GREMLIN Database
Q7LXS9 - Uncharacterized protein
UniProt: Q7LXS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (101)
Sequences: 2093 (1130)
Seq/√Len: 112.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_D35_N3.8851.00
41_D53_R3.0771.00
51_Y85_E2.7241.00
49_D83_S2.6501.00
53_R87_D2.5261.00
105_E108_K2.3141.00
95_T98_K2.1611.00
51_Y87_D2.1341.00
72_E76_K2.0961.00
53_R89_D2.0671.00
54_L71_V2.0441.00
44_I50_V2.0111.00
99_M103_G1.9001.00
38_L67_L1.8401.00
45_N49_D1.8201.00
33_I39_I1.8131.00
52_L75_I1.7801.00
29_I110_L1.7381.00
18_M34_V1.7211.00
66_D70_T1.6521.00
49_D85_E1.6291.00
35_N103_G1.6101.00
49_D82_K1.5601.00
22_K102_E1.5461.00
40_Y98_K1.4491.00
34_V39_I1.4271.00
54_L64_V1.3941.00
33_I67_L1.3771.00
102_E106_K1.3431.00
55_G92_T1.3361.00
45_N51_Y1.3331.00
89_D92_T1.3000.99
70_T73_Q1.2910.99
21_L34_V1.2770.99
23_D74_V1.2060.99
35_N106_K1.2040.99
25_Y30_P1.1980.99
76_K84_V1.1860.99
69_Y72_E1.1720.99
24_V74_V1.1700.99
22_K35_N1.1500.99
39_I71_V1.1140.98
16_K19_E1.1080.98
25_Y29_I1.1060.98
15_K19_E1.1040.98
20_A74_V1.0770.98
56_L63_V1.0770.98
11_E14_K1.0660.98
100_T103_G1.0620.98
105_E109_Q1.0580.98
16_K80_P1.0220.97
68_I72_E1.0170.97
75_I78_S1.0170.97
31_V110_L1.0070.97
30_P58_A1.0030.97
21_L39_I0.9660.96
14_K18_M0.9650.96
48_G82_K0.9550.96
22_K32_D0.9550.96
43_K53_R0.9310.95
11_E15_K0.9230.95
68_I86_V0.9220.95
65_D70_T0.9110.95
30_P63_V0.8990.94
69_Y73_Q0.8950.94
20_A79_V0.8750.93
68_I88_I0.8560.93
47_D82_K0.8540.92
101_A105_E0.8520.92
97_L107_F0.8480.92
103_G108_K0.8470.92
43_K51_Y0.8410.92
20_A24_V0.8400.92
38_L54_L0.8260.91
40_Y55_G0.8230.91
102_E105_E0.8080.90
21_L71_V0.8080.90
17_I75_I0.8010.90
10_K46_D0.7800.89
42_L62_P0.7750.88
20_A81_A0.7660.88
76_K83_S0.7640.88
58_A98_K0.7510.87
14_K42_L0.7410.86
90_L93_Q0.7360.86
38_L56_L0.7150.84
20_A78_S0.7080.83
64_V67_L0.7040.83
64_V68_I0.7030.83
14_K41_D0.6890.82
13_W81_A0.6860.81
35_N102_E0.6840.81
20_A77_E0.6800.81
70_T74_V0.6780.81
12_E16_K0.6690.80
56_L90_L0.6690.80
76_K82_K0.6670.79
67_L96_P0.6620.79
50_V81_A0.6560.78
58_A88_I0.6470.77
71_V86_V0.6470.77
99_M107_F0.6410.77
96_P104_R0.6400.77
59_P98_K0.6300.76
41_D51_Y0.6270.75
59_P90_L0.6230.75
25_Y32_D0.6160.74
72_E85_E0.6160.74
33_I89_D0.6130.74
10_K13_W0.6050.73
15_K51_Y0.6040.72
103_G109_Q0.5990.72
22_K34_V0.5980.72
99_M104_R0.5980.72
58_A62_P0.5970.72
38_L64_V0.5960.71
39_I64_V0.5920.71
37_G57_T0.5910.71
42_L50_V0.5880.70
24_V33_I0.5870.70
58_A63_V0.5760.69
40_Y92_T0.5760.69
13_W44_I0.5720.68
28_E37_G0.5680.68
62_P74_V0.5680.68
58_A64_V0.5640.67
60_G96_P0.5630.67
58_A96_P0.5600.67
55_G98_K0.5560.66
54_L67_L0.5560.66
32_D102_E0.5500.65
12_E15_K0.5450.65
29_I101_A0.5370.64
74_V79_V0.5350.63
71_V75_I0.5330.63
60_G69_Y0.5310.63
20_A23_D0.5300.63
16_K79_V0.5290.62
75_I84_V0.5260.62
42_L63_V0.5240.62
93_Q98_K0.5220.61
21_L33_I0.5220.61
30_P59_P0.5130.60
19_E43_K0.5130.60
25_Y38_L0.5120.60
28_E57_T0.5110.60
30_P96_P0.5090.59
52_L71_V0.5070.59
40_Y56_L0.5040.59
56_L60_G0.5020.58
54_L90_L0.5000.58
55_G64_V0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnoA 1 0.8106 100 0.372 Contact Map
1uwdA 1 0.7727 100 0.398 Contact Map
3cq1A 2 0.75 100 0.403 Contact Map
3ux2A 2 0.8712 99.9 0.433 Contact Map
2m5oA 1 0.6742 91.2 0.885 Contact Map
1vehA 1 0.6742 88.9 0.89 Contact Map
1xhjA 1 0.6515 88.2 0.892 Contact Map
1yg0A 1 0.4773 33.1 0.928 Contact Map
2aj0A 1 0.4773 28.2 0.931 Contact Map
4q2lA 1 0.4242 25.3 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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