GREMLIN Database
Q7LXX4 - Transposase ISC1359
UniProt: Q7LXX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (305)
Sequences: 158 (111)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_A276_F5.9051.00
327_S331_D3.9260.94
93_V154_M3.8370.93
173_A275_A3.3540.87
250_V288_T2.9580.79
60_L293_K2.9560.79
250_V270_W2.8400.76
175_R196_S2.7430.73
54_K102_H2.7280.73
161_L171_V2.6590.71
296_V300_L2.6340.70
63_L117_T2.6150.70
86_V236_I2.6130.70
168_L194_V2.4460.64
327_S330_L2.3120.60
94_D273_E2.3070.59
96_H280_E2.3040.59
135_F276_F2.2890.59
274_N277_R2.1980.56
24_I41_L2.1850.55
319_L329_L2.1520.54
125_A299_L2.1340.53
234_Y237_I2.1150.52
206_K209_L2.1120.52
126_I137_D2.0980.52
126_I161_L2.0230.49
108_L111_I2.0170.49
135_F302_Y2.0030.48
250_V305_L1.9960.48
95_F168_L1.9550.47
269_R273_E1.9350.46
94_D269_R1.9350.46
100_Q306_N1.8620.43
92_A182_V1.8480.43
57_R195_I1.8200.42
324_V328_N1.7920.41
223_G299_L1.7830.40
321_E324_V1.7610.40
312_R316_K1.7350.39
276_F286_T1.7100.38
174_D273_E1.7050.38
94_D174_D1.7050.38
195_I207_G1.6410.36
251_R300_L1.6350.35
266_Y272_I1.6210.35
27_V34_P1.5910.34
168_L279_L1.5870.34
28_L33_F1.5630.33
121_L276_F1.5270.32
274_N278_S1.4990.31
178_A274_N1.4690.30
31_I38_L1.4600.30
251_R282_F1.4590.30
92_A248_F1.4580.30
158_V183_I1.4490.29
204_K207_G1.4350.29
24_I32_L1.4220.29
296_V304_L1.4130.28
294_E308_W1.4100.28
37_L259_A1.4000.28
270_W288_T1.3940.28
80_R108_L1.3850.28
120_G270_W1.3840.27
282_F305_L1.3760.27
168_L276_F1.3720.27
228_R235_L1.3720.27
81_M204_K1.3630.27
80_R207_G1.3540.27
113_P116_G1.3430.26
97_A122_V1.3250.26
280_E288_T1.3250.26
324_V327_S1.3230.26
80_R110_R1.3120.25
24_I27_V1.3120.25
326_L329_L1.3100.25
125_A298_V1.3090.25
174_D269_R1.3050.25
79_G282_F1.3050.25
54_K125_A1.2970.25
129_L248_F1.2920.25
105_K235_L1.2780.25
171_V250_V1.2770.24
326_L330_L1.2750.24
133_R277_R1.2750.24
266_Y273_E1.2670.24
94_D266_Y1.2670.24
186_L191_L1.2660.24
32_L40_A1.2640.24
141_V154_M1.2630.24
154_M251_R1.2440.24
26_S35_E1.2430.24
194_V267_R1.2350.23
178_A197_A1.2350.23
24_I38_L1.2350.23
34_P37_L1.2250.23
30_K33_F1.2200.23
117_T299_L1.2160.23
140_P248_F1.2110.23
152_A190_G1.2080.23
63_L113_P1.2050.23
87_R296_V1.1920.22
110_R288_T1.1920.22
24_I30_K1.1910.22
274_N310_L1.1890.22
33_F37_L1.1610.21
27_V41_L1.1580.21
83_L186_L1.1580.21
75_L306_N1.1560.21
251_R288_T1.1550.21
63_L137_D1.1540.21
104_D128_L1.1530.21
157_I251_R1.1390.21
141_V172_F1.1340.21
105_K228_R1.1320.21
83_L166_L1.1320.21
328_N332_R1.1280.21
328_N331_D1.1280.21
176_E198_K1.1260.21
269_R286_T1.1240.21
202_Y209_L1.1200.20
94_D272_I1.1200.20
96_H288_T1.1190.20
267_R306_N1.1190.20
126_I306_N1.1170.20
273_E294_E1.1120.20
94_D294_E1.1120.20
102_H123_Q1.1050.20
59_A178_A1.0990.20
77_K182_V1.0990.20
32_L41_L1.0950.20
112_K285_R1.0920.20
56_G282_F1.0900.20
177_F277_R1.0880.20
157_I276_F1.0820.20
276_F287_R1.0740.19
139_I271_G1.0640.19
60_L236_I1.0640.19
177_F273_E1.0580.19
94_D177_F1.0580.19
141_V182_V1.0540.19
27_V31_I1.0540.19
317_V321_E1.0510.19
319_L323_S1.0460.19
111_I116_G1.0460.19
89_R302_Y1.0450.19
167_R175_R1.0390.19
183_I194_V1.0390.19
324_V333_E1.0310.18
97_A256_L1.0280.18
172_F284_I1.0250.18
182_V219_V1.0230.18
194_V209_L1.0220.18
271_G301_S1.0210.18
124_A157_I1.0170.18
168_L188_E1.0170.18
284_I298_V1.0140.18
27_V33_F1.0090.18
285_R330_L1.0080.18
97_A120_G1.0050.18
193_F290_D1.0040.18
40_A259_A1.0000.18
141_V207_G0.9910.18
153_V227_V0.9910.18
130_G140_P0.9900.18
35_E42_L0.9900.18
151_K186_L0.9900.18
324_V332_R0.9900.18
170_M281_E0.9850.17
207_G210_Q0.9850.17
124_A182_V0.9840.17
54_K93_V0.9810.17
78_M268_E0.9810.17
40_A295_L0.9800.17
253_E275_A0.9800.17
93_V191_L0.9790.17
148_E227_V0.9790.17
100_Q289_C0.9750.17
52_L106_S0.9740.17
257_Y309_F0.9710.17
175_R272_I0.9700.17
86_V310_L0.9660.17
202_Y247_A0.9650.17
93_V286_T0.9550.17
215_S218_G0.9520.17
161_L309_F0.9500.17
35_E40_A0.9430.17
129_L276_F0.9430.17
26_S40_A0.9410.17
159_K171_V0.9400.17
76_R137_D0.9360.16
111_I114_T0.9360.16
171_V204_K0.9280.16
66_V246_I0.9270.16
177_F306_N0.9230.16
309_F312_R0.9210.16
111_I120_G0.9160.16
95_F141_V0.9120.16
125_A129_L0.9050.16
51_R325_S0.9030.16
107_F110_R0.9020.16
325_S331_D0.9010.16
136_L209_L0.8960.16
72_R123_Q0.8930.16
270_W282_F0.8910.16
48_Y93_V0.8880.15
25_Y28_L0.8880.15
100_Q266_Y0.8880.15
63_L175_R0.8870.15
126_I176_E0.8850.15
68_V81_M0.8840.15
64_N92_A0.8820.15
133_R169_V0.8800.15
58_R280_E0.8770.15
154_M161_L0.8770.15
177_F272_I0.8750.15
108_L288_T0.8670.15
126_I168_L0.8650.15
63_L71_V0.8620.15
168_L235_L0.8610.15
72_R76_R0.8600.15
171_V280_E0.8600.15
298_V305_L0.8590.15
119_W194_V0.8590.15
60_L153_V0.8590.15
93_V182_V0.8570.15
56_G154_M0.8560.15
251_R298_V0.8550.15
116_G295_L0.8540.15
173_A178_A0.8530.15
72_R134_S0.8510.15
56_G266_Y0.8510.15
75_L79_G0.8500.15
100_Q203_K0.8490.15
29_T49_L0.8480.15
62_K290_D0.8470.15
135_F162_E0.8470.15
320_W326_L0.8470.15
176_E307_V0.8370.15
50_S153_V0.8360.15
101_Y176_E0.8360.15
250_V300_L0.8320.14
60_L275_A0.8290.14
171_V223_G0.8280.14
83_L218_G0.8270.14
169_V301_S0.8260.14
110_R250_V0.8250.14
266_Y269_R0.8250.14
251_R280_E0.8250.14
200_Q246_I0.8240.14
211_D226_C0.8130.14
279_L298_V0.8120.14
179_V289_C0.8110.14
208_M213_D0.8100.14
76_R275_A0.8060.14
36_E40_A0.8050.14
280_E305_L0.8030.14
167_R253_E0.8020.14
25_Y31_I0.8020.14
30_K39_S0.8010.14
61_R290_D0.8010.14
147_A183_I0.8010.14
174_D286_T0.7970.14
176_E225_L0.7930.14
68_V220_R0.7890.14
311_I314_W0.7890.14
130_G176_E0.7880.14
157_I305_L0.7850.14
183_I193_F0.7840.14
132_T184_R0.7830.14
128_L296_V0.7820.14
140_P298_V0.7790.14
237_I292_R0.7780.14
67_Q71_V0.7730.13
69_E82_T0.7720.13
293_K307_V0.7670.13
233_A237_I0.7640.13
157_I279_L0.7630.13
24_I88_D0.7630.13
76_R108_L0.7590.13
284_I297_L0.7570.13
74_A225_L0.7570.13
34_P41_L0.7560.13
244_K276_F0.7490.13
80_R250_V0.7400.13
324_V330_L0.7370.13
123_Q178_A0.7370.13
67_Q176_E0.7340.13
96_H110_R0.7330.13
106_S304_L0.7330.13
96_H133_R0.7300.13
248_F288_T0.7290.13
170_M194_V0.7270.13
288_T305_L0.7230.13
35_E38_L0.7200.13
149_G186_L0.7190.13
293_K297_L0.7140.12
64_N250_V0.7130.12
61_R267_R0.7100.12
121_L189_L0.7080.12
34_P135_F0.7080.12
82_T282_F0.7070.12
139_I235_L0.7050.12
113_P240_K0.7050.12
116_G268_E0.7040.12
123_Q296_V0.7000.12
23_I27_V0.6980.12
274_N292_R0.6950.12
115_K168_L0.6950.12
269_R272_I0.6940.12
56_G197_A0.6920.12
55_D332_R0.6920.12
175_R257_Y0.6910.12
148_E194_V0.6910.12
176_E240_K0.6890.12
130_G250_V0.6880.12
64_N110_R0.6880.12
269_R294_E0.6880.12
28_L32_L0.6860.12
92_A129_L0.6840.12
290_D303_L0.6820.12
24_I29_T0.6820.12
95_F161_L0.6800.12
56_G59_A0.6790.12
176_E301_S0.6740.12
319_L322_F0.6720.12
31_I194_V0.6720.12
165_K296_V0.6720.12
97_A114_T0.6680.12
68_V88_D0.6670.12
77_K276_F0.6670.12
128_L137_D0.6640.12
121_L282_F0.6570.12
78_M296_V0.6560.12
64_N288_T0.6560.12
288_T294_E0.6550.12
121_L134_S0.6540.12
188_E207_G0.6530.12
33_F36_E0.6500.11
318_K323_S0.6480.11
72_R137_D0.6470.11
41_L60_L0.6460.11
155_E288_T0.6430.11
325_S328_N0.6420.11
251_R270_W0.6390.11
99_P304_L0.6380.11
88_D105_K0.6340.11
55_D290_D0.6320.11
171_V282_F0.6320.11
50_S59_A0.6320.11
26_S32_L0.6300.11
79_G207_G0.6300.11
168_L292_R0.6290.11
121_L125_A0.6290.11
189_L232_G0.6270.11
320_W323_S0.6270.11
204_K210_Q0.6270.11
236_I282_F0.6260.11
230_G262_L0.6230.11
298_V314_W0.6210.11
329_L333_E0.6200.11
87_R158_V0.6150.11
174_D306_N0.6130.11
78_M135_F0.6130.11
102_H289_C0.6120.11
72_R296_V0.6100.11
91_V259_A0.6090.11
177_F269_R0.6090.11
237_I310_L0.6090.11
320_W331_D0.6050.11
24_I39_S0.6050.11
178_A198_K0.6050.11
171_V244_K0.6040.11
93_V276_F0.6030.11
259_A299_L0.6030.11
87_R162_E0.6000.11
307_V328_N0.5960.11
192_D222_T0.5950.11
184_R189_L0.5950.11
252_K262_L0.5940.11
305_L312_R0.5930.11
42_L69_E0.5930.11
276_F279_L0.5930.11
195_I259_A0.5930.11
50_S280_E0.5920.11
24_I31_I0.5910.11
80_R164_D0.5900.11
96_H297_L0.5890.11
250_V280_E0.5850.11
190_G270_W0.5820.10
323_S332_R0.5810.10
177_F286_T0.5800.10
94_D286_T0.5760.10
228_R310_L0.5760.10
273_E286_T0.5760.10
235_L247_A0.5760.10
142_T307_V0.5750.10
65_A306_N0.5750.10
30_K41_L0.5730.10
186_L195_I0.5720.10
147_A275_A0.5700.10
96_H263_A0.5690.10
23_I34_P0.5690.10
93_V282_F0.5680.10
30_K34_P0.5670.10
216_F219_V0.5660.10
157_I168_L0.5640.10
118_S193_F0.5630.10
168_L238_L0.5630.10
74_A189_L0.5620.10
158_V253_E0.5610.10
124_A314_W0.5570.10
106_S285_R0.5530.10
65_A290_D0.5520.10
35_E70_D0.5510.10
174_D266_Y0.5510.10
86_V181_E0.5480.10
49_L207_G0.5460.10
137_D286_T0.5460.10
57_R150_F0.5450.10
100_Q196_S0.5450.10
91_V161_L0.5440.10
61_R275_A0.5430.10
283_R295_L0.5430.10
130_G248_F0.5410.10
321_E326_L0.5410.10
161_L168_L0.5410.10
323_S333_E0.5400.10
220_R233_A0.5350.10
304_L315_R0.5340.10
166_L175_R0.5340.10
321_E328_N0.5330.10
24_I28_L0.5330.10
288_T298_V0.5320.10
77_K203_K0.5320.10
140_P280_E0.5310.10
121_L162_E0.5310.10
273_E288_T0.5300.10
94_D288_T0.5300.10
129_L300_L0.5250.10
27_V138_V0.5210.10
157_I161_L0.5190.10
23_I39_S0.5170.10
210_Q216_F0.5140.10
31_I37_L0.5140.10
238_L276_F0.5130.10
168_L232_G0.5130.10
26_S41_L0.5110.10
187_L298_V0.5100.10
111_I311_I0.5090.10
105_K255_D0.5080.10
128_L179_V0.5080.10
140_P282_F0.5080.10
74_A296_V0.5060.09
117_T306_N0.5060.09
267_R318_K0.5050.09
248_F251_R0.5020.09
326_L331_D0.5000.09
183_I249_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9201 99.5 0.864 Contact Map
4mq3A 1 0.3471 28.3 0.972 Contact Map
3kksA 2 0.4022 21.3 0.973 Contact Map
1b78A 2 0.4187 18.9 0.974 Contact Map
3wx4A 2 0.2534 13.4 0.976 Contact Map
4pc0C 1 0.0551 8.7 0.978 Contact Map
1cxqA 2 0.3884 7.7 0.978 Contact Map
2i4rA 6 0.1983 5.2 0.98 Contact Map
3k6qA 2 0.3747 5.1 0.98 Contact Map
1c6vA 4 0.405 5.1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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