GREMLIN Database
Q7LXV3 - Coenzyme PQQ synthesis protein E (PqqE-1)
UniProt: Q7LXV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (302)
Sequences: 8849 (6990)
Seq/√Len: 402.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_Q110_E4.0311.00
136_K153_A3.8931.00
57_I95_Y3.5341.00
114_D161_K3.2861.00
160_K194_S3.0551.00
61_N95_Y2.9471.00
55_E293_K2.9301.00
52_N55_E2.8291.00
18_S108_S2.6991.00
274_D291_N2.6511.00
58_S62_Q2.5701.00
118_T165_F2.5111.00
274_D288_K2.5021.00
260_T278_S2.4691.00
90_E119_K2.4181.00
53_L91_E2.3431.00
296_S299_E2.3391.00
152_V190_L2.3261.00
61_N99_Q2.2491.00
9_I63_I2.2261.00
161_K164_D2.1791.00
143_S150_N2.1731.00
16_K50_E2.1161.00
109_G130_I2.0541.00
97_T126_E2.0151.00
114_D164_D2.0141.00
295_D299_E2.0121.00
95_Y98_R1.9991.00
183_F186_E1.9751.00
141_I183_F1.9221.00
135_H183_F1.9191.00
22_I144_P1.9111.00
278_S333_F1.8891.00
270_A274_D1.8751.00
118_T122_E1.8721.00
56_W92_I1.8441.00
53_L57_I1.8431.00
64_K99_Q1.8031.00
119_K123_S1.7921.00
133_T146_M1.7921.00
291_N294_N1.7881.00
172_G191_A1.7661.00
130_I159_A1.7561.00
154_K157_N1.7281.00
189_E193_K1.7271.00
94_S98_R1.7261.00
57_I91_E1.7141.00
57_I61_N1.6751.00
113_S116_R1.6741.00
88_D91_E1.6741.00
94_S119_K1.6671.00
95_Y99_Q1.6671.00
157_N160_K1.6501.00
18_S111_P1.6211.00
55_E58_S1.6201.00
160_K164_D1.6081.00
190_L194_S1.6021.00
174_I187_I1.5961.00
84_L105_L1.5951.00
117_I161_K1.5901.00
186_E189_E1.5601.00
157_N161_K1.5541.00
91_E94_S1.5491.00
51_L55_E1.5381.00
270_A276_Y1.5331.00
153_A157_N1.5231.00
53_L88_D1.5201.00
135_H138_V1.4881.00
90_E116_R1.4821.00
130_I158_I1.4811.00
60_I96_V1.4761.00
76_V96_V1.4741.00
86_R92_I1.4591.00
97_T123_S1.4591.00
155_K158_I1.4541.00
62_Q296_S1.4501.00
160_K163_K1.4451.00
23_Y133_T1.4411.00
128_I162_F1.4271.00
225_R229_E1.4111.00
119_K122_E1.4111.00
152_V156_I1.3881.00
298_V302_F1.3861.00
156_I194_S1.3861.00
84_L111_P1.3681.00
78_I103_H1.3341.00
121_L165_F1.3331.00
134_S141_I1.3301.00
94_S123_S1.3221.00
305_L309_K1.3211.00
96_V103_H1.3181.00
13_L78_I1.3181.00
106_L129_R1.3061.00
114_D165_F1.3051.00
11_L56_W1.3021.00
78_I96_V1.2801.00
254_S257_P1.2781.00
116_R120_L1.2681.00
219_P223_D1.2631.00
136_K183_F1.2621.00
89_L93_L1.2511.00
275_I300_I1.2461.00
51_L56_W1.2351.00
93_L125_L1.2211.00
60_I99_Q1.2081.00
276_Y288_K1.2041.00
97_T103_H1.2021.00
163_K195_N1.2011.00
156_I160_K1.2011.00
174_I199_I1.1991.00
145_I154_K1.1951.00
50_E86_R1.1911.00
14_T50_E1.1871.00
112_I117_I1.1791.00
91_E95_Y1.1741.00
135_H141_I1.1731.00
15_Y271_P1.1651.00
260_T333_F1.1601.00
117_I158_I1.1581.00
161_K165_F1.1501.00
220_D223_D1.1281.00
158_I161_K1.1261.00
86_R89_L1.1221.00
143_S148_I1.1201.00
105_L120_L1.1151.00
135_H186_E1.1131.00
290_G300_I1.1101.00
230_K234_L1.1061.00
132_L172_G1.1061.00
297_L301_W1.1051.00
172_G196_L1.1051.00
93_L123_S1.1001.00
137_Y153_A1.0961.00
115_D118_T1.0911.00
318_E321_K1.0861.00
334_R337_A1.0831.00
189_E192_Y1.0751.00
18_S82_E1.0691.00
191_A196_L1.0691.00
135_H190_L1.0661.00
114_D118_T1.0641.00
305_L308_N1.0601.00
156_I190_L1.0531.00
130_I162_F1.0471.00
9_I267_L1.0461.00
59_V269_I1.0391.00
295_D300_I1.0381.00
301_W311_R1.0341.00
84_L116_R1.0311.00
229_E233_R1.0241.00
64_K101_L1.0141.00
116_R119_K1.0141.00
58_S293_K0.9991.00
129_R173_N0.9971.00
230_K233_R0.9951.00
142_Q155_K0.9931.00
240_E244_Q0.9921.00
18_S110_E0.9851.00
141_I179_Y0.9821.00
58_S61_N0.9821.00
159_A172_G0.9791.00
61_N65_R0.9731.00
112_I158_I0.9691.00
75_D104_M0.9651.00
163_K170_V0.9651.00
87_S90_E0.9651.00
117_I121_L0.9641.00
19_Q151_E0.9611.00
221_P225_R0.9541.00
105_L128_I0.9471.00
49_N272_N0.9451.00
233_R236_E0.9451.00
226_T229_E0.9421.00
62_Q66_L0.9411.00
11_L59_V0.9391.00
131_N175_V0.9381.00
113_S157_N0.9371.00
223_D226_T0.9321.00
23_Y145_I0.9311.00
25_H79_T0.9261.00
162_F167_V0.9261.00
154_K158_I0.9251.00
136_K152_V0.9191.00
134_S152_V0.9161.00
188_A192_Y0.9151.00
159_A170_V0.9141.00
185_E189_E0.9101.00
53_L95_Y0.9081.00
53_L86_R0.9071.00
228_Q232_K0.9041.00
12_E271_P0.9001.00
225_R228_Q0.8981.00
63_I76_V0.8981.00
143_S146_M0.8961.00
267_L297_L0.8941.00
172_G199_I0.8871.00
18_S85_L0.8841.00
241_N245_N0.8841.00
51_L59_V0.8831.00
185_E229_E0.8831.00
9_I269_I0.8791.00
118_T121_L0.8751.00
142_Q151_E0.8701.00
143_S151_E0.8681.00
115_D119_K0.8661.00
187_I191_A0.8661.00
84_L158_I0.8641.00
96_V99_Q0.8581.00
108_S111_P0.8441.00
289_L307_L0.8441.00
163_K194_S0.8431.00
92_I96_V0.8341.00
82_E108_S0.8341.00
90_E94_S0.8321.00
267_L301_W0.8321.00
260_T263_G0.8311.00
306_L309_K0.8261.00
79_T106_L0.8261.00
257_P260_T0.8241.00
13_L92_I0.8211.00
158_I162_F0.8211.00
178_S222_N0.8171.00
224_E228_Q0.8171.00
103_H125_L0.8141.00
112_I120_L0.8141.00
128_I167_V0.8101.00
190_L193_K0.8091.00
12_E268_V0.8031.00
60_I76_V0.7951.00
62_Q298_V0.7951.00
281_A335_F0.7871.00
227_I231_L0.7851.00
290_G295_D0.7831.00
54_S57_I0.7831.00
137_Y143_S0.7821.00
185_E230_K0.7811.00
74_M102_R0.7791.00
239_G242_F0.7791.00
145_I149_K0.7781.00
23_Y146_M0.7771.00
162_F170_V0.7761.00
132_L152_V0.7741.00
222_N226_T0.7721.00
76_V103_H0.7701.00
309_K312_S0.7671.00
110_E158_I0.7651.00
127_K171_G0.7651.00
144_P179_Y0.7641.00
20_Q146_M0.7631.00
93_L96_V0.7601.00
182_D226_T0.7591.00
93_L103_H0.7571.00
10_E266_G0.7561.00
163_K196_L0.7561.00
82_E85_L0.7551.00
232_K236_E0.7541.00
189_E233_R0.7491.00
163_K197_D0.7461.00
318_E322_S0.7431.00
55_E59_V0.7431.00
56_W86_R0.7381.00
62_Q65_R0.7381.00
75_D102_R0.7361.00
248_D251_I0.7351.00
185_E233_R0.7321.00
231_L235_I0.7321.00
222_N225_R0.7311.00
159_A196_L0.7301.00
77_V104_M0.7271.00
168_K197_D0.7231.00
142_Q177_T0.7221.00
308_N312_S0.7221.00
113_S158_I0.7211.00
307_L311_R0.7191.00
178_S223_D0.7151.00
316_L326_K0.7151.00
12_E79_T0.7141.00
56_W59_V0.7121.00
14_T86_R0.7111.00
77_V106_L0.7081.00
253_Y257_P0.7071.00
288_K291_N0.7061.00
233_R237_I0.7041.00
132_L156_I0.7041.00
86_R91_E0.7031.00
141_I144_P0.6991.00
132_L155_K0.6981.00
93_L119_K0.6961.00
79_T279_S0.6941.00
13_L86_R0.6891.00
65_R298_V0.6881.00
320_C323_C0.6871.00
87_S116_R0.6861.00
202_H205_I0.6861.00
173_N202_H0.6851.00
121_L166_G0.6841.00
232_K235_I0.6831.00
10_E279_S0.6820.99
246_Y249_T0.6780.99
226_T230_K0.6770.99
121_L167_V0.6740.99
238_Y241_N0.6730.99
76_V101_L0.6700.99
296_S300_I0.6690.99
148_I151_E0.6690.99
88_D92_I0.6680.99
90_E123_S0.6660.99
13_L89_L0.6620.99
153_A156_I0.6620.99
78_I93_L0.6610.99
106_L173_N0.6590.99
60_I101_L0.6570.99
138_V144_P0.6560.99
57_I98_R0.6530.99
237_I240_E0.6520.99
26_N79_T0.6520.99
129_R171_G0.6510.99
137_Y150_N0.6510.99
134_S137_Y0.6490.99
277_P281_A0.6480.99
59_V63_I0.6470.99
84_L89_L0.6470.99
142_Q146_M0.6460.99
320_C329_C0.6460.99
246_Y250_D0.6420.99
177_T180_Y0.6410.99
20_Q27_P0.6390.99
219_P222_N0.6360.99
53_L92_I0.6340.99
90_E93_L0.6330.99
174_I191_A0.6330.99
85_L111_P0.6320.99
86_R90_E0.6320.99
191_A194_S0.6300.99
114_D117_I0.6290.99
97_T124_G0.6250.99
106_L279_S0.6240.99
84_L112_I0.6240.99
112_I130_I0.6210.99
102_R127_K0.6210.99
16_K48_M0.6180.99
57_I99_Q0.6180.99
62_Q275_I0.6180.99
187_I199_I0.6170.99
63_I73_I0.6160.99
84_L120_L0.6150.99
104_M127_K0.6140.99
184_L201_I0.6140.99
185_E188_A0.6120.99
186_E190_L0.6120.99
269_I275_I0.6060.99
137_Y152_V0.6040.99
180_Y183_F0.6020.99
134_S183_F0.6010.99
107_S130_I0.6010.99
60_I95_Y0.6000.99
293_K296_S0.5990.99
100_K103_H0.5990.99
185_E226_T0.5980.99
56_W60_I0.5970.99
8_F77_V0.5950.99
21_C24_C0.5950.99
143_S147_H0.5930.99
53_L56_W0.5900.99
113_S161_K0.5860.98
62_Q297_L0.5850.98
268_V279_S0.5850.98
73_I102_R0.5840.98
12_E26_N0.5830.98
73_I100_K0.5830.98
275_I297_L0.5800.98
82_E107_S0.5800.98
332_G337_A0.5790.98
110_E154_K0.5790.98
9_I73_I0.5790.98
231_L234_L0.5780.98
277_P287_S0.5760.98
28_P209_H0.5710.98
23_Y26_N0.5700.98
20_Q148_I0.5690.98
240_E245_N0.5680.98
220_D224_E0.5680.98
54_S58_S0.5670.98
117_I162_F0.5670.98
49_N271_P0.5670.98
117_I165_F0.5650.98
217_I221_P0.5650.98
239_G243_I0.5630.98
135_H152_V0.5610.98
112_I162_F0.5600.98
184_L188_A0.5600.98
130_I155_K0.5600.98
239_G244_Q0.5600.98
66_L72_G0.5590.98
210_G213_N0.5580.98
136_K186_E0.5570.98
141_I182_D0.5560.98
204_V210_G0.5550.98
78_I92_I0.5540.98
273_G292_I0.5520.98
17_C21_C0.5520.98
234_L238_Y0.5500.98
10_E79_T0.5480.98
308_N311_R0.5480.98
106_L280_E0.5480.98
176_L201_I0.5480.98
290_G294_N0.5470.98
83_P89_L0.5450.98
234_L237_I0.5450.98
228_Q231_L0.5450.98
48_M52_N0.5440.98
309_K313_L0.5400.97
285_P288_K0.5380.97
176_L184_L0.5370.97
144_P147_H0.5360.97
241_N244_Q0.5360.97
299_E302_F0.5350.97
170_V196_L0.5350.97
184_L229_E0.5340.97
73_I101_L0.5330.97
223_D230_K0.5330.97
223_D232_K0.5320.97
145_I177_T0.5310.97
192_Y240_E0.5300.97
14_T81_G0.5290.97
10_E268_V0.5290.97
105_L125_L0.5290.97
223_D227_I0.5280.97
60_I78_I0.5270.97
112_I116_R0.5250.97
84_L110_E0.5250.97
61_N64_K0.5240.97
209_H212_I0.5240.97
310_I313_L0.5230.97
17_C24_C0.5200.97
208_G212_I0.5200.97
157_N164_D0.5180.97
8_F75_D0.5170.97
90_E122_E0.5150.97
273_G291_N0.5150.97
191_A199_I0.5150.97
218_V221_P0.5140.97
207_V210_G0.5130.97
96_V101_L0.5110.96
55_E273_G0.5100.96
228_Q235_I0.5090.96
224_E232_K0.5080.96
287_S338_Y0.5080.96
266_G279_S0.5060.96
82_E109_G0.5050.96
288_K294_N0.5020.96
335_F338_Y0.5010.96
332_G336_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9363 100 0.273 Contact Map
4m7tA 1 0.6537 100 0.458 Contact Map
1tv8A 2 0.831 100 0.479 Contact Map
4rtbA 2 0.8338 100 0.528 Contact Map
4wcxA 1 0.9003 100 0.564 Contact Map
3c8fA 1 0.6066 100 0.586 Contact Map
2yx0A 1 0.6842 100 0.605 Contact Map
2qgqA 1 0.6787 99.9 0.622 Contact Map
2z2uA 1 0.5956 99.9 0.633 Contact Map
2a5hA 4 0.7867 99.9 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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