GREMLIN Database
Q7LXT6 - GTP binding protein, hypothetical
UniProt: Q7LXT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (244)
Sequences: 3232 (2120)
Seq/√Len: 135.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_A231_P4.1571.00
57_V253_T3.9691.00
203_Y243_D3.3851.00
23_E174_A3.1771.00
37_V40_Y2.9281.00
128_S136_Y2.6501.00
62_K73_S2.5911.00
62_K75_Y2.5171.00
18_V115_V2.4911.00
209_N212_E2.3701.00
28_R33_E2.3571.00
199_L203_Y2.3261.00
197_E200_I2.3061.00
64_Y68_E2.2711.00
25_S65_F2.2241.00
90_T93_S2.0931.00
120_K143_F2.0661.00
213_L217_I2.0611.00
53_V58_L2.0341.00
46_V76_V2.0211.00
126_Q136_Y2.0091.00
173_N187_L1.9441.00
244_Y254_L1.9231.00
223_W239_A1.9111.00
59_K63_D1.9011.00
212_E216_R1.8981.00
57_V60_A1.8761.00
58_L75_Y1.8361.00
232_N235_M1.8311.00
55_L251_Y1.8231.00
217_I236_A1.8181.00
31_K34_D1.7951.00
52_L247_G1.7521.00
19_L45_L1.7421.00
46_V74_V1.7161.00
166_E170_R1.6691.00
142_L152_W1.6661.00
5_V103_V1.6491.00
16_V91_M1.6461.00
62_K66_K1.6451.00
185_L189_N1.6381.00
198_S201_S1.6371.00
77_S80_S1.6251.00
23_E27_T1.6201.00
214_L236_A1.6001.00
55_L59_K1.5981.00
242_R246_E1.5861.00
197_E201_S1.5471.00
16_V46_V1.5361.00
221_R239_A1.5281.00
87_L115_V1.5111.00
187_L244_Y1.4911.00
234_D238_R1.4671.00
219_I224_F1.4661.00
223_W235_M1.4651.00
104_F115_V1.4521.00
18_V48_N1.4431.00
120_K124_S1.4361.00
211_Y215_E1.4341.00
243_D248_K1.4301.00
225_Y232_N1.4301.00
92_K148_K1.4201.00
19_L47_L1.4161.00
144_K150_Y1.4131.00
87_L91_M1.4061.00
12_S103_V1.4021.00
182_K185_L1.3761.00
114_S127_T1.3601.00
198_S249_I1.3561.00
57_V256_P1.3561.00
44_L90_T1.3321.00
4_K8_L1.2961.00
186_M189_N1.2801.00
129_A246_E1.2731.00
33_E43_I1.2721.00
168_T177_L1.2581.00
219_I231_P1.2571.00
164_E167_K1.2571.00
218_A222_G1.2551.00
14_L95_L1.2371.00
8_L140_I1.2311.00
63_D67_T1.2301.00
181_V185_L1.2291.00
66_K72_E1.2291.00
48_N78_A1.2291.00
212_E215_E1.2261.00
16_V104_F1.2101.00
224_F229_K1.2041.00
56_W60_A1.1951.00
14_L94_L1.1931.00
19_L28_R1.1931.00
215_E219_I1.1881.00
65_F68_E1.1870.99
218_A236_A1.1820.99
46_V87_L1.1790.99
238_R242_R1.1760.99
170_R255_P1.1740.99
17_E28_R1.1700.99
93_S96_K1.1660.99
115_V119_L1.1460.99
217_I240_V1.1450.99
81_H118_A1.1290.99
162_G168_T1.1210.99
17_E45_L1.1180.99
183_P186_M1.1160.99
216_R219_I1.1140.99
188_I213_L1.1100.99
63_D66_K1.1060.99
91_M94_L1.0920.99
19_L27_T1.0880.99
58_L253_T1.0870.99
103_V154_T1.0870.99
184_A237_A1.0800.99
196_K206_D1.0770.99
215_E233_I1.0690.99
185_L210_P1.0570.99
60_A63_D1.0460.99
200_I205_V1.0410.99
181_V234_D1.0380.99
214_L240_V1.0370.99
171_G175_D1.0320.99
17_E43_I1.0320.99
72_E93_S1.0290.99
72_E90_T1.0180.98
6_I31_K1.0180.98
225_Y230_E1.0180.98
48_N77_S1.0050.98
182_K189_N0.9960.98
5_V157_V0.9940.98
184_A188_I0.9930.98
77_S82_L0.9910.98
15_V36_I0.9890.98
46_V115_V0.9820.98
71_I75_Y0.9810.98
233_I236_A0.9780.98
181_V186_M0.9760.98
140_I154_T0.9640.98
4_K7_Q0.9600.98
213_L218_A0.9600.98
170_R173_N0.9580.98
167_K171_G0.9550.98
195_S199_L0.9530.98
16_V102_V0.9520.98
168_T172_Y0.9470.98
223_W236_A0.9450.97
8_L11_R0.9430.97
94_L97_G0.9380.97
183_P189_N0.9330.97
49_K52_L0.9300.97
142_L150_Y0.9280.97
187_L254_L0.9240.97
86_I89_D0.9120.97
173_N244_Y0.9110.97
218_A221_R0.9100.97
54_P195_S0.9090.97
61_W64_Y0.9070.97
74_V78_A0.8970.97
170_R190_R0.8960.97
65_F69_E0.8950.96
195_S198_S0.8950.96
185_L188_I0.8930.96
183_P190_R0.8910.96
162_G167_K0.8910.96
211_Y233_I0.8850.96
239_A243_D0.8810.96
199_L202_V0.8800.96
216_R220_R0.8770.96
28_R45_L0.8720.96
179_D245_H0.8720.96
107_Y158_I0.8710.96
218_A223_W0.8670.96
34_D37_V0.8670.96
16_V44_L0.8660.96
81_H84_T0.8650.96
44_L94_L0.8550.95
187_L241_I0.8520.95
236_A240_V0.8510.95
182_K186_M0.8480.95
84_T88_R0.8470.95
187_L191_V0.8450.95
47_L61_W0.8390.95
245_H254_L0.8370.95
87_L95_L0.8360.95
226_K230_E0.8360.95
168_T171_G0.8360.95
244_Y247_G0.8340.95
218_A229_K0.8220.94
14_L102_V0.8210.94
26_L170_R0.8200.94
181_V184_A0.8050.94
183_P188_I0.8050.94
126_Q141_Q0.8020.94
72_E77_S0.8000.94
184_A190_R0.7980.93
244_Y252_Y0.7940.93
163_N167_K0.7870.93
26_L177_L0.7870.93
19_L141_Q0.7860.93
231_P236_A0.7800.93
116_I252_Y0.7790.93
72_E76_V0.7790.93
57_V257_S0.7790.93
4_K140_I0.7780.93
222_G227_S0.7770.93
196_K200_I0.7760.92
72_E94_L0.7750.92
224_F227_S0.7710.92
181_V189_N0.7680.92
226_K229_K0.7670.92
123_H127_T0.7670.92
72_E79_T0.7670.92
102_V149_I0.7620.92
91_M102_V0.7590.92
5_V105_V0.7580.92
171_G176_L0.7480.91
250_A254_L0.7400.91
177_L183_P0.7380.90
93_S97_G0.7370.90
76_V84_T0.7360.90
6_I10_K0.7360.90
60_A64_Y0.7340.90
42_N97_G0.7300.90
169_I182_K0.7270.90
88_R92_K0.7260.90
44_L87_L0.7260.90
173_N183_P0.7220.90
184_A240_V0.7150.89
72_E75_Y0.7130.89
252_Y255_P0.7100.89
16_V115_V0.7100.89
83_G90_T0.7070.89
185_L211_Y0.7050.88
36_I43_I0.7010.88
29_S154_T0.7010.88
91_M149_I0.6980.88
26_L167_K0.6970.88
214_L218_A0.6930.88
185_L214_L0.6900.87
218_A224_F0.6880.87
125_A154_T0.6870.87
213_L222_G0.6830.87
68_E71_I0.6820.87
50_G78_A0.6790.86
40_Y97_G0.6780.86
222_G229_K0.6770.86
241_I244_Y0.6760.86
53_V253_T0.6750.86
182_K188_I0.6740.86
32_I105_V0.6730.86
73_S76_V0.6730.86
219_I222_G0.6700.86
83_G86_I0.6680.86
89_D93_S0.6660.85
48_N145_I0.6660.85
79_T118_A0.6660.85
14_L91_M0.6650.85
130_H142_L0.6610.85
165_L168_T0.6600.85
48_N76_V0.6550.84
253_T257_S0.6550.84
95_L101_I0.6540.84
8_L103_V0.6530.84
54_P57_V0.6520.84
50_G58_L0.6510.84
202_V205_V0.6510.84
200_I206_D0.6450.84
149_I210_P0.6440.83
210_P213_L0.6420.83
76_V87_L0.6340.83
158_I175_D0.6300.82
21_A47_L0.6280.82
208_N213_L0.6270.82
214_L233_I0.6270.82
217_I239_A0.6250.82
76_V79_T0.6240.82
137_T155_P0.6240.82
36_I105_V0.6220.81
86_I90_T0.6220.81
201_S204_K0.6210.81
145_I151_A0.6210.81
56_W59_K0.6210.81
108_P135_G0.6190.81
208_N212_E0.6130.80
71_I74_V0.6120.80
137_T153_D0.6100.80
117_N153_D0.6100.80
55_L60_A0.6090.80
188_I210_P0.6090.80
128_S160_P0.6070.80
183_P187_L0.6060.80
111_G117_N0.6060.80
61_W65_F0.6020.79
90_T94_L0.6000.79
28_R32_I0.5960.78
111_G153_D0.5960.78
64_Y67_T0.5950.78
13_D41_K0.5940.78
215_E218_A0.5920.78
182_K187_L0.5920.78
124_S143_F0.5900.78
171_G245_H0.5900.78
221_R227_S0.5890.78
5_V241_I0.5870.77
197_E206_D0.5840.77
91_M101_I0.5790.76
225_Y229_K0.5780.76
188_I240_V0.5770.76
213_L240_V0.5760.76
116_I143_F0.5750.76
75_Y78_A0.5750.76
214_L222_G0.5750.76
79_T83_G0.5680.75
58_L251_Y0.5680.75
32_I157_V0.5680.75
61_W255_P0.5680.75
158_I161_D0.5640.75
83_G87_L0.5640.75
113_S117_N0.5610.74
153_D156_G0.5590.74
151_A203_Y0.5580.74
172_Y183_P0.5520.73
71_I76_V0.5500.73
47_L75_Y0.5500.73
100_G150_Y0.5500.73
200_I203_Y0.5500.73
31_K157_V0.5500.73
164_E171_G0.5490.73
202_V243_D0.5490.73
59_K147_N0.5480.73
14_L44_L0.5450.72
89_D92_K0.5450.72
211_Y216_R0.5450.72
184_A191_V0.5440.72
75_Y79_T0.5400.71
11_R150_Y0.5330.70
30_K159_P0.5320.70
37_V42_N0.5310.70
121_G139_S0.5240.69
217_I231_P0.5220.69
250_A255_P0.5200.69
80_S86_I0.5200.69
29_S159_P0.5190.68
25_S28_R0.5180.68
48_N244_Y0.5170.68
206_D210_P0.5170.68
184_A241_I0.5160.68
173_N176_L0.5160.68
23_E26_L0.5160.68
208_N211_Y0.5150.68
19_L43_I0.5140.68
218_A227_S0.5140.68
88_R149_I0.5130.68
119_L145_I0.5130.68
21_A53_V0.5120.67
84_T118_A0.5110.67
104_F235_M0.5110.67
25_S64_Y0.5110.67
204_K220_R0.5080.67
208_N216_R0.5070.67
197_E204_K0.5070.67
14_L101_I0.5070.67
59_K62_K0.5060.67
198_S203_Y0.5050.66
104_F116_I0.5040.66
6_I139_S0.5020.66
40_Y233_I0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pujA 1 0.8951 100 0.319 Contact Map
3cnlA 1 0.8652 100 0.477 Contact Map
2yv5A 1 0.7715 100 0.617 Contact Map
3h2yA 1 0.9101 100 0.626 Contact Map
3ec1A 1 0.97 99.9 0.629 Contact Map
1t9hA 1 0.7154 99.9 0.638 Contact Map
1u0lA 1 0.7266 99.9 0.644 Contact Map
2rcnA 2 0.7004 99.9 0.647 Contact Map
1mkyA 1 0.8727 99.9 0.653 Contact Map
4dcuA 1 0.9064 99.9 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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