GREMLIN Database
Q7LXU6 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putataive (PgsA)
UniProt: Q7LXU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (180)
Sequences: 2308 (1679)
Seq/√Len: 125.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_S32_F4.4751.00
24_A73_V3.6171.00
28_V36_L3.1201.00
30_A79_T3.0631.00
22_T26_L2.9181.00
38_L91_L2.8561.00
94_I179_A2.7211.00
20_A76_V2.6651.00
41_A95_E2.4011.00
83_L190_Y2.3521.00
155_I170_L2.1831.00
33_I73_V2.1791.00
47_E59_F2.1221.00
23_L28_V2.0861.00
48_I156_L1.9931.00
128_A131_E1.9451.00
72_E76_V1.8991.00
45_Y102_A1.8801.00
104_I113_V1.8471.00
42_I98_L1.8461.00
119_L179_A1.7891.00
131_E135_L1.7861.00
20_A73_V1.7671.00
93_R96_D1.7541.00
154_V158_L1.7391.00
67_D88_D1.6901.00
97_I118_G1.6791.00
35_M87_L1.6361.00
21_K76_V1.6311.00
94_I119_L1.5911.00
181_T185_R1.5681.00
37_G66_M1.5551.00
23_L69_I1.5551.00
31_N83_L1.5401.00
130_A133_L1.5401.00
24_A77_S1.5271.00
43_V59_F1.5251.00
132_S135_L1.4731.00
183_I187_Y1.4671.00
143_I177_L1.4091.00
45_Y98_L1.3981.00
116_A175_M1.3871.00
128_A134_G1.3681.00
96_D148_R1.3621.00
130_A135_L1.3601.00
48_I102_A1.3591.00
49_M102_A1.3581.00
39_I43_V1.3501.00
165_Q169_Y1.3491.00
47_E55_L1.3481.00
124_S127_R1.3451.00
85_S129_K1.3361.00
93_R148_R1.3111.00
40_F59_F1.2881.00
141_G181_T1.2831.00
133_L136_K1.2791.00
57_I153_F1.2661.00
97_I122_T1.2651.00
102_A106_L1.2521.00
22_T25_Q1.2471.00
93_R145_R1.2441.00
176_L180_I1.2431.00
49_M105_F1.2100.99
144_E147_E1.2070.99
30_A73_V1.1960.99
13_K72_E1.1890.99
41_A63_S1.1810.99
151_F170_L1.1760.99
20_A72_E1.1670.99
126_I186_F1.1660.99
96_D145_R1.1630.99
129_K132_S1.1490.99
29_S73_V1.1460.99
187_Y190_Y1.1290.99
86_F126_I1.1240.99
104_I114_A1.1160.99
33_I69_I1.1130.99
113_V171_F1.1100.99
141_G147_E1.1070.99
85_S133_L1.1050.99
123_I181_T1.1030.99
64_A145_R1.0970.99
13_K20_A1.0930.99
89_S148_R1.0930.99
116_A178_T1.0720.99
23_L26_L1.0620.98
18_P22_T1.0620.98
86_F189_V1.0540.98
21_K25_Q1.0490.98
54_T58_I1.0380.98
143_I151_F1.0370.98
48_I56_G1.0320.98
142_I147_E1.0270.98
69_I72_E1.0100.98
48_I106_L1.0040.98
175_M179_A0.9950.98
9_R13_K0.9920.98
131_E134_G0.9810.97
130_A189_V0.9790.97
115_I118_G0.9770.97
128_A132_S0.9710.97
187_Y191_S0.9690.97
46_F49_M0.9560.97
9_R20_A0.9510.97
115_I119_L0.9510.97
90_T126_I0.9480.97
15_V18_P0.9430.97
47_E52_N0.9410.97
86_F186_F0.9320.96
53_T106_L0.9300.96
54_T161_I0.9290.96
114_A117_V0.9240.96
140_R188_A0.9240.96
30_A80_V0.9240.96
174_F178_T0.9230.96
18_P21_K0.9220.96
117_V121_L0.9200.96
19_L69_I0.9130.96
35_M39_I0.9070.96
141_G185_R0.8970.96
165_Q173_L0.8970.96
130_A134_G0.8970.96
173_L177_L0.8890.95
51_S106_L0.8860.95
131_E136_K0.8820.95
61_V65_L0.8820.95
30_A48_I0.8810.95
112_L172_Y0.8790.95
125_Y129_K0.8740.95
63_S88_D0.8650.95
16_I72_E0.8650.95
167_S171_F0.8580.94
34_T91_L0.8580.94
64_A68_A0.8560.94
22_T43_V0.8440.94
44_Y99_Y0.8440.94
143_I174_F0.8360.94
93_R125_Y0.8340.94
63_S145_R0.8250.93
40_F66_M0.8230.93
44_Y59_F0.8200.93
141_G146_G0.8190.93
94_I182_V0.8190.93
68_A146_G0.8180.93
111_Y115_I0.8090.92
89_S127_R0.8050.92
61_V64_A0.8030.92
186_F189_V0.8020.92
132_S136_K0.7990.92
14_R18_P0.7980.92
11_Q14_R0.7840.91
63_S95_E0.7790.91
50_R55_L0.7650.90
35_M187_Y0.7620.90
122_T125_Y0.7610.90
181_T184_Q0.7570.90
34_T60_L0.7510.89
50_R53_T0.7400.89
85_S89_S0.7350.88
130_A136_K0.7230.88
89_S129_K0.7210.87
155_I167_S0.7150.87
123_I127_R0.7140.87
170_L174_F0.7020.86
48_I99_Y0.7020.86
88_D145_R0.6980.86
150_I154_V0.6900.85
131_E137_M0.6890.85
111_Y117_V0.6850.85
154_V191_S0.6840.85
175_M178_T0.6780.84
116_A120_S0.6770.84
44_Y60_L0.6730.84
128_A135_L0.6720.83
63_S67_D0.6720.83
97_I121_L0.6720.83
17_E76_V0.6710.83
36_L40_F0.6700.83
83_L189_V0.6700.83
118_G121_L0.6640.83
43_V46_F0.6630.83
12_I146_G0.6610.82
180_I184_Q0.6580.82
180_I183_I0.6580.82
152_V171_F0.6550.82
28_V32_F0.6550.82
57_I157_L0.6540.82
10_R14_R0.6540.82
37_G95_E0.6510.82
116_A119_L0.6510.82
43_V47_E0.6450.81
88_D142_I0.6450.81
40_F63_S0.6440.81
64_A93_R0.6420.81
55_L59_F0.6410.81
113_V120_S0.6400.80
119_L182_V0.6370.80
40_F58_I0.6370.80
145_R148_R0.6360.80
107_G120_S0.6310.79
188_A191_S0.6280.79
172_Y176_L0.6250.79
32_F36_L0.6250.79
60_L68_A0.6240.79
52_N55_L0.6190.78
26_L77_S0.6170.78
64_A153_F0.6150.78
13_K17_E0.6080.77
124_S131_E0.6070.77
31_N190_Y0.6060.77
113_V121_L0.6060.77
31_N79_T0.6050.77
129_K133_L0.5990.76
81_S155_I0.5990.76
153_F157_L0.5840.74
56_G156_L0.5780.73
67_D89_S0.5780.73
170_L173_L0.5740.73
171_F174_F0.5720.73
114_A124_S0.5720.73
127_R137_M0.5680.72
63_S89_S0.5680.72
113_V116_A0.5660.72
89_S96_D0.5660.72
50_R62_F0.5630.71
106_L113_V0.5610.71
68_A147_E0.5610.71
127_R144_E0.5590.71
167_S170_L0.5570.71
16_I20_A0.5570.71
146_G150_I0.5550.70
99_Y149_I0.5550.70
58_I62_F0.5540.70
104_I173_L0.5530.70
61_V153_F0.5530.70
86_F89_S0.5530.70
54_T157_L0.5510.70
137_M144_E0.5480.69
34_T147_E0.5480.69
67_D145_R0.5470.69
168_L176_L0.5460.69
158_L166_V0.5460.69
56_G103_F0.5460.69
129_K134_G0.5430.69
38_L94_I0.5410.68
21_K157_L0.5340.67
151_F174_F0.5310.67
164_K168_L0.5300.67
31_N187_Y0.5300.67
62_F160_I0.5290.67
46_F158_L0.5270.66
96_D147_E0.5270.66
56_G116_A0.5240.66
147_E150_I0.5230.66
58_I78_K0.5220.66
67_D75_R0.5200.65
19_L39_I0.5190.65
119_L122_T0.5180.65
44_Y48_I0.5160.65
75_R88_D0.5150.65
89_S93_R0.5130.64
65_L68_A0.5110.64
118_G122_T0.5110.64
23_L29_S0.5060.63
12_I68_A0.5040.63
12_I57_I0.5030.63
66_M69_I0.5010.62
107_G113_V0.5010.62
17_E21_K0.5000.62
141_G144_E0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6mA 2 0.9538 100 0.343 Contact Map
4mndA 2 0.9692 99.9 0.424 Contact Map
3tx3A 2 0.9538 4.3 0.952 Contact Map
1wy1A 3 0.2923 2.7 0.956 Contact Map
4m6bA 1 0.2821 2.3 0.958 Contact Map
2ww9A 1 0.4615 1.7 0.961 Contact Map
2eo2A 1 0.1846 1.4 0.963 Contact Map
3k3fA 3 0.5538 1.4 0.963 Contact Map
4q2eA 2 0.2667 1.3 0.963 Contact Map
4od4A 1 0.8513 1.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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