GREMLIN Database
Q7LXT1 - Uncharacterized protein
UniProt: Q7LXT1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (168)
Sequences: 2444 (1579)
Seq/√Len: 121.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_L119_A3.9821.00
126_A143_L3.6971.00
21_D131_K2.9661.00
2_F88_V2.8181.00
26_N125_N2.6931.00
12_N17_R2.6771.00
37_F114_V2.5091.00
38_I54_L2.4241.00
41_A112_L2.3651.00
77_E81_K2.3471.00
21_D128_A2.3321.00
42_L51_Q2.2941.00
44_K107_E2.2391.00
37_F118_I2.2201.00
14_I69_I2.0951.00
25_V28_L2.0211.00
53_D86_R2.0151.00
60_E142_Y1.9921.00
53_D149_L1.9101.00
38_I150_L1.8811.00
156_V160_R1.8661.00
19_G131_K1.8631.00
30_D125_N1.8561.00
60_E79_T1.8001.00
77_E138_W1.7961.00
5_T12_N1.7871.00
149_L153_M1.7801.00
107_E111_Y1.7281.00
118_I121_R1.7211.00
53_D90_Y1.6681.00
26_N30_D1.6411.00
21_D127_V1.6371.00
82_W86_R1.6281.00
93_E160_R1.6221.00
109_A158_N1.6191.00
62_F65_G1.5941.00
67_E136_N1.5791.00
1_M152_S1.5341.00
115_V150_L1.5251.00
90_Y149_L1.5201.00
86_R89_E1.5161.00
112_L157_A1.4641.00
37_F115_V1.4401.00
22_S133_L1.4361.00
125_N128_A1.4051.00
81_K85_S1.3851.00
80_I138_W1.3541.00
129_Y133_L1.3441.00
2_F84_E1.3421.00
68_I126_A1.3371.00
11_T25_V1.3121.00
158_N165_E1.3101.00
50_M153_M1.2961.00
33_E121_R1.2951.00
35_N62_F1.2811.00
50_M157_A1.2761.00
36_S117_S1.2561.00
44_K111_Y1.2430.99
18_V22_S1.2240.99
40_L114_V1.2200.99
56_R82_W1.2100.99
91_R152_S1.1980.99
40_L111_Y1.1890.99
77_E141_V1.1680.99
106_S158_N1.1600.99
75_I79_T1.1580.99
94_S152_S1.1360.99
28_L68_I1.1310.99
10_N19_G1.1300.99
111_Y114_V1.1170.99
37_F111_Y1.1130.99
90_Y156_V1.1070.99
49_D89_E1.1000.99
2_F87_T1.0990.99
43_T107_E1.0790.98
41_A115_V1.0790.98
43_T110_S1.0740.98
67_E74_R1.0580.98
87_T152_S1.0350.98
41_A157_A1.0300.98
19_G22_S1.0210.98
27_L126_A1.0190.98
60_E82_W1.0190.98
14_I70_Q1.0160.98
86_R149_L1.0090.98
70_Q73_G1.0090.98
49_D160_R1.0050.98
45_I108_Q1.0020.98
130_S140_I0.9930.97
108_Q157_A0.9760.97
5_T17_R0.9750.97
57_V142_Y0.9640.97
5_T10_N0.9640.97
37_F41_A0.9440.96
24_V133_L0.9350.96
42_L55_M0.9340.96
95_G159_K0.9330.96
138_W141_V0.9330.96
99_L167_I0.9310.96
30_D121_R0.9290.96
98_K167_I0.9200.96
26_N128_A0.9150.96
43_T111_Y0.9010.95
13_V18_V0.8840.95
64_L139_I0.8830.95
100_F151_F0.8810.95
126_A139_I0.8790.95
51_Q55_M0.8730.95
35_N65_G0.8670.94
35_N58_Q0.8660.94
109_A165_E0.8550.94
32_D116_R0.8510.94
31_I61_L0.8460.94
59_T63_I0.8440.93
128_A132_E0.8270.93
159_K164_K0.8260.93
122_V143_L0.8250.93
12_N15_S0.8190.92
53_D89_E0.8140.92
55_M166_R0.8110.92
84_E88_V0.8080.92
89_E93_E0.8030.92
22_S132_E0.7980.91
78_E81_K0.7980.91
30_D122_V0.7970.91
90_Y153_M0.7960.91
23_P125_N0.7950.91
24_V28_L0.7920.91
119_A150_L0.7910.91
56_R60_E0.7870.91
39_G58_Q0.7840.91
105_G158_N0.7800.90
5_T8_D0.7730.90
76_N79_T0.7720.90
31_I64_L0.7700.90
40_L107_E0.7680.90
28_L117_S0.7670.90
54_L112_L0.7480.89
94_S97_V0.7470.88
114_V118_I0.7460.88
11_T18_V0.7410.88
130_S135_F0.7400.88
130_S134_N0.7390.88
86_R90_Y0.7340.88
34_L115_V0.7340.88
30_D118_I0.7330.88
80_I141_V0.7280.87
148_S155_I0.7270.87
91_R94_S0.7200.87
84_E87_T0.7160.86
8_D137_K0.7150.86
106_S109_A0.7100.86
66_E70_Q0.7090.86
8_D12_N0.7080.86
53_D82_W0.7050.85
56_R86_R0.7020.85
23_P132_E0.6990.85
48_E52_S0.6880.84
41_A111_Y0.6830.84
40_L44_K0.6800.83
27_L125_N0.6750.83
18_V25_V0.6690.82
106_S163_V0.6680.82
103_P116_R0.6660.82
4_R81_K0.6660.82
102_I105_G0.6630.82
112_L153_M0.6590.81
111_Y115_V0.6560.81
27_L31_I0.6510.81
101_V151_F0.6490.80
39_G65_G0.6480.80
136_N139_I0.6470.80
126_A140_I0.6440.80
63_I168_Y0.6440.80
127_V140_I0.6350.79
104_G110_S0.6330.79
101_V154_A0.6320.79
28_L88_V0.6200.77
93_E156_V0.6200.77
127_V130_S0.6190.77
85_S89_E0.6160.77
89_E92_K0.6160.77
13_V24_V0.6150.77
27_L129_Y0.6140.77
35_N105_G0.6110.76
109_A154_A0.6080.76
45_I157_A0.6070.76
97_V151_F0.6060.76
57_V146_L0.6060.76
65_G105_G0.6010.75
33_E118_I0.6000.75
31_I143_L0.5990.75
4_R141_V0.5980.75
106_S165_E0.5980.75
1_M94_S0.5950.74
94_S99_L0.5940.74
29_G32_D0.5890.74
62_F168_Y0.5880.74
113_H154_A0.5880.74
50_M156_V0.5860.73
11_T24_V0.5840.73
23_P27_L0.5830.73
58_Q65_G0.5810.73
19_G127_V0.5800.73
50_M90_Y0.5790.72
59_T168_Y0.5780.72
159_K163_V0.5780.72
101_V155_I0.5780.72
34_L37_F0.5740.72
47_W160_R0.5700.71
8_D17_R0.5700.71
6_G9_G0.5660.71
16_K71_D0.5600.70
48_E51_Q0.5590.70
55_M59_T0.5580.70
75_I138_W0.5580.70
31_I122_V0.5550.69
23_P128_A0.5530.69
72_K134_N0.5510.69
4_R77_E0.5510.69
30_D124_R0.5490.68
34_L41_A0.5490.68
36_S154_A0.5430.68
12_N16_K0.5390.67
14_I91_R0.5380.67
119_A146_L0.5380.67
43_T106_S0.5370.67
113_H155_I0.5340.66
129_Y135_F0.5320.66
122_V129_Y0.5290.66
109_A112_L0.5280.65
151_F158_N0.5260.65
108_Q111_Y0.5230.65
49_D93_E0.5200.64
107_E110_S0.5200.64
24_V68_I0.5180.64
36_S40_L0.5180.64
42_L166_R0.5170.64
35_N103_P0.5170.64
32_D154_A0.5160.64
90_Y168_Y0.5130.63
59_T62_F0.5120.63
56_R138_W0.5110.63
129_Y134_N0.5100.63
52_S92_K0.5080.62
57_V90_Y0.5070.62
137_K141_V0.5050.62
50_M149_L0.5040.62
88_V148_S0.5030.62
49_D52_S0.5010.61
94_S168_Y0.5010.61
114_V117_S0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rtyA 3 0.908 100 0.076 Contact Map
1nogA 4 0.8448 100 0.076 Contact Map
1wozA 3 0.8966 100 0.078 Contact Map
2nt8A 3 0.977 100 0.078 Contact Map
3ke4A 3 0.9483 100 0.079 Contact Map
2ah6A 3 0.9023 100 0.08 Contact Map
3ci3A 3 1 100 0.082 Contact Map
2zhyA 3 0.9598 100 0.085 Contact Map
2idxA 3 0.977 100 0.089 Contact Map
2g2dA 3 0.8563 100 0.1 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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