GREMLIN Database
Q7LXW2 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-1)
UniProt: Q7LXW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (337)
Sequences: 15441 (8564)
Seq/√Len: 466.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_E220_N3.5981.00
168_K172_N3.5691.00
222_T226_V3.4871.00
161_Y279_E3.3871.00
102_V105_V3.1731.00
322_A334_K3.0651.00
90_L319_L2.9791.00
32_N35_G2.8961.00
168_K171_K2.7741.00
175_E179_A2.7651.00
220_N224_S2.7451.00
222_T225_A2.7431.00
250_L254_L2.7091.00
5_Y223_E2.6141.00
153_K198_D2.6141.00
30_Y106_L2.5971.00
9_S320_A2.5611.00
97_I217_L2.4791.00
33_F216_L2.3551.00
10_S36_E2.3201.00
250_L349_G2.2751.00
104_S218_S2.2511.00
158_D161_Y2.1901.00
97_I219_N2.1731.00
326_L331_K2.1611.00
93_A105_V2.1541.00
26_V47_V2.1081.00
7_N218_S2.0871.00
236_A254_L2.0541.00
263_G300_L2.0151.00
231_I327_I1.9821.00
160_N164_N1.9821.00
190_V203_F1.9661.00
213_A316_I1.9551.00
232_L323_H1.9401.00
151_Y157_V1.8691.00
41_S226_V1.8381.00
256_L333_K1.8311.00
262_T331_K1.7911.00
278_L295_S1.7701.00
278_L298_V1.7631.00
247_V337_V1.7571.00
168_K295_S1.7541.00
103_N219_N1.7271.00
177_P185_V1.7241.00
233_S351_V1.7241.00
218_S223_E1.7161.00
3_E233_S1.7131.00
248_R252_D1.7091.00
325_Q329_S1.7001.00
301_G325_Q1.6941.00
218_S222_T1.6801.00
189_T192_N1.6791.00
167_I171_K1.6761.00
174_T178_F1.6691.00
145_A197_S1.6651.00
236_A250_L1.6641.00
261_R264_I1.6561.00
219_N222_T1.6541.00
47_V108_V1.6491.00
103_N222_T1.6361.00
26_V65_I1.6311.00
256_L261_R1.6181.00
77_I92_T1.6081.00
215_L316_I1.6061.00
294_D297_N1.6061.00
258_F264_I1.5981.00
95_S101_M1.5881.00
180_Y301_G1.5721.00
28_E186_D1.5711.00
96_L102_V1.5551.00
237_R240_F1.5511.00
245_P248_R1.5451.00
93_A217_L1.5451.00
164_N168_K1.5291.00
112_K115_D1.5201.00
30_Y65_I1.4951.00
24_D68_K1.4891.00
104_S222_T1.4841.00
264_I335_A1.4721.00
8_S33_F1.4561.00
29_A214_I1.4531.00
263_G325_Q1.4531.00
325_Q328_G1.4511.00
261_R349_G1.4481.00
31_K35_G1.4431.00
33_F37_Y1.4391.00
256_L349_G1.4261.00
29_A212_A1.4061.00
32_N36_E1.4001.00
91_L348_L1.3971.00
32_N186_D1.3751.00
180_Y325_Q1.3621.00
249_M252_D1.3581.00
14_I313_A1.3471.00
251_R258_F1.3431.00
183_F327_I1.3411.00
171_K175_E1.3401.00
149_R198_D1.3261.00
20_Y28_E1.3211.00
248_R280_E1.3111.00
4_V217_L1.2941.00
84_A346_D1.2931.00
27_I68_K1.2841.00
61_I110_V1.2811.00
157_V162_F1.2801.00
319_L350_M1.2791.00
323_H327_I1.2761.00
332_G351_V1.2691.00
221_K225_A1.2621.00
154_R238_Y1.2591.00
90_L215_L1.2551.00
49_N52_S1.2491.00
335_A349_G1.2431.00
43_D102_V1.2371.00
159_R201_R1.2271.00
42_I104_S1.2121.00
320_A324_M1.2121.00
300_L325_Q1.2031.00
106_L216_L1.1981.00
47_V214_I1.1871.00
161_Y164_N1.1831.00
146_L198_D1.1811.00
246_S347_D1.1671.00
5_Y220_N1.1611.00
247_V335_A1.1591.00
9_S324_M1.1441.00
84_A340_Y1.1441.00
87_G319_L1.1401.00
46_V105_V1.1361.00
93_A107_I1.1321.00
14_I307_R1.1251.00
165_W274_A1.1241.00
88_A92_T1.1181.00
244_L248_R1.1151.00
150_Q154_R1.1151.00
8_S36_E1.1141.00
5_Y218_S1.1111.00
41_S222_T1.1091.00
261_R333_K1.1061.00
9_S323_H1.1051.00
43_D103_N1.1041.00
28_E32_N1.0981.00
165_W275_A1.0941.00
134_F139_S1.0881.00
257_K260_E1.0861.00
235_Q351_V1.0861.00
154_R237_R1.0851.00
258_F261_R1.0821.00
155_Y241_S1.0761.00
10_S186_D1.0701.00
234_A348_L1.0681.00
101_M253_K1.0681.00
5_Y233_S1.0661.00
180_Y328_G1.0641.00
98_K101_M1.0631.00
34_E39_V1.0621.00
30_Y71_K1.0621.00
177_P182_R1.0611.00
145_A196_I1.0611.00
167_I190_V1.0611.00
183_F328_G1.0491.00
90_L217_L1.0471.00
241_S244_L1.0461.00
132_Y136_N1.0421.00
262_T326_L1.0411.00
317_Y321_E1.0361.00
254_L349_G1.0351.00
262_T297_N1.0301.00
149_R153_K1.0291.00
263_G329_S1.0211.00
95_S99_S1.0201.00
157_V275_A1.0191.00
171_K174_T1.0121.00
48_A85_S1.0091.00
10_S32_N1.0031.00
34_E71_K0.9981.00
122_Y127_T0.9961.00
322_A336_S0.9941.00
41_S225_A0.9881.00
300_L329_S0.9801.00
184_Q321_E0.9791.00
241_S280_E0.9751.00
168_K296_V0.9731.00
14_I209_A0.9631.00
213_A313_A0.9591.00
6_L350_M0.9591.00
45_I66_A0.9521.00
261_R335_A0.9521.00
283_I298_V0.9411.00
27_I31_K0.9371.00
21_D24_D0.9341.00
49_N57_N0.9291.00
301_G328_G0.9241.00
231_I235_Q0.9231.00
132_Y135_Y0.9221.00
230_K234_A0.9211.00
193_S203_F0.9211.00
29_A32_N0.9191.00
12_I28_E0.9161.00
3_E98_K0.9151.00
12_I29_A0.9081.00
193_S201_R0.9061.00
236_A253_K0.9051.00
7_N228_I0.9041.00
71_K74_V0.9031.00
194_Q202_L0.8971.00
264_I283_I0.8971.00
263_G322_A0.8901.00
150_Q153_K0.8881.00
231_I323_H0.8851.00
13_P28_E0.8841.00
8_S37_Y0.8841.00
123_D126_S0.8781.00
4_V219_N0.8771.00
249_M253_K0.8751.00
318_Q336_S0.8731.00
261_R340_Y0.8721.00
271_S305_K0.8701.00
183_F324_M0.8701.00
46_V89_A0.8681.00
179_A328_G0.8661.00
33_F106_L0.8631.00
235_Q333_K0.8621.00
241_S276_L0.8601.00
14_I317_Y0.8581.00
213_A320_A0.8541.00
218_S228_I0.8531.00
247_V281_A0.8491.00
94_Y98_K0.8471.00
138_I141_H0.8471.00
46_V77_I0.8461.00
89_A316_I0.8441.00
151_Y241_S0.8411.00
266_I337_V0.8391.00
238_Y241_S0.8371.00
278_L283_I0.8361.00
107_I215_L0.8351.00
304_L314_S0.8351.00
322_A341_I0.8341.00
195_I198_D0.8321.00
4_V94_Y0.8321.00
167_I189_T0.8291.00
121_L124_A0.8291.00
333_K351_V0.8281.00
29_A33_F0.8281.00
131_D135_Y0.8271.00
152_M272_I0.8251.00
155_Y280_E0.8241.00
12_I25_L0.8231.00
9_S215_L0.8231.00
45_I74_V0.8221.00
236_A349_G0.8211.00
81_N88_A0.8211.00
56_N115_D0.8181.00
163_A204_D0.8181.00
125_I128_N0.8171.00
46_V93_A0.8161.00
126_S130_D0.8141.00
244_L280_E0.8121.00
151_Y276_L0.8111.00
220_N233_S0.8101.00
132_Y137_G0.8081.00
160_N191_I0.8071.00
43_D249_M0.8071.00
96_L101_M0.8011.00
133_M137_G0.8001.00
106_L214_I0.8001.00
87_G348_L0.8001.00
138_I142_S0.7981.00
26_V108_V0.7961.00
131_D136_N0.7931.00
139_S142_S0.7901.00
204_D271_S0.7831.00
44_L96_L0.7801.00
319_L348_L0.7741.00
136_N140_S0.7701.00
137_G140_S0.7671.00
256_L340_Y0.7671.00
333_K349_G0.7661.00
301_G329_S0.7661.00
274_A278_L0.7641.00
22_I110_V0.7631.00
124_A127_T0.7611.00
41_S104_S0.7591.00
20_Y24_D0.7581.00
92_T96_L0.7561.00
220_N223_E0.7531.00
248_R281_A0.7451.00
148_M272_I0.7451.00
92_T95_S0.7391.00
172_N175_E0.7381.00
340_Y346_D0.7371.00
4_V98_K0.7351.00
247_V347_D0.7341.00
10_S29_A0.7341.00
161_Y275_A0.7341.00
34_E42_I0.7331.00
131_D134_F0.7321.00
259_S297_N0.7311.00
132_Y139_S0.7281.00
229_N327_I0.7271.00
42_I106_L0.7271.00
133_M136_N0.7271.00
173_A306_A0.7251.00
135_Y141_H0.7211.00
256_L260_E0.7191.00
146_L150_Q0.7191.00
33_F214_I0.7191.00
221_K224_S0.7191.00
250_L335_A0.7181.00
43_D105_V0.7181.00
47_V62_A0.7121.00
6_L323_H0.7111.00
266_I277_M0.7111.00
71_K106_L0.7101.00
175_E178_F0.7081.00
122_Y125_I0.7011.00
282_G294_D0.7001.00
21_D115_D0.6961.00
136_N142_S0.6881.00
172_N295_S0.6881.00
163_A187_L0.6881.00
10_S33_F0.6861.00
95_S98_K0.6851.00
322_A343_I0.6821.00
147_L240_F0.6811.00
247_V266_I0.6811.00
143_V146_L0.6801.00
173_A177_P0.6771.00
131_D137_G0.6771.00
4_V97_I0.6761.00
170_H174_T0.6751.00
103_N253_K0.6751.00
251_R256_L0.6741.00
30_Y69_I0.6731.00
96_L105_V0.6721.00
8_S231_I0.6701.00
148_M152_M0.6681.00
258_F283_I0.6671.00
31_K69_I0.6671.00
188_N192_N0.6671.00
20_Y115_D0.6671.00
7_N223_E0.6661.00
330_F333_K0.6651.00
104_S226_V0.6641.00
136_N141_H0.6631.00
31_K70_G0.6611.00
134_F137_G0.6611.00
326_L334_K0.6571.00
124_A133_M0.6571.00
231_I324_M0.6571.00
170_H305_K0.6561.00
276_L280_E0.6541.00
200_V205_V0.6531.00
114_S210_D0.6491.00
131_D138_I0.6491.00
135_Y139_S0.6451.00
135_Y138_I0.6441.00
94_Y234_A0.6421.00
175_E180_Y0.6401.00
49_N61_I0.6381.00
5_Y222_T0.6371.00
30_Y214_I0.6351.00
246_S250_L0.6351.00
235_Q254_L0.6351.00
24_D27_I0.6341.00
28_E31_K0.6341.00
218_S226_V0.6331.00
262_T333_K0.6310.99
174_T177_P0.6300.99
130_D133_M0.6300.99
60_L344_S0.6300.99
215_L320_A0.6290.99
44_L81_N0.6290.99
217_L234_A0.6270.99
5_Y219_N0.6250.99
132_Y138_I0.6250.99
123_D128_N0.6220.99
273_M277_M0.6220.99
259_S282_G0.6210.99
103_N225_A0.6190.99
79_V92_T0.6190.99
87_G336_S0.6180.99
23_Y68_K0.6170.99
323_H350_M0.6160.99
252_D257_K0.6150.99
45_I106_L0.6150.99
66_A76_S0.6130.99
135_Y140_S0.6120.99
46_V92_T0.6120.99
157_V161_Y0.6110.99
50_A311_G0.6110.99
66_A71_K0.6110.99
340_Y344_S0.6100.99
120_Y123_D0.6100.99
93_A102_V0.6090.99
247_V258_F0.6080.99
230_K233_S0.6070.99
30_Y34_E0.6050.99
196_I202_L0.6050.99
52_S78_K0.6040.99
77_I88_A0.6030.99
136_N139_S0.6020.99
121_L130_D0.6020.99
307_R317_Y0.6010.99
145_A199_P0.6000.99
113_Q311_G0.5980.99
120_Y126_S0.5970.99
91_L346_D0.5960.99
47_V65_I0.5960.99
314_S318_Q0.5960.99
133_M142_S0.5950.99
26_V110_V0.5910.99
120_Y125_I0.5910.99
170_H207_A0.5910.99
148_M200_V0.5900.99
122_Y128_N0.5890.99
127_T130_D0.5870.99
151_Y155_Y0.5850.99
269_S309_H0.5850.99
163_A191_I0.5840.99
90_L107_I0.5840.99
334_K350_M0.5820.99
121_L125_I0.5810.99
232_L235_Q0.5770.99
42_I71_K0.5750.99
27_I69_I0.5750.99
130_D135_Y0.5740.99
186_D189_T0.5720.99
20_Y112_K0.5710.99
166_A271_S0.5710.99
134_F143_V0.5700.99
157_V279_E0.5680.99
46_V79_V0.5670.99
7_N222_T0.5670.99
274_A298_V0.5650.99
147_L239_D0.5650.99
167_I187_L0.5640.99
6_L217_L0.5640.99
245_P249_M0.5620.99
90_L316_I0.5620.99
108_V214_I0.5590.99
133_M140_S0.5590.99
44_L102_V0.5580.99
283_I294_D0.5570.99
247_V277_M0.5550.99
43_D74_V0.5540.99
65_I69_I0.5530.99
264_I337_V0.5530.99
335_A338_D0.5530.99
173_A307_R0.5520.99
251_R254_L0.5490.99
23_Y57_N0.5490.99
313_A316_I0.5480.99
319_L336_S0.5450.99
88_A91_L0.5440.98
40_N73_N0.5410.98
248_R282_G0.5410.98
250_L261_R0.5400.98
89_A107_I0.5400.98
149_R200_V0.5390.98
65_I110_V0.5370.98
164_N295_S0.5360.98
122_Y126_S0.5360.98
275_A279_E0.5360.98
46_V96_L0.5360.98
120_Y124_A0.5350.98
262_T332_G0.5350.98
34_E37_Y0.5350.98
137_G142_S0.5340.98
119_K124_A0.5330.98
121_L126_S0.5330.98
37_Y216_L0.5320.98
19_E115_D0.5310.98
44_L105_V0.5310.98
123_D127_T0.5300.98
229_N232_L0.5290.98
303_G306_A0.5280.98
166_A170_H0.5280.98
278_L294_D0.5270.98
266_I274_A0.5270.98
96_L99_S0.5230.98
233_S236_A0.5230.98
168_K274_A0.5230.98
88_A96_L0.5220.98
260_E333_K0.5190.98
164_N167_I0.5170.98
155_Y276_L0.5160.98
30_Y45_I0.5160.98
269_S273_M0.5150.98
135_Y142_S0.5150.98
133_M138_I0.5140.98
107_I316_I0.5130.98
307_R321_E0.5130.98
5_Y226_V0.5120.98
171_K184_Q0.5110.98
165_W303_G0.5100.98
58_A64_K0.5100.98
125_I130_D0.5100.98
85_S312_G0.5050.98
133_M139_S0.5040.98
118_S122_Y0.5030.98
272_I276_L0.5010.97
219_N223_E0.5000.97
124_A128_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9972 100 0.246 Contact Map
4u4eA 1 0.9081 100 0.327 Contact Map
1wdkC 2 0.9471 100 0.335 Contact Map
1ulqA 4 0.9526 100 0.335 Contact Map
3goaA 2 0.9304 100 0.345 Contact Map
4e1lA 4 0.9304 100 0.347 Contact Map
2vu1A 4 0.9499 100 0.351 Contact Map
4n46A 4 0.9499 100 0.355 Contact Map
2wu9A 2 0.961 100 0.356 Contact Map
1wl4A 4 0.9499 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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