GREMLIN Database
Q7LXW3 - Uncharacterized protein
UniProt: Q7LXW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (111)
Sequences: 2357 (1477)
Seq/√Len: 140.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_K49_E3.0141.00
26_C40_C2.6771.00
25_R44_N2.6481.00
56_L106_V2.6131.00
22_R48_I2.6091.00
24_E46_K2.5991.00
26_C37_C2.4391.00
37_C40_C2.3861.00
83_D105_K2.3621.00
6_P10_R2.2031.00
54_G106_V2.1171.00
23_C26_C2.0931.00
53_K83_D2.0791.00
81_R87_E2.0511.00
23_C37_C2.0021.00
11_N19_T1.9801.00
23_C40_C1.9701.00
30_S38_T1.9011.00
56_L78_G1.8351.00
20_A50_I1.7931.00
28_H39_K1.7441.00
24_E44_N1.7421.00
56_L100_L1.7421.00
16_Y112_R1.7371.00
53_K107_E1.7151.00
53_K105_K1.6651.00
96_D99_K1.5931.00
21_S30_S1.5791.00
52_G84_E1.5771.00
55_V105_K1.5511.00
7_Q47_K1.5251.00
19_T49_E1.4961.00
55_V81_R1.4701.00
29_I48_I1.4431.00
21_S45_V1.4381.00
80_V90_A1.3731.00
51_S83_D1.3691.00
30_S45_V1.3661.00
22_R29_I1.3251.00
57_E81_R1.3131.00
78_G92_I1.2961.00
59_Y102_E1.1761.00
54_G80_V1.1660.99
16_Y110_L1.1590.99
51_S84_E1.1580.99
58_S79_L1.1180.99
101_K104_V1.1180.99
10_R15_M1.1090.99
95_A104_V1.0420.99
12_K110_L1.0260.99
56_L104_V1.0250.99
20_A86_V1.0210.99
42_S45_V1.0110.99
55_V103_G1.0040.98
59_Y100_L0.9840.98
29_I50_I0.9780.98
112_R115_T0.9730.98
61_V76_V0.9720.98
57_E87_E0.9430.98
36_Y43_K0.9400.98
25_R42_S0.9350.98
22_R27_G0.9330.98
78_G90_A0.9290.97
92_I100_L0.8920.97
79_L89_V0.8740.96
22_R46_K0.8630.96
61_V97_L0.8580.96
79_L87_E0.8390.95
60_T77_I0.8390.95
95_A99_K0.8320.95
7_Q11_N0.8300.95
5_P9_W0.8280.95
59_Y92_I0.8250.95
11_N17_K0.8200.95
30_S34_S0.8120.95
63_Y74_P0.7930.94
59_Y104_V0.7880.94
8_V12_K0.7880.94
62_S75_S0.7710.93
11_N15_M0.7700.93
12_K108_A0.7650.93
7_Q10_R0.7640.93
56_L102_E0.7550.92
75_S91_P0.7540.92
36_Y41_G0.7520.92
59_Y76_V0.7470.92
97_L100_L0.7450.92
76_V100_L0.7400.91
82_L86_V0.7300.91
21_S31_F0.7230.90
33_Y47_K0.7200.90
20_A29_I0.7130.90
94_D109_T0.7030.89
99_K104_V0.7000.89
54_G88_I0.6970.89
18_L31_F0.6940.88
94_D107_E0.6900.88
93_V109_T0.6900.88
94_D111_R0.6760.87
36_Y45_V0.6740.87
15_M19_T0.6690.87
50_I82_L0.6680.86
76_V92_I0.6680.86
66_R73_L0.6670.86
65_S74_P0.6620.86
62_S69_H0.6580.86
100_L106_V0.6530.85
8_V11_N0.6500.85
18_L50_I0.6400.84
9_W74_P0.6300.83
21_S47_K0.6290.83
8_V108_A0.6260.83
90_A93_V0.6220.82
92_I95_A0.6200.82
81_R85_G0.6190.82
20_A48_I0.6160.82
12_K88_I0.6140.82
70_E96_D0.5980.80
80_V106_V0.5960.80
57_E79_L0.5920.79
57_E102_E0.5880.79
64_Q73_L0.5870.79
54_G83_D0.5850.78
34_S38_T0.5790.78
31_F88_I0.5780.78
37_C42_S0.5770.77
34_S47_K0.5740.77
113_V116_D0.5720.77
6_P111_R0.5610.75
50_I86_V0.5580.75
20_A82_L0.5570.75
54_G90_A0.5560.75
10_R14_F0.5530.74
79_L90_A0.5520.74
51_S108_A0.5510.74
45_V79_L0.5500.74
20_A31_F0.5500.74
16_Y111_R0.5480.74
57_E69_H0.5460.73
65_S73_L0.5450.73
15_M49_E0.5440.73
66_R69_H0.5350.72
77_I109_T0.5350.72
52_G107_E0.5300.71
5_P31_F0.5280.71
76_V96_D0.5270.71
11_N58_S0.5240.70
64_Q79_L0.5230.70
27_G101_K0.5190.70
14_F116_D0.5180.70
65_S75_S0.5170.69
76_V97_L0.5170.69
53_K84_E0.5160.69
57_E104_V0.5160.69
63_Y98_D0.5130.69
56_L103_G0.5130.69
23_C44_N0.5130.69
101_K105_K0.5100.68
19_T47_K0.5100.68
23_C42_S0.5090.68
43_K60_T0.5060.68
76_V95_A0.5050.68
9_W91_P0.5020.67
25_R101_K0.5020.67
52_G108_A0.5020.67
81_R86_V0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.8647 100 0.275 Contact Map
2lcqA 1 0.3759 85.3 0.888 Contact Map
2kdxA 1 0.4662 75.4 0.899 Contact Map
5aunA 1 0.4662 73.3 0.901 Contact Map
3pwfA 4 0.3684 63.7 0.907 Contact Map
4aybP 1 0.2857 59.4 0.91 Contact Map
4d02A 2 0.015 57.4 0.911 Contact Map
1lkoA 3 0.3985 56 0.911 Contact Map
1yuzA 2 0.3759 54.9 0.912 Contact Map
2gmgA 1 0.4135 50.3 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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