GREMLIN Database
Q7LXX7 - Uncharacterized protein
UniProt: Q7LXX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 506 (465)
Sequences: 417 (334)
Seq/√Len: 15.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
373_A376_N4.5281.00
434_T485_L4.3331.00
277_L282_I4.0061.00
278_Y282_I3.8461.00
105_A118_T3.7841.00
239_F243_F3.6221.00
148_S151_S3.5550.99
442_F446_I3.5140.99
120_E143_E3.2140.99
138_L169_Y3.1930.99
94_I160_H3.0800.98
277_L281_P2.8960.98
284_F288_F2.8790.97
468_S472_A2.7290.96
45_F362_G2.7020.96
375_S452_A2.6390.96
280_L284_F2.5290.95
470_I476_R2.4400.93
210_E233_S2.4160.93
94_I168_I2.3790.93
278_Y281_P2.3270.92
295_E305_F2.3260.92
469_I479_V2.2990.91
468_S482_F2.2770.91
63_P66_L2.2540.90
45_F61_I2.1360.88
277_L280_L2.0980.87
277_L290_F2.0950.87
48_P324_N2.0810.86
246_L347_I2.0660.86
470_I474_V2.0600.86
42_V75_I2.0470.85
231_Y467_L2.0030.84
54_S208_V2.0030.84
280_L285_I1.9780.83
297_E301_F1.9770.83
138_L153_M1.9690.83
482_F485_L1.9680.83
323_L381_I1.9320.82
57_L124_N1.9140.81
35_R42_V1.8900.80
109_S128_F1.8900.80
62_S78_F1.8800.80
171_V189_L1.8730.80
294_L298_I1.8290.78
140_K312_I1.8240.78
322_I447_M1.8180.77
104_F334_A1.8140.77
243_F249_P1.8120.77
168_I356_H1.7990.77
479_V482_F1.7960.77
219_F344_K1.7880.76
47_M57_L1.7830.76
71_M74_F1.7810.76
179_G213_E1.7690.75
255_I263_G1.7690.75
288_F291_H1.7540.75
55_I74_F1.7220.73
171_V185_R1.6990.72
276_S283_P1.6990.72
240_E247_L1.6840.72
444_L448_S1.6670.71
292_L300_V1.6630.71
55_I452_A1.6440.70
205_V422_V1.6420.70
99_P390_L1.6320.69
46_L59_L1.6300.69
101_F105_A1.6200.69
330_L405_F1.6180.69
487_L490_M1.6130.68
40_Y48_P1.6060.68
103_L176_E1.6030.68
464_T468_S1.5980.68
471_Y476_R1.5930.67
282_I285_I1.5750.66
285_I298_I1.5660.66
482_F486_V1.5570.65
49_L305_F1.5340.64
470_I479_V1.5340.64
215_L485_L1.5330.64
145_L323_L1.5320.64
256_S260_P1.5250.64
37_R242_I1.5160.63
302_Y461_V1.5150.63
316_I347_I1.5140.63
40_Y245_L1.5060.63
138_L229_F1.4950.62
373_A421_K1.4910.62
66_L301_F1.4760.61
96_N334_A1.4510.60
285_I292_L1.4490.60
46_L69_N1.4480.60
56_I306_I1.4440.59
24_E27_K1.4410.59
46_L52_S1.4400.59
243_F247_L1.4390.59
145_L334_A1.4320.59
53_I58_Y1.4260.58
215_L357_F1.4020.57
52_S55_I1.3980.57
301_F304_I1.3950.57
107_V178_I1.3910.56
286_L372_E1.3900.56
440_F445_G1.3860.56
394_I404_T1.3850.56
71_M285_I1.3830.56
472_A482_F1.3770.56
46_L71_M1.3760.56
45_F53_I1.3760.56
471_Y477_F1.3690.55
62_S494_I1.3670.55
373_A461_V1.3660.55
334_A378_R1.3520.54
338_K371_N1.3500.54
469_I473_K1.3480.54
52_S58_Y1.3430.54
442_F445_G1.3390.54
160_H213_E1.3370.53
225_I232_I1.3350.53
280_L298_I1.3260.53
191_N455_N1.3260.53
59_L67_L1.3250.53
305_F483_P1.3200.52
287_V291_H1.3200.52
138_L491_N1.3150.52
158_K300_V1.3140.52
109_S205_V1.3120.52
334_A381_I1.3110.52
57_L292_L1.3090.52
65_F69_N1.3030.51
277_L285_I1.3020.51
128_F386_A1.2920.51
276_S280_L1.2880.51
289_L487_L1.2870.51
242_I249_P1.2830.50
128_F422_V1.2790.50
439_V444_L1.2760.50
167_K434_T1.2710.50
48_P293_S1.2700.50
204_Y223_P1.2570.49
91_R483_P1.2460.48
41_I46_L1.2410.48
45_F66_L1.2410.48
289_L304_I1.2380.48
111_L337_L1.2360.48
436_T440_F1.2340.48
239_F250_I1.2280.47
168_I334_A1.2220.47
219_F223_P1.2130.46
292_L299_L1.2120.46
248_F286_L1.2070.46
39_E79_P1.2070.46
56_I294_L1.2020.46
484_L496_L1.2000.46
106_Y404_T1.1920.45
70_I290_F1.1920.45
310_F324_N1.1890.45
151_S322_I1.1860.45
56_I246_L1.1810.45
57_L300_V1.1810.45
278_Y291_H1.1760.44
280_L290_F1.1720.44
329_I434_T1.1690.44
275_N310_F1.1670.44
46_L288_F1.1660.44
329_I354_N1.1660.44
433_A436_T1.1640.44
467_L472_A1.1630.44
51_S253_F1.1540.43
56_I62_S1.1540.43
195_D462_L1.1500.43
491_N499_G1.1490.43
488_A493_I1.1440.42
354_N434_T1.1420.42
283_P302_Y1.1420.42
178_I422_V1.1410.42
285_I288_F1.1380.42
115_L255_I1.1360.42
248_F251_I1.1310.42
52_S361_L1.1310.42
276_S289_L1.1300.42
170_T442_F1.1290.42
198_N414_N1.1280.42
299_L304_I1.1270.42
294_L452_A1.1270.42
40_Y182_M1.1260.41
472_A486_V1.1260.41
318_V498_F1.1240.41
377_V432_L1.1180.41
207_K388_L1.1150.41
135_A368_I1.1150.41
44_L48_P1.1090.41
195_D459_I1.1070.40
202_Q342_S1.1060.40
154_E185_R1.1050.40
168_I211_L1.1050.40
425_N461_V1.1030.40
238_I279_I1.0990.40
295_E298_I1.0960.40
130_G218_L1.0930.40
251_I279_I1.0920.40
426_L475_S1.0900.39
203_G259_Q1.0880.39
55_I242_I1.0870.39
313_Y317_S1.0850.39
214_I230_Q1.0840.39
224_M337_L1.0830.39
82_I260_P1.0820.39
43_M373_A1.0820.39
162_G213_E1.0800.39
282_I291_H1.0790.39
119_F122_I1.0730.39
225_I424_Q1.0710.38
64_Y452_A1.0710.38
26_I47_M1.0700.38
172_Y259_Q1.0630.38
107_V408_L1.0620.38
94_I134_E1.0580.38
240_E250_I1.0570.38
237_N286_L1.0510.37
351_N424_Q1.0510.37
240_E243_F1.0510.37
218_L233_S1.0500.37
472_A475_S1.0500.37
353_D364_L1.0500.37
295_E300_V1.0490.37
276_S288_F1.0480.37
154_E168_I1.0480.37
241_L476_R1.0440.37
362_G494_I1.0430.37
487_L494_I1.0430.37
255_I260_P1.0420.37
251_I293_S1.0410.37
354_N485_L1.0400.37
44_L279_I1.0370.37
84_Q87_K1.0360.37
49_L78_F1.0350.37
407_D436_T1.0280.36
168_I231_Y1.0280.36
169_Y306_I1.0210.36
99_P190_L1.0180.36
61_I70_I1.0150.35
49_L282_I1.0110.35
57_L494_I1.0090.35
46_L49_L1.0080.35
242_I364_L1.0030.35
68_L420_K1.0010.35
35_R154_E0.9980.35
256_S261_N0.9970.35
27_K30_G0.9970.35
44_L320_D0.9960.34
70_I310_F0.9940.34
329_I361_L0.9910.34
201_F327_P0.9910.34
297_E304_I0.9910.34
48_P306_I0.9870.34
275_N494_I0.9860.34
57_L61_I0.9860.34
488_A491_N0.9850.34
216_F474_V0.9800.34
407_D422_V0.9790.34
191_N433_A0.9790.34
301_F305_F0.9790.34
39_E67_L0.9770.34
286_L290_F0.9750.33
278_Y283_P0.9720.33
26_I241_L0.9690.33
277_L487_L0.9680.33
361_L373_A0.9680.33
55_I265_D0.9640.33
493_I496_L0.9600.33
110_L216_F0.9580.33
49_L359_M0.9570.32
100_V397_K0.9570.32
361_L368_I0.9560.32
285_I291_H0.9530.32
139_V241_L0.9520.32
300_V304_I0.9520.32
40_Y361_L0.9510.32
57_L65_F0.9470.32
124_N359_M0.9470.32
97_E411_I0.9450.32
25_N120_E0.9450.32
162_G482_F0.9400.32
106_Y463_Y0.9370.31
135_A165_L0.9290.31
197_L418_L0.9260.31
171_V408_L0.9260.31
77_F80_I0.9250.31
74_F294_L0.9230.31
168_I179_G0.9230.31
183_P491_N0.9220.31
32_D78_F0.9210.31
152_A175_G0.9200.31
87_K99_P0.9200.31
283_P294_L0.9200.31
168_I226_L0.9160.30
458_L463_Y0.9150.30
34_E49_L0.9150.30
216_F220_L0.9140.30
231_Y368_I0.9120.30
331_S439_V0.9110.30
175_G180_I0.9090.30
290_F491_N0.9080.30
144_V219_F0.9070.30
51_S55_I0.9060.30
330_L340_G0.9040.30
476_R481_N0.9020.30
48_P295_E0.9020.30
114_N138_L0.9010.30
96_N200_N0.9000.30
49_L292_L0.8970.30
48_P452_A0.8950.29
95_E164_F0.8940.29
39_E47_M0.8930.29
117_K494_I0.8920.29
294_L305_F0.8880.29
33_M63_P0.8870.29
469_I476_R0.8870.29
216_F219_F0.8860.29
284_F293_S0.8860.29
299_L305_F0.8850.29
122_I182_M0.8840.29
312_I481_N0.8830.29
26_I30_G0.8800.29
29_Y53_I0.8790.29
45_F297_E0.8760.29
237_N494_I0.8760.29
229_F447_M0.8750.29
293_S296_Y0.8740.28
165_L217_M0.8730.28
450_I491_N0.8700.28
370_K449_K0.8680.28
245_L462_L0.8670.28
108_N113_R0.8660.28
162_G357_F0.8650.28
248_F285_I0.8650.28
57_L60_K0.8640.28
442_F448_S0.8640.28
132_R490_M0.8640.28
102_L159_A0.8620.28
171_V365_A0.8620.28
442_F451_R0.8570.28
32_D41_I0.8560.28
236_I335_D0.8550.28
280_L283_P0.8540.28
220_L460_I0.8540.28
33_M48_P0.8530.28
119_F345_S0.8530.28
443_A447_M0.8480.27
36_L56_I0.8460.27
26_I31_D0.8460.27
335_D439_V0.8450.27
51_S289_L0.8450.27
212_V220_L0.8410.27
333_I350_L0.8400.27
61_I292_L0.8390.27
147_K442_F0.8360.27
196_G377_V0.8350.27
148_S333_I0.8350.27
438_I448_S0.8300.26
119_F410_L0.8300.26
440_F444_L0.8290.26
265_D299_L0.8290.26
334_A428_L0.8260.26
165_L227_L0.8250.26
65_F275_N0.8240.26
60_K352_V0.8240.26
69_N465_M0.8220.26
62_S114_N0.8220.26
371_N490_M0.8220.26
238_I276_S0.8220.26
99_P145_L0.8170.26
37_R41_I0.8160.26
294_L297_E0.8160.26
476_R484_L0.8140.26
361_L487_L0.8120.26
36_L39_E0.8110.26
158_K373_A0.8090.26
284_F466_A0.8090.26
202_Q421_K0.8090.26
49_L57_L0.8060.25
57_L288_F0.8060.25
112_G482_F0.8060.25
338_K357_F0.8040.25
187_K452_A0.8030.25
131_L171_V0.8030.25
171_V405_F0.8000.25
148_S412_L0.7990.25
259_Q323_L0.7970.25
319_A380_N0.7960.25
52_S302_Y0.7940.25
52_S78_F0.7930.25
323_L330_L0.7920.25
77_F452_A0.7900.25
37_R40_Y0.7890.25
229_F234_S0.7890.25
41_I45_F0.7860.25
53_I306_I0.7800.24
53_I93_L0.7790.24
238_I277_L0.7780.24
277_L283_P0.7770.24
186_L369_R0.7760.24
71_M82_I0.7740.24
141_E309_S0.7730.24
215_L434_T0.7690.24
40_Y488_A0.7670.24
56_I71_M0.7640.24
27_K31_D0.7570.23
47_M58_Y0.7550.23
101_F131_L0.7550.23
71_M288_F0.7550.23
45_F359_M0.7530.23
245_L278_Y0.7530.23
61_I124_N0.7530.23
99_P340_G0.7530.23
319_A459_I0.7510.23
65_F237_N0.7500.23
167_K256_S0.7470.23
459_I463_Y0.7440.23
326_L394_I0.7420.23
41_I44_L0.7410.23
168_I189_L0.7400.23
445_G495_V0.7400.23
122_I389_E0.7400.23
225_I419_R0.7380.23
421_K459_I0.7380.23
61_I78_F0.7370.23
44_L78_F0.7340.22
90_Q129_K0.7340.22
238_I285_I0.7340.22
461_V464_T0.7330.22
70_I245_L0.7310.22
73_V284_F0.7290.22
171_V180_I0.7280.22
148_S370_K0.7270.22
50_I71_M0.7250.22
487_L495_V0.7240.22
331_S413_Y0.7230.22
77_F282_I0.7210.22
369_R444_L0.7210.22
256_S259_Q0.7200.22
123_R423_L0.7200.22
162_G168_I0.7200.22
34_E38_K0.7190.22
69_N481_N0.7180.22
46_L275_N0.7160.22
281_P285_I0.7150.22
53_I282_I0.7150.22
71_M286_L0.7140.22
98_M363_E0.7120.22
242_I265_D0.7110.22
287_V462_L0.7100.21
278_Y452_A0.7100.21
240_E248_F0.7100.21
229_F441_Y0.7080.21
69_N487_L0.7080.21
101_F132_R0.7060.21
237_N251_I0.7060.21
130_G134_E0.7040.21
265_D288_F0.7040.21
126_K369_R0.7030.21
212_V475_S0.7030.21
86_R278_Y0.7030.21
334_A409_S0.7030.21
309_S483_P0.7020.21
223_P340_G0.7010.21
104_F340_G0.7000.21
45_F183_P0.7000.21
73_V305_F0.7000.21
319_A323_L0.6990.21
201_F229_F0.6990.21
101_F138_L0.6980.21
171_V398_G0.6960.21
48_P77_F0.6930.21
204_Y219_F0.6920.21
133_R284_F0.6900.21
282_I299_L0.6900.21
97_E225_I0.6890.21
46_L285_I0.6890.21
59_L275_N0.6870.21
227_L328_Y0.6860.21
276_S281_P0.6830.20
200_N280_L0.6830.20
62_S186_L0.6830.20
52_S66_L0.6820.20
285_I289_L0.6800.20
379_T383_I0.6800.20
459_I464_T0.6790.20
104_F107_V0.6790.20
104_F393_N0.6780.20
160_H432_L0.6780.20
115_L204_Y0.6780.20
390_L499_G0.6770.20
286_L310_F0.6770.20
206_E456_L0.6760.20
35_R39_E0.6750.20
154_E464_T0.6740.20
262_I477_F0.6740.20
276_S287_V0.6730.20
366_A420_K0.6700.20
117_K342_S0.6700.20
300_V303_S0.6690.20
175_G216_F0.6670.20
284_F291_H0.6670.20
279_I322_I0.6650.20
431_I477_F0.6650.20
194_I418_L0.6640.20
67_L70_I0.6610.20
112_G128_F0.6600.20
132_R467_L0.6600.20
145_L333_I0.6600.20
67_L81_L0.6590.20
78_F289_L0.6570.20
50_I56_I0.6570.20
247_L251_I0.6570.20
158_K265_D0.6530.19
40_Y44_L0.6530.19
239_F459_I0.6520.19
219_F435_I0.6500.19
329_I355_T0.6500.19
165_L232_I0.6500.19
91_R165_L0.6460.19
301_F358_R0.6450.19
149_S218_L0.6440.19
282_I302_Y0.6430.19
479_V484_L0.6430.19
476_R479_V0.6410.19
238_I466_A0.6400.19
24_E53_I0.6380.19
28_Y410_L0.6360.19
174_S217_M0.6360.19
346_A351_N0.6350.19
179_G422_V0.6350.19
289_L306_I0.6350.19
62_S290_F0.6350.19
294_L348_L0.6350.19
411_I432_L0.6340.19
28_Y40_Y0.6330.19
62_S277_L0.6280.19
39_E43_M0.6280.19
75_I290_F0.6280.19
111_L215_L0.6270.18
55_I275_N0.6270.18
313_Y484_L0.6260.18
283_P303_S0.6230.18
220_L423_L0.6220.18
419_R435_I0.6190.18
293_S297_E0.6190.18
483_P491_N0.6180.18
306_I348_L0.6180.18
491_N495_V0.6170.18
263_G350_L0.6160.18
439_V475_S0.6160.18
51_S54_S0.6150.18
198_N369_R0.6150.18
47_M54_S0.6140.18
67_L71_M0.6130.18
426_L429_F0.6130.18
58_Y487_L0.6130.18
57_L275_N0.6120.18
152_A205_V0.6120.18
327_P440_F0.6120.18
281_P292_L0.6110.18
24_E34_E0.6100.18
66_L226_L0.6090.18
359_M491_N0.6070.18
69_N362_G0.6070.18
478_T486_V0.6050.18
467_L470_I0.6040.18
279_I452_A0.6040.18
323_L380_N0.6030.18
111_L167_K0.6000.18
109_S256_S0.5990.18
108_N111_L0.5980.17
432_L474_V0.5970.17
62_S241_L0.5960.17
265_D489_L0.5960.17
50_I74_F0.5950.17
387_I441_Y0.5950.17
365_A408_L0.5950.17
73_V77_F0.5940.17
65_F246_L0.5920.17
286_L289_L0.5910.17
109_S361_L0.5910.17
224_M439_V0.5910.17
49_L487_L0.5900.17
378_R484_L0.5880.17
70_I489_L0.5870.17
220_L263_G0.5870.17
237_N248_F0.5870.17
111_L339_I0.5860.17
56_I290_F0.5860.17
24_E285_I0.5850.17
426_L436_T0.5840.17
329_I383_I0.5830.17
281_P284_F0.5820.17
244_P374_I0.5820.17
418_L422_V0.5810.17
198_N494_I0.5790.17
122_I135_A0.5750.17
186_L410_L0.5740.17
31_D403_Y0.5740.17
323_L374_I0.5730.17
246_L377_V0.5730.17
70_I74_F0.5720.17
293_S300_V0.5720.17
140_K145_L0.5720.17
52_S56_I0.5710.17
197_L201_F0.5710.17
133_R206_E0.5700.17
47_M50_I0.5690.17
59_L310_F0.5670.16
311_F390_L0.5670.16
41_I245_L0.5660.16
150_F425_N0.5660.16
460_I492_L0.5660.16
334_A419_R0.5660.16
309_S398_G0.5660.16
161_R485_L0.5650.16
123_R286_L0.5640.16
36_L44_L0.5630.16
337_L340_G0.5630.16
36_L80_I0.5620.16
235_S361_L0.5620.16
41_I142_V0.5590.16
169_Y387_I0.5580.16
102_L301_F0.5580.16
96_N446_I0.5580.16
34_E67_L0.5570.16
67_L314_R0.5550.16
69_N289_L0.5550.16
204_Y461_V0.5540.16
70_I280_L0.5540.16
92_K129_K0.5530.16
77_F123_R0.5510.16
55_I352_V0.5500.16
179_G189_L0.5490.16
347_I452_A0.5480.16
91_R300_V0.5470.16
149_S373_A0.5470.16
48_P358_R0.5460.16
436_T444_L0.5450.16
352_V376_N0.5440.16
110_L405_F0.5440.16
45_F290_F0.5430.16
50_I285_I0.5430.16
141_E330_L0.5430.16
147_K373_A0.5430.16
223_P496_L0.5420.16
243_F452_A0.5410.16
279_I310_F0.5410.16
119_F328_Y0.5400.16
302_Y305_F0.5400.16
133_R136_M0.5390.16
318_V469_I0.5390.16
178_I342_S0.5380.16
36_L45_F0.5380.16
135_A433_A0.5370.16
241_L244_P0.5360.16
196_G432_L0.5350.16
338_K406_K0.5340.15
275_N289_L0.5340.15
224_M472_A0.5320.15
215_L422_V0.5310.15
256_S263_G0.5290.15
335_D338_K0.5270.15
241_L291_H0.5240.15
56_I462_L0.5240.15
275_N291_H0.5210.15
404_T407_D0.5210.15
265_D304_I0.5200.15
436_T473_K0.5200.15
129_K134_E0.5190.15
283_P305_F0.5190.15
153_M295_E0.5190.15
288_F369_R0.5190.15
213_E468_S0.5180.15
108_N420_K0.5160.15
73_V282_I0.5160.15
296_Y300_V0.5130.15
354_N358_R0.5130.15
376_N492_L0.5090.15
98_M108_N0.5090.15
168_I215_L0.5090.15
189_L329_I0.5090.15
117_K242_I0.5080.15
55_I183_P0.5080.15
49_L86_R0.5080.15
178_I228_A0.5070.15
65_F359_M0.5040.15
228_A392_E0.5030.15
278_Y284_F0.5030.15
243_F468_S0.5030.15
177_S342_S0.5020.15
333_I426_L0.5010.15
57_L498_F0.5000.14
242_I284_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2whnA 1 0.2134 98 0.916 Contact Map
3c1qA 2 0.2332 97.8 0.92 Contact Map
4hhxA 1 0.1957 97.6 0.923 Contact Map
1rh1A 1 0.1976 12.3 0.974 Contact Map
3aqpA 1 0.1581 10.5 0.975 Contact Map
3w9iA 3 0.166 8.3 0.976 Contact Map
3tweA 2 0.0514 6.9 0.977 Contact Map
2lv7A 1 0.1858 6.6 0.977 Contact Map
2o3lA 1 0.1443 6.3 0.978 Contact Map
3fx7A 2 0.1581 6.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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