GREMLIN Database
Q7LXY2 - Uncharacterized protein
UniProt: Q7LXY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (388)
Sequences: 8936 (6547)
Seq/√Len: 332.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_R92_Y5.0001.00
74_I151_I4.9231.00
216_R220_E4.6881.00
135_L154_Y3.6171.00
50_S133_G3.4951.00
81_E109_R3.4571.00
52_I85_V3.1711.00
137_L213_I3.1391.00
218_A245_F3.0721.00
92_Y95_K3.0171.00
81_E133_G3.0071.00
50_S81_E2.9981.00
135_L157_M2.8281.00
152_K251_S2.8231.00
221_A243_K2.8081.00
85_V127_G2.7801.00
86_S112_R2.6831.00
162_C248_C2.6801.00
94_D98_S2.6601.00
148_D152_K2.6081.00
86_S89_E2.4661.00
135_L213_I2.4411.00
49_L154_Y2.4361.00
53_V70_I2.4041.00
177_T180_A2.3761.00
49_L150_L2.3411.00
261_N264_A2.2441.00
207_P212_T2.2231.00
340_W344_L2.2081.00
307_Y311_I2.1971.00
153_A213_I2.1711.00
163_D245_F2.1251.00
50_S131_S2.0881.00
74_I148_D2.0551.00
95_K99_T2.0361.00
217_S221_A2.0151.00
159_N246_K2.0101.00
161_G246_K2.0021.00
97_L110_I1.9901.00
64_Q68_D1.9621.00
48_K132_T1.9221.00
370_G373_S1.9071.00
48_K134_D1.8941.00
48_K79_K1.8821.00
50_S83_I1.8801.00
268_Q272_W1.8621.00
293_K296_Q1.8371.00
383_L386_G1.8371.00
76_D79_K1.8341.00
164_A247_V1.8281.00
221_A245_F1.8151.00
69_N145_I1.7931.00
57_G89_E1.7701.00
64_Q99_T1.7631.00
307_Y310_I1.7591.00
92_Y96_L1.7261.00
25_L28_F1.7161.00
25_L29_G1.7151.00
157_M213_I1.7101.00
48_K133_G1.6931.00
340_W343_T1.6741.00
341_A344_L1.6611.00
218_A240_L1.6611.00
93_F97_L1.6381.00
18_A22_Q1.6361.00
382_F386_G1.6301.00
48_K81_E1.5961.00
186_S269_Q1.5951.00
137_L150_L1.5921.00
46_L76_D1.5751.00
135_L215_K1.5651.00
235_E239_R1.5651.00
397_Y402_K1.5581.00
47_P154_Y1.5581.00
373_S377_V1.5571.00
73_A150_L1.5501.00
111_F130_K1.5321.00
22_Q25_L1.5321.00
21_N25_L1.5161.00
47_P75_W1.5141.00
171_G258_V1.4801.00
20_W24_I1.4701.00
127_G131_S1.4661.00
81_E132_T1.4401.00
64_Q96_L1.4401.00
143_A254_V1.4341.00
231_Q275_G1.4271.00
343_T346_I1.4071.00
84_I97_L1.4051.00
131_S216_R1.4011.00
98_S112_R1.3981.00
303_Y306_Q1.3971.00
74_I147_K1.3921.00
128_L136_I1.3921.00
152_K155_N1.3681.00
136_I219_L1.3581.00
121_S125_A1.3461.00
85_V123_A1.3411.00
120_K124_L1.3351.00
316_S320_F1.3271.00
17_L21_N1.3211.00
17_L20_W1.3161.00
58_E141_V1.3161.00
19_V22_Q1.3151.00
145_I149_S1.3151.00
15_P18_A1.3131.00
50_S216_R1.3101.00
86_S94_D1.3101.00
379_I383_L1.3051.00
15_P22_Q1.3021.00
16_S20_W1.2771.00
293_K297_K1.2711.00
69_N144_R1.2601.00
75_W154_Y1.2571.00
337_F340_W1.2471.00
299_E303_Y1.2441.00
51_I137_L1.2421.00
134_D217_S1.2411.00
339_I343_T1.2401.00
20_W28_F1.2381.00
164_A240_L1.2341.00
18_A21_N1.2321.00
15_P19_V1.2291.00
68_D100_L1.2271.00
373_S376_T1.2271.00
126_F130_K1.2251.00
96_L99_T1.2171.00
173_S180_A1.2161.00
95_K98_S1.2151.00
136_I216_R1.2131.00
275_G278_E1.2081.00
24_I28_F1.2081.00
55_T63_I1.2081.00
107_D113_R1.2021.00
303_Y307_Y1.1911.00
336_M340_W1.1911.00
164_A207_P1.1901.00
296_Q299_E1.1891.00
336_M344_L1.1821.00
19_V26_Y1.1791.00
340_W347_Y1.1771.00
21_N28_F1.1751.00
9_L13_I1.1731.00
306_Q310_I1.1711.00
306_Q309_P1.1661.00
10_A14_I1.1571.00
169_W210_C1.1501.00
75_W80_L1.1491.00
139_L145_I1.1441.00
124_L225_W1.1431.00
286_Y289_S1.1411.00
22_Q26_Y1.1401.00
344_L348_A1.1311.00
14_I18_A1.1221.00
67_I100_L1.1201.00
83_I109_R1.1181.00
149_S211_G1.1151.00
21_N29_G1.1121.00
361_D364_T1.1101.00
70_I145_I1.1091.00
15_P25_L1.1061.00
379_I382_F1.1021.00
63_I84_I1.0931.00
133_G216_R1.0931.00
353_N357_K1.0881.00
344_L347_Y1.0851.00
51_I73_A1.0771.00
365_A368_A1.0741.00
94_D112_R1.0681.00
105_D108_V1.0671.00
15_P21_N1.0581.00
336_M343_T1.0521.00
322_I326_V1.0481.00
43_E46_L1.0471.00
364_T367_K1.0451.00
88_D91_E1.0421.00
14_I22_Q1.0421.00
14_I17_L1.0371.00
11_I22_Q1.0331.00
72_E147_K1.0271.00
57_G90_Q1.0271.00
70_I82_I1.0221.00
156_H248_C1.0201.00
338_I341_A1.0201.00
18_A28_F1.0191.00
292_I296_Q1.0131.00
26_Y29_G1.0111.00
302_A306_Q1.0091.00
285_K289_S1.0061.00
143_A256_V1.0051.00
124_L138_T1.0041.00
80_L150_L1.0031.00
399_V402_K0.9991.00
341_A345_S0.9981.00
355_A358_S0.9961.00
397_Y401_P0.9871.00
22_Q29_G0.9831.00
153_A167_M0.9821.00
303_Y310_I0.9801.00
265_F269_Q0.9751.00
111_F127_G0.9721.00
75_W79_K0.9691.00
222_V240_L0.9691.00
381_P384_L0.9671.00
183_L186_S0.9671.00
162_C165_I0.9661.00
146_E255_Y0.9641.00
343_T347_Y0.9631.00
65_G68_D0.9631.00
265_F268_Q0.9631.00
342_I346_I0.9601.00
320_F323_A0.9541.00
71_H105_D0.9461.00
63_I93_F0.9451.00
295_W299_E0.9441.00
306_Q311_I0.9351.00
13_I17_L0.9351.00
241_I247_V0.9331.00
379_I386_G0.9331.00
385_I389_N0.9291.00
163_D218_A0.9241.00
68_D72_E0.9221.00
224_G228_K0.9141.00
211_G254_V0.9141.00
23_I27_I0.9141.00
166_T169_W0.9121.00
144_R172_Y0.9121.00
294_L298_L0.9111.00
42_N45_N0.9041.00
93_F96_L0.9031.00
137_L149_S0.9001.00
317_A324_G0.9001.00
163_D215_K0.8981.00
346_I351_F0.8971.00
354_S357_K0.8961.00
9_L20_W0.8901.00
55_T93_F0.8881.00
348_A351_F0.8881.00
125_A128_L0.8881.00
11_I14_I0.8871.00
372_L376_T0.8861.00
123_A127_G0.8851.00
313_T317_A0.8841.00
19_V25_L0.8811.00
63_I67_I0.8781.00
97_L100_L0.8781.00
163_D240_L0.8771.00
11_I19_V0.8721.00
17_L22_Q0.8711.00
46_L79_K0.8701.00
11_I28_F0.8661.00
240_L245_F0.8641.00
20_W25_L0.8631.00
188_V191_S0.8621.00
22_Q28_F0.8611.00
111_F126_F0.8591.00
109_R114_E0.8571.00
125_A129_Q0.8531.00
225_W228_K0.8521.00
347_Y351_F0.8501.00
307_Y312_L0.8491.00
183_L187_T0.8461.00
157_M162_C0.8441.00
96_L100_L0.8401.00
368_A376_T0.8371.00
314_F318_I0.8351.00
19_V23_I0.8351.00
107_D112_R0.8341.00
382_F385_I0.8331.00
18_A25_L0.8301.00
66_L70_I0.8291.00
28_F32_G0.8291.00
153_A165_I0.8251.00
306_Q312_L0.8241.00
11_I18_A0.8231.00
368_A371_R0.8221.00
224_G229_M0.8201.00
217_S220_E0.8171.00
11_I15_P0.8151.00
378_G382_F0.8141.00
126_F129_Q0.8121.00
51_I150_L0.8111.00
237_G247_V0.8081.00
57_G91_E0.8081.00
17_L24_I0.8081.00
81_E131_S0.8051.00
344_L351_F0.8051.00
317_A321_A0.8041.00
10_A18_A0.8011.00
14_I24_I0.7991.00
215_K245_F0.7971.00
296_Q300_I0.7951.00
347_Y350_I0.7941.00
14_I25_L0.7931.00
230_I275_G0.7901.00
368_A373_S0.7901.00
46_L151_I0.7881.00
51_I80_L0.7881.00
113_R126_F0.7881.00
15_P28_F0.7871.00
324_G327_G0.7791.00
366_I370_G0.7771.00
16_S19_V0.7741.00
87_D113_R0.7731.00
38_I41_N0.7681.00
342_I345_S0.7661.00
364_T368_A0.7641.00
337_F342_I0.7621.00
343_T350_I0.7611.00
290_S297_K0.7601.00
187_T191_S0.7601.00
301_I307_Y0.7601.00
176_S260_D0.7591.00
24_I29_G0.7571.00
18_A24_I0.7561.00
210_C268_Q0.7520.99
128_L131_S0.7510.99
17_L29_G0.7480.99
10_A17_L0.7480.99
338_I342_I0.7430.99
331_S335_P0.7430.99
10_A13_I0.7420.99
71_H100_L0.7400.99
290_S296_Q0.7390.99
297_K301_I0.7380.99
342_I349_S0.7380.99
367_K370_G0.7380.99
232_D275_G0.7380.99
83_I127_G0.7370.99
20_W29_G0.7370.99
386_G389_N0.7350.99
348_A352_V0.7310.99
148_D151_I0.7300.99
167_M252_S0.7290.99
196_R250_S0.7290.99
12_F15_P0.7280.99
94_D97_L0.7250.99
143_A211_G0.7250.99
206_L234_Y0.7250.99
187_T198_R0.7250.99
166_T207_P0.7230.99
47_P133_G0.7220.99
55_T141_V0.7200.99
210_C256_V0.7180.99
224_G227_Y0.7180.99
18_A29_G0.7170.99
89_E93_F0.7170.99
316_S319_I0.7160.99
15_P20_W0.7120.99
300_I303_Y0.7120.99
312_L315_I0.7110.99
357_K364_T0.7100.99
317_A320_F0.7060.99
378_G386_G0.7040.99
226_D229_M0.7040.99
242_N283_R0.7040.99
383_L387_T0.7010.99
368_A377_V0.6980.99
376_T379_I0.6960.99
333_N343_T0.6960.99
359_G362_T0.6950.99
11_I17_L0.6940.99
318_I321_A0.6940.99
105_D111_F0.6940.99
268_Q271_R0.6930.99
337_F352_V0.6920.99
143_A210_C0.6900.99
274_M278_E0.6890.99
369_L373_S0.6830.99
371_R376_T0.6810.99
109_R112_R0.6790.99
167_M211_G0.6780.99
363_V367_K0.6770.99
13_I20_W0.6750.99
313_T316_S0.6750.99
128_L138_T0.6740.99
382_F390_A0.6740.99
380_S383_L0.6730.99
121_S124_L0.6720.99
338_I346_I0.6720.99
172_Y257_E0.6720.99
321_A324_G0.6700.99
12_F18_A0.6690.99
169_W187_T0.6680.99
169_W256_V0.6680.99
346_I350_I0.6670.99
73_A145_I0.6670.99
345_S348_A0.6650.99
86_S142_D0.6650.99
30_K33_D0.6650.99
18_A26_Y0.6640.99
339_I346_I0.6620.99
339_I342_I0.6590.99
138_T207_P0.6580.99
316_S324_G0.6560.99
156_H165_I0.6560.99
223_N226_D0.6550.99
333_N347_Y0.6550.99
316_S328_I0.6540.99
337_F346_I0.6530.99
259_P268_Q0.6520.99
16_S25_L0.6520.99
353_N358_S0.6510.99
15_P23_I0.6510.99
159_N248_C0.6510.99
354_S358_S0.6500.99
15_P29_G0.6490.99
137_L153_A0.6490.99
256_V259_P0.6490.99
336_M346_I0.6490.99
320_F328_I0.6490.99
17_L28_F0.6490.99
66_L71_H0.6480.99
299_E302_A0.6480.99
349_S352_V0.6460.98
296_Q303_Y0.6460.98
232_D279_V0.6460.98
15_P24_I0.6440.98
11_I21_N0.6440.98
150_L213_I0.6410.98
329_R332_M0.6400.98
291_D297_K0.6400.98
140_D209_G0.6320.98
138_T212_T0.6300.98
71_H108_V0.6300.98
166_T171_G0.6270.98
109_R130_K0.6270.98
333_N344_L0.6250.98
292_I297_K0.6240.98
53_V66_L0.6230.98
311_I315_I0.6220.98
23_I26_Y0.6210.98
320_F327_G0.6210.98
301_I306_Q0.6200.98
267_V398_I0.6190.98
52_I131_S0.6190.98
16_S22_Q0.6190.98
218_A221_A0.6180.98
66_L139_L0.6180.98
269_Q272_W0.6180.98
14_I21_N0.6170.98
199_D248_C0.6160.98
195_L198_R0.6160.98
14_I23_I0.6150.98
301_I305_S0.6140.98
375_Y378_G0.6140.98
310_I314_F0.6130.98
15_P26_Y0.6110.98
19_V28_F0.6090.98
63_I97_L0.6070.98
337_F344_L0.6070.98
14_I19_V0.6060.98
20_W26_Y0.6050.98
47_P158_V0.6020.98
340_W345_S0.6010.98
9_L17_L0.6000.98
124_L128_L0.6000.98
169_W208_I0.5980.97
66_L69_N0.5980.97
377_V380_S0.5970.97
335_P338_I0.5970.97
59_R93_F0.5960.97
329_R333_N0.5960.97
46_L75_W0.5950.97
302_A305_S0.5950.97
146_E253_P0.5920.97
297_K300_I0.5920.97
226_D239_R0.5910.97
10_A25_L0.5890.97
21_N24_I0.5890.97
17_L26_Y0.5890.97
26_Y31_S0.5880.97
352_V356_K0.5870.97
225_W229_M0.5870.97
290_S293_K0.5860.97
111_F114_E0.5860.97
353_N356_K0.5860.97
74_I146_E0.5860.97
162_C246_K0.5860.97
143_A169_W0.5830.97
71_H107_D0.5820.97
226_D282_W0.5810.97
187_T195_L0.5810.97
108_V111_F0.5810.97
272_W275_G0.5810.97
107_D111_F0.5810.97
381_P386_G0.5800.97
57_G93_F0.5790.97
333_N337_F0.5770.97
308_I311_I0.5770.97
310_I313_T0.5760.97
168_E249_A0.5760.97
183_L258_V0.5750.97
124_L127_G0.5740.97
47_P135_L0.5730.97
195_L249_A0.5730.97
36_N40_L0.5720.97
17_L25_L0.5710.97
315_I318_I0.5690.97
10_A19_V0.5690.97
104_P107_D0.5690.97
359_G364_T0.5680.97
190_T195_L0.5670.97
299_E307_Y0.5640.96
212_T237_G0.5640.96
139_L211_G0.5640.96
91_E95_K0.5610.96
368_A372_L0.5600.96
62_V141_V0.5580.96
223_N229_M0.5580.96
381_P385_I0.5570.96
210_C231_Q0.5560.96
67_I84_I0.5540.96
319_I322_I0.5540.96
91_E94_D0.5540.96
270_T385_I0.5520.96
384_L388_I0.5520.96
71_H82_I0.5510.96
347_Y352_V0.5510.96
319_I323_A0.5500.96
332_M336_M0.5490.96
360_I365_A0.5490.96
58_E87_D0.5480.96
153_A252_S0.5480.96
19_V29_G0.5480.96
114_E117_L0.5470.96
117_L122_G0.5460.96
284_F289_S0.5450.96
335_P339_I0.5450.96
317_A323_A0.5450.96
336_M339_I0.5430.96
89_E123_A0.5430.96
121_S275_G0.5420.96
25_L33_D0.5410.96
52_I128_L0.5410.96
9_L30_K0.5390.95
187_T258_V0.5380.95
298_L302_A0.5370.95
63_I96_L0.5370.95
265_F272_W0.5360.95
121_S232_D0.5360.95
210_C275_G0.5360.95
384_L387_T0.5340.95
376_T382_F0.5330.95
319_I324_G0.5330.95
341_A348_A0.5320.95
176_S180_A0.5310.95
62_V257_E0.5300.95
333_N336_M0.5290.95
16_S21_N0.5290.95
357_K361_D0.5290.95
256_V268_Q0.5280.95
332_M344_L0.5270.95
109_R113_R0.5260.95
323_A326_V0.5260.95
179_L185_V0.5250.95
44_S47_P0.5250.95
94_D110_I0.5240.95
180_A183_L0.5240.95
24_I27_I0.5230.95
365_A370_G0.5230.95
350_I354_S0.5220.95
338_I352_V0.5220.95
9_L16_S0.5200.94
74_I80_L0.5200.94
324_G328_I0.5200.94
191_S208_I0.5190.94
70_I73_A0.5180.94
106_L111_F0.5170.94
372_L377_V0.5160.94
364_T371_R0.5130.94
313_T320_F0.5110.94
368_A374_A0.5110.94
318_I324_G0.5100.94
49_L135_L0.5100.94
214_Y240_L0.5090.94
376_T380_S0.5080.94
57_G86_S0.5070.94
223_N228_K0.5040.94
56_K116_K0.5040.94
362_T365_A0.5020.93
56_K88_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9694 100 0.329 Contact Map
2z86A 2 0.6223 100 0.584 Contact Map
3bcvA 2 0.3952 100 0.603 Contact Map
1qg8A 1 0.4672 100 0.614 Contact Map
1xhbA 1 0.8712 100 0.625 Contact Map
3ckjA 2 0.6026 100 0.627 Contact Map
3l7iA 4 0.1638 100 0.639 Contact Map
2bo4A 4 0.7227 100 0.639 Contact Map
2d7iA 1 0.7729 100 0.641 Contact Map
2nxvA 4 0.5284 100 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.