Q7LXV3 - SULSO - GREMLIN Contacts

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Q7LXV3 - Coenzyme PQQ synthesis protein E (PqqE-1)

UniProt:	Q7LXV3	Sequences: MINRKPFFIELELTYKCSQQCIYCHNPPKDLKFYIADKVPKPRSVIEMNELNLSEWISVINQIKRLDEKYEGIMDVVITGGEPLLRSDLEEILSYVTRQKLRHMLLSSGEPISDDRITKLLESGLEKIRINLTSHKYVFNIQSPIMHIKNEVAKKINIAKKFKDFGVKEVGGNIVLTSYYLDFLEEIAELAYKSNLDWIEIHSVIKVGHGYINQKFIVPDPNDERTIQEKLKRLIEIYGENFIQNYVDTDILYSRIPIPTNWGEVGLVIAPNGDIYPSSEATSIPLSKLGNIKNDSLVEIWFNNLLLNKIRSLSFLREPCKSCEVKKLCRGGFRFNAYITKNDLFAPDPSCQIVKDYIGKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	361 (302)
Sequences:	8849 (6990)
Seq/√Len:	402.2

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q7LXV3 Q97XA7 Q97XS7 Q97XZ2 Q97XS8 Q97XA6 Q97Y04 Q97WC3 Q97WK5 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_Q	110_E	4.031	1.00
136_K	153_A	3.893	1.00
57_I	95_Y	3.534	1.00
114_D	161_K	3.286	1.00
160_K	194_S	3.055	1.00
61_N	95_Y	2.947	1.00
55_E	293_K	2.930	1.00
52_N	55_E	2.829	1.00
18_S	108_S	2.699	1.00
274_D	291_N	2.651	1.00
58_S	62_Q	2.570	1.00
118_T	165_F	2.511	1.00
274_D	288_K	2.502	1.00
260_T	278_S	2.469	1.00
90_E	119_K	2.418	1.00
53_L	91_E	2.343	1.00
296_S	299_E	2.339	1.00
152_V	190_L	2.326	1.00
61_N	99_Q	2.249	1.00
9_I	63_I	2.226	1.00
161_K	164_D	2.179	1.00
143_S	150_N	2.173	1.00
16_K	50_E	2.116	1.00
109_G	130_I	2.054	1.00
97_T	126_E	2.015	1.00
114_D	164_D	2.014	1.00
295_D	299_E	2.012	1.00
95_Y	98_R	1.999	1.00
183_F	186_E	1.975	1.00
141_I	183_F	1.922	1.00
135_H	183_F	1.919	1.00
22_I	144_P	1.911	1.00
278_S	333_F	1.889	1.00
270_A	274_D	1.875	1.00
118_T	122_E	1.872	1.00
56_W	92_I	1.844	1.00
53_L	57_I	1.843	1.00
64_K	99_Q	1.803	1.00
119_K	123_S	1.792	1.00
133_T	146_M	1.792	1.00
291_N	294_N	1.788	1.00
172_G	191_A	1.766	1.00
130_I	159_A	1.756	1.00
154_K	157_N	1.728	1.00
189_E	193_K	1.727	1.00
94_S	98_R	1.726	1.00
57_I	91_E	1.714	1.00
57_I	61_N	1.675	1.00
113_S	116_R	1.674	1.00
88_D	91_E	1.674	1.00
94_S	119_K	1.667	1.00
95_Y	99_Q	1.667	1.00
157_N	160_K	1.650	1.00
18_S	111_P	1.621	1.00
55_E	58_S	1.620	1.00
160_K	164_D	1.608	1.00
190_L	194_S	1.602	1.00
174_I	187_I	1.596	1.00
84_L	105_L	1.595	1.00
117_I	161_K	1.590	1.00
186_E	189_E	1.560	1.00
157_N	161_K	1.554	1.00
91_E	94_S	1.549	1.00
51_L	55_E	1.538	1.00
270_A	276_Y	1.533	1.00
153_A	157_N	1.523	1.00
53_L	88_D	1.520	1.00
135_H	138_V	1.488	1.00
90_E	116_R	1.482	1.00
130_I	158_I	1.481	1.00
60_I	96_V	1.476	1.00
76_V	96_V	1.474	1.00
86_R	92_I	1.459	1.00
97_T	123_S	1.459	1.00
155_K	158_I	1.454	1.00
62_Q	296_S	1.450	1.00
160_K	163_K	1.445	1.00
23_Y	133_T	1.441	1.00
128_I	162_F	1.427	1.00
225_R	229_E	1.411	1.00
119_K	122_E	1.411	1.00
152_V	156_I	1.388	1.00
298_V	302_F	1.386	1.00
156_I	194_S	1.386	1.00
84_L	111_P	1.368	1.00
78_I	103_H	1.334	1.00
121_L	165_F	1.333	1.00
134_S	141_I	1.330	1.00
94_S	123_S	1.322	1.00
305_L	309_K	1.321	1.00
96_V	103_H	1.318	1.00
13_L	78_I	1.318	1.00
106_L	129_R	1.306	1.00
114_D	165_F	1.305	1.00
11_L	56_W	1.302	1.00
78_I	96_V	1.280	1.00
254_S	257_P	1.278	1.00
116_R	120_L	1.268	1.00
219_P	223_D	1.263	1.00
136_K	183_F	1.262	1.00
89_L	93_L	1.251	1.00
275_I	300_I	1.246	1.00
51_L	56_W	1.235	1.00
93_L	125_L	1.221	1.00
60_I	99_Q	1.208	1.00
276_Y	288_K	1.204	1.00
97_T	103_H	1.202	1.00
163_K	195_N	1.201	1.00
156_I	160_K	1.201	1.00
174_I	199_I	1.199	1.00
145_I	154_K	1.195	1.00
50_E	86_R	1.191	1.00
14_T	50_E	1.187	1.00
112_I	117_I	1.179	1.00
91_E	95_Y	1.174	1.00
135_H	141_I	1.173	1.00
15_Y	271_P	1.165	1.00
260_T	333_F	1.160	1.00
117_I	158_I	1.158	1.00
161_K	165_F	1.150	1.00
220_D	223_D	1.128	1.00
158_I	161_K	1.126	1.00
86_R	89_L	1.122	1.00
143_S	148_I	1.120	1.00
105_L	120_L	1.115	1.00
135_H	186_E	1.113	1.00
290_G	300_I	1.110	1.00
230_K	234_L	1.106	1.00
132_L	172_G	1.106	1.00
297_L	301_W	1.105	1.00
172_G	196_L	1.105	1.00
93_L	123_S	1.100	1.00
137_Y	153_A	1.096	1.00
115_D	118_T	1.091	1.00
318_E	321_K	1.086	1.00
334_R	337_A	1.083	1.00
189_E	192_Y	1.075	1.00
18_S	82_E	1.069	1.00
191_A	196_L	1.069	1.00
135_H	190_L	1.066	1.00
114_D	118_T	1.064	1.00
305_L	308_N	1.060	1.00
156_I	190_L	1.053	1.00
130_I	162_F	1.047	1.00
9_I	267_L	1.046	1.00
59_V	269_I	1.039	1.00
295_D	300_I	1.038	1.00
301_W	311_R	1.034	1.00
84_L	116_R	1.031	1.00
229_E	233_R	1.024	1.00
64_K	101_L	1.014	1.00
116_R	119_K	1.014	1.00
58_S	293_K	0.999	1.00
129_R	173_N	0.997	1.00
230_K	233_R	0.995	1.00
142_Q	155_K	0.993	1.00
240_E	244_Q	0.992	1.00
18_S	110_E	0.985	1.00
141_I	179_Y	0.982	1.00
58_S	61_N	0.982	1.00
159_A	172_G	0.979	1.00
61_N	65_R	0.973	1.00
112_I	158_I	0.969	1.00
75_D	104_M	0.965	1.00
163_K	170_V	0.965	1.00
87_S	90_E	0.965	1.00
117_I	121_L	0.964	1.00
19_Q	151_E	0.961	1.00
221_P	225_R	0.954	1.00
105_L	128_I	0.947	1.00
49_N	272_N	0.945	1.00
233_R	236_E	0.945	1.00
226_T	229_E	0.942	1.00
62_Q	66_L	0.941	1.00
11_L	59_V	0.939	1.00
131_N	175_V	0.938	1.00
113_S	157_N	0.937	1.00
223_D	226_T	0.932	1.00
23_Y	145_I	0.931	1.00
25_H	79_T	0.926	1.00
162_F	167_V	0.926	1.00
154_K	158_I	0.925	1.00
136_K	152_V	0.919	1.00
134_S	152_V	0.916	1.00
188_A	192_Y	0.915	1.00
159_A	170_V	0.914	1.00
185_E	189_E	0.910	1.00
53_L	95_Y	0.908	1.00
53_L	86_R	0.907	1.00
228_Q	232_K	0.904	1.00
12_E	271_P	0.900	1.00
225_R	228_Q	0.898	1.00
63_I	76_V	0.898	1.00
143_S	146_M	0.896	1.00
267_L	297_L	0.894	1.00
172_G	199_I	0.887	1.00
18_S	85_L	0.884	1.00
241_N	245_N	0.884	1.00
51_L	59_V	0.883	1.00
185_E	229_E	0.883	1.00
9_I	269_I	0.879	1.00
118_T	121_L	0.875	1.00
142_Q	151_E	0.870	1.00
143_S	151_E	0.868	1.00
115_D	119_K	0.866	1.00
187_I	191_A	0.866	1.00
84_L	158_I	0.864	1.00
96_V	99_Q	0.858	1.00
108_S	111_P	0.844	1.00
289_L	307_L	0.844	1.00
163_K	194_S	0.843	1.00
92_I	96_V	0.834	1.00
82_E	108_S	0.834	1.00
90_E	94_S	0.832	1.00
267_L	301_W	0.832	1.00
260_T	263_G	0.831	1.00
306_L	309_K	0.826	1.00
79_T	106_L	0.826	1.00
257_P	260_T	0.824	1.00
13_L	92_I	0.821	1.00
158_I	162_F	0.821	1.00
178_S	222_N	0.817	1.00
224_E	228_Q	0.817	1.00
103_H	125_L	0.814	1.00
112_I	120_L	0.814	1.00
128_I	167_V	0.810	1.00
190_L	193_K	0.809	1.00
12_E	268_V	0.803	1.00
60_I	76_V	0.795	1.00
62_Q	298_V	0.795	1.00
281_A	335_F	0.787	1.00
227_I	231_L	0.785	1.00
290_G	295_D	0.783	1.00
54_S	57_I	0.783	1.00
137_Y	143_S	0.782	1.00
185_E	230_K	0.781	1.00
74_M	102_R	0.779	1.00
239_G	242_F	0.779	1.00
145_I	149_K	0.778	1.00
23_Y	146_M	0.777	1.00
162_F	170_V	0.776	1.00
132_L	152_V	0.774	1.00
222_N	226_T	0.772	1.00
76_V	103_H	0.770	1.00
309_K	312_S	0.767	1.00
110_E	158_I	0.765	1.00
127_K	171_G	0.765	1.00
144_P	179_Y	0.764	1.00
20_Q	146_M	0.763	1.00
93_L	96_V	0.760	1.00
182_D	226_T	0.759	1.00
93_L	103_H	0.757	1.00
10_E	266_G	0.756	1.00
163_K	196_L	0.756	1.00
82_E	85_L	0.755	1.00
232_K	236_E	0.754	1.00
189_E	233_R	0.749	1.00
163_K	197_D	0.746	1.00
318_E	322_S	0.743	1.00
55_E	59_V	0.743	1.00
56_W	86_R	0.738	1.00
62_Q	65_R	0.738	1.00
75_D	102_R	0.736	1.00
248_D	251_I	0.735	1.00
185_E	233_R	0.732	1.00
231_L	235_I	0.732	1.00
222_N	225_R	0.731	1.00
159_A	196_L	0.730	1.00
77_V	104_M	0.727	1.00
168_K	197_D	0.723	1.00
142_Q	177_T	0.722	1.00
308_N	312_S	0.722	1.00
113_S	158_I	0.721	1.00
307_L	311_R	0.719	1.00
178_S	223_D	0.715	1.00
316_L	326_K	0.715	1.00
12_E	79_T	0.714	1.00
56_W	59_V	0.712	1.00
14_T	86_R	0.711	1.00
77_V	106_L	0.708	1.00
253_Y	257_P	0.707	1.00
288_K	291_N	0.706	1.00
233_R	237_I	0.704	1.00
132_L	156_I	0.704	1.00
86_R	91_E	0.703	1.00
141_I	144_P	0.699	1.00
132_L	155_K	0.698	1.00
93_L	119_K	0.696	1.00
79_T	279_S	0.694	1.00
13_L	86_R	0.689	1.00
65_R	298_V	0.688	1.00
320_C	323_C	0.687	1.00
87_S	116_R	0.686	1.00
202_H	205_I	0.686	1.00
173_N	202_H	0.685	1.00
121_L	166_G	0.684	1.00
232_K	235_I	0.683	1.00
10_E	279_S	0.682	0.99
246_Y	249_T	0.678	0.99
226_T	230_K	0.677	0.99
121_L	167_V	0.674	0.99
238_Y	241_N	0.673	0.99
76_V	101_L	0.670	0.99
296_S	300_I	0.669	0.99
148_I	151_E	0.669	0.99
88_D	92_I	0.668	0.99
90_E	123_S	0.666	0.99
13_L	89_L	0.662	0.99
153_A	156_I	0.662	0.99
78_I	93_L	0.661	0.99
106_L	173_N	0.659	0.99
60_I	101_L	0.657	0.99
138_V	144_P	0.656	0.99
57_I	98_R	0.653	0.99
237_I	240_E	0.652	0.99
26_N	79_T	0.652	0.99
129_R	171_G	0.651	0.99
137_Y	150_N	0.651	0.99
134_S	137_Y	0.649	0.99
277_P	281_A	0.648	0.99
59_V	63_I	0.647	0.99
84_L	89_L	0.647	0.99
142_Q	146_M	0.646	0.99
320_C	329_C	0.646	0.99
246_Y	250_D	0.642	0.99
177_T	180_Y	0.641	0.99
20_Q	27_P	0.639	0.99
219_P	222_N	0.636	0.99
53_L	92_I	0.634	0.99
90_E	93_L	0.633	0.99
174_I	191_A	0.633	0.99
85_L	111_P	0.632	0.99
86_R	90_E	0.632	0.99
191_A	194_S	0.630	0.99
114_D	117_I	0.629	0.99
97_T	124_G	0.625	0.99
106_L	279_S	0.624	0.99
84_L	112_I	0.624	0.99
112_I	130_I	0.621	0.99
102_R	127_K	0.621	0.99
16_K	48_M	0.618	0.99
57_I	99_Q	0.618	0.99
62_Q	275_I	0.618	0.99
187_I	199_I	0.617	0.99
63_I	73_I	0.616	0.99
84_L	120_L	0.615	0.99
104_M	127_K	0.614	0.99
184_L	201_I	0.614	0.99
185_E	188_A	0.612	0.99
186_E	190_L	0.612	0.99
269_I	275_I	0.606	0.99
137_Y	152_V	0.604	0.99
180_Y	183_F	0.602	0.99
134_S	183_F	0.601	0.99
107_S	130_I	0.601	0.99
60_I	95_Y	0.600	0.99
293_K	296_S	0.599	0.99
100_K	103_H	0.599	0.99
185_E	226_T	0.598	0.99
56_W	60_I	0.597	0.99
8_F	77_V	0.595	0.99
21_C	24_C	0.595	0.99
143_S	147_H	0.593	0.99
53_L	56_W	0.590	0.99
113_S	161_K	0.586	0.98
62_Q	297_L	0.585	0.98
268_V	279_S	0.585	0.98
73_I	102_R	0.584	0.98
12_E	26_N	0.583	0.98
73_I	100_K	0.583	0.98
275_I	297_L	0.580	0.98
82_E	107_S	0.580	0.98
332_G	337_A	0.579	0.98
110_E	154_K	0.579	0.98
9_I	73_I	0.579	0.98
231_L	234_L	0.578	0.98
277_P	287_S	0.576	0.98
28_P	209_H	0.571	0.98
23_Y	26_N	0.570	0.98
20_Q	148_I	0.569	0.98
240_E	245_N	0.568	0.98
220_D	224_E	0.568	0.98
54_S	58_S	0.567	0.98
117_I	162_F	0.567	0.98
49_N	271_P	0.567	0.98
117_I	165_F	0.565	0.98
217_I	221_P	0.565	0.98
239_G	243_I	0.563	0.98
135_H	152_V	0.561	0.98
112_I	162_F	0.560	0.98
184_L	188_A	0.560	0.98
130_I	155_K	0.560	0.98
239_G	244_Q	0.560	0.98
66_L	72_G	0.559	0.98
210_G	213_N	0.558	0.98
136_K	186_E	0.557	0.98
141_I	182_D	0.556	0.98
204_V	210_G	0.555	0.98
78_I	92_I	0.554	0.98
273_G	292_I	0.552	0.98
17_C	21_C	0.552	0.98
234_L	238_Y	0.550	0.98
10_E	79_T	0.548	0.98
308_N	311_R	0.548	0.98
106_L	280_E	0.548	0.98
176_L	201_I	0.548	0.98
290_G	294_N	0.547	0.98
83_P	89_L	0.545	0.98
234_L	237_I	0.545	0.98
228_Q	231_L	0.545	0.98
48_M	52_N	0.544	0.98
309_K	313_L	0.540	0.97
285_P	288_K	0.538	0.97
176_L	184_L	0.537	0.97
144_P	147_H	0.536	0.97
241_N	244_Q	0.536	0.97
299_E	302_F	0.535	0.97
170_V	196_L	0.535	0.97
184_L	229_E	0.534	0.97
73_I	101_L	0.533	0.97
223_D	230_K	0.533	0.97
223_D	232_K	0.532	0.97
145_I	177_T	0.531	0.97
192_Y	240_E	0.530	0.97
14_T	81_G	0.529	0.97
10_E	268_V	0.529	0.97
105_L	125_L	0.529	0.97
223_D	227_I	0.528	0.97
60_I	78_I	0.527	0.97
112_I	116_R	0.525	0.97
84_L	110_E	0.525	0.97
61_N	64_K	0.524	0.97
209_H	212_I	0.524	0.97
310_I	313_L	0.523	0.97
17_C	24_C	0.520	0.97
208_G	212_I	0.520	0.97
157_N	164_D	0.518	0.97
8_F	75_D	0.517	0.97
90_E	122_E	0.515	0.97
273_G	291_N	0.515	0.97
191_A	199_I	0.515	0.97
218_V	221_P	0.514	0.97
207_V	210_G	0.513	0.97
96_V	101_L	0.511	0.96
55_E	273_G	0.510	0.96
228_Q	235_I	0.509	0.96
224_E	232_K	0.508	0.96
287_S	338_Y	0.508	0.96
266_G	279_S	0.506	0.96
82_E	109_G	0.505	0.96
288_K	294_N	0.502	0.96
335_F	338_Y	0.501	0.96
332_G	336_N	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.9363	100	0.273	Contact Map
4m7tA	1	0.6537	100	0.458	Contact Map
1tv8A	2	0.831	100	0.479	Contact Map
4rtbA	2	0.8338	100	0.528	Contact Map
4wcxA	1	0.9003	100	0.564	Contact Map
3c8fA	1	0.6066	100	0.586	Contact Map
2yx0A	1	0.6842	100	0.605	Contact Map
2qgqA	1	0.6787	99.9	0.622	Contact Map
2z2uA	1	0.5956	99.9	0.633	Contact Map
2a5hA	4	0.7867	99.9	0.641	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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