GREMLIN Database
Q7LXX6 - Type II secretion system protein, virB homolog (GspE-1)
UniProt: Q7LXX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (432)
Sequences: 5023 (3581)
Seq/√Len: 172.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
423_S449_K4.6561.00
375_R399_R4.5951.00
222_Y250_I3.9891.00
225_F365_G3.8631.00
381_R400_P3.6981.00
429_I443_E3.6911.00
151_I194_F3.5411.00
193_T259_K3.5081.00
339_N342_E3.3541.00
380_R397_R3.3101.00
258_F307_Y3.1461.00
382_I395_K3.1251.00
378_N404_W3.1241.00
223_I253_M3.0481.00
381_R398_F2.9441.00
234_L333_A2.8121.00
261_I300_S2.7811.00
429_I434_E2.7251.00
375_R468_Y2.7021.00
458_N472_I2.5281.00
383_I396_L2.5091.00
263_I296_L2.4801.00
374_D414_N2.4731.00
447_R456_S2.3841.00
443_E449_K2.3791.00
189_L267_P2.3631.00
236_I335_F2.3551.00
423_S443_E2.3391.00
383_I398_F2.3171.00
375_R380_R2.2821.00
177_H200_P2.2791.00
219_M223_I2.2701.00
367_I419_L2.2641.00
226_L250_I2.2631.00
313_I321_L2.2571.00
167_P289_F2.2381.00
66_I74_L2.2281.00
422_R430_S2.1851.00
122_V147_V2.1831.00
181_A196_I2.1581.00
443_E448_V2.1331.00
426_I440_I2.1311.00
386_I390_V2.1261.00
224_W421_K2.1141.00
385_S388_E2.1021.00
436_P439_E2.0911.00
425_R449_K2.0751.00
452_N460_L2.0621.00
414_N466_S2.0551.00
186_E277_I2.0441.00
457_N461_D2.0161.00
101_L150_V1.9581.00
460_L464_E1.9221.00
399_R468_Y1.9221.00
70_V74_L1.9171.00
109_Y411_F1.9071.00
137_T140_I1.9051.00
193_T275_N1.8951.00
339_N441_T1.8511.00
217_S452_N1.8421.00
341_H420_I1.8371.00
446_N450_T1.8151.00
69_T74_L1.7871.00
218_L417_D1.7861.00
263_I300_S1.7851.00
292_S295_D1.7851.00
280_F288_Q1.7831.00
134_R474_Q1.7761.00
428_Y432_T1.7661.00
160_K185_R1.7621.00
218_L419_L1.7261.00
254_I307_Y1.7181.00
459_I463_E1.7151.00
158_A183_V1.6971.00
121_P140_I1.6901.00
239_T305_P1.6861.00
184_S303_Y1.6721.00
185_R194_F1.6461.00
181_A198_K1.6401.00
216_S220_L1.6361.00
215_I218_L1.6351.00
39_E42_L1.6341.00
199_F269_I1.6281.00
378_N411_F1.6231.00
49_I57_I1.6141.00
188_S275_N1.6101.00
228_D364_W1.5881.00
32_I58_Y1.5881.00
344_L363_L1.5841.00
208_S211_K1.5831.00
462_L472_I1.5681.00
434_E439_E1.5621.00
402_L405_S1.5511.00
414_N461_D1.5391.00
461_D466_S1.5131.00
35_Y49_I1.4991.00
396_L462_L1.4831.00
43_D47_I1.4781.00
348_L359_F1.4731.00
425_R443_E1.4561.00
376_N379_I1.4521.00
115_C122_V1.4491.00
218_L457_N1.4431.00
154_L183_V1.4411.00
62_S65_N1.4351.00
102_T106_A1.4261.00
420_I451_L1.4201.00
218_L221_A1.4141.00
34_Y60_T1.4141.00
233_F330_G1.4051.00
453_N456_S1.3951.00
442_K448_V1.3931.00
376_N405_S1.3921.00
379_I405_S1.3881.00
66_I69_T1.3831.00
424_Y427_S1.3821.00
239_T329_H1.3741.00
379_I402_L1.3731.00
134_R373_R1.3711.00
217_S221_A1.3611.00
116_K125_V1.3611.00
439_E442_K1.3601.00
246_L369_L1.3601.00
255_N260_V1.3561.00
375_R400_P1.3491.00
387_Y390_V1.3481.00
382_I397_R1.3441.00
123_T137_T1.3311.00
425_R448_V1.3311.00
280_F289_F1.3281.00
376_N402_L1.3261.00
375_R397_R1.3261.00
319_E323_H1.3121.00
277_I300_S1.3121.00
234_L313_I1.3081.00
296_L300_S1.3051.00
214_S417_D1.3001.00
377_G380_R1.2941.00
102_T105_L1.2831.00
398_F470_K1.2741.00
227_L253_M1.2621.00
126_H138_N1.2621.00
220_L224_W1.2601.00
46_E59_S1.2601.00
214_S222_Y1.2591.00
233_F365_G1.2471.00
69_T72_K1.2271.00
224_W228_D1.2261.00
66_I70_V1.2241.00
193_T261_I1.2121.00
302_R314_R1.2021.00
318_I353_K1.1951.00
221_A421_K1.1871.00
225_F419_L1.1841.00
354_D357_K1.1831.00
348_L356_A1.1811.00
210_I223_I1.1771.00
37_V59_S1.1731.00
313_I333_A1.1661.00
335_F343_A1.1611.00
386_I389_I1.1551.00
254_I332_L1.1541.00
214_S246_L1.1541.00
27_Y34_Y1.1511.00
36_K40_P1.1441.00
366_I420_I1.1411.00
318_I347_L1.1411.00
416_I458_N1.1401.00
432_T439_E1.1291.00
210_I219_M1.1221.00
410_T468_Y1.1181.00
33_G53_I1.1131.00
173_L181_A1.1071.00
410_T467_V1.0961.00
297_A320_A1.0941.00
48_E51_N1.0911.00
322_V353_K1.0801.00
323_H326_A1.0761.00
53_I57_I1.0711.00
341_H440_I1.0691.00
368_V454_F1.0631.00
66_I73_I1.0611.00
218_L367_I1.0561.00
308_L324_A1.0551.00
100_E104_P1.0470.99
341_H441_T1.0430.99
316_K319_E1.0410.99
61_P65_N1.0390.99
236_I337_A1.0300.99
447_R451_L1.0260.99
67_E71_V1.0200.99
463_E466_S1.0160.99
459_I462_L1.0160.99
61_P64_P1.0150.99
426_I443_E1.0140.99
446_N451_L1.0100.99
50_L56_Y1.0050.99
215_I460_L1.0010.99
300_S308_L0.9950.99
235_I246_L0.9940.99
215_I464_E0.9900.99
401_V405_S0.9870.99
323_H349_S0.9860.99
326_A358_L0.9820.99
209_L249_S0.9790.99
385_S390_V0.9790.99
143_Q147_V0.9780.99
157_K173_L0.9770.99
312_E336_H0.9760.99
178_R201_L0.9750.99
179_V198_K0.9720.99
363_L366_I0.9680.99
232_F331_S0.9680.99
33_G40_P0.9660.99
385_S389_I0.9650.99
462_L469_L0.9640.99
459_I469_L0.9630.99
193_T303_Y0.9590.99
294_M317_E0.9560.99
391_Y394_G0.9540.99
461_D464_E0.9520.99
298_K317_E0.9470.99
96_I99_D0.9450.99
441_T447_R0.9430.99
28_E34_Y0.9380.99
238_S370_G0.9370.99
372_L467_V0.9370.99
50_L57_I0.9350.99
37_V42_L0.9300.99
46_E50_L0.9290.99
42_L45_N0.9290.99
98_Y102_T0.9260.99
32_I56_Y0.9220.99
343_A366_I0.9170.99
460_L463_E0.9120.99
69_T73_I0.9100.99
70_V73_I0.9010.98
76_N80_S0.8990.98
215_I461_D0.8960.98
167_P291_V0.8960.98
261_I277_I0.8950.98
255_N273_H0.8910.98
246_L367_I0.8900.98
179_V200_P0.8900.98
241_S369_L0.8900.98
77_K80_S0.8890.98
153_K157_K0.8850.98
359_F363_L0.8830.98
254_I260_V0.8830.98
373_R471_K0.8780.98
341_H437_I0.8770.98
428_Y442_K0.8770.98
68_E72_K0.8750.98
33_G36_K0.8740.98
31_G55_E0.8740.98
452_N456_S0.8730.98
267_P278_R0.8730.98
341_H451_L0.8690.98
170_E184_S0.8680.98
348_L433_Y0.8680.98
121_P272_I0.8670.98
247_L309_V0.8630.98
230_K339_N0.8630.98
67_E70_V0.8620.98
447_R453_N0.8610.98
396_L399_R0.8600.98
114_E195_D0.8550.98
268_E336_H0.8550.98
433_Y436_P0.8550.98
53_I56_Y0.8550.98
215_I457_N0.8550.98
226_L233_F0.8530.98
230_K364_W0.8520.98
429_I439_E0.8510.98
214_S415_N0.8490.98
158_A173_L0.8470.98
55_E59_S0.8450.98
74_L81_D0.8440.98
155_A192_S0.8440.98
247_L332_L0.8430.98
395_K398_F0.8430.98
118_F123_T0.8430.98
277_I296_L0.8390.98
236_I343_A0.8390.98
243_K312_E0.8380.98
239_T327_S0.8360.97
222_Y419_L0.8330.97
225_F364_W0.8310.97
236_I368_V0.8310.97
209_L223_I0.8310.97
47_I50_L0.8290.97
344_L430_S0.8280.97
422_R426_I0.8280.97
243_K336_H0.8260.97
38_N41_N0.8240.97
259_K275_N0.8230.97
42_L46_E0.8230.97
259_K303_Y0.8220.97
239_T306_D0.8210.97
301_L324_A0.8210.97
261_I275_N0.8180.97
468_Y471_K0.8170.97
291_V296_L0.8120.97
360_L431_K0.8110.97
374_D466_S0.8110.97
226_L332_L0.8090.97
108_P406_F0.8040.97
37_V40_P0.8020.97
467_V471_K0.8020.97
322_V358_L0.7990.97
457_N460_L0.7950.97
379_I401_V0.7950.97
221_A224_W0.7940.97
29_E55_E0.7930.97
426_I446_N0.7890.96
31_G34_Y0.7850.96
183_V196_I0.7850.96
105_L181_A0.7840.96
442_K447_R0.7830.96
101_L154_L0.7820.96
27_Y30_N0.7780.96
50_L54_L0.7780.96
68_E74_L0.7770.96
446_N449_K0.7750.96
313_I318_I0.7740.96
155_A169_L0.7740.96
225_F233_F0.7730.96
447_R450_T0.7690.96
111_E195_D0.7670.96
345_T437_I0.7660.96
66_I72_K0.7650.96
416_I475_G0.7640.96
268_E312_E0.7640.96
263_I279_F0.7620.96
37_V46_E0.7620.96
232_F363_L0.7620.96
305_P329_H0.7610.96
160_K184_S0.7600.96
302_R312_E0.7570.95
36_K62_S0.7540.95
127_R304_R0.7530.95
27_Y60_T0.7520.95
425_R429_I0.7510.95
76_N79_I0.7500.95
385_S400_P0.7440.95
184_S195_D0.7430.95
254_I258_F0.7430.95
44_Q48_E0.7410.95
90_Y93_R0.7410.95
302_R336_H0.7410.95
337_A340_P0.7400.95
195_D303_Y0.7390.95
329_H346_R0.7380.95
232_F321_L0.7360.95
29_E32_I0.7340.95
339_N454_F0.7330.95
290_E295_D0.7330.95
31_G35_Y0.7320.95
265_D278_R0.7280.94
422_R427_S0.7260.94
424_Y442_K0.7250.94
108_P136_Y0.7240.94
35_Y40_P0.7220.94
36_K60_T0.7190.94
118_F121_P0.7170.94
314_R336_H0.7170.94
167_P295_D0.7170.94
372_L416_I0.7160.94
174_P178_R0.7140.94
469_L473_S0.7120.94
218_L452_N0.7100.94
384_R395_K0.7100.94
438_S442_K0.7090.94
251_L309_V0.7080.94
104_P124_V0.7080.94
420_I426_I0.7070.94
33_G55_E0.7030.93
421_K451_L0.7030.93
190_P278_R0.7020.93
356_A433_Y0.7020.93
434_E440_I0.7010.93
252_S255_N0.7000.93
396_L463_E0.7000.93
424_Y438_S0.7000.93
42_L48_E0.6980.93
61_P66_I0.6960.93
160_K194_F0.6950.93
37_V43_D0.6930.93
298_K315_G0.6920.93
189_L270_N0.6920.93
316_K352_N0.6900.93
235_I247_L0.6890.93
37_V45_N0.6890.93
425_R428_Y0.6880.93
420_I440_I0.6880.93
397_R400_P0.6880.93
114_E304_R0.6880.93
217_S460_L0.6850.92
235_I367_I0.6850.92
42_L47_I0.6840.92
209_L219_M0.6840.92
71_V74_L0.6830.92
161_P288_Q0.6820.92
300_S310_I0.6820.92
74_L77_K0.6790.92
162_V166_K0.6790.92
428_Y438_S0.6780.92
32_I38_N0.6770.92
376_N401_V0.6770.92
325_S331_S0.6770.92
319_E354_D0.6760.92
455_V459_I0.6750.92
184_S299_L0.6750.92
115_C147_V0.6740.92
34_Y58_Y0.6720.92
30_N33_G0.6680.91
244_T269_I0.6680.91
458_N467_V0.6670.91
197_R336_H0.6660.91
372_L414_N0.6660.91
204_I208_S0.6650.91
99_D103_V0.6620.91
45_N49_I0.6620.91
116_K259_K0.6620.91
103_V107_D0.6610.91
311_G336_H0.6610.91
182_T187_V0.6600.91
154_L196_I0.6600.91
197_R312_E0.6600.91
88_I92_L0.6580.91
287_S291_V0.6560.91
244_T271_I0.6550.91
134_R257_F0.6540.91
40_P43_D0.6530.91
119_S190_P0.6530.91
154_L194_F0.6530.91
439_E443_E0.6510.90
263_I277_I0.6470.90
365_G419_L0.6460.90
360_L364_W0.6460.90
322_V326_A0.6450.90
234_L335_F0.6430.90
136_Y406_F0.6420.90
48_E52_S0.6410.90
39_E45_N0.6400.90
292_S317_E0.6390.90
443_E446_N0.6360.89
186_E303_Y0.6340.89
28_E31_G0.6330.89
120_Y272_I0.6330.89
208_S253_M0.6330.89
40_P60_T0.6310.89
458_N461_D0.6300.89
84_I87_K0.6300.89
94_K104_P0.6300.89
30_N58_Y0.6300.89
381_R384_R0.6290.89
210_I216_S0.6280.89
141_L150_V0.6280.89
98_Y104_P0.6270.89
287_S292_S0.6270.89
116_K165_A0.6260.89
96_I104_P0.6250.89
334_T337_A0.6240.88
197_R243_K0.6220.88
232_F322_V0.6210.88
98_Y153_K0.6200.88
225_F421_K0.6190.88
378_N469_L0.6160.88
97_G102_T0.6160.88
243_K268_E0.6120.87
75_K79_I0.6120.87
47_I51_N0.6090.87
375_R381_R0.6070.87
49_I53_I0.6070.87
427_S431_K0.6070.87
405_S409_N0.6070.87
173_L183_V0.6060.87
180_A201_L0.6060.87
455_V458_N0.6050.87
217_S220_L0.6040.87
397_R401_V0.6040.87
201_L269_I0.6030.87
29_E33_G0.6030.87
216_S219_M0.6010.87
167_P290_E0.6000.86
421_K424_Y0.5960.86
340_P420_I0.5950.86
263_I320_A0.5950.86
244_T248_N0.5950.86
308_L329_H0.5950.86
100_E141_L0.5940.86
405_S412_M0.5940.86
86_E89_I0.5930.86
68_E71_V0.5930.86
243_K302_R0.5930.86
147_V151_I0.5920.86
67_E74_L0.5920.86
74_L82_Q0.5920.86
425_R432_T0.5920.86
221_A419_L0.5910.86
197_R268_E0.5910.86
400_P403_R0.5900.86
156_N162_V0.5900.86
66_I76_N0.5880.85
326_A362_N0.5870.85
112_E336_H0.5870.85
233_F367_I0.5870.85
73_I76_N0.5860.85
37_V44_Q0.5850.85
456_S460_L0.5850.85
35_Y41_N0.5840.85
100_E150_V0.5840.85
467_V472_I0.5840.85
327_S346_R0.5830.85
170_E302_R0.5820.85
297_A300_S0.5810.85
35_Y59_S0.5800.85
212_N417_D0.5800.85
112_E293_L0.5790.84
30_N34_Y0.5790.84
104_P107_D0.5770.84
416_I461_D0.5760.84
268_E314_R0.5750.84
248_N271_I0.5730.84
311_G314_R0.5720.84
156_N259_K0.5700.84
56_Y59_S0.5700.84
193_T277_I0.5700.84
36_K41_N0.5680.83
132_F373_R0.5680.83
342_E345_T0.5680.83
94_K99_D0.5660.83
289_F295_D0.5650.83
104_P139_I0.5640.83
147_V194_F0.5640.83
168_Y299_L0.5640.83
112_E243_K0.5630.83
151_I192_S0.5630.83
29_E34_Y0.5620.83
447_R452_N0.5620.83
177_H202_K0.5610.83
49_I54_L0.5590.82
309_V333_A0.5580.82
137_T256_P0.5560.82
161_P166_K0.5550.82
122_V151_I0.5540.82
232_F364_W0.5540.82
96_I102_T0.5540.82
455_V473_S0.5520.82
112_E302_R0.5520.82
39_E47_I0.5510.81
170_E298_K0.5510.81
373_R410_T0.5500.81
245_T269_I0.5480.81
42_L50_L0.5470.81
51_N54_L0.5450.81
377_G404_W0.5450.81
115_C194_F0.5450.81
104_P115_C0.5450.81
434_E443_E0.5440.81
232_F365_G0.5440.81
43_D46_E0.5440.81
46_E57_I0.5440.81
170_E314_R0.5430.81
112_E304_R0.5410.80
239_T346_R0.5410.80
459_I472_I0.5410.80
112_E312_E0.5410.80
100_E103_V0.5370.80
95_R104_P0.5370.80
54_L57_I0.5350.80
104_P113_I0.5350.80
360_L430_S0.5340.79
45_N48_E0.5340.79
378_N403_R0.5340.79
240_G329_H0.5340.79
319_E349_S0.5330.79
54_L58_Y0.5330.79
456_S459_I0.5320.79
396_L407_S0.5320.79
243_K314_R0.5310.79
70_V76_N0.5310.79
101_L105_L0.5300.79
341_H345_T0.5300.79
431_K437_I0.5300.79
275_N303_Y0.5300.79
220_L227_L0.5290.79
215_I452_N0.5290.79
95_R100_E0.5290.79
172_S180_A0.5290.79
46_E51_N0.5290.79
249_S253_M0.5290.79
230_K245_T0.5280.79
302_R311_G0.5280.79
114_E293_L0.5270.79
94_K102_T0.5260.78
98_Y101_L0.5260.78
232_F325_S0.5260.78
321_L331_S0.5260.78
237_G243_K0.5250.78
186_E300_S0.5250.78
101_L104_P0.5240.78
271_I274_D0.5240.78
172_S323_H0.5230.78
455_V472_I0.5220.78
112_E195_D0.5220.78
448_V451_L0.5220.78
32_I55_E0.5210.78
240_G268_E0.5200.78
222_Y226_L0.5190.78
116_K123_T0.5170.77
431_K438_S0.5150.77
416_I472_I0.5140.77
260_V274_D0.5140.77
36_K39_E0.5140.77
437_I440_I0.5130.77
49_I52_S0.5120.77
138_N178_R0.5120.77
200_P203_P0.5110.76
339_N418_D0.5110.76
471_K474_Q0.5100.76
37_V41_N0.5090.76
305_P346_R0.5090.76
325_S362_N0.5080.76
276_W369_L0.5070.76
402_L409_N0.5070.76
115_C196_I0.5070.76
30_N81_D0.5060.76
152_E162_V0.5060.76
437_I441_T0.5060.76
37_V57_I0.5050.76
203_P208_S0.5050.76
302_R334_T0.5040.75
268_E346_R0.5040.75
71_V75_K0.5040.75
34_Y38_N0.5030.75
170_E299_L0.5030.75
98_Y107_D0.5020.75
58_Y65_N0.5020.75
166_K289_F0.5020.75
420_I450_T0.5010.75
186_E299_L0.5010.75
466_S472_I0.5010.75
240_G336_H0.5000.75
114_E266_T0.5000.75
237_G311_G0.5000.75
38_N63_V0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4phtA 1 0.8758 100 0.357 Contact Map
4ksrA 3 0.7329 100 0.426 Contact Map
2oap1 3 0.9441 100 0.449 Contact Map
1p9rA 1 0.7598 100 0.45 Contact Map
4ihqA 3 0.9731 100 0.47 Contact Map
2ewvA 3 0.6832 100 0.561 Contact Map
3jvvA 3 0.6729 100 0.575 Contact Map
2gzaA 3 0.6232 100 0.633 Contact Map
2eyuA 1 0.4845 100 0.68 Contact Map
4bloA 4 0.5424 100 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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