Q7LXW2 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q7LXW2 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-1)

UniProt:	Q7LXW2	Sequences: MVEVYLNSSSMIPIDRYYEYDIYDLVIEAYKNFEGEYDVNSIDLIVVANAYSQKLNNASLIAPKIAEKIGKPNVPSIKVDNADASGGAALLTAYSLIKSNMVNSVLIVGVEKQSDYPSKYLYDAISTNLDDYMFYNGISSHSVAALLMRQYMKRYGVDRNYFANWAIKMHKNATENPFAYLRFQVDLNTVINSQIISDPVRLFDVGARADGAAILLLSNNKTESAVKINKILSAQARYDFSPSLPSVRMLRDKLELKFSERTGIDIHDSYSIMAALMLEEAGIFESGKSLHNLDSVNVNLGGGLKARGHVGGASAIYQLAEAHMQLIGSFKGKKASVDNYIVISSDDLGMVSYGINLSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	359 (337)
Sequences:	15441 (8564)
Seq/√Len:	466.5

ECOLI - PAAJ ATOB YQEF FADA FADI
BACSU - THL YHFS FADA
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q7LXW2 Q97UW8 Q97VJ9 Q97WQ6 Q97VU9 Q97VD4 Q97UA5 Q97VV9 Q97WQ7 Q97W61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
3_E	220_N	3.598	1.00
168_K	172_N	3.569	1.00
222_T	226_V	3.487	1.00
161_Y	279_E	3.387	1.00
102_V	105_V	3.173	1.00
322_A	334_K	3.065	1.00
90_L	319_L	2.979	1.00
32_N	35_G	2.896	1.00
168_K	171_K	2.774	1.00
175_E	179_A	2.765	1.00
220_N	224_S	2.745	1.00
222_T	225_A	2.743	1.00
250_L	254_L	2.709	1.00
5_Y	223_E	2.614	1.00
153_K	198_D	2.614	1.00
30_Y	106_L	2.597	1.00
9_S	320_A	2.561	1.00
97_I	217_L	2.479	1.00
33_F	216_L	2.355	1.00
10_S	36_E	2.320	1.00
250_L	349_G	2.275	1.00
104_S	218_S	2.251	1.00
158_D	161_Y	2.190	1.00
97_I	219_N	2.173	1.00
326_L	331_K	2.161	1.00
93_A	105_V	2.154	1.00
26_V	47_V	2.108	1.00
7_N	218_S	2.087	1.00
236_A	254_L	2.054	1.00
263_G	300_L	2.015	1.00
231_I	327_I	1.982	1.00
160_N	164_N	1.982	1.00
190_V	203_F	1.966	1.00
213_A	316_I	1.955	1.00
232_L	323_H	1.940	1.00
151_Y	157_V	1.869	1.00
41_S	226_V	1.838	1.00
256_L	333_K	1.831	1.00
262_T	331_K	1.791	1.00
278_L	295_S	1.770	1.00
278_L	298_V	1.763	1.00
247_V	337_V	1.757	1.00
168_K	295_S	1.754	1.00
103_N	219_N	1.727	1.00
177_P	185_V	1.724	1.00
233_S	351_V	1.724	1.00
218_S	223_E	1.716	1.00
3_E	233_S	1.713	1.00
248_R	252_D	1.709	1.00
325_Q	329_S	1.700	1.00
301_G	325_Q	1.694	1.00
218_S	222_T	1.680	1.00
189_T	192_N	1.679	1.00
167_I	171_K	1.676	1.00
174_T	178_F	1.669	1.00
145_A	197_S	1.665	1.00
236_A	250_L	1.664	1.00
261_R	264_I	1.656	1.00
219_N	222_T	1.654	1.00
47_V	108_V	1.649	1.00
103_N	222_T	1.636	1.00
26_V	65_I	1.631	1.00
256_L	261_R	1.618	1.00
77_I	92_T	1.608	1.00
215_L	316_I	1.606	1.00
294_D	297_N	1.606	1.00
258_F	264_I	1.598	1.00
95_S	101_M	1.588	1.00
180_Y	301_G	1.572	1.00
28_E	186_D	1.571	1.00
96_L	102_V	1.555	1.00
237_R	240_F	1.551	1.00
245_P	248_R	1.545	1.00
93_A	217_L	1.545	1.00
164_N	168_K	1.529	1.00
112_K	115_D	1.520	1.00
30_Y	65_I	1.495	1.00
24_D	68_K	1.489	1.00
104_S	222_T	1.484	1.00
264_I	335_A	1.472	1.00
8_S	33_F	1.456	1.00
29_A	214_I	1.453	1.00
263_G	325_Q	1.453	1.00
325_Q	328_G	1.451	1.00
261_R	349_G	1.448	1.00
31_K	35_G	1.443	1.00
33_F	37_Y	1.439	1.00
256_L	349_G	1.426	1.00
29_A	212_A	1.406	1.00
32_N	36_E	1.400	1.00
91_L	348_L	1.397	1.00
32_N	186_D	1.375	1.00
180_Y	325_Q	1.362	1.00
249_M	252_D	1.358	1.00
14_I	313_A	1.347	1.00
251_R	258_F	1.343	1.00
183_F	327_I	1.341	1.00
171_K	175_E	1.340	1.00
149_R	198_D	1.326	1.00
20_Y	28_E	1.321	1.00
248_R	280_E	1.311	1.00
4_V	217_L	1.294	1.00
84_A	346_D	1.293	1.00
27_I	68_K	1.284	1.00
61_I	110_V	1.281	1.00
157_V	162_F	1.280	1.00
319_L	350_M	1.279	1.00
323_H	327_I	1.276	1.00
332_G	351_V	1.269	1.00
221_K	225_A	1.262	1.00
154_R	238_Y	1.259	1.00
90_L	215_L	1.255	1.00
49_N	52_S	1.249	1.00
335_A	349_G	1.243	1.00
43_D	102_V	1.237	1.00
159_R	201_R	1.227	1.00
42_I	104_S	1.212	1.00
320_A	324_M	1.212	1.00
300_L	325_Q	1.203	1.00
106_L	216_L	1.198	1.00
47_V	214_I	1.187	1.00
161_Y	164_N	1.183	1.00
146_L	198_D	1.181	1.00
246_S	347_D	1.167	1.00
5_Y	220_N	1.161	1.00
247_V	335_A	1.159	1.00
9_S	324_M	1.144	1.00
84_A	340_Y	1.144	1.00
87_G	319_L	1.140	1.00
46_V	105_V	1.136	1.00
93_A	107_I	1.132	1.00
14_I	307_R	1.125	1.00
165_W	274_A	1.124	1.00
88_A	92_T	1.118	1.00
244_L	248_R	1.115	1.00
150_Q	154_R	1.115	1.00
8_S	36_E	1.114	1.00
5_Y	218_S	1.111	1.00
41_S	222_T	1.109	1.00
261_R	333_K	1.106	1.00
9_S	323_H	1.105	1.00
43_D	103_N	1.104	1.00
28_E	32_N	1.098	1.00
165_W	275_A	1.094	1.00
134_F	139_S	1.088	1.00
257_K	260_E	1.086	1.00
235_Q	351_V	1.086	1.00
154_R	237_R	1.085	1.00
258_F	261_R	1.082	1.00
155_Y	241_S	1.076	1.00
10_S	186_D	1.070	1.00
234_A	348_L	1.068	1.00
101_M	253_K	1.068	1.00
5_Y	233_S	1.066	1.00
180_Y	328_G	1.064	1.00
98_K	101_M	1.063	1.00
34_E	39_V	1.062	1.00
30_Y	71_K	1.062	1.00
177_P	182_R	1.061	1.00
145_A	196_I	1.061	1.00
167_I	190_V	1.061	1.00
183_F	328_G	1.049	1.00
90_L	217_L	1.047	1.00
241_S	244_L	1.046	1.00
132_Y	136_N	1.042	1.00
262_T	326_L	1.041	1.00
317_Y	321_E	1.036	1.00
254_L	349_G	1.035	1.00
262_T	297_N	1.030	1.00
149_R	153_K	1.029	1.00
263_G	329_S	1.021	1.00
95_S	99_S	1.020	1.00
157_V	275_A	1.019	1.00
171_K	174_T	1.012	1.00
48_A	85_S	1.009	1.00
10_S	32_N	1.003	1.00
34_E	71_K	0.998	1.00
122_Y	127_T	0.996	1.00
322_A	336_S	0.994	1.00
41_S	225_A	0.988	1.00
300_L	329_S	0.980	1.00
184_Q	321_E	0.979	1.00
241_S	280_E	0.975	1.00
168_K	296_V	0.973	1.00
14_I	209_A	0.963	1.00
213_A	313_A	0.959	1.00
6_L	350_M	0.959	1.00
45_I	66_A	0.952	1.00
261_R	335_A	0.952	1.00
283_I	298_V	0.941	1.00
27_I	31_K	0.937	1.00
21_D	24_D	0.934	1.00
49_N	57_N	0.929	1.00
301_G	328_G	0.924	1.00
231_I	235_Q	0.923	1.00
132_Y	135_Y	0.922	1.00
230_K	234_A	0.921	1.00
193_S	203_F	0.921	1.00
29_A	32_N	0.919	1.00
12_I	28_E	0.916	1.00
3_E	98_K	0.915	1.00
12_I	29_A	0.908	1.00
193_S	201_R	0.906	1.00
236_A	253_K	0.905	1.00
7_N	228_I	0.904	1.00
71_K	74_V	0.903	1.00
194_Q	202_L	0.897	1.00
264_I	283_I	0.897	1.00
263_G	322_A	0.890	1.00
150_Q	153_K	0.888	1.00
231_I	323_H	0.885	1.00
13_P	28_E	0.884	1.00
8_S	37_Y	0.884	1.00
123_D	126_S	0.878	1.00
4_V	219_N	0.877	1.00
249_M	253_K	0.875	1.00
318_Q	336_S	0.873	1.00
261_R	340_Y	0.872	1.00
271_S	305_K	0.870	1.00
183_F	324_M	0.870	1.00
46_V	89_A	0.868	1.00
179_A	328_G	0.866	1.00
33_F	106_L	0.863	1.00
235_Q	333_K	0.862	1.00
241_S	276_L	0.860	1.00
14_I	317_Y	0.858	1.00
213_A	320_A	0.854	1.00
218_S	228_I	0.853	1.00
247_V	281_A	0.849	1.00
94_Y	98_K	0.847	1.00
138_I	141_H	0.847	1.00
46_V	77_I	0.846	1.00
89_A	316_I	0.844	1.00
151_Y	241_S	0.841	1.00
266_I	337_V	0.839	1.00
238_Y	241_S	0.837	1.00
278_L	283_I	0.836	1.00
107_I	215_L	0.835	1.00
304_L	314_S	0.835	1.00
322_A	341_I	0.834	1.00
195_I	198_D	0.832	1.00
4_V	94_Y	0.832	1.00
167_I	189_T	0.829	1.00
121_L	124_A	0.829	1.00
333_K	351_V	0.828	1.00
29_A	33_F	0.828	1.00
131_D	135_Y	0.827	1.00
152_M	272_I	0.825	1.00
155_Y	280_E	0.824	1.00
12_I	25_L	0.823	1.00
9_S	215_L	0.823	1.00
45_I	74_V	0.822	1.00
236_A	349_G	0.821	1.00
81_N	88_A	0.821	1.00
56_N	115_D	0.818	1.00
163_A	204_D	0.818	1.00
125_I	128_N	0.817	1.00
46_V	93_A	0.816	1.00
126_S	130_D	0.814	1.00
244_L	280_E	0.812	1.00
151_Y	276_L	0.811	1.00
220_N	233_S	0.810	1.00
132_Y	137_G	0.808	1.00
160_N	191_I	0.807	1.00
43_D	249_M	0.807	1.00
96_L	101_M	0.801	1.00
133_M	137_G	0.800	1.00
106_L	214_I	0.800	1.00
87_G	348_L	0.800	1.00
138_I	142_S	0.798	1.00
26_V	108_V	0.796	1.00
131_D	136_N	0.793	1.00
139_S	142_S	0.790	1.00
204_D	271_S	0.783	1.00
44_L	96_L	0.780	1.00
319_L	348_L	0.774	1.00
136_N	140_S	0.770	1.00
137_G	140_S	0.767	1.00
256_L	340_Y	0.767	1.00
333_K	349_G	0.766	1.00
301_G	329_S	0.766	1.00
274_A	278_L	0.764	1.00
22_I	110_V	0.763	1.00
124_A	127_T	0.761	1.00
41_S	104_S	0.759	1.00
20_Y	24_D	0.758	1.00
92_T	96_L	0.756	1.00
220_N	223_E	0.753	1.00
248_R	281_A	0.745	1.00
148_M	272_I	0.745	1.00
92_T	95_S	0.739	1.00
172_N	175_E	0.738	1.00
340_Y	346_D	0.737	1.00
4_V	98_K	0.735	1.00
247_V	347_D	0.734	1.00
10_S	29_A	0.734	1.00
161_Y	275_A	0.734	1.00
34_E	42_I	0.733	1.00
131_D	134_F	0.732	1.00
259_S	297_N	0.731	1.00
132_Y	139_S	0.728	1.00
229_N	327_I	0.727	1.00
42_I	106_L	0.727	1.00
133_M	136_N	0.727	1.00
173_A	306_A	0.725	1.00
135_Y	141_H	0.721	1.00
256_L	260_E	0.719	1.00
146_L	150_Q	0.719	1.00
33_F	214_I	0.719	1.00
221_K	224_S	0.719	1.00
250_L	335_A	0.718	1.00
43_D	105_V	0.718	1.00
47_V	62_A	0.712	1.00
6_L	323_H	0.711	1.00
266_I	277_M	0.711	1.00
71_K	106_L	0.710	1.00
175_E	178_F	0.708	1.00
122_Y	125_I	0.701	1.00
282_G	294_D	0.700	1.00
21_D	115_D	0.696	1.00
136_N	142_S	0.688	1.00
172_N	295_S	0.688	1.00
163_A	187_L	0.688	1.00
10_S	33_F	0.686	1.00
95_S	98_K	0.685	1.00
322_A	343_I	0.682	1.00
147_L	240_F	0.681	1.00
247_V	266_I	0.681	1.00
143_V	146_L	0.680	1.00
173_A	177_P	0.677	1.00
131_D	137_G	0.677	1.00
4_V	97_I	0.676	1.00
170_H	174_T	0.675	1.00
103_N	253_K	0.675	1.00
251_R	256_L	0.674	1.00
30_Y	69_I	0.673	1.00
96_L	105_V	0.672	1.00
8_S	231_I	0.670	1.00
148_M	152_M	0.668	1.00
258_F	283_I	0.667	1.00
31_K	69_I	0.667	1.00
188_N	192_N	0.667	1.00
20_Y	115_D	0.667	1.00
7_N	223_E	0.666	1.00
330_F	333_K	0.665	1.00
104_S	226_V	0.664	1.00
136_N	141_H	0.663	1.00
31_K	70_G	0.661	1.00
134_F	137_G	0.661	1.00
326_L	334_K	0.657	1.00
124_A	133_M	0.657	1.00
231_I	324_M	0.657	1.00
170_H	305_K	0.656	1.00
276_L	280_E	0.654	1.00
200_V	205_V	0.653	1.00
114_S	210_D	0.649	1.00
131_D	138_I	0.649	1.00
135_Y	139_S	0.645	1.00
135_Y	138_I	0.644	1.00
94_Y	234_A	0.642	1.00
175_E	180_Y	0.640	1.00
49_N	61_I	0.638	1.00
5_Y	222_T	0.637	1.00
30_Y	214_I	0.635	1.00
246_S	250_L	0.635	1.00
235_Q	254_L	0.635	1.00
24_D	27_I	0.634	1.00
28_E	31_K	0.634	1.00
218_S	226_V	0.633	1.00
262_T	333_K	0.631	0.99
174_T	177_P	0.630	0.99
130_D	133_M	0.630	0.99
60_L	344_S	0.630	0.99
215_L	320_A	0.629	0.99
44_L	81_N	0.629	0.99
217_L	234_A	0.627	0.99
5_Y	219_N	0.625	0.99
132_Y	138_I	0.625	0.99
123_D	128_N	0.622	0.99
273_M	277_M	0.622	0.99
259_S	282_G	0.621	0.99
103_N	225_A	0.619	0.99
79_V	92_T	0.619	0.99
87_G	336_S	0.618	0.99
23_Y	68_K	0.617	0.99
323_H	350_M	0.616	0.99
252_D	257_K	0.615	0.99
45_I	106_L	0.615	0.99
66_A	76_S	0.613	0.99
135_Y	140_S	0.612	0.99
46_V	92_T	0.612	0.99
157_V	161_Y	0.611	0.99
50_A	311_G	0.611	0.99
66_A	71_K	0.611	0.99
340_Y	344_S	0.610	0.99
120_Y	123_D	0.610	0.99
93_A	102_V	0.609	0.99
247_V	258_F	0.608	0.99
230_K	233_S	0.607	0.99
30_Y	34_E	0.605	0.99
196_I	202_L	0.605	0.99
52_S	78_K	0.604	0.99
77_I	88_A	0.603	0.99
136_N	139_S	0.602	0.99
121_L	130_D	0.602	0.99
307_R	317_Y	0.601	0.99
145_A	199_P	0.600	0.99
113_Q	311_G	0.598	0.99
120_Y	126_S	0.597	0.99
91_L	346_D	0.596	0.99
47_V	65_I	0.596	0.99
314_S	318_Q	0.596	0.99
133_M	142_S	0.595	0.99
26_V	110_V	0.591	0.99
120_Y	125_I	0.591	0.99
170_H	207_A	0.591	0.99
148_M	200_V	0.590	0.99
122_Y	128_N	0.589	0.99
127_T	130_D	0.587	0.99
151_Y	155_Y	0.585	0.99
269_S	309_H	0.585	0.99
163_A	191_I	0.584	0.99
90_L	107_I	0.584	0.99
334_K	350_M	0.582	0.99
121_L	125_I	0.581	0.99
232_L	235_Q	0.577	0.99
42_I	71_K	0.575	0.99
27_I	69_I	0.575	0.99
130_D	135_Y	0.574	0.99
186_D	189_T	0.572	0.99
20_Y	112_K	0.571	0.99
166_A	271_S	0.571	0.99
134_F	143_V	0.570	0.99
157_V	279_E	0.568	0.99
46_V	79_V	0.567	0.99
7_N	222_T	0.567	0.99
274_A	298_V	0.565	0.99
147_L	239_D	0.565	0.99
167_I	187_L	0.564	0.99
6_L	217_L	0.564	0.99
245_P	249_M	0.562	0.99
90_L	316_I	0.562	0.99
108_V	214_I	0.559	0.99
133_M	140_S	0.559	0.99
44_L	102_V	0.558	0.99
283_I	294_D	0.557	0.99
247_V	277_M	0.555	0.99
43_D	74_V	0.554	0.99
65_I	69_I	0.553	0.99
264_I	337_V	0.553	0.99
335_A	338_D	0.553	0.99
173_A	307_R	0.552	0.99
251_R	254_L	0.549	0.99
23_Y	57_N	0.549	0.99
313_A	316_I	0.548	0.99
319_L	336_S	0.545	0.99
88_A	91_L	0.544	0.98
40_N	73_N	0.541	0.98
248_R	282_G	0.541	0.98
250_L	261_R	0.540	0.98
89_A	107_I	0.540	0.98
149_R	200_V	0.539	0.98
65_I	110_V	0.537	0.98
164_N	295_S	0.536	0.98
122_Y	126_S	0.536	0.98
275_A	279_E	0.536	0.98
46_V	96_L	0.536	0.98
120_Y	124_A	0.535	0.98
262_T	332_G	0.535	0.98
34_E	37_Y	0.535	0.98
137_G	142_S	0.534	0.98
119_K	124_A	0.533	0.98
121_L	126_S	0.533	0.98
37_Y	216_L	0.532	0.98
19_E	115_D	0.531	0.98
44_L	105_V	0.531	0.98
123_D	127_T	0.530	0.98
229_N	232_L	0.529	0.98
303_G	306_A	0.528	0.98
166_A	170_H	0.528	0.98
278_L	294_D	0.527	0.98
266_I	274_A	0.527	0.98
96_L	99_S	0.523	0.98
233_S	236_A	0.523	0.98
168_K	274_A	0.523	0.98
88_A	96_L	0.522	0.98
260_E	333_K	0.519	0.98
164_N	167_I	0.517	0.98
155_Y	276_L	0.516	0.98
30_Y	45_I	0.516	0.98
269_S	273_M	0.515	0.98
135_Y	142_S	0.515	0.98
133_M	138_I	0.514	0.98
107_I	316_I	0.513	0.98
307_R	321_E	0.513	0.98
5_Y	226_V	0.512	0.98
171_K	184_Q	0.511	0.98
165_W	303_G	0.510	0.98
58_A	64_K	0.510	0.98
125_I	130_D	0.510	0.98
85_S	312_G	0.505	0.98
133_M	139_S	0.504	0.98
118_S	122_Y	0.503	0.98
272_I	276_L	0.501	0.97
219_N	223_E	0.500	0.97
124_A	128_N	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.9972	100	0.246	Contact Map
4u4eA	1	0.9081	100	0.327	Contact Map
1wdkC	2	0.9471	100	0.335	Contact Map
1ulqA	4	0.9526	100	0.335	Contact Map
3goaA	2	0.9304	100	0.345	Contact Map
4e1lA	4	0.9304	100	0.347	Contact Map
2vu1A	4	0.9499	100	0.351	Contact Map
4n46A	4	0.9499	100	0.355	Contact Map
2wu9A	2	0.961	100	0.356	Contact Map
1wl4A	4	0.9499	100	0.359	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.