Q7LXU6 - SULSO - GREMLIN Contacts

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Q7LXU6 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putataive (PgsA)

UniProt:	Q7LXU6	Sequences: MVSMLTRIRRQIKRVIEPLAKTLAQLKVSANFITMLGLIFAIVYYFEIMRSNTTLGIIFLVFSALMDAIDGEVARVSKTVSPLGSFLDSTLDRIEDILYISAFIFLGFSSYLVAIAVGLSLTISYIRAKAESLGLKMEGRGIIERGERIIFVFVILLLYIIVSKQVSLYLFYLFMLLTAITVIQRFYAVYSLLRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	195 (180)
Sequences:	2308 (1679)
Seq/√Len:	125.1

ECOLI - YNBA YNJF
HALSA - Q9HQS2
SULSO - Q7LXU6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_S	32_F	4.475	1.00
24_A	73_V	3.617	1.00
28_V	36_L	3.120	1.00
30_A	79_T	3.063	1.00
22_T	26_L	2.918	1.00
38_L	91_L	2.856	1.00
94_I	179_A	2.721	1.00
20_A	76_V	2.665	1.00
41_A	95_E	2.401	1.00
83_L	190_Y	2.352	1.00
155_I	170_L	2.183	1.00
33_I	73_V	2.179	1.00
47_E	59_F	2.122	1.00
23_L	28_V	2.086	1.00
48_I	156_L	1.993	1.00
128_A	131_E	1.945	1.00
72_E	76_V	1.899	1.00
45_Y	102_A	1.880	1.00
104_I	113_V	1.847	1.00
42_I	98_L	1.846	1.00
119_L	179_A	1.789	1.00
131_E	135_L	1.786	1.00
20_A	73_V	1.767	1.00
93_R	96_D	1.754	1.00
154_V	158_L	1.739	1.00
67_D	88_D	1.690	1.00
97_I	118_G	1.679	1.00
35_M	87_L	1.636	1.00
21_K	76_V	1.631	1.00
94_I	119_L	1.591	1.00
181_T	185_R	1.568	1.00
37_G	66_M	1.555	1.00
23_L	69_I	1.555	1.00
31_N	83_L	1.540	1.00
130_A	133_L	1.540	1.00
24_A	77_S	1.527	1.00
43_V	59_F	1.525	1.00
132_S	135_L	1.473	1.00
183_I	187_Y	1.467	1.00
143_I	177_L	1.409	1.00
45_Y	98_L	1.398	1.00
116_A	175_M	1.387	1.00
128_A	134_G	1.368	1.00
96_D	148_R	1.362	1.00
130_A	135_L	1.360	1.00
48_I	102_A	1.359	1.00
49_M	102_A	1.358	1.00
39_I	43_V	1.350	1.00
165_Q	169_Y	1.349	1.00
47_E	55_L	1.348	1.00
124_S	127_R	1.345	1.00
85_S	129_K	1.336	1.00
93_R	148_R	1.311	1.00
40_F	59_F	1.288	1.00
141_G	181_T	1.283	1.00
133_L	136_K	1.279	1.00
57_I	153_F	1.266	1.00
97_I	122_T	1.265	1.00
102_A	106_L	1.252	1.00
22_T	25_Q	1.247	1.00
93_R	145_R	1.244	1.00
176_L	180_I	1.243	1.00
49_M	105_F	1.210	0.99
144_E	147_E	1.207	0.99
30_A	73_V	1.196	0.99
13_K	72_E	1.189	0.99
41_A	63_S	1.181	0.99
151_F	170_L	1.176	0.99
20_A	72_E	1.167	0.99
126_I	186_F	1.166	0.99
96_D	145_R	1.163	0.99
129_K	132_S	1.149	0.99
29_S	73_V	1.146	0.99
187_Y	190_Y	1.129	0.99
86_F	126_I	1.124	0.99
104_I	114_A	1.116	0.99
33_I	69_I	1.113	0.99
113_V	171_F	1.110	0.99
141_G	147_E	1.107	0.99
85_S	133_L	1.105	0.99
123_I	181_T	1.103	0.99
64_A	145_R	1.097	0.99
13_K	20_A	1.093	0.99
89_S	148_R	1.093	0.99
116_A	178_T	1.072	0.99
23_L	26_L	1.062	0.98
18_P	22_T	1.062	0.98
86_F	189_V	1.054	0.98
21_K	25_Q	1.049	0.98
54_T	58_I	1.038	0.98
143_I	151_F	1.037	0.98
48_I	56_G	1.032	0.98
142_I	147_E	1.027	0.98
69_I	72_E	1.010	0.98
48_I	106_L	1.004	0.98
175_M	179_A	0.995	0.98
9_R	13_K	0.992	0.98
131_E	134_G	0.981	0.97
130_A	189_V	0.979	0.97
115_I	118_G	0.977	0.97
128_A	132_S	0.971	0.97
187_Y	191_S	0.969	0.97
46_F	49_M	0.956	0.97
9_R	20_A	0.951	0.97
115_I	119_L	0.951	0.97
90_T	126_I	0.948	0.97
15_V	18_P	0.943	0.97
47_E	52_N	0.941	0.97
86_F	186_F	0.932	0.96
53_T	106_L	0.930	0.96
54_T	161_I	0.929	0.96
114_A	117_V	0.924	0.96
140_R	188_A	0.924	0.96
30_A	80_V	0.924	0.96
174_F	178_T	0.923	0.96
18_P	21_K	0.922	0.96
117_V	121_L	0.920	0.96
19_L	69_I	0.913	0.96
35_M	39_I	0.907	0.96
141_G	185_R	0.897	0.96
165_Q	173_L	0.897	0.96
130_A	134_G	0.897	0.96
173_L	177_L	0.889	0.95
51_S	106_L	0.886	0.95
131_E	136_K	0.882	0.95
61_V	65_L	0.882	0.95
30_A	48_I	0.881	0.95
112_L	172_Y	0.879	0.95
125_Y	129_K	0.874	0.95
63_S	88_D	0.865	0.95
16_I	72_E	0.865	0.95
167_S	171_F	0.858	0.94
34_T	91_L	0.858	0.94
64_A	68_A	0.856	0.94
22_T	43_V	0.844	0.94
44_Y	99_Y	0.844	0.94
143_I	174_F	0.836	0.94
93_R	125_Y	0.834	0.94
63_S	145_R	0.825	0.93
40_F	66_M	0.823	0.93
44_Y	59_F	0.820	0.93
141_G	146_G	0.819	0.93
94_I	182_V	0.819	0.93
68_A	146_G	0.818	0.93
111_Y	115_I	0.809	0.92
89_S	127_R	0.805	0.92
61_V	64_A	0.803	0.92
186_F	189_V	0.802	0.92
132_S	136_K	0.799	0.92
14_R	18_P	0.798	0.92
11_Q	14_R	0.784	0.91
63_S	95_E	0.779	0.91
50_R	55_L	0.765	0.90
35_M	187_Y	0.762	0.90
122_T	125_Y	0.761	0.90
181_T	184_Q	0.757	0.90
34_T	60_L	0.751	0.89
50_R	53_T	0.740	0.89
85_S	89_S	0.735	0.88
130_A	136_K	0.723	0.88
89_S	129_K	0.721	0.87
155_I	167_S	0.715	0.87
123_I	127_R	0.714	0.87
170_L	174_F	0.702	0.86
48_I	99_Y	0.702	0.86
88_D	145_R	0.698	0.86
150_I	154_V	0.690	0.85
131_E	137_M	0.689	0.85
111_Y	117_V	0.685	0.85
154_V	191_S	0.684	0.85
175_M	178_T	0.678	0.84
116_A	120_S	0.677	0.84
44_Y	60_L	0.673	0.84
128_A	135_L	0.672	0.83
63_S	67_D	0.672	0.83
97_I	121_L	0.672	0.83
17_E	76_V	0.671	0.83
36_L	40_F	0.670	0.83
83_L	189_V	0.670	0.83
118_G	121_L	0.664	0.83
43_V	46_F	0.663	0.83
12_I	146_G	0.661	0.82
180_I	184_Q	0.658	0.82
180_I	183_I	0.658	0.82
152_V	171_F	0.655	0.82
28_V	32_F	0.655	0.82
57_I	157_L	0.654	0.82
10_R	14_R	0.654	0.82
37_G	95_E	0.651	0.82
116_A	119_L	0.651	0.82
43_V	47_E	0.645	0.81
88_D	142_I	0.645	0.81
40_F	63_S	0.644	0.81
64_A	93_R	0.642	0.81
55_L	59_F	0.641	0.81
113_V	120_S	0.640	0.80
119_L	182_V	0.637	0.80
40_F	58_I	0.637	0.80
145_R	148_R	0.636	0.80
107_G	120_S	0.631	0.79
188_A	191_S	0.628	0.79
172_Y	176_L	0.625	0.79
32_F	36_L	0.625	0.79
60_L	68_A	0.624	0.79
52_N	55_L	0.619	0.78
26_L	77_S	0.617	0.78
64_A	153_F	0.615	0.78
13_K	17_E	0.608	0.77
124_S	131_E	0.607	0.77
31_N	190_Y	0.606	0.77
113_V	121_L	0.606	0.77
31_N	79_T	0.605	0.77
129_K	133_L	0.599	0.76
81_S	155_I	0.599	0.76
153_F	157_L	0.584	0.74
56_G	156_L	0.578	0.73
67_D	89_S	0.578	0.73
170_L	173_L	0.574	0.73
171_F	174_F	0.572	0.73
114_A	124_S	0.572	0.73
127_R	137_M	0.568	0.72
63_S	89_S	0.568	0.72
113_V	116_A	0.566	0.72
89_S	96_D	0.566	0.72
50_R	62_F	0.563	0.71
106_L	113_V	0.561	0.71
68_A	147_E	0.561	0.71
127_R	144_E	0.559	0.71
167_S	170_L	0.557	0.71
16_I	20_A	0.557	0.71
146_G	150_I	0.555	0.70
99_Y	149_I	0.555	0.70
58_I	62_F	0.554	0.70
104_I	173_L	0.553	0.70
61_V	153_F	0.553	0.70
86_F	89_S	0.553	0.70
54_T	157_L	0.551	0.70
137_M	144_E	0.548	0.69
34_T	147_E	0.548	0.69
67_D	145_R	0.547	0.69
168_L	176_L	0.546	0.69
158_L	166_V	0.546	0.69
56_G	103_F	0.546	0.69
129_K	134_G	0.543	0.69
38_L	94_I	0.541	0.68
21_K	157_L	0.534	0.67
151_F	174_F	0.531	0.67
164_K	168_L	0.530	0.67
31_N	187_Y	0.530	0.67
62_F	160_I	0.529	0.67
46_F	158_L	0.527	0.66
96_D	147_E	0.527	0.66
56_G	116_A	0.524	0.66
147_E	150_I	0.523	0.66
58_I	78_K	0.522	0.66
67_D	75_R	0.520	0.65
19_L	39_I	0.519	0.65
119_L	122_T	0.518	0.65
44_Y	48_I	0.516	0.65
75_R	88_D	0.515	0.65
89_S	93_R	0.513	0.64
65_L	68_A	0.511	0.64
118_G	122_T	0.511	0.64
23_L	29_S	0.506	0.63
12_I	68_A	0.504	0.63
12_I	57_I	0.503	0.63
66_M	69_I	0.501	0.62
107_G	113_V	0.501	0.62
17_E	21_K	0.500	0.62
141_G	144_E	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o6mA	2	0.9538	100	0.343	Contact Map
4mndA	2	0.9692	99.9	0.424	Contact Map
3tx3A	2	0.9538	4.3	0.952	Contact Map
1wy1A	3	0.2923	2.7	0.956	Contact Map
4m6bA	1	0.2821	2.3	0.958	Contact Map
2ww9A	1	0.4615	1.7	0.961	Contact Map
2eo2A	1	0.1846	1.4	0.963	Contact Map
3k3fA	3	0.5538	1.4	0.963	Contact Map
4q2eA	2	0.2667	1.3	0.963	Contact Map
4od4A	1	0.8513	1.3	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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