GREMLIN Database
Q7LXT2 - Uncharacterized protein
UniProt: Q7LXT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (279)
Sequences: 1371 (1014)
Seq/√Len: 60.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_K75_R5.0061.00
35_V66_T4.6011.00
62_V219_A4.1701.00
162_A204_V4.0361.00
48_N160_Y3.9681.00
48_N159_D3.4811.00
77_I158_A3.2671.00
287_V298_M3.1941.00
95_K98_E2.7661.00
49_K77_I2.7461.00
51_L158_A2.6911.00
45_V204_V2.6731.00
252_E259_L2.5141.00
95_K99_E2.3501.00
120_S123_E2.2671.00
94_V98_E2.2361.00
99_E225_E2.2281.00
64_A78_A2.2221.00
58_K219_A2.1851.00
62_V207_L2.1731.00
78_A106_I2.1721.00
50_I162_A2.1701.00
32_R69_Q2.1471.00
57_G164_G2.0951.00
65_D69_Q2.0741.00
83_E145_R2.0711.00
65_D222_K2.0681.00
77_I109_I2.0271.00
168_D259_L2.0231.00
151_E155_K2.0121.00
52_L67_L1.9701.00
163_T203_R1.9391.00
66_T70_F1.9371.00
31_I66_T1.9191.00
51_L79_F1.9181.00
34_R214_E1.8791.00
152_A156_V1.8591.00
171_V174_I1.8441.00
61_L100_Y1.8391.00
138_C231_C1.8261.00
174_I266_F1.8021.00
9_R25_E1.7850.99
171_V262_I1.7830.99
82_N94_V1.7810.99
24_K28_I1.7600.99
165_H173_T1.7480.99
58_K212_E1.7450.99
286_C289_C1.7310.99
78_A101_L1.7130.99
63_L67_L1.7010.99
59_D169_D1.6730.99
82_N112_G1.6080.99
100_Y104_L1.5990.99
265_Q269_I1.5800.99
54_V61_L1.5720.99
99_E103_D1.5660.99
45_V48_N1.5590.99
54_V97_L1.5360.98
171_V263_L1.5000.98
69_Q222_K1.4930.98
250_K254_K1.4480.98
246_D250_K1.4220.97
98_E102_K1.4190.97
39_A45_V1.3910.97
61_L224_F1.3830.97
138_C146_R1.3800.97
67_L162_A1.3670.97
243_K254_K1.3600.97
38_E209_K1.3580.97
23_C26_C1.3560.97
39_A44_I1.3510.96
85_I122_D1.3450.96
15_Q30_D1.3410.96
6_C23_C1.3320.96
173_T241_R1.3210.96
39_A48_N1.3160.96
138_C141_C1.3130.96
145_R241_R1.3070.96
240_L243_K1.3050.96
45_V74_S1.3040.96
32_R218_Y1.2830.95
207_L210_I1.2800.95
31_I210_I1.2790.95
45_V160_Y1.2690.95
80_N108_L1.2660.95
28_I222_K1.2630.95
79_F148_L1.2540.95
82_N91_N1.2520.95
53_A149_I1.2400.94
172_Q241_R1.2350.94
55_S164_G1.2310.94
55_S60_S1.2280.94
63_L207_L1.2180.94
75_R107_E1.2170.94
175_V244_V1.2160.94
212_E216_T1.2120.94
116_E119_F1.2120.94
176_I241_R1.2110.94
101_L106_I1.2100.94
79_F152_A1.2090.93
252_E257_G1.2090.93
79_F149_I1.1990.93
81_I111_S1.1920.93
149_I161_V1.1900.93
58_K138_C1.1650.92
63_L162_A1.1650.92
68_S105_G1.1530.92
231_C234_I1.1520.92
138_C142_G1.1490.92
65_D218_Y1.1330.91
247_L251_L1.1240.91
261_R264_E1.1120.90
93_Y227_Q1.1010.90
109_I152_A1.0970.90
176_I240_L1.0900.89
64_A106_I1.0820.89
81_I113_F1.0760.89
153_G161_V1.0730.89
57_G60_S1.0710.88
52_L64_A1.0680.88
83_E90_R1.0680.88
51_L77_I1.0620.88
174_I263_L1.0590.88
154_I291_E1.0540.88
65_D104_L1.0530.88
169_D241_R1.0530.88
123_E126_E1.0530.88
80_N227_Q1.0500.87
52_L63_L1.0480.87
53_A57_G1.0480.87
59_D165_H1.0410.87
109_I155_K1.0220.86
121_L125_L1.0100.85
242_A245_R1.0020.85
66_T210_I0.9950.85
173_T176_I0.9800.84
51_L109_I0.9740.83
36_E260_L0.9650.83
38_E208_R0.9490.82
232_P235_S0.9480.82
85_I88_Y0.9460.81
21_K24_K0.9450.81
50_I74_S0.9400.81
83_E142_G0.9380.81
226_F229_T0.9350.81
80_N94_V0.9330.80
12_V24_K0.9310.80
243_K247_L0.9310.80
152_A159_D0.9230.80
94_V112_G0.9230.80
22_L30_D0.9160.79
138_C169_D0.9110.79
250_K253_E0.9100.79
12_V21_K0.9080.79
64_A68_S0.9060.78
81_I148_L0.9010.78
53_A161_V0.9010.78
146_R212_E0.8930.77
47_S50_I0.8910.77
169_D173_T0.8900.77
163_T166_N0.8880.77
243_K255_K0.8850.77
83_E121_L0.8840.77
123_E127_A0.8840.77
37_M41_K0.8830.77
179_I251_L0.8780.76
138_C212_E0.8760.76
34_R209_K0.8760.76
20_R30_D0.8730.76
99_E102_K0.8720.76
141_C231_C0.8700.76
64_A101_L0.8680.75
58_K141_C0.8650.75
165_H169_D0.8640.75
170_E177_N0.8630.75
160_Y202_M0.8630.75
62_V218_Y0.8600.75
6_C26_C0.8600.75
121_L144_F0.8570.75
125_L133_L0.8550.74
179_I255_K0.8550.74
57_G241_R0.8510.74
293_T297_R0.8510.74
163_T205_K0.8500.74
65_D68_S0.8480.74
69_Q218_Y0.8440.73
142_G169_D0.8430.73
194_L198_S0.8410.73
170_E190_G0.8370.73
11_A21_K0.8350.73
36_E40_R0.8350.73
146_R169_D0.8330.72
28_I32_R0.8320.72
109_I156_V0.8320.72
154_I199_K0.8310.72
167_L259_L0.8280.72
194_L197_S0.8230.71
44_I190_G0.8170.71
169_D212_E0.8170.71
39_A160_Y0.8150.71
31_I215_T0.8090.70
145_R169_D0.8050.70
211_Y261_R0.8030.70
59_D241_R0.8000.69
168_D212_E0.7970.69
164_G256_P0.7940.69
35_V210_I0.7930.69
284_P298_M0.7890.68
166_N169_D0.7880.68
55_S241_R0.7880.68
58_K228_E0.7870.68
98_E108_L0.7860.68
26_C29_E0.7860.68
49_K99_E0.7840.68
177_N239_T0.7830.68
166_N212_E0.7800.67
53_A56_G0.7800.67
150_N203_R0.7770.67
60_S164_G0.7720.67
152_A155_K0.7690.66
69_Q246_D0.7660.66
170_E205_K0.7630.66
213_W216_T0.7620.66
54_V78_A0.7600.65
214_E289_C0.7570.65
262_I265_Q0.7570.65
288_I299_I0.7570.65
101_L108_L0.7540.65
59_D168_D0.7510.64
58_K231_C0.7490.64
170_E189_F0.7470.64
124_M177_N0.7470.64
90_R141_C0.7420.63
116_E148_L0.7350.63
87_G91_N0.7340.63
9_R253_E0.7300.62
172_Q245_R0.7280.62
169_D245_R0.7250.62
183_L265_Q0.7250.62
142_G231_C0.7240.62
32_R65_D0.7160.61
289_C292_P0.7130.60
141_C212_E0.7110.60
180_R241_R0.7100.60
54_V261_R0.7090.60
212_E245_R0.7080.60
219_A228_E0.7080.60
26_C97_L0.7070.60
141_C146_R0.7050.60
17_H21_K0.7050.60
77_I156_V0.7050.60
38_E163_T0.7010.59
208_R267_D0.6990.59
283_L286_C0.6960.59
111_S152_A0.6950.58
81_I275_K0.6940.58
7_K12_V0.6930.58
105_G157_A0.6920.58
139_T301_K0.6920.58
201_V262_I0.6910.58
255_K258_T0.6900.58
59_D173_T0.6890.58
51_L152_A0.6880.58
21_K30_D0.6840.57
183_L186_L0.6840.57
23_C27_F0.6820.57
53_A163_T0.6810.57
84_G90_R0.6810.57
297_R300_C0.6800.57
55_S59_D0.6780.57
153_G201_V0.6750.56
90_R93_Y0.6730.56
59_D138_C0.6730.56
160_Y204_V0.6710.56
193_P196_V0.6640.55
45_V53_A0.6630.55
58_K142_G0.6630.55
244_V247_L0.6580.54
271_E274_K0.6560.54
213_W220_H0.6560.54
39_A204_V0.6540.54
84_G141_C0.6520.54
186_L189_F0.6500.53
14_L21_K0.6500.53
12_V117_V0.6490.53
7_K299_I0.6490.53
58_K62_V0.6430.53
141_C169_D0.6420.53
209_K264_E0.6390.52
59_D146_R0.6380.52
9_R12_V0.6370.52
149_I203_R0.6370.52
52_L76_L0.6360.52
190_G266_F0.6340.52
186_L211_Y0.6330.52
152_A158_A0.6330.52
88_Y230_E0.6330.52
59_D141_C0.6310.51
82_N230_E0.6290.51
70_F209_K0.6260.51
50_I204_V0.6230.50
167_L170_E0.6220.50
183_L261_R0.6200.50
87_G93_Y0.6170.50
42_Q251_L0.6170.50
69_Q76_L0.6160.50
242_A249_Y0.6120.49
142_G232_P0.6120.49
75_R222_K0.6110.49
183_L268_E0.6110.49
56_G251_L0.6070.49
243_K248_L0.6060.48
165_H205_K0.6050.48
179_I244_V0.6050.48
183_L264_E0.6050.48
145_R172_Q0.6040.48
258_T261_R0.6030.48
163_T177_N0.6000.48
137_A240_L0.6000.48
66_T207_L0.5990.48
168_D176_I0.5990.48
282_E292_P0.5980.48
171_V214_E0.5970.47
178_L265_Q0.5970.47
31_I235_S0.5970.47
213_W256_P0.5960.47
294_T300_C0.5960.47
255_K261_R0.5960.47
196_V201_V0.5940.47
156_V175_V0.5930.47
139_T182_D0.5930.47
12_V22_L0.5900.47
279_L282_E0.5880.46
68_S72_H0.5870.46
62_V230_E0.5870.46
64_A255_K0.5870.46
14_L17_H0.5860.46
283_L293_T0.5860.46
142_G212_E0.5800.46
121_L137_A0.5800.46
173_T177_N0.5800.46
93_Y97_L0.5800.46
45_V159_D0.5800.46
62_V215_T0.5790.45
47_S204_V0.5780.45
83_E94_V0.5720.45
53_A292_P0.5700.44
93_Y230_E0.5700.44
172_Q212_E0.5670.44
125_L137_A0.5670.44
108_L218_Y0.5660.44
80_N97_L0.5640.44
83_E241_R0.5620.44
103_D225_E0.5590.43
175_V248_L0.5570.43
35_V70_F0.5560.43
180_R240_L0.5540.43
10_E17_H0.5540.43
90_R94_V0.5520.42
92_E227_Q0.5510.42
107_E127_A0.5500.42
85_I137_A0.5490.42
135_V243_K0.5480.42
94_V149_I0.5480.42
167_L252_E0.5460.42
178_L230_E0.5460.42
10_E14_L0.5450.42
244_V255_K0.5440.42
248_L257_G0.5430.41
34_R240_L0.5430.41
47_S75_R0.5420.41
180_R245_R0.5410.41
59_D245_R0.5410.41
174_I262_I0.5390.41
83_E172_Q0.5380.41
266_F274_K0.5330.40
72_H157_A0.5310.40
105_G293_T0.5300.40
289_C300_C0.5300.40
75_R285_N0.5290.40
153_G158_A0.5280.40
34_R210_I0.5280.40
49_K156_V0.5270.40
11_A16_P0.5260.40
62_V65_D0.5260.40
28_I69_Q0.5250.39
235_S246_D0.5250.39
280_T284_P0.5240.39
51_L175_V0.5240.39
9_R115_E0.5240.39
266_F269_I0.5210.39
36_E99_E0.5200.39
44_I208_R0.5180.39
179_I265_Q0.5180.39
239_T242_A0.5150.38
193_P197_S0.5140.38
124_M140_F0.5140.38
182_D187_I0.5140.38
91_N95_K0.5140.38
9_R29_E0.5140.38
11_A15_Q0.5130.38
146_R231_C0.5130.38
286_C290_G0.5130.38
136_S301_K0.5120.38
241_R245_R0.5120.38
46_N160_Y0.5120.38
51_L201_V0.5120.38
243_K265_Q0.5110.38
88_Y112_G0.5100.38
95_K103_D0.5100.38
70_F291_E0.5090.38
35_V38_E0.5090.38
176_I262_I0.5070.38
229_T232_P0.5050.37
59_D145_R0.5040.37
186_L239_T0.5030.37
210_I218_Y0.5020.37
138_C166_N0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vrhA 2 0.9102 100 0.315 Contact Map
3a2kA 1 0.8607 100 0.406 Contact Map
1wy5A 4 0.8607 100 0.454 Contact Map
1ni5A 2 0.8266 100 0.459 Contact Map
2derA 1 0.8111 100 0.658 Contact Map
2hmaA 2 0.8328 99.9 0.672 Contact Map
4kr6A 2 0.7678 99.9 0.672 Contact Map
3tqiA 3 0.7957 99.9 0.679 Contact Map
3k32A 2 0.5975 99.9 0.682 Contact Map
1surA 2 0.6533 99.9 0.687 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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