Q7LXV0 - SULSO - GREMLIN Contacts

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Q7LXV0 - Uncharacterized protein

UniProt:	Q7LXV0	Sequences: MRMSLRIAILLFLLFLAFSLGFVIQYFLQVFGITNQSTINSVIFYLRIALYVFIGLWIVSSISEAIRVYSQRRLGIRANVIANSVRYFGYVIVFLLVLLPLGVGSSTLIAGSTFAGLIIGLALQPVLSNFFAGLLIMLTGYIVVGDKIRVLSTQVPFFPAQFPAYKYFSTDFIEQGYKGTVVEIDLFYSRVLLENLRELRVPNIVLLNSAVLDYTSKYSEEHVINVRVEFPLAFIDINKLEDIVKEELKDFNVVEGPYINEQSDKDHVIVLARLKVGVSEDWRKIKSNALKRLLRLRQELIDKKSQDSQQTKIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (253)
Sequences:	11032 (8089)
Seq/√Len:	508.5

ECOLI - YBIO YNAI MSCM MSCK MSCS YBDG
BACSU - YHDY YFKC YKUT
HALSA - Q9HQH2 Q9HNG6 Q9HQ04
SULSO - Q7LXV0 Q97V66 Q97V08 Q97V46

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
294_L	298_Q	3.875	1.00
55_G	93_V	3.678	1.00
238_N	295_R	3.547	1.00
149_R	178_K	3.337	1.00
182_V	192_L	3.179	1.00
245_K	249_K	3.173	1.00
241_E	291_K	2.935	1.00
263_S	269_I	2.917	1.00
239_K	300_L	2.891	1.00
296_L	299_E	2.788	1.00
296_L	300_L	2.717	1.00
147_K	178_K	2.565	1.00
242_D	246_E	2.560	1.00
251_F	288_N	2.426	1.00
262_Q	271_L	2.409	1.00
205_V	209_S	2.388	1.00
264_D	269_I	2.380	1.00
246_E	250_D	2.256	1.00
229_E	267_H	2.252	1.00
124_Q	128_S	2.250	1.00
244_V	293_L	2.224	1.00
227_R	271_L	2.141	1.00
239_K	242_D	2.131	1.00
243_I	296_L	2.046	1.00
246_E	296_L	2.036	1.00
261_E	268_V	2.034	1.00
286_K	290_L	1.991	1.00
183_E	190_R	1.947	1.00
147_K	180_T	1.945	1.00
227_R	269_I	1.940	1.00
231_P	303_K	1.916	1.00
230_F	240_L	1.916	1.00
236_D	239_K	1.906	1.00
241_E	245_K	1.902	1.00
292_R	295_R	1.881	1.00
239_K	243_I	1.860	1.00
243_I	300_L	1.856	1.00
274_L	289_A	1.805	1.00
254_V	257_P	1.793	1.00
278_V	281_D	1.791	1.00
250_D	292_R	1.762	1.00
288_N	292_R	1.761	1.00
247_E	296_L	1.724	1.00
139_T	187_F	1.724	1.00
149_R	214_Y	1.697	1.00
229_E	269_I	1.647	1.00
295_R	299_E	1.640	1.00
193_L	199_L	1.636	1.00
248_L	272_A	1.623	1.00
238_N	291_K	1.623	1.00
240_L	270_V	1.622	1.00
182_V	198_E	1.615	1.00
247_E	292_R	1.595	1.00
147_K	194_E	1.580	1.00
149_R	212_L	1.570	1.00
149_R	152_S	1.557	1.00
125_P	128_S	1.549	1.00
48_I	101_L	1.543	1.00
228_V	293_L	1.520	1.00
189_S	203_N	1.506	1.00
235_I	303_K	1.503	1.00
265_K	309_Q	1.480	1.00
225_N	271_L	1.465	1.00
238_N	242_D	1.433	1.00
297_R	302_D	1.431	1.00
117_L	120_G	1.429	1.00
63_S	86_R	1.421	1.00
151_L	210_A	1.419	1.00
67_R	82_A	1.384	1.00
251_F	292_R	1.372	1.00
151_L	209_S	1.354	1.00
243_I	246_E	1.339	1.00
146_D	216_S	1.337	1.00
276_V	285_I	1.312	1.00
142_I	189_S	1.310	1.00
199_L	212_L	1.305	1.00
148_I	181_V	1.299	1.00
235_I	240_L	1.291	1.00
291_K	295_R	1.276	1.00
179_G	191_V	1.271	1.00
246_E	249_K	1.267	1.00
89_G	93_V	1.267	1.00
57_W	61_S	1.265	1.00
250_D	296_L	1.247	1.00
177_Y	210_A	1.242	1.00
51_Y	100_P	1.238	1.00
242_D	245_K	1.235	1.00
190_R	198_E	1.231	1.00
265_K	269_I	1.194	1.00
233_A	306_Q	1.187	1.00
48_I	97_V	1.184	1.00
244_V	272_A	1.180	1.00
197_R	212_L	1.165	1.00
143_V	216_S	1.162	1.00
55_G	59_V	1.150	1.00
111_G	114_F	1.141	1.00
98_L	103_V	1.132	1.00
292_R	296_L	1.123	1.00
52_V	56_L	1.114	1.00
229_E	266_D	1.110	1.00
97_V	101_L	1.109	1.00
44_F	47_R	1.096	1.00
230_F	235_I	1.089	1.00
233_A	294_L	1.086	1.00
51_Y	93_V	1.077	1.00
262_Q	269_I	1.069	1.00
86_R	90_Y	1.068	1.00
282_W	286_K	1.068	1.00
229_E	264_D	1.064	1.00
224_I	274_L	1.057	1.00
227_R	263_S	1.046	1.00
245_K	259_I	1.044	1.00
150_V	206_L	1.041	1.00
223_V	275_K	1.035	1.00
193_L	197_R	1.034	1.00
232_L	304_K	1.034	1.00
260_N	287_S	1.034	1.00
56_L	90_Y	1.033	1.00
205_V	208_N	1.032	1.00
205_V	210_A	1.024	1.00
152_S	177_Y	1.020	1.00
249_K	255_E	1.019	1.00
277_G	280_E	1.014	1.00
107_T	110_A	1.011	1.00
198_E	216_S	1.010	1.00
251_F	289_A	1.007	1.00
41_S	45_Y	1.007	1.00
233_A	303_K	0.996	1.00
266_D	306_Q	0.996	1.00
59_V	86_R	0.982	1.00
238_N	241_E	0.981	1.00
289_A	293_L	0.977	1.00
93_V	97_V	0.976	1.00
237_I	270_V	0.975	1.00
253_V	257_P	0.975	1.00
63_S	82_A	0.960	1.00
263_S	290_L	0.960	1.00
224_I	286_K	0.949	1.00
230_F	297_R	0.946	1.00
248_L	274_L	0.944	1.00
115_A	119_I	0.940	1.00
43_I	47_R	0.937	1.00
122_A	127_L	0.927	1.00
240_L	297_R	0.921	1.00
192_L	198_E	0.921	1.00
188_Y	200_R	0.914	1.00
230_F	237_I	0.905	1.00
181_V	191_V	0.903	1.00
109_I	113_T	0.903	1.00
230_F	270_V	0.902	1.00
196_L	275_K	0.899	1.00
297_R	304_K	0.898	1.00
225_N	273_R	0.890	1.00
114_F	123_L	0.885	1.00
232_L	306_Q	0.885	1.00
247_E	289_A	0.881	1.00
79_N	83_N	0.878	1.00
39_I	43_I	0.874	1.00
115_A	118_I	0.867	1.00
33_I	36_Q	0.867	1.00
139_T	188_Y	0.865	1.00
243_I	302_D	0.861	1.00
247_E	251_F	0.857	1.00
228_V	244_V	0.857	1.00
148_I	191_V	0.856	1.00
235_I	239_K	0.856	1.00
123_L	131_F	0.850	1.00
185_D	190_R	0.846	1.00
128_S	204_I	0.836	1.00
132_A	207_L	0.836	1.00
243_I	247_E	0.834	1.00
261_E	290_L	0.834	1.00
55_G	89_G	0.832	1.00
231_P	305_S	0.828	1.00
287_S	291_K	0.826	1.00
227_R	262_Q	0.825	1.00
135_L	207_L	0.825	1.00
140_G	143_V	0.825	1.00
229_E	232_L	0.824	1.00
126_V	132_A	0.823	1.00
66_I	69_Y	0.814	1.00
177_Y	199_L	0.810	1.00
221_E	257_P	0.807	1.00
180_T	192_L	0.806	1.00
288_N	291_K	0.804	1.00
244_V	297_R	0.803	1.00
253_V	285_I	0.800	1.00
47_R	100_P	0.799	1.00
230_F	302_D	0.798	1.00
236_D	295_R	0.797	1.00
259_I	272_A	0.789	1.00
237_I	294_L	0.787	1.00
231_P	235_I	0.784	1.00
277_G	281_D	0.781	1.00
151_L	205_V	0.775	1.00
229_E	265_K	0.772	1.00
232_L	268_V	0.767	1.00
59_V	89_G	0.767	1.00
112_S	116_G	0.762	1.00
37_S	40_N	0.761	1.00
241_E	287_S	0.760	1.00
248_L	289_A	0.759	1.00
240_L	244_V	0.755	1.00
138_L	141_Y	0.755	1.00
82_A	86_R	0.754	1.00
90_Y	94_F	0.752	1.00
56_L	60_S	0.750	1.00
224_I	276_V	0.748	1.00
237_I	268_V	0.744	1.00
303_K	308_S	0.742	1.00
265_K	307_D	0.735	1.00
142_I	206_L	0.734	1.00
260_N	271_L	0.726	1.00
226_V	290_L	0.724	1.00
243_I	297_R	0.724	1.00
50_L	54_I	0.724	1.00
59_V	93_V	0.723	1.00
258_Y	273_R	0.719	1.00
229_E	306_Q	0.714	1.00
29_Q	32_G	0.710	1.00
254_V	277_G	0.708	1.00
48_I	52_V	0.706	1.00
244_V	248_L	0.704	1.00
266_D	309_Q	0.698	1.00
99_L	104_G	0.694	1.00
268_V	294_L	0.693	1.00
231_P	304_K	0.693	1.00
41_S	44_F	0.692	1.00
119_I	127_L	0.691	1.00
192_L	196_L	0.690	1.00
71_Q	74_L	0.684	1.00
126_V	207_L	0.683	1.00
266_D	308_S	0.682	1.00
109_I	118_I	0.679	1.00
59_V	63_S	0.678	1.00
128_S	208_N	0.678	1.00
93_V	96_L	0.674	1.00
237_I	261_E	0.674	1.00
272_A	293_L	0.673	1.00
62_I	89_G	0.667	1.00
222_H	282_W	0.664	1.00
57_W	60_S	0.664	1.00
195_N	223_V	0.664	1.00
50_L	53_F	0.662	1.00
243_I	299_E	0.662	1.00
264_D	267_H	0.662	1.00
114_F	118_I	0.658	1.00
65_A	69_Y	0.657	1.00
139_T	190_R	0.656	1.00
142_I	148_I	0.656	1.00
125_P	204_I	0.655	1.00
242_D	249_K	0.655	1.00
261_E	270_V	0.654	1.00
150_V	177_Y	0.651	1.00
262_Q	286_K	0.651	1.00
91_V	95_L	0.649	1.00
62_I	85_V	0.649	1.00
177_Y	212_L	0.648	1.00
150_V	201_V	0.648	1.00
223_V	273_R	0.646	1.00
132_A	204_I	0.644	1.00
231_P	308_S	0.644	1.00
192_L	219_S	0.644	1.00
279_S	282_W	0.642	1.00
111_G	115_A	0.640	1.00
241_E	270_V	0.639	1.00
38_T	41_S	0.631	1.00
113_T	117_L	0.626	1.00
306_Q	309_Q	0.626	1.00
40_N	44_F	0.626	1.00
237_I	241_E	0.626	1.00
226_V	274_L	0.624	1.00
111_G	116_G	0.623	1.00
248_L	253_V	0.620	1.00
263_S	286_K	0.619	1.00
247_E	297_R	0.616	1.00
51_Y	55_G	0.616	1.00
113_T	124_Q	0.614	1.00
248_L	259_I	0.613	1.00
79_N	183_E	0.611	1.00
185_D	188_Y	0.607	1.00
110_A	113_T	0.607	1.00
195_N	225_N	0.604	0.99
180_T	194_E	0.600	0.99
297_R	300_L	0.599	0.99
246_E	300_L	0.598	0.99
87_Y	91_V	0.598	0.99
104_G	107_T	0.597	0.99
178_K	214_Y	0.595	0.99
44_F	100_P	0.595	0.99
70_S	78_A	0.595	0.99
245_K	248_L	0.594	0.99
124_Q	204_I	0.593	0.99
129_N	204_I	0.593	0.99
46_L	50_L	0.593	0.99
240_L	302_D	0.591	0.99
151_L	177_Y	0.591	0.99
106_S	110_A	0.591	0.99
127_L	131_F	0.588	0.99
247_E	300_L	0.587	0.99
198_E	219_S	0.586	0.99
119_I	131_F	0.586	0.99
178_K	194_E	0.585	0.99
280_E	283_R	0.584	0.99
60_S	64_E	0.581	0.99
67_R	71_Q	0.581	0.99
112_S	115_A	0.580	0.99
69_Y	72_R	0.578	0.99
232_L	265_K	0.577	0.99
73_R	76_I	0.577	0.99
258_Y	262_Q	0.575	0.99
253_V	274_L	0.575	0.99
240_L	243_I	0.574	0.99
53_F	57_W	0.570	0.99
247_E	250_D	0.568	0.99
267_H	306_Q	0.565	0.99
114_F	117_L	0.564	0.99
236_D	243_I	0.563	0.99
95_L	99_L	0.563	0.99
52_V	55_G	0.563	0.99
96_L	100_P	0.562	0.99
228_V	272_A	0.562	0.99
258_Y	271_L	0.560	0.99
304_K	308_S	0.559	0.99
92_I	96_L	0.558	0.99
190_R	200_R	0.558	0.99
32_G	35_N	0.553	0.99
237_I	295_R	0.553	0.99
36_Q	40_N	0.553	0.99
236_D	240_L	0.553	0.99
271_L	287_S	0.552	0.99
150_V	209_S	0.550	0.99
232_L	266_D	0.548	0.99
121_L	126_V	0.547	0.99
142_I	203_N	0.547	0.99
59_V	90_Y	0.546	0.99
32_G	36_Q	0.546	0.99
31_F	34_T	0.541	0.99
42_V	46_L	0.540	0.99
83_N	183_E	0.537	0.99
115_A	122_A	0.537	0.99
53_F	56_L	0.537	0.99
182_V	219_S	0.536	0.99
45_Y	49_A	0.534	0.99
149_R	177_Y	0.530	0.99
241_E	259_I	0.529	0.99
182_V	190_R	0.528	0.99
113_T	116_G	0.527	0.99
147_K	222_H	0.526	0.99
29_Q	33_I	0.526	0.99
204_I	207_L	0.524	0.99
201_V	206_L	0.523	0.99
126_V	135_L	0.523	0.99
231_P	306_Q	0.521	0.99
148_I	206_L	0.520	0.98
37_S	41_S	0.520	0.98
121_L	125_P	0.519	0.98
236_D	298_Q	0.519	0.98
64_E	68_V	0.517	0.98
96_L	99_L	0.514	0.98
264_D	306_Q	0.513	0.98
121_L	124_Q	0.512	0.98
283_R	288_N	0.512	0.98
229_E	268_V	0.512	0.98
235_I	268_V	0.511	0.98
239_K	246_E	0.511	0.98
117_L	125_P	0.511	0.98
282_W	287_S	0.510	0.98
109_I	114_F	0.509	0.98
83_N	86_R	0.507	0.98
152_S	209_S	0.507	0.98
251_F	285_I	0.507	0.98
142_I	211_V	0.505	0.98
84_S	88_F	0.503	0.98
52_V	90_Y	0.503	0.98
266_D	307_D	0.503	0.98
232_L	267_H	0.502	0.98
233_A	298_Q	0.501	0.98
247_E	288_N	0.500	0.98
201_V	210_A	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hw9A	3	0.7866	100	0.296	Contact Map
5ajiA	3	0.8089	100	0.3	Contact Map
3udcA	3	0.7866	100	0.332	Contact Map
1nz9A	1	0.1688	33.8	0.948	Contact Map
2e6zA	1	0.1783	19.4	0.954	Contact Map
1uwvA	1	0.3694	17.4	0.955	Contact Map
2mi6A	1	0.1815	17	0.955	Contact Map
3g13A	2	0.3057	14.7	0.956	Contact Map
3mlqE	1	0.1274	11.3	0.958	Contact Map
3j1zP	8	0.8822	10.1	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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