GREMLIN Database
Q7LXY0 - DNA endonuclease III, probable (NtH-1)
UniProt: Q7LXY0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (201)
Sequences: 8153 (5134)
Seq/√Len: 362.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_A123_E3.9971.00
67_T70_K3.6461.00
210_L213_S3.3831.00
102_I106_R3.2331.00
205_K210_L2.7641.00
63_K78_D2.7091.00
102_I128_E2.6741.00
79_I97_K2.4931.00
113_S148_Y2.4851.00
97_K101_R2.3521.00
81_S84_K2.2941.00
63_K82_A2.2901.00
107_Y126_K2.2391.00
121_R125_L2.2311.00
69_E104_L2.0601.00
174_S178_S2.0471.00
43_I99_I2.0171.00
34_D37_K2.0081.00
101_R105_E1.9981.00
95_R98_E1.9701.00
217_K223_Y1.9291.00
75_N78_D1.9281.00
76_L80_E1.9121.00
66_V70_K1.9011.00
98_E128_E1.9011.00
26_Y31_K1.8871.00
76_L97_K1.8231.00
91_T95_R1.8091.00
106_R126_K1.7831.00
69_E73_N1.7291.00
40_V96_L1.7281.00
36_F68_P1.7071.00
177_S181_K1.6631.00
58_L62_R1.6391.00
158_T176_I1.6231.00
123_E126_K1.5931.00
167_V179_T1.5751.00
59_E62_R1.5571.00
176_I180_L1.5551.00
104_L109_G1.5511.00
33_K37_K1.5381.00
64_V82_A1.5201.00
48_S52_S1.5111.00
113_S143_Y1.4991.00
121_R150_V1.4971.00
36_F100_S1.4691.00
64_V74_A1.4681.00
110_L113_S1.4681.00
37_K61_E1.4391.00
98_E101_R1.4121.00
121_R139_L1.4111.00
221_E225_H1.4111.00
91_T94_K1.4071.00
59_E82_A1.3461.00
102_I126_K1.3451.00
74_A79_I1.3371.00
15_T219_C1.3271.00
80_E89_Y1.3231.00
164_L216_I1.3171.00
198_A202_Q1.3031.00
132_E177_S1.3001.00
184_F192_L1.2651.00
48_S86_S1.2621.00
52_S55_K1.2561.00
21_E188_D1.2561.00
164_L219_C1.2511.00
125_L132_E1.2321.00
166_I221_E1.2211.00
188_D191_H1.2191.00
76_L94_K1.2061.00
77_A80_E1.2011.00
103_I111_I1.1991.00
177_S180_L1.1801.00
17_I21_E1.1791.00
99_I127_L1.1791.00
40_V61_E1.1711.00
139_L148_Y1.1671.00
113_S120_A1.1641.00
55_K58_L1.1591.00
191_H195_M1.1591.00
45_S50_D1.1511.00
102_I107_Y1.1491.00
203_T215_I1.1481.00
35_C142_C1.1421.00
98_E102_I1.1211.00
75_N97_K1.1201.00
124_L139_L1.1121.00
31_K58_L1.1011.00
39_L43_I1.1001.00
161_S180_L1.0901.00
107_Y123_E1.0811.00
106_R123_E1.0811.00
216_I219_C1.0791.00
49_T52_S1.0701.00
29_W202_Q1.0641.00
71_L79_I1.0531.00
144_G190_L1.0421.00
36_F71_L1.0371.00
169_T175_L1.0281.00
211_C220_C1.0271.00
76_L93_A1.0251.00
39_L138_V1.0211.00
174_S177_S1.0031.00
172_K175_L1.0021.00
199_H203_T1.0011.00
139_L150_V0.9991.00
71_L100_S0.9931.00
14_A17_I0.9901.00
57_Y61_E0.9871.00
14_A18_I0.9861.00
37_K57_Y0.9851.00
18_I22_D0.9821.00
149_K186_A0.9711.00
51_K55_K0.9651.00
21_E191_H0.9641.00
20_E188_D0.9611.00
186_A189_L0.9601.00
151_F181_K0.9551.00
99_I102_I0.9521.00
94_K98_E0.9401.00
162_K176_I0.9341.00
32_T38_V0.9201.00
199_H215_I0.9171.00
68_P104_L0.9161.00
175_L179_T0.9091.00
99_I103_I0.9051.00
76_L101_R0.9041.00
20_E24_I0.9021.00
54_I58_L0.8971.00
20_E191_H0.8961.00
140_L193_H0.8911.00
178_S181_K0.8881.00
122_D125_L0.8781.00
161_S196_L0.8771.00
42_T138_V0.8731.00
39_L99_I0.8731.00
179_T182_E0.8731.00
140_L152_P0.8681.00
78_D82_A0.8641.00
18_I218_E0.8641.00
15_T216_I0.8631.00
192_L196_L0.8631.00
52_S85_I0.8541.00
140_L190_L0.8511.00
19_K23_F0.8511.00
166_I225_H0.8501.00
204_C211_C0.8471.00
72_S100_S0.8371.00
204_C214_C0.8341.00
169_T176_I0.8281.00
152_P193_H0.8271.00
37_K66_V0.8241.00
72_S104_L0.8231.00
151_F189_L0.8191.00
46_Q134_T0.8181.00
139_L143_Y0.8131.00
221_E224_S0.8061.00
18_I21_E0.8051.00
203_T213_S0.8031.00
121_R136_D0.8021.00
59_E85_I0.8001.00
17_I188_D0.7831.00
56_A59_E0.7791.00
158_T162_K0.7741.00
40_V99_I0.7731.00
130_I134_T0.7731.00
162_K167_V0.7721.00
74_A78_D0.7681.00
55_K59_E0.7541.00
78_D81_S0.7511.00
121_R135_A0.7511.00
96_L100_S0.7501.00
38_V142_C0.7481.00
27_Y30_L0.7411.00
59_E63_K0.7321.00
141_T190_L0.7301.00
68_P111_I0.7271.00
104_L107_Y0.7261.00
178_S182_E0.7251.00
111_I124_L0.7251.00
132_E136_D0.7241.00
17_I20_E0.7241.00
181_K189_L0.7241.00
150_V181_K0.7170.99
42_T134_T0.7140.99
172_K176_I0.7130.99
32_T37_K0.7120.99
121_R148_Y0.7110.99
160_V199_H0.7080.99
69_E109_G0.7070.99
153_V176_I0.7050.99
52_S86_S0.7010.99
136_D151_F0.6990.99
22_D215_I0.6940.99
173_Y176_I0.6940.99
44_L53_A0.6930.99
42_T141_T0.6880.99
72_S101_R0.6750.99
209_P220_C0.6740.99
93_A97_K0.6700.99
17_I191_H0.6680.99
188_D195_M0.6670.99
163_R209_P0.6670.99
64_V79_I0.6660.99
175_L178_S0.6660.99
173_Y177_S0.6630.99
72_S75_N0.6620.99
126_K139_L0.6590.99
219_C223_Y0.6590.99
144_G148_Y0.6580.99
93_A96_L0.6480.99
64_V78_D0.6470.99
211_C214_C0.6440.99
185_S189_L0.6390.99
140_L150_V0.6390.99
199_H202_Q0.6390.99
103_I109_G0.6380.99
51_K54_I0.6380.99
217_K222_Y0.6370.99
82_A85_I0.6340.99
74_A97_K0.6330.99
130_I138_V0.6320.99
151_F184_F0.6300.99
138_V142_C0.6290.99
20_E194_H0.6220.99
68_P100_S0.6180.98
125_L135_A0.6170.98
124_L138_V0.6170.98
141_T194_H0.6130.98
44_L86_S0.6130.98
165_G168_P0.6080.98
144_G149_K0.6080.98
24_I198_A0.6070.98
70_K73_N0.6070.98
37_K71_L0.6010.98
150_V189_L0.5920.98
184_F189_L0.5890.98
205_K208_K0.5880.98
79_I83_L0.5860.98
124_L130_I0.5850.98
40_V43_I0.5830.98
66_V71_L0.5830.98
53_A86_S0.5830.98
80_E93_A0.5820.98
72_S97_K0.5810.98
102_I127_L0.5800.98
136_D177_S0.5800.98
16_Y195_M0.5790.98
43_I96_L0.5790.98
113_S123_E0.5740.98
179_T183_L0.5710.97
151_F192_L0.5680.97
34_D66_V0.5680.97
157_I196_L0.5680.97
130_I135_A0.5650.97
204_C220_C0.5630.97
27_Y50_D0.5620.97
121_R132_E0.5610.97
158_T172_K0.5600.97
155_T206_A0.5600.97
120_A139_L0.5590.97
136_D152_P0.5520.97
132_E174_S0.5510.97
20_E195_M0.5500.97
20_E30_L0.5500.97
16_Y196_L0.5490.97
41_A57_Y0.5470.97
13_S185_S0.5450.97
34_D38_V0.5450.97
134_T138_V0.5450.97
217_K224_S0.5410.97
153_V158_T0.5390.96
39_L103_I0.5380.96
169_T172_K0.5340.96
185_S188_D0.5320.96
29_W32_T0.5320.96
162_K169_T0.5320.96
15_T164_L0.5270.96
133_K156_H0.5250.96
163_R211_C0.5250.96
40_V100_S0.5220.96
101_R104_L0.5200.96
13_S17_I0.5170.95
16_Y184_F0.5170.95
26_Y29_W0.5170.95
214_C220_C0.5150.95
163_R205_K0.5130.95
50_D53_A0.5120.95
45_S197_I0.5110.95
39_L111_I0.5110.95
180_L183_L0.5110.95
153_V157_I0.5090.95
189_L193_H0.5080.95
172_K177_S0.5070.95
149_K187_Y0.5060.95
24_I30_L0.5050.95
73_N104_L0.5040.95
56_A86_S0.5030.95
35_C143_Y0.5020.95
136_D150_V0.5010.95
55_K85_I0.5000.95
163_R204_C0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.928 100 0.235 Contact Map
1kg2A 1 0.928 100 0.241 Contact Map
3n5nX 1 0.9534 100 0.245 Contact Map
1keaA 2 0.9068 100 0.251 Contact Map
4unfA 1 0.9364 100 0.255 Contact Map
2abkA 1 0.8941 100 0.258 Contact Map
4uobA 1 0.9534 100 0.258 Contact Map
1ornA 1 0.9025 100 0.26 Contact Map
1pu6A 1 0.822 100 0.375 Contact Map
3s6iA 1 0.8178 100 0.484 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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