GREMLIN Database
Q7LXV0 - Uncharacterized protein
UniProt: Q7LXV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (253)
Sequences: 11032 (8089)
Seq/√Len: 508.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_L298_Q3.8751.00
55_G93_V3.6781.00
238_N295_R3.5471.00
149_R178_K3.3371.00
182_V192_L3.1791.00
245_K249_K3.1731.00
241_E291_K2.9351.00
263_S269_I2.9171.00
239_K300_L2.8911.00
296_L299_E2.7881.00
296_L300_L2.7171.00
147_K178_K2.5651.00
242_D246_E2.5601.00
251_F288_N2.4261.00
262_Q271_L2.4091.00
205_V209_S2.3881.00
264_D269_I2.3801.00
246_E250_D2.2561.00
229_E267_H2.2521.00
124_Q128_S2.2501.00
244_V293_L2.2241.00
227_R271_L2.1411.00
239_K242_D2.1311.00
243_I296_L2.0461.00
246_E296_L2.0361.00
261_E268_V2.0341.00
286_K290_L1.9911.00
183_E190_R1.9471.00
147_K180_T1.9451.00
227_R269_I1.9401.00
231_P303_K1.9161.00
230_F240_L1.9161.00
236_D239_K1.9061.00
241_E245_K1.9021.00
292_R295_R1.8811.00
239_K243_I1.8601.00
243_I300_L1.8561.00
274_L289_A1.8051.00
254_V257_P1.7931.00
278_V281_D1.7911.00
250_D292_R1.7621.00
288_N292_R1.7611.00
247_E296_L1.7241.00
139_T187_F1.7241.00
149_R214_Y1.6971.00
229_E269_I1.6471.00
295_R299_E1.6401.00
193_L199_L1.6361.00
248_L272_A1.6231.00
238_N291_K1.6231.00
240_L270_V1.6221.00
182_V198_E1.6151.00
247_E292_R1.5951.00
147_K194_E1.5801.00
149_R212_L1.5701.00
149_R152_S1.5571.00
125_P128_S1.5491.00
48_I101_L1.5431.00
228_V293_L1.5201.00
189_S203_N1.5061.00
235_I303_K1.5031.00
265_K309_Q1.4801.00
225_N271_L1.4651.00
238_N242_D1.4331.00
297_R302_D1.4311.00
117_L120_G1.4291.00
63_S86_R1.4211.00
151_L210_A1.4191.00
67_R82_A1.3841.00
251_F292_R1.3721.00
151_L209_S1.3541.00
243_I246_E1.3391.00
146_D216_S1.3371.00
276_V285_I1.3121.00
142_I189_S1.3101.00
199_L212_L1.3051.00
148_I181_V1.2991.00
235_I240_L1.2911.00
291_K295_R1.2761.00
179_G191_V1.2711.00
246_E249_K1.2671.00
89_G93_V1.2671.00
57_W61_S1.2651.00
250_D296_L1.2471.00
177_Y210_A1.2421.00
51_Y100_P1.2381.00
242_D245_K1.2351.00
190_R198_E1.2311.00
265_K269_I1.1941.00
233_A306_Q1.1871.00
48_I97_V1.1841.00
244_V272_A1.1801.00
197_R212_L1.1651.00
143_V216_S1.1621.00
55_G59_V1.1501.00
111_G114_F1.1411.00
98_L103_V1.1321.00
292_R296_L1.1231.00
52_V56_L1.1141.00
229_E266_D1.1101.00
97_V101_L1.1091.00
44_F47_R1.0961.00
230_F235_I1.0891.00
233_A294_L1.0861.00
51_Y93_V1.0771.00
262_Q269_I1.0691.00
86_R90_Y1.0681.00
282_W286_K1.0681.00
229_E264_D1.0641.00
224_I274_L1.0571.00
227_R263_S1.0461.00
245_K259_I1.0441.00
150_V206_L1.0411.00
223_V275_K1.0351.00
193_L197_R1.0341.00
232_L304_K1.0341.00
260_N287_S1.0341.00
56_L90_Y1.0331.00
205_V208_N1.0321.00
205_V210_A1.0241.00
152_S177_Y1.0201.00
249_K255_E1.0191.00
277_G280_E1.0141.00
107_T110_A1.0111.00
198_E216_S1.0101.00
251_F289_A1.0071.00
41_S45_Y1.0071.00
233_A303_K0.9961.00
266_D306_Q0.9961.00
59_V86_R0.9821.00
238_N241_E0.9811.00
289_A293_L0.9771.00
93_V97_V0.9761.00
237_I270_V0.9751.00
253_V257_P0.9751.00
63_S82_A0.9601.00
263_S290_L0.9601.00
224_I286_K0.9491.00
230_F297_R0.9461.00
248_L274_L0.9441.00
115_A119_I0.9401.00
43_I47_R0.9371.00
122_A127_L0.9271.00
240_L297_R0.9211.00
192_L198_E0.9211.00
188_Y200_R0.9141.00
230_F237_I0.9051.00
181_V191_V0.9031.00
109_I113_T0.9031.00
230_F270_V0.9021.00
196_L275_K0.8991.00
297_R304_K0.8981.00
225_N273_R0.8901.00
114_F123_L0.8851.00
232_L306_Q0.8851.00
247_E289_A0.8811.00
79_N83_N0.8781.00
39_I43_I0.8741.00
115_A118_I0.8671.00
33_I36_Q0.8671.00
139_T188_Y0.8651.00
243_I302_D0.8611.00
247_E251_F0.8571.00
228_V244_V0.8571.00
148_I191_V0.8561.00
235_I239_K0.8561.00
123_L131_F0.8501.00
185_D190_R0.8461.00
128_S204_I0.8361.00
132_A207_L0.8361.00
243_I247_E0.8341.00
261_E290_L0.8341.00
55_G89_G0.8321.00
231_P305_S0.8281.00
287_S291_K0.8261.00
227_R262_Q0.8251.00
135_L207_L0.8251.00
140_G143_V0.8251.00
229_E232_L0.8241.00
126_V132_A0.8231.00
66_I69_Y0.8141.00
177_Y199_L0.8101.00
221_E257_P0.8071.00
180_T192_L0.8061.00
288_N291_K0.8041.00
244_V297_R0.8031.00
253_V285_I0.8001.00
47_R100_P0.7991.00
230_F302_D0.7981.00
236_D295_R0.7971.00
259_I272_A0.7891.00
237_I294_L0.7871.00
231_P235_I0.7841.00
277_G281_D0.7811.00
151_L205_V0.7751.00
229_E265_K0.7721.00
232_L268_V0.7671.00
59_V89_G0.7671.00
112_S116_G0.7621.00
37_S40_N0.7611.00
241_E287_S0.7601.00
248_L289_A0.7591.00
240_L244_V0.7551.00
138_L141_Y0.7551.00
82_A86_R0.7541.00
90_Y94_F0.7521.00
56_L60_S0.7501.00
224_I276_V0.7481.00
237_I268_V0.7441.00
303_K308_S0.7421.00
265_K307_D0.7351.00
142_I206_L0.7341.00
260_N271_L0.7261.00
226_V290_L0.7241.00
243_I297_R0.7241.00
50_L54_I0.7241.00
59_V93_V0.7231.00
258_Y273_R0.7191.00
229_E306_Q0.7141.00
29_Q32_G0.7101.00
254_V277_G0.7081.00
48_I52_V0.7061.00
244_V248_L0.7041.00
266_D309_Q0.6981.00
99_L104_G0.6941.00
268_V294_L0.6931.00
231_P304_K0.6931.00
41_S44_F0.6921.00
119_I127_L0.6911.00
192_L196_L0.6901.00
71_Q74_L0.6841.00
126_V207_L0.6831.00
266_D308_S0.6821.00
109_I118_I0.6791.00
59_V63_S0.6781.00
128_S208_N0.6781.00
93_V96_L0.6741.00
237_I261_E0.6741.00
272_A293_L0.6731.00
62_I89_G0.6671.00
222_H282_W0.6641.00
57_W60_S0.6641.00
195_N223_V0.6641.00
50_L53_F0.6621.00
243_I299_E0.6621.00
264_D267_H0.6621.00
114_F118_I0.6581.00
65_A69_Y0.6571.00
139_T190_R0.6561.00
142_I148_I0.6561.00
125_P204_I0.6551.00
242_D249_K0.6551.00
261_E270_V0.6541.00
150_V177_Y0.6511.00
262_Q286_K0.6511.00
91_V95_L0.6491.00
62_I85_V0.6491.00
177_Y212_L0.6481.00
150_V201_V0.6481.00
223_V273_R0.6461.00
132_A204_I0.6441.00
231_P308_S0.6441.00
192_L219_S0.6441.00
279_S282_W0.6421.00
111_G115_A0.6401.00
241_E270_V0.6391.00
38_T41_S0.6311.00
113_T117_L0.6261.00
306_Q309_Q0.6261.00
40_N44_F0.6261.00
237_I241_E0.6261.00
226_V274_L0.6241.00
111_G116_G0.6231.00
248_L253_V0.6201.00
263_S286_K0.6191.00
247_E297_R0.6161.00
51_Y55_G0.6161.00
113_T124_Q0.6141.00
248_L259_I0.6131.00
79_N183_E0.6111.00
185_D188_Y0.6071.00
110_A113_T0.6071.00
195_N225_N0.6040.99
180_T194_E0.6000.99
297_R300_L0.5990.99
246_E300_L0.5980.99
87_Y91_V0.5980.99
104_G107_T0.5970.99
178_K214_Y0.5950.99
44_F100_P0.5950.99
70_S78_A0.5950.99
245_K248_L0.5940.99
124_Q204_I0.5930.99
129_N204_I0.5930.99
46_L50_L0.5930.99
240_L302_D0.5910.99
151_L177_Y0.5910.99
106_S110_A0.5910.99
127_L131_F0.5880.99
247_E300_L0.5870.99
198_E219_S0.5860.99
119_I131_F0.5860.99
178_K194_E0.5850.99
280_E283_R0.5840.99
60_S64_E0.5810.99
67_R71_Q0.5810.99
112_S115_A0.5800.99
69_Y72_R0.5780.99
232_L265_K0.5770.99
73_R76_I0.5770.99
258_Y262_Q0.5750.99
253_V274_L0.5750.99
240_L243_I0.5740.99
53_F57_W0.5700.99
247_E250_D0.5680.99
267_H306_Q0.5650.99
114_F117_L0.5640.99
236_D243_I0.5630.99
95_L99_L0.5630.99
52_V55_G0.5630.99
96_L100_P0.5620.99
228_V272_A0.5620.99
258_Y271_L0.5600.99
304_K308_S0.5590.99
92_I96_L0.5580.99
190_R200_R0.5580.99
32_G35_N0.5530.99
237_I295_R0.5530.99
36_Q40_N0.5530.99
236_D240_L0.5530.99
271_L287_S0.5520.99
150_V209_S0.5500.99
232_L266_D0.5480.99
121_L126_V0.5470.99
142_I203_N0.5470.99
59_V90_Y0.5460.99
32_G36_Q0.5460.99
31_F34_T0.5410.99
42_V46_L0.5400.99
83_N183_E0.5370.99
115_A122_A0.5370.99
53_F56_L0.5370.99
182_V219_S0.5360.99
45_Y49_A0.5340.99
149_R177_Y0.5300.99
241_E259_I0.5290.99
182_V190_R0.5280.99
113_T116_G0.5270.99
147_K222_H0.5260.99
29_Q33_I0.5260.99
204_I207_L0.5240.99
201_V206_L0.5230.99
126_V135_L0.5230.99
231_P306_Q0.5210.99
148_I206_L0.5200.98
37_S41_S0.5200.98
121_L125_P0.5190.98
236_D298_Q0.5190.98
64_E68_V0.5170.98
96_L99_L0.5140.98
264_D306_Q0.5130.98
121_L124_Q0.5120.98
283_R288_N0.5120.98
229_E268_V0.5120.98
235_I268_V0.5110.98
239_K246_E0.5110.98
117_L125_P0.5110.98
282_W287_S0.5100.98
109_I114_F0.5090.98
83_N86_R0.5070.98
152_S209_S0.5070.98
251_F285_I0.5070.98
142_I211_V0.5050.98
84_S88_F0.5030.98
52_V90_Y0.5030.98
266_D307_D0.5030.98
232_L267_H0.5020.98
233_A298_Q0.5010.98
247_E288_N0.5000.98
201_V210_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.7866 100 0.296 Contact Map
5ajiA 3 0.8089 100 0.3 Contact Map
3udcA 3 0.7866 100 0.332 Contact Map
1nz9A 1 0.1688 33.8 0.948 Contact Map
2e6zA 1 0.1783 19.4 0.954 Contact Map
1uwvA 1 0.3694 17.4 0.955 Contact Map
2mi6A 1 0.1815 17 0.955 Contact Map
3g13A 2 0.3057 14.7 0.956 Contact Map
3mlqE 1 0.1274 11.3 0.958 Contact Map
3j1zP 8 0.8822 10.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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