1.00
50_S	83_K	0.821	1.00
25_T	62_I	0.820	1.00
194_N	207_T	0.820	1.00
168_Y	171_E	0.815	1.00
211_Y	215_L	0.813	1.00
151_T	154_G	0.811	1.00
220_P	224_S	0.810	1.00
18_P	22_L	0.809	1.00
140_W	144_L	0.802	1.00
3_I	67_L	0.800	1.00
102_E	106_K	0.790	1.00
101_S	105_E	0.789	1.00
51_N	54_R	0.788	1.00
48_D	51_N	0.788	1.00
3_I	29_Y	0.788	1.00
155_Y	158_A	0.783	1.00
17_I	21_S	0.777	1.00
70_H	93_G	0.776	1.00
161_G	165_A	0.772	1.00
142_S	145_E	0.771	1.00
137_Y	140_W	0.769	1.00
30_D	36_R	0.768	1.00
82_L	174_G	0.766	1.00
81_A	177_A	0.766	1.00
93_G	184_G	0.763	1.00
132_T	135_S	0.759	1.00
55_R	58_V	0.757	1.00
156_K	160_E	0.756	1.00
16_V	223_L	0.755	1.00
67_L	86_I	0.752	1.00
145_E	148_E	0.752	1.00
103_V	107_Y	0.750	1.00
114_F	119_L	0.749	1.00
69_G	74_S	0.745	1.00
143_L	147_Y	0.743	1.00
31_L	49_H	0.743	1.00
130_T	133_L	0.736	1.00
86_I	177_A	0.732	1.00
75_L	95_L	0.731	1.00
157_N	160_E	0.730	1.00
182_V	223_L	0.728	1.00
224_S	228_K	0.722	1.00
186_Y	210_G	0.719	1.00
157_N	161_G	0.717	1.00
103_V	106_K	0.715	1.00
81_A	175_I	0.714	1.00
127_K	130_T	0.713	1.00
131_E	135_S	0.711	1.00
210_G	219_N	0.710	1.00
139_A	142_S	0.707	1.00
22_L	228_K	0.704	1.00
78_I	96_Y	0.700	1.00
23_D	26_V	0.699	1.00
131_E	134_A	0.696	1.00
6_L	72_I	0.689	1.00
68_I	90_V	0.687	1.00
16_V	20_L	0.682	1.00
118_A	121_E	0.681	1.00
185_T	192_N	0.680	1.00
117_R	121_E	0.678	1.00
47_E	51_N	0.676	1.00
143_L	146_V	0.673	1.00
107_Y	112_V	0.672	1.00
124_R	128_E	0.669	1.00
133_L	136_N	0.667	1.00
2_L	20_L	0.662	1.00
140_W	143_L	0.660	1.00
108_V	112_V	0.659	1.00
69_G	73_G	0.658	1.00
32_R	49_H	0.658	1.00
105_E	112_V	0.655	1.00
187_D	213_H	0.654	1.00
65_P	87_E	0.654	1.00
13_W	16_V	0.654	1.00
184_G	215_L	0.654	1.00
162_L	165_A	0.649	1.00
125_F	129_F	0.648	1.00
70_H	92_I	0.645	1.00
169_S	195_V	0.645	1.00
161_G	164_K	0.645	1.00
31_L	34_H	0.643	1.00
14_K	18_P	0.634	1.00
50_S	54_R	0.631	1.00
181_I	205_I	0.629	1.00
128_E	131_E	0.622	1.00
117_R	122_Y	0.620	1.00
102_E	105_E	0.620	1.00
169_S	199_N	0.619	1.00
158_A	162_L	0.617	1.00
91_L	181_I	0.614	1.00
83_K	171_E	0.612	1.00
167_D	171_E	0.612	1.00
215_L	223_L	0.610	1.00
103_V	111_A	0.609	1.00
13_W	17_I	0.608	1.00
46_I	79_D	0.602	1.00
183_Y	190_I	0.600	1.00
4_H	29_Y	0.599	1.00
7_A	72_I	0.597	1.00
20_L	227_I	0.595	1.00
225_E	228_K	0.595	1.00
136_N	139_A	0.594	1.00
49_H	52_D	0.593	1.00
159_V	163_L	0.593	1.00
65_P	80_Y	0.591	1.00
139_A	143_L	0.590	1.00
119_L	122_Y	0.589	1.00
116_M	120_A	0.588	1.00
12_S	70_H	0.588	1.00
31_L	53_L	0.584	1.00
115_G	122_Y	0.584	1.00
154_G	157_N	0.582	1.00
128_E	132_T	0.581	1.00
56_L	59_Q	0.578	1.00
6_L	34_H	0.573	1.00
176_N	202_N	0.572	1.00
153_I	156_K	0.570	1.00
170_D	173_M	0.570	1.00
160_E	163_L	0.569	1.00
224_S	229_N	0.566	1.00
127_K	131_E	0.564	1.00
87_E	90_V	0.562	1.00
49_H	76_I	0.562	1.00
114_F	117_R	0.561	1.00
116_M	122_Y	0.558	1.00
113_N	116_M	0.555	1.00
105_E	111_A	0.553	1.00
152_P	155_Y	0.553	1.00
204_E	229_N	0.552	1.00
181_I	200_M	0.552	1.00
216_N	223_L	0.550	1.00
12_S	217_F	0.549	1.00
88_K	180_L	0.549	1.00
71_S	214_F	0.548	1.00
167_D	170_D	0.547	1.00
51_N	84_Y	0.546	1.00
78_I	94_A	0.546	1.00
15_F	220_P	0.545	1.00
117_R	120_A	0.543	1.00
2_L	13_W	0.542	1.00
175_I	179_T	0.540	1.00
46_I	76_I	0.535	1.00
32_R	40_P	0.535	1.00
10_Y	17_I	0.532	1.00
114_F	120_A	0.530	1.00
209_D	222_L	0.529	1.00
147_Y	150_T	0.529	1.00
138_Q	142_S	0.528	1.00
89_L	177_A	0.526	1.00
9_S	34_H	0.525	1.00
104_Y	109_R	0.525	1.00
92_I	182_V	0.525	1.00
181_I	197_K	0.524	1.00
106_K	111_A	0.524	1.00
138_Q	141_N	0.524	1.00
126_H	131_E	0.523	1.00
116_M	121_E	0.519	1.00
13_W	68_I	0.519	1.00
8_G	217_F	0.518	1.00
175_I	200_M	0.518	1.00
4_H	13_W	0.517	1.00
125_F	128_E	0.512	1.00
158_A	163_L	0.512	1.00
97_R	100_S	0.511	1.00
72_I	76_I	0.511	1.00
115_G	121_E	0.510	1.00
33_G	44_Y	0.508	1.00
90_V	182_V	0.508	1.00
79_D	168_Y	0.508	1.00
8_G	214_F	0.505	1.00
2_L	28_A	0.503	1.00
48_D	52_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3om8A	4	0.987	100	0.161	Contact Map
1ehyA	1	0.974	100	0.17	Contact Map
2xuaA	2	0.987	100	0.171	Contact Map
4inzA	1	1	100	0.174	Contact Map
3oosA	1	0.987	100	0.18	Contact Map
1womA	1	0.9913	100	0.185	Contact Map
3bf7A	1	0.974	100	0.187	Contact Map
2xmzA	1	1	100	0.198	Contact Map
2pujA	4	1	100	0.208	Contact Map
4psuA	1	0.9784	100	0.212	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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