GREMLIN Database
Q7LXX5 - Third ORF in transposon ISC1229
UniProt: Q7LXX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (130)
Sequences: 4120 (2916)
Seq/√Len: 255.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V133_P2.5051.00
20_T133_P2.4381.00
103_H106_K2.3621.00
48_F121_P2.3121.00
13_P131_N2.2461.00
32_I124_R2.2431.00
52_C78_L2.0751.00
36_V48_F2.0451.00
43_P47_S2.0431.00
118_R122_K2.0281.00
108_K111_K1.9611.00
60_R65_E1.9481.00
44_R47_S1.8291.00
52_C121_P1.8211.00
31_I81_L1.7991.00
17_V127_V1.7801.00
97_L101_E1.7731.00
24_I29_A1.7671.00
54_L117_A1.7541.00
19_L26_K1.7491.00
126_S130_N1.7391.00
132_K135_E1.7241.00
70_I114_T1.7211.00
99_F119_K1.7211.00
49_V55_D1.7081.00
96_L116_L1.6231.00
28_A81_L1.6051.00
107_L111_K1.5871.00
102_A106_K1.5851.00
14_Q131_N1.5851.00
84_F87_E1.5721.00
21_I124_R1.5711.00
125_W129_Y1.5671.00
28_A85_L1.5461.00
18_L124_R1.5181.00
100_Y116_L1.5071.00
42_F51_Y1.4851.00
96_L123_Y1.4471.00
17_V20_T1.4391.00
123_Y127_V1.4061.00
127_V133_P1.3951.00
86_A116_L1.3911.00
21_I127_V1.3691.00
14_Q128_W1.3651.00
49_V118_R1.3621.00
7_M10_G1.3551.00
83_Y117_A1.3521.00
39_I128_W1.2781.00
35_I75_N1.2641.00
21_I120_L1.2361.00
9_E26_K1.2311.00
35_I77_Y1.2001.00
13_P17_V1.1971.00
94_P98_K1.1961.00
36_V39_I1.1741.00
103_H112_L1.1571.00
100_Y112_L1.1511.00
99_F103_H1.1441.00
101_E105_D1.1411.00
86_A117_A1.1271.00
83_Y87_E1.0971.00
12_V16_H1.0971.00
99_F116_L1.0761.00
61_S65_E1.0741.00
87_E110_R1.0451.00
90_Y100_Y1.0351.00
82_F121_P1.0301.00
104_K109_G1.0281.00
24_I28_A1.0191.00
99_F102_A1.0151.00
94_P97_L1.0111.00
80_S84_F0.9991.00
83_Y114_T0.9661.00
24_I124_R0.9591.00
85_L120_L0.9491.00
70_I79_R0.9311.00
108_K112_L0.9301.00
83_Y110_R0.9251.00
12_V33_I0.9111.00
87_E90_Y0.9111.00
58_V65_E0.9061.00
32_I78_L0.8981.00
57_V71_S0.8941.00
15_D19_L0.8911.00
95_T134_Y0.8871.00
19_L29_A0.8861.00
98_K101_E0.8821.00
98_K102_A0.8741.00
14_Q17_V0.8691.00
51_Y75_N0.8681.00
96_L120_L0.8460.99
102_A105_D0.8440.99
110_R113_Y0.8420.99
110_R114_T0.8380.99
124_R127_V0.8340.99
103_H107_L0.8280.99
70_I115_A0.8250.99
88_T92_R0.8190.99
126_S129_Y0.8180.99
114_T117_A0.8120.99
15_D30_G0.7980.99
46_E118_R0.7890.99
55_D71_S0.7770.99
100_Y104_K0.7760.99
24_I120_L0.7740.99
18_L128_W0.7740.99
84_F110_R0.7740.99
89_Q96_L0.7730.99
59_E64_I0.7730.99
93_N97_L0.7730.99
127_V132_K0.7670.99
17_V131_N0.7660.99
103_H115_A0.7560.99
55_D58_V0.7480.99
15_D29_A0.7410.99
87_E113_Y0.7400.98
44_R125_W0.7350.98
18_L29_A0.7350.98
69_G111_K0.7320.98
42_F48_F0.7260.98
27_L31_I0.7200.98
55_D79_R0.7180.98
85_L89_Q0.7170.98
86_A113_Y0.7090.98
55_D72_K0.7080.98
72_K79_R0.7070.98
24_I32_I0.7040.98
123_Y126_S0.6990.98
74_G79_R0.6990.98
54_L118_R0.6890.98
90_Y104_K0.6880.98
104_K112_L0.6800.97
58_V67_R0.6790.97
81_L85_L0.6780.97
13_P16_H0.6770.97
47_S50_A0.6760.97
85_L117_A0.6720.97
45_P122_K0.6700.97
21_I24_I0.6670.97
82_F124_R0.6620.97
87_E117_A0.6610.97
101_E104_K0.6570.97
15_D33_I0.6500.97
87_E91_S0.6490.97
11_N14_Q0.6480.97
16_H133_P0.6400.96
21_I123_Y0.6360.96
104_K107_L0.6300.96
12_V15_D0.6230.96
50_A55_D0.6220.96
31_I35_I0.6210.96
64_I68_K0.6210.96
55_D73_R0.6180.95
19_L25_G0.6150.95
45_P125_W0.6130.95
35_I52_C0.6090.95
119_K122_K0.6080.95
39_I125_W0.6070.95
55_D75_N0.6010.95
70_I74_G0.6000.95
86_A120_L0.5940.94
6_K10_G0.5940.94
77_Y81_L0.5940.94
71_S74_G0.5930.94
14_Q33_I0.5840.94
80_S83_Y0.5820.94
49_V54_L0.5720.93
93_N98_K0.5650.93
26_K30_G0.5590.92
8_I30_G0.5550.92
122_K126_S0.5540.92
52_C81_L0.5540.92
49_V122_K0.5520.92
45_P49_V0.5510.92
15_D26_K0.5490.92
32_I36_V0.5470.92
37_G41_R0.5470.92
90_Y116_L0.5460.92
89_Q93_N0.5430.91
58_V68_K0.5400.91
30_G77_Y0.5370.91
99_F115_A0.5360.91
31_I77_Y0.5320.90
28_A82_F0.5270.90
59_E68_K0.5260.90
112_L116_L0.5170.89
11_N16_H0.5160.89
49_V121_P0.5150.89
60_R64_I0.5130.89
80_S126_S0.5110.89
79_R114_T0.5100.89
93_N123_Y0.5080.88
11_N15_D0.5060.88
28_A32_I0.5020.88
35_I84_F0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a1jB 2 0.5328 88.5 0.884 Contact Map
3c65A 1 0.0438 88.3 0.885 Contact Map
1pu6A 1 0.7226 87.7 0.886 Contact Map
3fhfA 1 0.7299 86.7 0.888 Contact Map
2lyhA 1 0.4964 86.6 0.888 Contact Map
4pj0U 1 0.5839 86.2 0.889 Contact Map
2bgwA 2 0.5182 85.9 0.889 Contact Map
3n0uA 1 0.7445 85.6 0.889 Contact Map
4ofaA 1 0.4526 85.4 0.89 Contact Map
1keaA 2 0.7956 83 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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