GREMLIN Database
Q7LXW4 - Uncharacterized protein
UniProt: Q7LXW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 136 (124)
Sequences: 20911 (17336)
Seq/√Len: 1556.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K44_T2.9631.00
44_T80_N2.8831.00
87_S123_A2.7841.00
16_L99_Y2.7011.00
31_L133_I2.5541.00
14_K42_K2.4711.00
42_K78_K2.3241.00
101_A133_I2.1931.00
93_V97_E2.1781.00
102_I130_V2.0631.00
80_N93_V2.0461.00
44_T97_E1.8721.00
104_M124_I1.8531.00
122_L126_I1.8511.00
82_K89_E1.8371.00
44_T99_Y1.8071.00
44_T78_K1.7371.00
18_P90_I1.7331.00
59_Q63_E1.7181.00
46_I93_V1.7171.00
48_V89_E1.7001.00
84_S89_E1.6331.00
94_I102_I1.6041.00
18_P104_M1.5641.00
17_V32_A1.5481.00
67_N79_I1.5311.00
89_E92_K1.5001.00
44_T93_V1.4861.00
35_F39_Y1.4611.00
67_N71_E1.4471.00
14_K100_D1.4401.00
63_E67_N1.4361.00
91_L127_N1.4151.00
41_S100_D1.4041.00
62_I66_I1.4001.00
42_K76_I1.3951.00
102_I128_A1.3551.00
123_A127_N1.3311.00
30_D69_K1.2871.00
46_I82_K1.2371.00
17_V29_L1.2291.00
93_V96_E1.1671.00
55_M59_Q1.1631.00
112_N116_N1.1531.00
32_A36_G1.1521.00
106_A134_L1.1381.00
86_V120_T1.1321.00
58_I62_I1.1191.00
65_R68_N1.1021.00
60_S64_K1.0971.00
69_K73_D1.0901.00
70_I74_L1.0871.00
82_K93_V1.0741.00
63_E69_K1.0701.00
62_I65_R1.0671.00
69_K72_Y1.0671.00
102_I124_I1.0621.00
70_I73_D1.0471.00
12_L131_S1.0411.00
26_L69_K1.0401.00
49_C83_E1.0361.00
32_A103_I1.0271.00
15_I101_A1.0031.00
48_V86_V1.0031.00
128_A132_V0.9831.00
95_N129_P0.9641.00
104_M121_A0.9531.00
94_I130_V0.9401.00
58_I61_L0.9361.00
106_A121_A0.9251.00
21_G47_H0.9241.00
52_C56_N0.9211.00
55_M58_I0.9151.00
56_N60_S0.9101.00
56_N59_Q0.8961.00
16_L46_I0.8901.00
22_S25_S0.8851.00
31_L35_F0.8841.00
65_R69_K0.8831.00
49_C81_I0.8801.00
34_D38_R0.8801.00
59_Q62_I0.8801.00
46_I90_I0.8791.00
64_K67_N0.8761.00
47_H59_Q0.8681.00
14_K99_Y0.8671.00
66_I70_I0.8661.00
64_K68_N0.8521.00
29_L45_I0.8451.00
92_K96_E0.8451.00
111_L114_D0.8421.00
125_S134_L0.8411.00
19_V26_L0.8351.00
93_V99_Y0.8301.00
114_D122_L0.8131.00
31_L135_V0.8111.00
36_G43_I0.8071.00
68_N72_Y0.8071.00
31_L34_D0.8011.00
63_E79_I0.7981.00
26_L30_D0.7961.00
109_T113_S0.7921.00
25_S28_A0.7901.00
57_D61_L0.7791.00
14_K97_E0.7731.00
80_N97_E0.7651.00
103_I133_I0.7631.00
66_I69_K0.7631.00
111_L115_I0.7621.00
94_I99_Y0.7601.00
39_Y100_D0.7601.00
12_L100_D0.7591.00
16_L93_V0.7511.00
91_L94_I0.7511.00
33_V37_M0.7441.00
27_R30_D0.7431.00
82_K96_E0.7391.00
85_S88_N0.7361.00
16_L102_I0.7241.00
26_L65_R0.7231.00
19_V45_I0.7181.00
45_I77_V0.7171.00
52_C55_M0.7161.00
12_L31_L0.7141.00
53_N57_D0.7141.00
13_R100_D0.7131.00
33_V73_D0.7061.00
14_K41_S0.7041.00
54_N57_D0.7041.00
13_R41_S0.7011.00
61_L65_R0.7011.00
71_E74_L0.6961.00
31_L131_S0.6961.00
19_V25_S0.6871.00
68_N71_E0.6831.00
32_A43_I0.6801.00
121_A134_L0.6771.00
35_F38_R0.6761.00
91_L124_I0.6731.00
12_L101_A0.6721.00
112_N115_I0.6711.00
63_E66_I0.6701.00
19_V28_A0.6701.00
91_L128_A0.6671.00
19_V29_L0.6611.00
29_L33_V0.6581.00
90_I124_I0.6571.00
94_I129_P0.6431.00
61_L64_K0.6341.00
117_I121_A0.6301.00
70_I75_K0.6281.00
108_G117_I0.6261.00
46_I89_E0.6191.00
47_H62_I0.6151.00
54_N58_I0.6051.00
34_D37_M0.5991.00
18_P105_G0.5981.00
17_V43_I0.5981.00
62_I69_K0.5961.00
45_I66_I0.5931.00
87_S91_L0.5901.00
53_N56_N0.5771.00
60_S63_E0.5751.00
107_R121_A0.5741.00
17_V28_A0.5731.00
103_I135_V0.5721.00
35_F103_I0.5701.00
87_S127_N0.5591.00
24_N27_R0.5571.00
15_I36_G0.5551.00
87_S120_T0.5541.00
104_M134_L0.5431.00
32_A41_S0.5321.00
98_P130_V0.5311.00
84_S92_K0.5291.00
124_I132_V0.5281.00
36_G41_S0.5271.00
12_L41_S0.5241.00
30_D73_D0.5231.00
51_D83_E0.5231.00
70_I77_V0.5211.00
20_D25_S0.5191.00
57_D60_S0.5171.00
27_R31_L0.5071.00
88_N92_K0.5031.00
91_L123_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s3tA 4 0.9412 99.9 0.183 Contact Map
5ahwA 4 0.9338 99.9 0.184 Contact Map
3fg9A 3 0.9926 99.9 0.187 Contact Map
2gm3A 2 0.8382 99.9 0.189 Contact Map
3hgmA 2 0.9191 99.9 0.195 Contact Map
1mjhA 2 0.9338 99.9 0.198 Contact Map
3dloA 2 0.9779 99.9 0.204 Contact Map
4wnyA 2 0.8456 99.9 0.204 Contact Map
1tq8A 4 0.9118 99.9 0.209 Contact Map
3mt0A 1 0.9559 99.9 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0059 seconds.