GREMLIN Database
Q7LXU8 - Ribosomal protein L11 methyltransferase, putative
UniProt: Q7LXU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (146)
Sequences: 624 (469)
Seq/√Len: 38.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_K118_E6.1611.00
37_C68_A4.4911.00
59_E64_R3.2411.00
72_I83_I3.1391.00
58_V91_V3.0931.00
26_A98_V3.0791.00
8_P107_V2.7871.00
30_D97_T2.6371.00
72_I77_V2.5731.00
59_E65_I2.4321.00
35_L93_I2.3521.00
37_C59_E2.3461.00
7_V107_V2.1620.99
99_V115_L2.1140.99
23_I154_L2.0290.99
43_I81_A1.9770.99
32_V52_V1.9080.98
20_M100_T1.8810.98
19_R22_E1.8750.98
33_Y96_A1.8520.98
43_I83_I1.7670.97
33_Y56_I1.7670.97
24_A98_V1.7570.97
112_K132_I1.6940.96
65_I83_I1.6380.96
137_P140_V1.5950.95
26_A52_V1.5880.95
46_A55_A1.5780.95
99_V119_L1.5100.93
31_I97_T1.4780.92
7_V103_L1.4380.91
18_R49_D1.3480.88
48_K75_N1.3250.88
87_N90_E1.3120.87
52_V55_A1.3080.87
59_E68_A1.3000.87
11_P130_F1.2900.86
83_I88_F1.2870.86
102_F129_E1.2860.86
21_L46_A1.2740.85
37_C43_I1.2410.84
45_T49_D1.2390.84
115_L119_L1.2390.84
30_D124_R1.2270.83
70_A74_K1.1940.81
133_R155_Y1.1890.81
58_V93_I1.1890.81
44_I77_V1.1880.81
14_E45_T1.1810.81
131_E155_Y1.1750.80
71_N75_N1.1640.80
20_M128_H1.1620.80
8_P64_R1.1530.79
22_E49_D1.1490.79
119_L125_V1.1410.78
31_I56_I1.1240.77
89_F111_L1.1220.77
61_N64_R1.1110.76
37_C65_I1.1100.76
47_V55_A1.1030.76
112_K134_G1.1010.76
42_I100_T1.0840.75
38_G57_G1.0780.74
125_V157_I1.0540.73
89_F110_M1.0540.73
93_I114_K1.0520.72
32_V100_T1.0460.72
103_L107_V1.0390.71
108_N130_F1.0390.71
46_A124_R1.0380.71
56_I84_V1.0290.71
33_Y95_E1.0040.69
102_F155_Y0.9770.67
47_V51_N0.9730.66
56_I96_A0.9720.66
129_E150_H0.9690.66
54_K95_E0.9500.64
22_E25_K0.9490.64
119_L123_T0.9430.64
44_I76_G0.9200.62
42_I87_N0.9110.61
23_I58_V0.9090.61
40_G43_I0.9050.61
16_V128_H0.9050.61
59_E83_I0.8980.60
64_R67_E0.8950.60
66_R70_A0.8870.59
17_V42_I0.8860.59
43_I55_A0.8840.59
116_E132_I0.8710.58
17_V39_D0.8600.57
96_A119_L0.8590.57
49_D76_G0.8550.56
13_P150_H0.8530.56
56_I95_E0.8480.56
142_K151_T0.8460.55
10_V104_L0.8450.55
145_D150_H0.8440.55
17_V43_I0.8250.54
19_R141_V0.8130.52
18_R22_E0.8040.52
100_T128_H0.7980.51
116_E157_I0.7970.51
21_L45_T0.7930.51
36_G40_G0.7910.50
14_E18_R0.7890.50
103_L111_L0.7830.50
106_N110_M0.7830.50
62_D85_K0.7770.49
58_V88_F0.7710.49
18_R45_T0.7680.48
15_K140_V0.7650.48
37_C83_I0.7630.48
21_L124_R0.7620.48
12_T20_M0.7570.47
73_E78_T0.7570.47
17_V41_R0.7530.47
102_F107_V0.7530.47
18_R145_D0.7520.47
144_E150_H0.7490.47
112_K155_Y0.7470.47
89_F118_E0.7300.45
32_V106_N0.7290.45
25_K139_E0.7250.45
86_G93_I0.7210.44
138_K156_V0.7180.44
59_E67_E0.7160.44
39_D101_M0.7110.43
46_A51_N0.7080.43
138_K155_Y0.6960.42
24_A124_R0.6910.42
72_I76_G0.6900.41
86_G91_V0.6890.41
63_E66_R0.6880.41
64_R87_N0.6760.40
55_A80_R0.6600.39
44_I71_N0.6570.39
88_F111_L0.6490.38
37_C40_G0.6470.38
6_H62_D0.6470.38
96_A108_N0.6460.38
99_V123_T0.6400.37
29_D97_T0.6370.37
34_D92_D0.6310.36
58_V85_K0.6280.36
89_F107_V0.6270.36
33_Y92_D0.6200.35
12_T103_L0.6190.35
93_I130_F0.6190.35
115_L135_W0.6170.35
7_V127_S0.6160.35
25_K80_R0.6160.35
79_G126_V0.6150.35
51_N55_A0.6140.35
27_S30_D0.6100.35
20_M152_V0.6050.34
129_E145_D0.6050.34
82_S139_E0.6050.34
23_I115_L0.6010.34
65_I72_I0.5990.34
122_G127_S0.5990.34
55_A126_V0.5970.34
34_D39_D0.5970.34
37_C64_R0.5960.34
20_M126_V0.5930.33
10_V101_M0.5910.33
55_A61_N0.5890.33
124_R135_W0.5870.33
127_S130_F0.5860.33
43_I47_V0.5840.33
31_I96_A0.5830.32
125_V135_W0.5820.32
41_R115_L0.5790.32
32_V42_I0.5770.32
35_L58_V0.5770.32
39_D55_A0.5750.32
16_V129_E0.5750.32
17_V32_V0.5710.32
47_V71_N0.5700.31
17_V45_T0.5690.31
33_Y97_T0.5660.31
13_P128_H0.5630.31
106_N109_E0.5620.31
10_V39_D0.5600.31
7_V61_N0.5600.31
132_I155_Y0.5540.30
32_V98_V0.5540.30
104_L129_E0.5480.30
89_F108_N0.5480.30
61_N107_V0.5470.30
35_L132_I0.5470.30
116_E125_V0.5470.30
31_I54_K0.5460.30
117_K157_I0.5460.30
34_D41_R0.5460.30
109_E138_K0.5450.30
20_M24_A0.5440.29
54_K84_V0.5430.29
6_H104_L0.5400.29
114_K117_K0.5400.29
107_V119_L0.5390.29
54_K88_F0.5360.29
13_P129_E0.5340.29
109_E155_Y0.5320.29
25_K76_G0.5310.29
56_I91_V0.5280.28
39_D115_L0.5240.28
117_K136_N0.5230.28
118_E123_T0.5210.28
46_A126_V0.5130.27
77_V81_A0.5130.27
19_R152_V0.5110.27
65_I68_A0.5090.27
62_D99_V0.5080.27
68_A83_I0.5080.27
7_V129_E0.5050.27
19_R131_E0.5050.27
23_I126_V0.5040.27
39_D104_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bxyA 1 0.9317 99.9 0.569 Contact Map
3uwpA 1 1 99.6 0.667 Contact Map
1u2zA 1 1 99.6 0.675 Contact Map
1ws6A 1 0.9193 99.5 0.692 Contact Map
3tm4A 1 0.9814 99.5 0.696 Contact Map
3tmaA 2 0.9627 99.5 0.696 Contact Map
3hemA 2 0.9814 99.5 0.697 Contact Map
2o57A 2 0.9689 99.5 0.697 Contact Map
2iftA 1 0.9193 99.5 0.699 Contact Map
2fpoA 1 0.9565 99.5 0.699 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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