GREMLIN Database
HJC - Holliday junction resolvase Hjc
UniProt: Q7LXU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (125)
Sequences: 118 (85)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_L102_F3.0200.86
5_K9_S2.9590.85
27_V44_I2.9380.85
47_K51_I2.7050.79
7_K60_K2.5190.74
46_L83_S2.5160.74
33_G41_P2.4690.72
53_L85_G2.4320.71
16_V43_I2.1800.62
19_L124_L2.1370.61
5_K31_A2.0650.58
50_V86_S2.0110.56
68_V72_Q1.9950.55
15_I97_L1.9950.55
5_K30_P1.9900.55
126_D129_R1.9110.52
31_A35_K1.9090.52
124_L128_V1.8360.49
26_V39_P1.8330.49
99_F112_N1.8200.48
29_A35_K1.7160.44
104_K120_E1.7120.44
24_F79_F1.6720.42
93_K115_A1.6660.42
30_P41_P1.6380.41
45_A91_V1.6130.40
19_L45_A1.6110.40
69_R127_L1.5830.39
43_I120_E1.5730.38
21_D100_I1.5700.38
59_R98_K1.5260.37
41_P72_Q1.5190.36
75_G121_G1.4180.33
25_A84_G1.4040.32
86_S115_A1.3930.32
14_N20_R1.3790.31
30_P72_Q1.3730.31
44_I87_L1.3710.31
22_K115_A1.3690.31
100_I125_E1.2260.26
33_G72_Q1.2210.26
9_S96_V1.2200.26
70_R91_V1.2080.26
7_K98_K1.2040.26
26_V71_E1.2010.26
129_R133_A1.1900.25
26_V29_A1.1890.25
70_R128_V1.1840.25
59_R94_P1.1770.25
7_K82_K1.1700.25
45_A110_T1.1680.25
52_I85_G1.1490.24
19_L26_V1.1430.24
123_D126_D1.1050.23
25_A79_F1.0930.22
29_A33_G1.0840.22
5_K41_P1.0750.22
73_A76_I1.0700.22
88_F116_D1.0630.22
14_N97_L1.0450.21
76_I102_F1.0430.21
66_I90_G1.0280.21
30_P111_G1.0220.21
20_R72_Q1.0200.21
15_I76_I1.0060.20
73_A133_A0.9990.20
48_N115_A0.9820.20
9_S34_S0.9730.19
67_Y121_G0.9690.19
20_R33_G0.9600.19
67_Y114_V0.9530.19
54_I99_F0.9450.19
47_K54_I0.9450.19
86_S103_E0.9380.18
52_I127_L0.9360.18
44_I77_I0.9360.18
73_A102_F0.9340.18
46_L129_R0.9320.18
61_D68_V0.9130.18
18_R22_K0.9060.18
106_R114_V0.9030.18
27_V74_E0.8960.17
31_A111_G0.8910.17
83_S129_R0.8860.17
50_V66_I0.8740.17
71_E123_D0.8720.17
85_G89_L0.8670.17
97_L114_V0.8530.17
38_D87_L0.8530.17
22_K125_E0.8410.16
21_D74_E0.8410.16
77_I102_F0.8300.16
41_P108_T0.8260.16
53_L97_L0.8250.16
10_A89_L0.8180.16
26_V85_G0.8050.15
61_D101_P0.7910.15
25_A97_L0.7900.15
7_K65_K0.7900.15
105_L113_Y0.7830.15
90_G111_G0.7810.15
17_S65_K0.7810.15
44_I124_L0.7730.15
89_L125_E0.7660.15
8_G59_R0.7510.14
31_A67_Y0.7430.14
66_I114_V0.7410.14
33_G108_T0.7380.14
67_Y84_G0.7250.14
19_L78_E0.7250.14
15_I35_K0.7130.14
76_I130_L0.7130.14
50_V89_L0.7120.14
53_L129_R0.7110.14
107_R128_V0.7040.13
10_A14_N0.7040.13
77_I125_E0.6930.13
65_K114_V0.6920.13
25_A31_A0.6890.13
20_R41_P0.6880.13
78_E81_R0.6760.13
58_S85_G0.6740.13
43_I91_V0.6720.13
89_L124_L0.6680.13
23_G27_V0.6540.13
48_N93_K0.6520.13
5_K20_R0.6500.13
58_S64_G0.6480.12
27_V116_D0.6460.12
77_I81_R0.6450.12
33_G127_L0.6430.12
81_R111_G0.6390.12
29_A41_P0.6370.12
6_R125_E0.6300.12
112_N115_A0.6300.12
31_A41_P0.6300.12
73_A132_E0.6290.12
34_S88_F0.6270.12
60_K121_G0.6260.12
24_F84_G0.6260.12
19_L58_S0.6090.12
76_I97_L0.6010.12
99_F108_T0.5940.12
54_I118_E0.5880.11
17_S132_E0.5860.11
19_L132_E0.5840.11
11_V111_G0.5780.11
17_S60_K0.5760.11
120_E133_A0.5750.11
20_R97_L0.5740.11
48_N97_L0.5690.11
51_I54_I0.5680.11
89_L118_E0.5660.11
54_I64_G0.5630.11
76_I87_L0.5600.11
81_R101_P0.5580.11
116_D122_L0.5550.11
126_D130_L0.5550.11
70_R87_L0.5540.11
35_K85_G0.5500.11
35_K40_I0.5470.11
51_I56_M0.5450.11
16_V26_V0.5410.11
30_P108_T0.5340.11
20_R102_F0.5340.11
53_L76_I0.5340.11
71_E98_K0.5330.11
6_R92_K0.5260.11
9_S13_R0.5230.10
30_P45_A0.5210.10
10_A85_G0.5190.10
29_A90_G0.5130.10
77_I110_T0.5080.10
43_I116_D0.5080.10
28_R57_K0.5000.10
42_D57_K0.5000.10
12_E57_K0.5000.10
12_E55_E0.5000.10
42_D55_E0.5000.10
12_E42_D0.5000.10
12_E28_R0.5000.10
32_S57_K0.5000.10
28_R42_D0.5000.10
32_S55_E0.5000.10
32_S42_D0.5000.10
12_E32_S0.5000.10
28_R32_S0.5000.10
28_R55_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eo0A 2 0.8951 100 0.464 Contact Map
1hh1A 2 0.8741 100 0.476 Contact Map
2wcwA 2 0.8671 99.9 0.528 Contact Map
1ob8A 1 0.8601 99.9 0.583 Contact Map
1gefA 2 0.8322 99.8 0.626 Contact Map
2ostA 4 0.9161 96.9 0.87 Contact Map
1y88A 5 0.8811 95.7 0.885 Contact Map
3fovA 2 0.6503 95.3 0.888 Contact Map
2fcoA 2 0.8601 94.8 0.891 Contact Map
4qbnA 2 0.5944 93.2 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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