GREMLIN Database
Q7LXS8 - Uncharacterized protein
UniProt: Q7LXS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 506 (389)
Sequences: 5183 (3280)
Seq/√Len: 166.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_I257_L4.3731.00
261_V301_Y4.1651.00
350_V367_E3.8711.00
349_S405_R3.7951.00
349_S402_D3.5821.00
351_K402_D3.4421.00
442_L446_H3.3841.00
325_S379_I3.2951.00
370_P412_N2.8691.00
296_L299_K2.7401.00
298_K330_I2.6921.00
295_T329_E2.6871.00
351_K355_E2.6761.00
317_S375_E2.6401.00
255_K258_Q2.6361.00
257_L297_V2.6091.00
258_Q262_R2.5511.00
250_L296_L2.5381.00
374_E412_N2.5371.00
408_E411_D2.4871.00
448_E451_R2.4861.00
408_E412_N2.4721.00
266_R302_K2.4421.00
182_V185_K2.4261.00
257_L268_G2.4051.00
370_P413_L2.2601.00
436_W439_R2.2471.00
399_T402_D2.2051.00
403_V446_H2.1311.00
298_K336_Q2.1171.00
345_I409_L2.0701.00
374_E378_K2.0261.00
261_V300_Y2.0231.00
404_Y408_E2.0061.00
298_K335_E2.0021.00
325_S329_E1.9961.00
312_A316_Y1.9961.00
295_T326_K1.9731.00
163_E167_E1.9431.00
414_R455_W1.9221.00
164_D169_V1.9201.00
448_E452_K1.9121.00
453_V456_H1.8931.00
422_P429_G1.8821.00
347_T406_T1.8761.00
313_A316_Y1.8661.00
404_Y446_H1.8651.00
164_D168_K1.8461.00
289_P292_K1.8421.00
111_P114_S1.8381.00
350_V362_A1.8341.00
371_E374_E1.8291.00
400_E439_R1.8151.00
362_A405_R1.8091.00
362_A408_E1.7861.00
254_E258_Q1.7551.00
259_T263_A1.7241.00
175_V186_L1.6691.00
328_G379_I1.6551.00
419_I444_E1.6481.00
258_Q300_Y1.6381.00
439_R442_L1.6271.00
288_E296_L1.6121.00
449_L452_K1.6071.00
368_E371_E1.5981.00
289_P318_E1.5891.00
110_G114_S1.5861.00
362_A409_L1.5751.00
303_T308_H1.5721.00
458_V461_A1.5461.00
248_Y256_E1.5361.00
311_L316_Y1.5341.00
156_T174_L1.5171.00
482_L488_F1.4861.00
254_E296_L1.4711.00
249_P252_K1.4511.00
150_L173_T1.4491.00
85_D95_Y1.4261.00
255_K259_T1.4181.00
466_N483_K1.4111.00
123_E126_N1.4001.00
308_H311_L1.3911.00
141_E172_D1.3901.00
405_R408_E1.3881.00
339_L485_F1.3861.00
362_A370_P1.3851.00
407_I446_H1.3851.00
292_K296_L1.3841.00
402_D405_R1.3701.00
352_L355_E1.3681.00
83_I95_Y1.3641.00
88_H91_R1.3571.00
298_K326_K1.3561.00
257_L300_Y1.3561.00
302_K466_N1.3561.00
391_M410_V1.3541.00
400_E404_Y1.3531.00
477_P480_F1.3511.00
317_S325_S1.3451.00
162_R168_K1.3411.00
234_S242_I1.3331.00
427_P430_F1.3151.00
375_E378_K1.3121.00
308_H312_A1.3111.00
236_R357_M1.3101.00
327_L341_V1.3071.00
173_T190_I1.3051.00
312_A315_R1.2961.00
375_E379_I1.2931.00
422_P434_R1.2931.00
367_E370_P1.2921.00
326_K330_I1.2901.00
341_V376_A1.2881.00
306_W310_S1.2871.00
371_E375_E1.2711.00
162_R165_M1.2681.00
327_L337_R1.2571.00
401_D405_R1.2551.00
482_L486_L1.2521.00
124_P130_F1.2501.00
441_K445_A1.2451.00
324_I379_I1.2441.00
414_R456_H1.2441.00
372_I375_E1.2351.00
303_T306_W1.2351.00
361_S368_E1.2341.00
370_P374_E1.2331.00
95_Y98_A1.2311.00
288_E292_K1.2251.00
457_D460_W1.2221.00
355_E431_F1.2151.00
152_G175_V1.2141.00
236_R427_P1.2101.00
456_H459_Y1.2081.00
248_Y252_K1.2031.00
91_R94_K1.2011.00
148_K190_I1.1991.00
291_I326_K1.1981.00
301_Y304_I1.1861.00
481_A487_R1.1851.00
290_L294_H1.1851.00
407_I450_Y1.1831.00
400_E442_L1.1811.00
87_D91_R1.1791.00
294_H330_I1.1791.00
339_L483_K1.1781.00
250_L254_E1.1751.00
377_F381_H1.1741.00
97_K101_F1.1701.00
310_S313_A1.1701.00
189_M194_E1.1671.00
361_S367_E1.1671.00
437_F441_K1.1651.00
295_T299_K1.1631.00
211_D215_E1.1531.00
140_Q147_M1.1491.00
485_F488_F1.1431.00
368_E372_I1.1411.00
295_T318_E1.1361.00
355_E402_D1.1351.00
115_T150_L1.1301.00
349_S352_L1.1201.00
482_L487_R1.1161.00
188_Q192_D1.1141.00
454_F458_V1.1101.00
259_T262_R1.1091.00
350_V405_R1.1081.00
309_A312_A1.1061.00
401_D404_Y1.1011.00
325_S328_G1.0911.00
270_V297_V1.0911.00
85_D88_H1.0891.00
311_L314_I1.0841.00
225_I253_I1.0841.00
482_L485_F1.0831.00
357_M427_P1.0781.00
480_F488_F1.0751.00
330_I335_E1.0751.00
460_W465_I1.0731.00
339_L382_E1.0721.00
294_H337_R1.0700.99
419_I441_K1.0650.99
330_I337_R1.0650.99
309_A316_Y1.0600.99
166_I169_V1.0510.99
185_K189_M1.0470.99
144_K147_M1.0410.99
348_G409_L1.0390.99
189_M193_N1.0380.99
327_L380_M1.0370.99
162_R169_V1.0300.99
117_W120_T1.0300.99
116_W119_I1.0290.99
295_T330_I1.0250.99
478_V482_L1.0250.99
292_K318_E1.0180.99
308_H313_A1.0170.99
94_K98_A1.0160.99
369_Y415_P1.0160.99
384_K387_P1.0150.99
251_E255_K1.0140.99
341_V383_N1.0130.99
208_P211_D1.0100.99
201_Y204_G1.0090.99
105_D188_Q1.0050.99
407_I411_D1.0030.99
373_V377_F1.0020.99
376_A380_M1.0020.99
82_A86_P1.0000.99
199_Y202_V0.9980.99
277_F314_I0.9960.99
481_A488_F0.9720.99
391_M447_I0.9690.99
382_E385_I0.9680.99
311_L315_R0.9670.99
355_E397_E0.9660.99
312_A317_S0.9620.99
324_I376_A0.9620.99
208_P215_E0.9600.99
250_L292_K0.9580.99
480_F485_F0.9570.99
397_E433_N0.9500.99
122_K125_I0.9490.99
397_E434_R0.9490.99
104_H107_F0.9460.99
123_E127_Y0.9440.99
340_G388_A0.9440.99
367_E371_E0.9400.99
131_Q134_I0.9390.99
350_V361_S0.9370.99
96_A100_M0.9360.99
310_S315_R0.9350.99
372_I376_A0.9290.99
198_K201_Y0.9290.99
400_E446_H0.9280.99
404_Y407_I0.9200.98
98_A152_G0.9140.98
157_W176_D0.9120.98
326_K329_E0.9110.98
148_K191_L0.9110.98
376_A383_N0.9110.98
85_D91_R0.9080.98
437_F440_V0.9060.98
443_S446_H0.9030.98
122_K151_V0.8990.98
121_K125_I0.8970.98
162_R166_I0.8950.98
481_A485_F0.8940.98
302_K336_Q0.8930.98
472_G477_P0.8930.98
107_F110_G0.8920.98
473_P476_M0.8910.98
115_T118_G0.8910.98
440_V444_E0.8900.98
326_K337_R0.8900.98
107_F111_P0.8880.98
255_K262_R0.8870.98
164_D167_E0.8860.98
150_L175_V0.8840.98
99_L103_H0.8830.98
410_V447_I0.8750.98
232_A280_A0.8750.98
484_L488_F0.8720.98
165_M171_V0.8710.98
419_I437_F0.8700.98
102_S187_A0.8690.98
177_G180_E0.8570.98
112_P119_I0.8530.97
97_K100_M0.8530.97
382_E463_D0.8530.97
310_S316_Y0.8530.97
210_I214_S0.8500.97
115_T119_I0.8490.97
228_M245_T0.8480.97
316_Y323_L0.8450.97
258_Q296_L0.8430.97
302_K335_E0.8420.97
86_P89_L0.8410.97
234_S357_M0.8380.97
435_D438_T0.8360.97
298_K337_R0.8360.97
282_G285_P0.8350.97
351_K399_T0.8310.97
141_E145_R0.8290.97
294_H323_L0.8290.97
330_I336_Q0.8270.97
132_A135_S0.8250.97
87_D94_K0.8240.97
85_D89_L0.8230.97
254_E297_V0.8230.97
250_L293_L0.8200.97
88_H94_K0.8190.97
253_I293_L0.8170.97
242_I427_P0.8140.97
393_V403_V0.8140.97
456_H460_W0.8100.97
128_K131_Q0.8100.97
362_A367_E0.8080.97
90_D93_L0.8070.97
82_A119_I0.8060.96
223_G260_N0.8030.96
87_D90_D0.8020.96
309_A314_I0.8010.96
201_Y205_D0.7980.96
188_Q191_L0.7970.96
86_P90_D0.7960.96
82_A85_D0.7960.96
304_I336_Q0.7960.96
110_G113_S0.7930.96
434_R437_F0.7930.96
268_G301_Y0.7910.96
311_L317_S0.7910.96
116_W120_T0.7860.96
279_G282_G0.7850.96
197_P200_V0.7840.96
460_W463_D0.7810.96
438_T442_L0.7800.96
352_L402_D0.7800.96
466_N485_F0.7790.96
250_L288_E0.7790.96
461_A464_I0.7760.96
403_V447_I0.7700.95
179_G182_V0.7690.95
483_K487_R0.7680.95
233_R277_F0.7660.95
236_R395_L0.7630.95
233_R274_D0.7620.95
351_K354_K0.7610.95
138_E142_A0.7570.95
434_R438_T0.7570.95
224_M269_V0.7550.95
137_P151_V0.7540.95
409_L413_L0.7520.95
148_K173_T0.7510.95
443_S447_I0.7490.95
139_I142_A0.7480.95
291_I323_L0.7450.95
275_V306_W0.7450.95
95_Y102_S0.7450.95
122_K126_N0.7420.94
226_E229_R0.7370.94
212_D252_K0.7370.94
200_V203_S0.7350.94
317_S324_I0.7340.94
122_K133_L0.7320.94
306_W309_A0.7300.94
124_P128_K0.7290.94
215_E218_G0.7290.94
393_V447_I0.7280.94
309_A313_A0.7260.94
220_S223_G0.7250.94
377_F380_M0.7250.94
395_L428_M0.7240.94
377_F414_R0.7220.94
410_V414_R0.7210.94
267_H305_A0.7200.94
85_D93_L0.7200.94
213_I217_K0.7190.93
175_V179_G0.7160.93
328_G380_M0.7150.93
483_K486_L0.7130.93
141_E149_I0.7120.93
85_D92_H0.7120.93
165_M168_K0.7100.93
102_S106_Y0.7080.93
133_L151_V0.7080.93
308_H314_I0.7080.93
137_P149_I0.7070.93
251_E258_Q0.7060.93
98_A101_F0.7050.93
404_Y411_D0.7050.93
373_V413_L0.7030.93
306_W327_L0.7020.93
209_D212_D0.7020.93
303_T312_A0.7010.93
208_P217_K0.7010.93
369_Y373_V0.7000.93
250_L278_Y0.7000.93
431_F434_R0.6990.92
210_I217_K0.6980.92
183_V187_A0.6980.92
308_H315_R0.6970.92
85_D90_D0.6920.92
97_K102_S0.6910.92
323_L326_K0.6900.92
217_K263_A0.6900.92
81_A85_D0.6880.92
445_A449_L0.6850.92
434_R440_V0.6840.92
227_I293_L0.6840.92
237_F360_K0.6830.92
404_Y442_L0.6830.92
118_G125_I0.6800.91
251_E296_L0.6790.91
190_I193_N0.6790.91
208_P213_I0.6770.91
210_I215_E0.6760.91
180_E229_R0.6760.91
313_A317_S0.6740.91
355_E433_N0.6720.91
317_S379_I0.6710.91
190_I194_E0.6680.91
304_I308_H0.6680.91
292_K295_T0.6660.91
411_D453_V0.6640.90
236_R355_E0.6620.90
296_L300_Y0.6620.90
348_G406_T0.6610.90
370_P409_L0.6580.90
433_N436_W0.6580.90
87_D102_S0.6580.90
480_F487_R0.6540.90
277_F313_A0.6540.90
245_T277_F0.6530.90
112_P140_Q0.6530.90
376_A385_I0.6530.90
81_A86_P0.6510.90
139_I143_K0.6510.90
465_I483_K0.6500.90
227_I253_I0.6490.89
373_V387_P0.6490.89
106_Y110_G0.6460.89
88_H102_S0.6450.89
480_F484_L0.6450.89
95_Y99_L0.6440.89
460_W486_L0.6440.89
107_F140_Q0.6440.89
350_V354_K0.6440.89
381_H384_K0.6420.89
103_H106_Y0.6420.89
480_F486_L0.6380.89
173_T186_L0.6370.89
310_S314_I0.6370.89
444_E448_E0.6370.89
91_R102_S0.6370.89
306_W316_Y0.6370.89
208_P216_I0.6350.88
380_M383_N0.6330.88
260_N265_V0.6330.88
82_A110_G0.6320.88
478_V488_F0.6310.88
214_S217_K0.6300.88
483_K488_F0.6290.88
302_K308_H0.6280.88
101_F107_F0.6280.88
252_K255_K0.6240.88
189_M192_D0.6230.87
297_V301_Y0.6200.87
435_D443_S0.6190.87
478_V481_A0.6180.87
455_W458_V0.6150.87
410_V415_P0.6140.87
90_D94_K0.6140.87
351_K405_R0.6110.86
393_V419_I0.6070.86
476_M479_R0.6050.86
141_E147_M0.6040.86
118_G122_K0.6020.86
116_W136_K0.6020.86
406_T410_V0.6010.86
204_G207_V0.5990.85
121_K239_S0.5970.85
346_E358_P0.5930.85
467_S470_M0.5920.85
250_L289_P0.5910.85
88_H93_L0.5910.85
276_L344_G0.5910.85
148_K187_A0.5900.85
237_F420_L0.5890.84
200_V204_G0.5890.84
122_K130_F0.5890.84
342_E390_T0.5860.84
484_L487_R0.5850.84
85_D94_K0.5850.84
211_D214_S0.5850.84
313_A359_A0.5820.84
210_I213_I0.5820.84
282_G286_R0.5820.84
400_E407_I0.5810.84
103_H107_F0.5810.84
390_T423_M0.5800.84
103_H108_A0.5770.83
345_I391_M0.5770.83
453_V457_D0.5770.83
289_P316_Y0.5760.83
481_A486_L0.5750.83
150_L186_L0.5720.83
126_N129_S0.5720.83
315_R323_L0.5710.83
236_R428_M0.5690.82
291_I295_T0.5690.82
82_A87_D0.5690.82
85_D102_S0.5680.82
80_K88_H0.5680.82
459_Y463_D0.5660.82
86_P91_R0.5660.82
248_Y253_I0.5650.82
119_I125_I0.5640.82
121_K126_N0.5640.82
118_G121_K0.5610.81
87_D93_L0.5610.81
403_V407_I0.5600.81
481_A489_A0.5570.81
81_A88_H0.5560.81
82_A88_H0.5560.81
483_K489_A0.5560.81
120_T126_N0.5540.81
163_E168_K0.5540.81
455_W459_Y0.5540.81
420_L428_M0.5520.80
165_M169_V0.5520.80
373_V381_H0.5520.80
100_M104_H0.5520.80
212_D215_E0.5510.80
300_Y336_Q0.5500.80
424_F429_G0.5490.80
97_K107_F0.5480.80
383_N387_P0.5470.80
124_P392_I0.5430.79
89_L94_K0.5430.79
101_F106_Y0.5420.79
391_M406_T0.5420.79
324_I375_E0.5400.79
477_P489_A0.5390.79
367_E374_E0.5390.79
223_G265_V0.5380.79
297_V304_I0.5380.79
251_E254_E0.5370.79
98_A102_S0.5370.79
452_K455_W0.5370.79
435_D440_V0.5350.78
254_E293_L0.5350.78
261_V302_K0.5340.78
303_T311_L0.5330.78
242_I357_M0.5320.78
290_L323_L0.5310.78
122_K137_P0.5310.78
151_V156_T0.5310.78
228_M272_S0.5310.78
185_K188_Q0.5310.78
98_A107_F0.5290.78
236_R431_F0.5280.77
119_I122_K0.5280.77
117_W122_K0.5280.77
81_A109_F0.5260.77
140_Q144_K0.5250.77
285_P288_E0.5250.77
134_I137_P0.5250.77
178_E237_F0.5250.77
339_L380_M0.5230.77
86_P93_L0.5220.77
94_K102_S0.5220.77
242_I425_F0.5200.76
441_K444_E0.5200.76
350_V371_E0.5190.76
81_A102_S0.5180.76
83_I99_L0.5170.76
482_L489_A0.5170.76
407_I449_L0.5150.76
88_H98_A0.5140.76
88_H92_H0.5140.76
306_W313_A0.5140.76
268_G303_T0.5140.76
86_P133_L0.5130.75
301_Y336_Q0.5120.75
116_W121_K0.5120.75
324_I328_G0.5110.75
355_E395_L0.5110.75
225_I260_N0.5110.75
281_V285_P0.5100.75
121_K130_F0.5100.75
91_R95_Y0.5100.75
93_L226_E0.5100.75
119_I123_E0.5090.75
373_V376_A0.5080.75
342_E423_M0.5050.74
460_W484_L0.5050.74
95_Y106_Y0.5050.74
117_W121_K0.5050.74
183_V188_Q0.5030.74
81_A84_I0.5020.74
221_V265_V0.5010.74
81_A94_K0.5000.74
123_E130_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.7688 100 0.579 Contact Map
2qgqA 1 0.4901 100 0.697 Contact Map
1oltA 1 0.585 99.9 0.796 Contact Map
4u0oB 1 0.5059 99.9 0.813 Contact Map
1r30A 2 0.5711 99.9 0.825 Contact Map
3iixA 1 0.6008 99.9 0.825 Contact Map
4r33A 2 0.6502 99.9 0.825 Contact Map
3t7vA 1 0.5731 99.9 0.826 Contact Map
4wcxA 1 0.6225 99.8 0.833 Contact Map
4rtbA 2 0.6087 99.8 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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