Q7LXY4 - SULSO - GREMLIN Contacts

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Q7LXY4 - Uncharacterized protein

UniProt:	Q7LXY4	Sequences: MQNLSPTQREILLALTDLYNRQKRMIKSKEVADIIGKDEGTVRNIILSLKVLGLVESKPGPNGGYMPTLKAYEIINNPTLTPILDKLNLYKGMIETDIKVENIEIIDITNPSANRVLLKVEGDLRKLKIGDAVRLGPTPYSRLVIEGLILHLDENSKEIVVDVKRMISIPKEKVKNLISKKLIALKPETSLREASMIFYKEAIRGAPVINQDEKVVGILTTADIIKAFFEGNYTAKVSDYMKTNVISINENEDLLDAIRKMIIYNVGRLLVLDSNNKAVGIVTRTDILRSIAGLEGLWTT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (262)
Sequences:	719 (504)
Seq/√Len:	31.1

BACSU - YTOI
SULSO - Q7LXY4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_L	52_L	5.402	1.00
273_D	277_K	4.296	1.00
189_T	193_E	3.909	1.00
208_V	237_V	3.862	1.00
41_T	48_S	3.736	1.00
48_S	51_V	3.607	1.00
174_V	257_A	3.346	1.00
157_K	162_D	3.315	1.00
165_R	168_S	3.247	1.00
68_T	71_A	3.055	1.00
156_S	161_V	2.822	1.00
131_D	152_L	2.670	1.00
175_K	251_N	2.660	1.00
187_P	216_V	2.554	1.00
223_D	242_K	2.490	0.99
268_R	281_I	2.487	0.99
219_L	237_V	2.433	0.99
248_I	271_V	2.418	0.99
175_K	250_E	2.368	0.99
155_N	161_V	2.325	0.99
58_K	63_G	2.258	0.99
41_T	50_K	2.216	0.99
219_L	240_Y	2.203	0.99
193_E	196_M	2.148	0.98
98_I	101_E	2.111	0.98
186_K	211_Q	2.073	0.98
103_I	108_I	2.048	0.98
66_M	281_I	1.984	0.97
133_V	137_P	1.974	0.97
76_N	116_V	1.924	0.97
248_I	252_E	1.878	0.96
143_L	284_R	1.873	0.96
250_E	279_V	1.873	0.96
196_M	200_K	1.822	0.95
154_E	157_K	1.816	0.95
161_V	164_K	1.812	0.95
44_N	49_L	1.686	0.93
215_V	247_S	1.659	0.93
224_I	291_I	1.640	0.92
185_L	237_V	1.635	0.92
139_P	142_R	1.621	0.92
187_P	238_S	1.611	0.91
190_S	193_E	1.601	0.91
131_D	136_G	1.553	0.90
185_L	189_T	1.552	0.90
246_I	266_V	1.529	0.89
154_E	158_E	1.527	0.89
92_G	96_T	1.521	0.89
207_P	268_R	1.518	0.89
177_L	254_L	1.498	0.88
155_N	164_K	1.492	0.88
53_G	56_E	1.490	0.88
249_N	274_S	1.482	0.87
212_D	238_S	1.473	0.87
182_L	198_F	1.470	0.87
156_S	164_K	1.467	0.87
41_T	223_D	1.446	0.86
23_K	27_K	1.424	0.85
66_M	152_L	1.396	0.84
271_V	282_V	1.395	0.84
181_K	200_K	1.391	0.84
191_L	237_V	1.390	0.84
41_T	45_I	1.387	0.84
69_L	107_D	1.379	0.83
167_I	176_N	1.377	0.83
248_I	269_L	1.365	0.83
205_G	267_G	1.350	0.82
100_V	110_N	1.350	0.82
78_P	114_N	1.342	0.82
223_D	237_V	1.335	0.81
182_L	210_N	1.333	0.81
235_A	239_D	1.320	0.80
188_E	210_N	1.316	0.80
36_G	175_K	1.294	0.79
127_L	130_G	1.294	0.79
117_L	141_S	1.285	0.79
220_T	267_G	1.278	0.78
257_A	269_L	1.273	0.78
33_D	61_P	1.271	0.78
166_M	255_L	1.262	0.77
249_N	252_E	1.247	0.76
131_D	140_Y	1.246	0.76
210_N	277_K	1.245	0.76
79_T	243_T	1.245	0.76
130_G	138_T	1.229	0.75
156_S	159_I	1.222	0.75
120_V	123_D	1.212	0.74
179_S	281_I	1.202	0.74
129_I	134_R	1.201	0.74
273_D	279_V	1.201	0.74
220_T	266_V	1.179	0.72
71_A	125_R	1.171	0.72
209_I	213_E	1.163	0.71
161_V	165_R	1.160	0.71
140_Y	151_H	1.149	0.70
261_M	289_R	1.138	0.70
237_V	291_I	1.130	0.69
207_P	287_I	1.130	0.69
188_E	238_S	1.127	0.69
134_R	138_T	1.125	0.69
62_N	88_N	1.121	0.68
30_E	61_P	1.110	0.68
68_T	131_D	1.107	0.67
128_K	149_I	1.107	0.67
205_G	291_I	1.106	0.67
139_P	152_L	1.097	0.67
218_I	268_R	1.092	0.66
173_K	176_N	1.086	0.66
248_I	257_A	1.084	0.66
238_S	243_T	1.077	0.65
78_P	96_T	1.076	0.65
93_M	97_D	1.066	0.64
200_K	229_F	1.046	0.63
43_R	92_G	1.041	0.63
136_G	139_P	1.038	0.62
207_P	215_V	1.036	0.62
137_P	140_Y	1.033	0.62
132_A	136_G	1.012	0.60
237_V	277_K	1.012	0.60
61_P	178_I	1.001	0.59
235_A	274_S	0.995	0.59
66_M	175_K	0.992	0.59
133_V	141_S	0.992	0.59
44_N	47_L	0.986	0.58
72_Y	103_I	0.981	0.58
101_E	123_D	0.974	0.57
157_K	168_S	0.973	0.57
211_Q	238_S	0.972	0.57
222_A	267_G	0.970	0.57
136_G	190_S	0.968	0.57
61_P	120_V	0.961	0.56
141_S	151_H	0.960	0.56
128_K	148_L	0.956	0.56
29_K	34_I	0.956	0.56
31_V	241_M	0.954	0.56
188_E	196_M	0.941	0.55
263_I	289_R	0.937	0.54
197_I	201_E	0.936	0.54
39_E	257_A	0.934	0.54
210_N	214_K	0.934	0.54
99_K	113_A	0.929	0.54
186_K	189_T	0.924	0.53
66_M	140_Y	0.924	0.53
159_I	164_K	0.922	0.53
188_E	211_Q	0.914	0.53
184_A	276_N	0.913	0.52
157_K	161_V	0.908	0.52
129_I	132_A	0.901	0.52
52_L	178_I	0.898	0.51
117_L	131_D	0.894	0.51
193_E	200_K	0.894	0.51
185_L	206_A	0.894	0.51
47_L	158_E	0.892	0.51
181_K	184_A	0.886	0.50
249_N	276_N	0.885	0.50
103_I	127_L	0.883	0.50
153_D	198_F	0.882	0.50
245_V	282_V	0.882	0.50
163_V	166_M	0.880	0.50
283_T	286_D	0.878	0.50
177_L	252_E	0.877	0.50
33_D	151_H	0.876	0.49
216_V	236_K	0.875	0.49
185_L	208_V	0.872	0.49
207_P	281_I	0.870	0.49
23_K	144_V	0.861	0.48
164_K	168_S	0.860	0.48
258_I	276_N	0.860	0.48
211_Q	251_N	0.858	0.48
128_K	144_V	0.856	0.48
191_L	256_D	0.852	0.48
162_D	239_D	0.850	0.47
131_D	137_P	0.848	0.47
174_V	248_I	0.847	0.47
191_L	243_T	0.846	0.47
164_K	167_I	0.844	0.47
162_D	168_S	0.840	0.47
104_E	245_V	0.838	0.46
131_D	153_D	0.832	0.46
269_L	275_N	0.831	0.46
214_K	236_K	0.830	0.46
134_R	137_P	0.824	0.45
63_G	257_A	0.824	0.45
131_D	139_P	0.823	0.45
29_K	107_D	0.820	0.45
185_L	207_P	0.817	0.45
207_P	255_L	0.814	0.44
125_R	153_D	0.813	0.44
132_A	137_P	0.811	0.44
166_M	258_I	0.810	0.44
208_V	230_E	0.809	0.44
36_G	246_I	0.808	0.44
213_E	238_S	0.803	0.44
115_R	156_S	0.801	0.43
218_I	279_V	0.801	0.43
271_V	280_G	0.795	0.43
178_I	271_V	0.792	0.43
218_I	254_L	0.788	0.42
38_D	104_E	0.787	0.42
131_D	134_R	0.776	0.41
135_L	139_P	0.774	0.41
109_T	132_A	0.772	0.41
276_N	279_V	0.769	0.41
181_K	256_D	0.768	0.41
172_E	175_K	0.767	0.41
261_M	288_L	0.767	0.41
208_V	253_D	0.765	0.41
212_D	226_K	0.765	0.41
224_I	227_A	0.762	0.40
24_R	117_L	0.760	0.40
24_R	131_D	0.757	0.40
41_T	56_E	0.756	0.40
36_G	193_E	0.756	0.40
61_P	122_G	0.755	0.40
184_A	209_I	0.755	0.40
130_G	136_G	0.747	0.39
22_Q	34_I	0.746	0.39
261_M	287_I	0.740	0.39
91_K	94_I	0.739	0.39
128_K	146_E	0.738	0.39
225_I	240_Y	0.736	0.38
182_L	288_L	0.736	0.38
38_D	43_R	0.735	0.38
116_V	128_K	0.734	0.38
112_S	223_D	0.733	0.38
27_K	108_I	0.732	0.38
69_L	77_N	0.731	0.38
79_T	176_N	0.729	0.38
214_K	243_T	0.728	0.38
186_K	208_V	0.726	0.38
188_E	212_D	0.725	0.38
61_P	151_H	0.722	0.37
95_E	143_L	0.719	0.37
70_K	198_F	0.703	0.36
117_L	135_L	0.703	0.36
215_V	218_I	0.703	0.36
91_K	98_I	0.701	0.36
154_E	235_A	0.701	0.36
202_A	275_N	0.700	0.36
146_E	161_V	0.698	0.36
154_E	161_V	0.695	0.35
117_L	283_T	0.694	0.35
43_R	47_L	0.693	0.35
183_I	203_I	0.692	0.35
112_S	238_S	0.690	0.35
162_D	169_I	0.687	0.35
23_K	76_N	0.685	0.35
33_D	54_L	0.682	0.34
228_F	239_D	0.681	0.34
61_P	163_V	0.681	0.34
68_T	198_F	0.680	0.34
169_I	172_E	0.679	0.34
159_I	168_S	0.677	0.34
125_R	137_P	0.671	0.34
103_I	290_S	0.670	0.33
218_I	282_V	0.668	0.33
80_L	85_D	0.666	0.33
123_D	269_L	0.666	0.33
169_I	289_R	0.666	0.33
195_S	282_V	0.664	0.33
197_I	267_G	0.662	0.33
55_V	166_M	0.662	0.33
88_N	96_T	0.657	0.33
262_I	267_G	0.657	0.33
38_D	97_D	0.657	0.33
177_L	289_R	0.657	0.33
207_P	275_N	0.656	0.32
31_V	222_A	0.654	0.32
267_G	288_L	0.652	0.32
250_E	273_D	0.652	0.32
30_E	33_D	0.651	0.32
247_S	272_L	0.651	0.32
131_D	150_L	0.650	0.32
123_D	126_K	0.648	0.32
205_G	224_I	0.647	0.32
126_K	148_L	0.644	0.32
114_N	288_L	0.642	0.31
275_N	279_V	0.642	0.31
160_V	165_R	0.640	0.31
77_N	206_A	0.638	0.31
236_K	244_N	0.636	0.31
205_G	261_M	0.635	0.31
186_K	244_N	0.634	0.31
38_D	45_I	0.634	0.31
257_A	262_I	0.632	0.31
126_K	144_V	0.628	0.31
49_L	88_N	0.627	0.30
100_V	113_A	0.626	0.30
117_L	121_E	0.622	0.30
84_L	172_E	0.622	0.30
289_R	292_A	0.614	0.30
42_V	49_L	0.611	0.29
25_M	63_G	0.611	0.29
123_D	183_I	0.610	0.29
175_K	252_E	0.609	0.29
245_V	284_R	0.609	0.29
31_V	41_T	0.605	0.29
136_G	140_Y	0.600	0.29
254_L	290_S	0.597	0.28
252_E	256_D	0.596	0.28
162_D	165_R	0.594	0.28
41_T	224_I	0.593	0.28
58_K	66_M	0.593	0.28
68_T	80_L	0.591	0.28
117_L	123_D	0.588	0.28
58_K	117_L	0.588	0.28
247_S	275_N	0.587	0.28
111_P	196_M	0.586	0.28
192_R	229_F	0.586	0.28
84_L	257_A	0.586	0.28
66_M	117_L	0.581	0.27
66_M	128_K	0.580	0.27
57_S	152_L	0.577	0.27
133_V	136_G	0.577	0.27
177_L	221_T	0.576	0.27
97_D	236_K	0.574	0.27
202_A	243_T	0.571	0.27
237_V	241_M	0.571	0.27
68_T	151_H	0.570	0.27
251_N	277_K	0.569	0.27
27_K	95_E	0.569	0.27
177_L	222_A	0.567	0.26
134_R	140_Y	0.567	0.26
24_R	204_R	0.567	0.26
29_K	162_D	0.566	0.26
58_K	68_T	0.564	0.26
177_L	261_M	0.563	0.26
229_F	279_V	0.562	0.26
68_T	152_L	0.559	0.26
43_R	241_M	0.559	0.26
105_I	171_K	0.558	0.26
239_D	274_S	0.558	0.26
131_D	198_F	0.557	0.26
240_Y	244_N	0.557	0.26
226_K	274_S	0.555	0.26
24_R	34_I	0.553	0.26
193_E	237_V	0.553	0.26
218_I	223_D	0.553	0.26
186_K	277_K	0.552	0.26
157_K	267_G	0.549	0.25
144_V	149_I	0.547	0.25
30_E	34_I	0.547	0.25
83_I	88_N	0.545	0.25
215_V	246_I	0.544	0.25
235_A	257_A	0.543	0.25
221_T	259_R	0.543	0.25
76_N	128_K	0.540	0.25
187_P	190_S	0.539	0.25
117_L	120_V	0.538	0.25
80_L	126_K	0.538	0.25
178_I	269_L	0.538	0.25
174_V	287_I	0.537	0.25
157_K	165_R	0.537	0.25
188_E	240_Y	0.536	0.25
210_N	276_N	0.536	0.25
120_V	131_D	0.535	0.25
48_S	201_E	0.535	0.25
136_G	281_I	0.535	0.25
117_L	140_Y	0.534	0.24
157_K	255_L	0.533	0.24
262_I	283_T	0.532	0.24
211_Q	235_A	0.531	0.24
51_V	174_V	0.531	0.24
95_E	105_I	0.531	0.24
26_I	32_A	0.528	0.24
67_P	146_E	0.527	0.24
112_S	115_R	0.527	0.24
192_R	228_F	0.526	0.24
34_I	152_L	0.525	0.24
244_N	273_D	0.525	0.24
27_K	38_D	0.525	0.24
120_V	178_I	0.521	0.24
37_K	43_R	0.520	0.24
24_R	58_K	0.519	0.24
178_I	182_L	0.516	0.23
74_I	131_D	0.516	0.23
122_G	163_V	0.516	0.23
227_A	235_A	0.514	0.23
193_E	221_T	0.513	0.23
82_P	95_E	0.510	0.23
24_R	120_V	0.509	0.23
238_S	260_K	0.509	0.23
200_K	277_K	0.508	0.23
131_D	151_H	0.508	0.23
78_P	100_V	0.508	0.23
153_D	194_A	0.507	0.23
214_K	239_D	0.507	0.23
126_K	149_I	0.504	0.23
214_K	277_K	0.503	0.23
62_N	158_E	0.502	0.23
157_K	166_M	0.502	0.23
68_T	153_D	0.501	0.23
177_L	224_I	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zy9A	2	0.63	100	0.72	Contact Map
2yvyA	2	0.65	99.9	0.737	Contact Map
3l2bA	2	0.39	99.9	0.74	Contact Map
4cooA	2	0.8033	99.9	0.751	Contact Map
3fhmA	2	0.4333	99.9	0.752	Contact Map
1vr9A	1	0.4033	99.9	0.753	Contact Map
3pc3A	2	0.8033	99.9	0.756	Contact Map
3gbyA	2	0.42	99.9	0.757	Contact Map
4esyA	2	0.4633	99.9	0.757	Contact Map
2rihA	2	0.4267	99.9	0.758	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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