Q7LXY0 - SULSO - GREMLIN Contacts

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Q7LXY0 - DNA endonuclease III, probable (NtH-1)

UniProt:	Q7LXY0	Sequences: MKCTAETIFHKLSATYIIKEEDFIAYYVWLKTKDCFKVLVATILSQNSTDKSAIKAYLELERKVGVTPEKLSNANLADIESALKISGLYRTKAKRLKEISRIILERYNGLIDSLLNTSNARDELLKLEGIGEKTADVVLLTCYGYYGYKVFPVDTHITRVSKRLGIVPTNAKYSLISSTLKELFSAYDLLHLHHMLIAHGRQTCKARKPLCNSCIIKECCEYYSHRDGEAWRSNTS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	236 (201)
Sequences:	8153 (5134)
Seq/√Len:	362.1

ECOLI - END3 MUTY
BACSU - END3 YFHQ
HALSA - Q9HRQ5 Q9HPQ6 Q9HS56
SULSO - Q7LXY0 Q97VX0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
120_A	123_E	3.997	1.00
67_T	70_K	3.646	1.00
210_L	213_S	3.383	1.00
102_I	106_R	3.233	1.00
205_K	210_L	2.764	1.00
63_K	78_D	2.709	1.00
102_I	128_E	2.674	1.00
79_I	97_K	2.493	1.00
113_S	148_Y	2.485	1.00
97_K	101_R	2.352	1.00
81_S	84_K	2.294	1.00
63_K	82_A	2.290	1.00
107_Y	126_K	2.239	1.00
121_R	125_L	2.231	1.00
69_E	104_L	2.060	1.00
174_S	178_S	2.047	1.00
43_I	99_I	2.017	1.00
34_D	37_K	2.008	1.00
101_R	105_E	1.998	1.00
95_R	98_E	1.970	1.00
217_K	223_Y	1.929	1.00
75_N	78_D	1.928	1.00
76_L	80_E	1.912	1.00
66_V	70_K	1.901	1.00
98_E	128_E	1.901	1.00
26_Y	31_K	1.887	1.00
76_L	97_K	1.823	1.00
91_T	95_R	1.809	1.00
106_R	126_K	1.783	1.00
69_E	73_N	1.729	1.00
40_V	96_L	1.728	1.00
36_F	68_P	1.707	1.00
177_S	181_K	1.663	1.00
58_L	62_R	1.639	1.00
158_T	176_I	1.623	1.00
123_E	126_K	1.593	1.00
167_V	179_T	1.575	1.00
59_E	62_R	1.557	1.00
176_I	180_L	1.555	1.00
104_L	109_G	1.551	1.00
33_K	37_K	1.538	1.00
64_V	82_A	1.520	1.00
48_S	52_S	1.511	1.00
113_S	143_Y	1.499	1.00
121_R	150_V	1.497	1.00
36_F	100_S	1.469	1.00
64_V	74_A	1.468	1.00
110_L	113_S	1.468	1.00
37_K	61_E	1.439	1.00
98_E	101_R	1.412	1.00
121_R	139_L	1.411	1.00
221_E	225_H	1.411	1.00
91_T	94_K	1.407	1.00
59_E	82_A	1.346	1.00
102_I	126_K	1.345	1.00
74_A	79_I	1.337	1.00
15_T	219_C	1.327	1.00
80_E	89_Y	1.323	1.00
164_L	216_I	1.317	1.00
198_A	202_Q	1.303	1.00
132_E	177_S	1.300	1.00
184_F	192_L	1.265	1.00
48_S	86_S	1.262	1.00
52_S	55_K	1.256	1.00
21_E	188_D	1.256	1.00
164_L	219_C	1.251	1.00
125_L	132_E	1.232	1.00
166_I	221_E	1.221	1.00
188_D	191_H	1.219	1.00
76_L	94_K	1.206	1.00
77_A	80_E	1.201	1.00
103_I	111_I	1.199	1.00
177_S	180_L	1.180	1.00
17_I	21_E	1.179	1.00
99_I	127_L	1.179	1.00
40_V	61_E	1.171	1.00
139_L	148_Y	1.167	1.00
113_S	120_A	1.164	1.00
55_K	58_L	1.159	1.00
191_H	195_M	1.159	1.00
45_S	50_D	1.151	1.00
102_I	107_Y	1.149	1.00
203_T	215_I	1.148	1.00
35_C	142_C	1.142	1.00
98_E	102_I	1.121	1.00
75_N	97_K	1.120	1.00
124_L	139_L	1.112	1.00
31_K	58_L	1.101	1.00
39_L	43_I	1.100	1.00
161_S	180_L	1.090	1.00
107_Y	123_E	1.081	1.00
106_R	123_E	1.081	1.00
216_I	219_C	1.079	1.00
49_T	52_S	1.070	1.00
29_W	202_Q	1.064	1.00
71_L	79_I	1.053	1.00
144_G	190_L	1.042	1.00
36_F	71_L	1.037	1.00
169_T	175_L	1.028	1.00
211_C	220_C	1.027	1.00
76_L	93_A	1.025	1.00
39_L	138_V	1.021	1.00
174_S	177_S	1.003	1.00
172_K	175_L	1.002	1.00
199_H	203_T	1.001	1.00
139_L	150_V	0.999	1.00
71_L	100_S	0.993	1.00
14_A	17_I	0.990	1.00
57_Y	61_E	0.987	1.00
14_A	18_I	0.986	1.00
37_K	57_Y	0.985	1.00
18_I	22_D	0.982	1.00
149_K	186_A	0.971	1.00
51_K	55_K	0.965	1.00
21_E	191_H	0.964	1.00
20_E	188_D	0.961	1.00
186_A	189_L	0.960	1.00
151_F	181_K	0.955	1.00
99_I	102_I	0.952	1.00
94_K	98_E	0.940	1.00
162_K	176_I	0.934	1.00
32_T	38_V	0.920	1.00
199_H	215_I	0.917	1.00
68_P	104_L	0.916	1.00
175_L	179_T	0.909	1.00
99_I	103_I	0.905	1.00
76_L	101_R	0.904	1.00
20_E	24_I	0.902	1.00
54_I	58_L	0.897	1.00
20_E	191_H	0.896	1.00
140_L	193_H	0.891	1.00
178_S	181_K	0.888	1.00
122_D	125_L	0.878	1.00
161_S	196_L	0.877	1.00
42_T	138_V	0.873	1.00
39_L	99_I	0.873	1.00
179_T	182_E	0.873	1.00
140_L	152_P	0.868	1.00
78_D	82_A	0.864	1.00
18_I	218_E	0.864	1.00
15_T	216_I	0.863	1.00
192_L	196_L	0.863	1.00
52_S	85_I	0.854	1.00
140_L	190_L	0.851	1.00
19_K	23_F	0.851	1.00
166_I	225_H	0.850	1.00
204_C	211_C	0.847	1.00
72_S	100_S	0.837	1.00
204_C	214_C	0.834	1.00
169_T	176_I	0.828	1.00
152_P	193_H	0.827	1.00
37_K	66_V	0.824	1.00
72_S	104_L	0.823	1.00
151_F	189_L	0.819	1.00
46_Q	134_T	0.818	1.00
139_L	143_Y	0.813	1.00
221_E	224_S	0.806	1.00
18_I	21_E	0.805	1.00
203_T	213_S	0.803	1.00
121_R	136_D	0.802	1.00
59_E	85_I	0.800	1.00
17_I	188_D	0.783	1.00
56_A	59_E	0.779	1.00
158_T	162_K	0.774	1.00
40_V	99_I	0.773	1.00
130_I	134_T	0.773	1.00
162_K	167_V	0.772	1.00
74_A	78_D	0.768	1.00
55_K	59_E	0.754	1.00
78_D	81_S	0.751	1.00
121_R	135_A	0.751	1.00
96_L	100_S	0.750	1.00
38_V	142_C	0.748	1.00
27_Y	30_L	0.741	1.00
59_E	63_K	0.732	1.00
141_T	190_L	0.730	1.00
68_P	111_I	0.727	1.00
104_L	107_Y	0.726	1.00
178_S	182_E	0.725	1.00
111_I	124_L	0.725	1.00
132_E	136_D	0.724	1.00
17_I	20_E	0.724	1.00
181_K	189_L	0.724	1.00
150_V	181_K	0.717	0.99
42_T	134_T	0.714	0.99
172_K	176_I	0.713	0.99
32_T	37_K	0.712	0.99
121_R	148_Y	0.711	0.99
160_V	199_H	0.708	0.99
69_E	109_G	0.707	0.99
153_V	176_I	0.705	0.99
52_S	86_S	0.701	0.99
136_D	151_F	0.699	0.99
22_D	215_I	0.694	0.99
173_Y	176_I	0.694	0.99
44_L	53_A	0.693	0.99
42_T	141_T	0.688	0.99
72_S	101_R	0.675	0.99
209_P	220_C	0.674	0.99
93_A	97_K	0.670	0.99
17_I	191_H	0.668	0.99
188_D	195_M	0.667	0.99
163_R	209_P	0.667	0.99
64_V	79_I	0.666	0.99
175_L	178_S	0.666	0.99
173_Y	177_S	0.663	0.99
72_S	75_N	0.662	0.99
126_K	139_L	0.659	0.99
219_C	223_Y	0.659	0.99
144_G	148_Y	0.658	0.99
93_A	96_L	0.648	0.99
64_V	78_D	0.647	0.99
211_C	214_C	0.644	0.99
185_S	189_L	0.639	0.99
140_L	150_V	0.639	0.99
199_H	202_Q	0.639	0.99
103_I	109_G	0.638	0.99
51_K	54_I	0.638	0.99
217_K	222_Y	0.637	0.99
82_A	85_I	0.634	0.99
74_A	97_K	0.633	0.99
130_I	138_V	0.632	0.99
151_F	184_F	0.630	0.99
138_V	142_C	0.629	0.99
20_E	194_H	0.622	0.99
68_P	100_S	0.618	0.98
125_L	135_A	0.617	0.98
124_L	138_V	0.617	0.98
141_T	194_H	0.613	0.98
44_L	86_S	0.613	0.98
165_G	168_P	0.608	0.98
144_G	149_K	0.608	0.98
24_I	198_A	0.607	0.98
70_K	73_N	0.607	0.98
37_K	71_L	0.601	0.98
150_V	189_L	0.592	0.98
184_F	189_L	0.589	0.98
205_K	208_K	0.588	0.98
79_I	83_L	0.586	0.98
124_L	130_I	0.585	0.98
40_V	43_I	0.583	0.98
66_V	71_L	0.583	0.98
53_A	86_S	0.583	0.98
80_E	93_A	0.582	0.98
72_S	97_K	0.581	0.98
102_I	127_L	0.580	0.98
136_D	177_S	0.580	0.98
16_Y	195_M	0.579	0.98
43_I	96_L	0.579	0.98
113_S	123_E	0.574	0.98
179_T	183_L	0.571	0.97
151_F	192_L	0.568	0.97
34_D	66_V	0.568	0.97
157_I	196_L	0.568	0.97
130_I	135_A	0.565	0.97
204_C	220_C	0.563	0.97
27_Y	50_D	0.562	0.97
121_R	132_E	0.561	0.97
158_T	172_K	0.560	0.97
155_T	206_A	0.560	0.97
120_A	139_L	0.559	0.97
136_D	152_P	0.552	0.97
132_E	174_S	0.551	0.97
20_E	195_M	0.550	0.97
20_E	30_L	0.550	0.97
16_Y	196_L	0.549	0.97
41_A	57_Y	0.547	0.97
13_S	185_S	0.545	0.97
34_D	38_V	0.545	0.97
134_T	138_V	0.545	0.97
217_K	224_S	0.541	0.97
153_V	158_T	0.539	0.96
39_L	103_I	0.538	0.96
169_T	172_K	0.534	0.96
185_S	188_D	0.532	0.96
29_W	32_T	0.532	0.96
162_K	169_T	0.532	0.96
15_T	164_L	0.527	0.96
133_K	156_H	0.525	0.96
163_R	211_C	0.525	0.96
40_V	100_S	0.522	0.96
101_R	104_L	0.520	0.96
13_S	17_I	0.517	0.95
16_Y	184_F	0.517	0.95
26_Y	29_W	0.517	0.95
214_C	220_C	0.515	0.95
163_R	205_K	0.513	0.95
50_D	53_A	0.512	0.95
45_S	197_I	0.511	0.95
39_L	111_I	0.511	0.95
180_L	183_L	0.511	0.95
153_V	157_I	0.509	0.95
189_L	193_H	0.508	0.95
172_K	177_S	0.507	0.95
149_K	187_Y	0.506	0.95
24_I	30_L	0.505	0.95
73_N	104_L	0.504	0.95
56_A	86_S	0.503	0.95
35_C	143_Y	0.502	0.95
136_D	150_V	0.501	0.95
55_K	85_I	0.500	0.95
163_R	204_C	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fspA	1	0.928	100	0.235	Contact Map
1kg2A	1	0.928	100	0.241	Contact Map
3n5nX	1	0.9534	100	0.245	Contact Map
1keaA	2	0.9068	100	0.251	Contact Map
4unfA	1	0.9364	100	0.255	Contact Map
2abkA	1	0.8941	100	0.258	Contact Map
4uobA	1	0.9534	100	0.258	Contact Map
1ornA	1	0.9025	100	0.26	Contact Map
1pu6A	1	0.822	100	0.375	Contact Map
3s6iA	1	0.8178	100	0.484	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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