GREMLIN Database
Q7LXY4 - Uncharacterized protein
UniProt: Q7LXY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (262)
Sequences: 719 (504)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L52_L5.4021.00
273_D277_K4.2961.00
189_T193_E3.9091.00
208_V237_V3.8621.00
41_T48_S3.7361.00
48_S51_V3.6071.00
174_V257_A3.3461.00
157_K162_D3.3151.00
165_R168_S3.2471.00
68_T71_A3.0551.00
156_S161_V2.8221.00
131_D152_L2.6701.00
175_K251_N2.6601.00
187_P216_V2.5541.00
223_D242_K2.4900.99
268_R281_I2.4870.99
219_L237_V2.4330.99
248_I271_V2.4180.99
175_K250_E2.3680.99
155_N161_V2.3250.99
58_K63_G2.2580.99
41_T50_K2.2160.99
219_L240_Y2.2030.99
193_E196_M2.1480.98
98_I101_E2.1110.98
186_K211_Q2.0730.98
103_I108_I2.0480.98
66_M281_I1.9840.97
133_V137_P1.9740.97
76_N116_V1.9240.97
248_I252_E1.8780.96
143_L284_R1.8730.96
250_E279_V1.8730.96
196_M200_K1.8220.95
154_E157_K1.8160.95
161_V164_K1.8120.95
44_N49_L1.6860.93
215_V247_S1.6590.93
224_I291_I1.6400.92
185_L237_V1.6350.92
139_P142_R1.6210.92
187_P238_S1.6110.91
190_S193_E1.6010.91
131_D136_G1.5530.90
185_L189_T1.5520.90
246_I266_V1.5290.89
154_E158_E1.5270.89
92_G96_T1.5210.89
207_P268_R1.5180.89
177_L254_L1.4980.88
155_N164_K1.4920.88
53_G56_E1.4900.88
249_N274_S1.4820.87
212_D238_S1.4730.87
182_L198_F1.4700.87
156_S164_K1.4670.87
41_T223_D1.4460.86
23_K27_K1.4240.85
66_M152_L1.3960.84
271_V282_V1.3950.84
181_K200_K1.3910.84
191_L237_V1.3900.84
41_T45_I1.3870.84
69_L107_D1.3790.83
167_I176_N1.3770.83
248_I269_L1.3650.83
205_G267_G1.3500.82
100_V110_N1.3500.82
78_P114_N1.3420.82
223_D237_V1.3350.81
182_L210_N1.3330.81
235_A239_D1.3200.80
188_E210_N1.3160.80
36_G175_K1.2940.79
127_L130_G1.2940.79
117_L141_S1.2850.79
220_T267_G1.2780.78
257_A269_L1.2730.78
33_D61_P1.2710.78
166_M255_L1.2620.77
249_N252_E1.2470.76
131_D140_Y1.2460.76
210_N277_K1.2450.76
79_T243_T1.2450.76
130_G138_T1.2290.75
156_S159_I1.2220.75
120_V123_D1.2120.74
179_S281_I1.2020.74
129_I134_R1.2010.74
273_D279_V1.2010.74
220_T266_V1.1790.72
71_A125_R1.1710.72
209_I213_E1.1630.71
161_V165_R1.1600.71
140_Y151_H1.1490.70
261_M289_R1.1380.70
237_V291_I1.1300.69
207_P287_I1.1300.69
188_E238_S1.1270.69
134_R138_T1.1250.69
62_N88_N1.1210.68
30_E61_P1.1100.68
68_T131_D1.1070.67
128_K149_I1.1070.67
205_G291_I1.1060.67
139_P152_L1.0970.67
218_I268_R1.0920.66
173_K176_N1.0860.66
248_I257_A1.0840.66
238_S243_T1.0770.65
78_P96_T1.0760.65
93_M97_D1.0660.64
200_K229_F1.0460.63
43_R92_G1.0410.63
136_G139_P1.0380.62
207_P215_V1.0360.62
137_P140_Y1.0330.62
132_A136_G1.0120.60
237_V277_K1.0120.60
61_P178_I1.0010.59
235_A274_S0.9950.59
66_M175_K0.9920.59
133_V141_S0.9920.59
44_N47_L0.9860.58
72_Y103_I0.9810.58
101_E123_D0.9740.57
157_K168_S0.9730.57
211_Q238_S0.9720.57
222_A267_G0.9700.57
136_G190_S0.9680.57
61_P120_V0.9610.56
141_S151_H0.9600.56
128_K148_L0.9560.56
29_K34_I0.9560.56
31_V241_M0.9540.56
188_E196_M0.9410.55
263_I289_R0.9370.54
197_I201_E0.9360.54
39_E257_A0.9340.54
210_N214_K0.9340.54
99_K113_A0.9290.54
186_K189_T0.9240.53
66_M140_Y0.9240.53
159_I164_K0.9220.53
188_E211_Q0.9140.53
184_A276_N0.9130.52
157_K161_V0.9080.52
129_I132_A0.9010.52
52_L178_I0.8980.51
117_L131_D0.8940.51
193_E200_K0.8940.51
185_L206_A0.8940.51
47_L158_E0.8920.51
181_K184_A0.8860.50
249_N276_N0.8850.50
103_I127_L0.8830.50
153_D198_F0.8820.50
245_V282_V0.8820.50
163_V166_M0.8800.50
283_T286_D0.8780.50
177_L252_E0.8770.50
33_D151_H0.8760.49
216_V236_K0.8750.49
185_L208_V0.8720.49
207_P281_I0.8700.49
23_K144_V0.8610.48
164_K168_S0.8600.48
258_I276_N0.8600.48
211_Q251_N0.8580.48
128_K144_V0.8560.48
191_L256_D0.8520.48
162_D239_D0.8500.47
131_D137_P0.8480.47
174_V248_I0.8470.47
191_L243_T0.8460.47
164_K167_I0.8440.47
162_D168_S0.8400.47
104_E245_V0.8380.46
131_D153_D0.8320.46
269_L275_N0.8310.46
214_K236_K0.8300.46
134_R137_P0.8240.45
63_G257_A0.8240.45
131_D139_P0.8230.45
29_K107_D0.8200.45
185_L207_P0.8170.45
207_P255_L0.8140.44
125_R153_D0.8130.44
132_A137_P0.8110.44
166_M258_I0.8100.44
208_V230_E0.8090.44
36_G246_I0.8080.44
213_E238_S0.8030.44
115_R156_S0.8010.43
218_I279_V0.8010.43
271_V280_G0.7950.43
178_I271_V0.7920.43
218_I254_L0.7880.42
38_D104_E0.7870.42
131_D134_R0.7760.41
135_L139_P0.7740.41
109_T132_A0.7720.41
276_N279_V0.7690.41
181_K256_D0.7680.41
172_E175_K0.7670.41
261_M288_L0.7670.41
208_V253_D0.7650.41
212_D226_K0.7650.41
224_I227_A0.7620.40
24_R117_L0.7600.40
24_R131_D0.7570.40
41_T56_E0.7560.40
36_G193_E0.7560.40
61_P122_G0.7550.40
184_A209_I0.7550.40
130_G136_G0.7470.39
22_Q34_I0.7460.39
261_M287_I0.7400.39
91_K94_I0.7390.39
128_K146_E0.7380.39
225_I240_Y0.7360.38
182_L288_L0.7360.38
38_D43_R0.7350.38
116_V128_K0.7340.38
112_S223_D0.7330.38
27_K108_I0.7320.38
69_L77_N0.7310.38
79_T176_N0.7290.38
214_K243_T0.7280.38
186_K208_V0.7260.38
188_E212_D0.7250.38
61_P151_H0.7220.37
95_E143_L0.7190.37
70_K198_F0.7030.36
117_L135_L0.7030.36
215_V218_I0.7030.36
91_K98_I0.7010.36
154_E235_A0.7010.36
202_A275_N0.7000.36
146_E161_V0.6980.36
154_E161_V0.6950.35
117_L283_T0.6940.35
43_R47_L0.6930.35
183_I203_I0.6920.35
112_S238_S0.6900.35
162_D169_I0.6870.35
23_K76_N0.6850.35
33_D54_L0.6820.34
228_F239_D0.6810.34
61_P163_V0.6810.34
68_T198_F0.6800.34
169_I172_E0.6790.34
159_I168_S0.6770.34
125_R137_P0.6710.34
103_I290_S0.6700.33
218_I282_V0.6680.33
80_L85_D0.6660.33
123_D269_L0.6660.33
169_I289_R0.6660.33
195_S282_V0.6640.33
197_I267_G0.6620.33
55_V166_M0.6620.33
88_N96_T0.6570.33
262_I267_G0.6570.33
38_D97_D0.6570.33
177_L289_R0.6570.33
207_P275_N0.6560.32
31_V222_A0.6540.32
267_G288_L0.6520.32
250_E273_D0.6520.32
30_E33_D0.6510.32
247_S272_L0.6510.32
131_D150_L0.6500.32
123_D126_K0.6480.32
205_G224_I0.6470.32
126_K148_L0.6440.32
114_N288_L0.6420.31
275_N279_V0.6420.31
160_V165_R0.6400.31
77_N206_A0.6380.31
236_K244_N0.6360.31
205_G261_M0.6350.31
186_K244_N0.6340.31
38_D45_I0.6340.31
257_A262_I0.6320.31
126_K144_V0.6280.31
49_L88_N0.6270.30
100_V113_A0.6260.30
117_L121_E0.6220.30
84_L172_E0.6220.30
289_R292_A0.6140.30
42_V49_L0.6110.29
25_M63_G0.6110.29
123_D183_I0.6100.29
175_K252_E0.6090.29
245_V284_R0.6090.29
31_V41_T0.6050.29
136_G140_Y0.6000.29
254_L290_S0.5970.28
252_E256_D0.5960.28
162_D165_R0.5940.28
41_T224_I0.5930.28
58_K66_M0.5930.28
68_T80_L0.5910.28
117_L123_D0.5880.28
58_K117_L0.5880.28
247_S275_N0.5870.28
111_P196_M0.5860.28
192_R229_F0.5860.28
84_L257_A0.5860.28
66_M117_L0.5810.27
66_M128_K0.5800.27
57_S152_L0.5770.27
133_V136_G0.5770.27
177_L221_T0.5760.27
97_D236_K0.5740.27
202_A243_T0.5710.27
237_V241_M0.5710.27
68_T151_H0.5700.27
251_N277_K0.5690.27
27_K95_E0.5690.27
177_L222_A0.5670.26
134_R140_Y0.5670.26
24_R204_R0.5670.26
29_K162_D0.5660.26
58_K68_T0.5640.26
177_L261_M0.5630.26
229_F279_V0.5620.26
68_T152_L0.5590.26
43_R241_M0.5590.26
105_I171_K0.5580.26
239_D274_S0.5580.26
131_D198_F0.5570.26
240_Y244_N0.5570.26
226_K274_S0.5550.26
24_R34_I0.5530.26
193_E237_V0.5530.26
218_I223_D0.5530.26
186_K277_K0.5520.26
157_K267_G0.5490.25
144_V149_I0.5470.25
30_E34_I0.5470.25
83_I88_N0.5450.25
215_V246_I0.5440.25
235_A257_A0.5430.25
221_T259_R0.5430.25
76_N128_K0.5400.25
187_P190_S0.5390.25
117_L120_V0.5380.25
80_L126_K0.5380.25
178_I269_L0.5380.25
174_V287_I0.5370.25
157_K165_R0.5370.25
188_E240_Y0.5360.25
210_N276_N0.5360.25
120_V131_D0.5350.25
48_S201_E0.5350.25
136_G281_I0.5350.25
117_L140_Y0.5340.24
157_K255_L0.5330.24
262_I283_T0.5320.24
211_Q235_A0.5310.24
51_V174_V0.5310.24
95_E105_I0.5310.24
26_I32_A0.5280.24
67_P146_E0.5270.24
112_S115_R0.5270.24
192_R228_F0.5260.24
34_I152_L0.5250.24
244_N273_D0.5250.24
27_K38_D0.5250.24
120_V178_I0.5210.24
37_K43_R0.5200.24
24_R58_K0.5190.24
178_I182_L0.5160.23
74_I131_D0.5160.23
122_G163_V0.5160.23
227_A235_A0.5140.23
193_E221_T0.5130.23
82_P95_E0.5100.23
24_R120_V0.5090.23
238_S260_K0.5090.23
200_K277_K0.5080.23
131_D151_H0.5080.23
78_P100_V0.5080.23
153_D194_A0.5070.23
214_K239_D0.5070.23
126_K149_I0.5040.23
214_K277_K0.5030.23
62_N158_E0.5020.23
157_K166_M0.5020.23
68_T153_D0.5010.23
177_L224_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.63 100 0.72 Contact Map
2yvyA 2 0.65 99.9 0.737 Contact Map
3l2bA 2 0.39 99.9 0.74 Contact Map
4cooA 2 0.8033 99.9 0.751 Contact Map
3fhmA 2 0.4333 99.9 0.752 Contact Map
1vr9A 1 0.4033 99.9 0.753 Contact Map
3pc3A 2 0.8033 99.9 0.756 Contact Map
3gbyA 2 0.42 99.9 0.757 Contact Map
4esyA 2 0.4633 99.9 0.757 Contact Map
2rihA 2 0.4267 99.9 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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