GREMLIN Database
Q7LXS6 - Transcriptional regulator, putative
UniProt: Q7LXS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (140)
Sequences: 13727 (8876)
Seq/√Len: 750.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E36_E2.9171.00
52_V60_F2.8451.00
80_K138_R2.5501.00
108_E140_Y2.5421.00
101_A114_I2.5301.00
30_L48_M2.2991.00
118_R122_E2.2881.00
67_S121_E2.1051.00
15_D47_R2.0791.00
21_E28_T2.0121.00
50_R54_E2.0091.00
58_K65_D1.9701.00
96_A129_Q1.9391.00
82_D137_E1.8871.00
58_K63_L1.8081.00
74_T114_I1.8031.00
76_I103_Y1.7901.00
100_T116_K1.7341.00
14_I39_V1.7331.00
96_A126_F1.7131.00
49_T53_Q1.6871.00
21_E24_R1.6681.00
39_V43_T1.6321.00
78_M142_S1.5971.00
31_R35_E1.5951.00
28_T36_E1.5511.00
92_E133_N1.5321.00
119_S122_E1.5281.00
122_E125_S1.5171.00
92_E95_N1.5131.00
32_R35_E1.5021.00
31_R41_P1.4961.00
98_N122_E1.4751.00
39_V44_L1.4601.00
40_S43_T1.4321.00
30_L45_H1.4031.00
79_A113_I1.3941.00
18_L33_L1.3881.00
147_V150_E1.3861.00
89_F93_I1.3791.00
90_E94_A1.3731.00
80_K108_E1.3601.00
27_R60_F1.3571.00
37_M44_L1.3331.00
78_M109_Y1.3221.00
87_V91_K1.3041.00
125_S128_K1.2991.00
13_A17_R1.2841.00
85_H88_E1.2791.00
73_L120_V1.2671.00
71_F118_R1.2601.00
32_R36_E1.2591.00
77_I115_A1.2571.00
28_T33_L1.2311.00
81_V89_F1.2231.00
80_K137_E1.2061.00
14_I17_R1.2031.00
22_L48_M1.1991.00
24_R36_E1.1991.00
124_D146_N1.1801.00
90_E146_N1.1751.00
49_T52_V1.1731.00
29_S32_R1.1481.00
12_D47_R1.1441.00
98_N129_Q1.1271.00
25_D36_E1.1181.00
21_E33_L1.1011.00
14_I37_M1.0931.00
78_M140_Y1.0931.00
59_S63_L1.0881.00
74_T116_K1.0751.00
30_L34_A1.0641.00
17_R20_I1.0371.00
99_V115_A1.0231.00
17_R21_E1.0211.00
102_V113_I0.9981.00
90_E111_V0.9891.00
20_I24_R0.9861.00
117_F122_E0.9861.00
28_T32_R0.9831.00
45_H49_T0.9811.00
65_D68_K0.9761.00
26_A60_F0.9661.00
88_E92_E0.9621.00
34_A44_L0.9551.00
27_R52_V0.9521.00
91_K94_A0.9511.00
76_I112_V0.9471.00
105_V112_V0.9381.00
41_P45_H0.9331.00
103_Y114_I0.9171.00
117_F123_L0.9171.00
91_K95_N0.9141.00
76_I114_I0.9101.00
108_E138_R0.9051.00
117_F126_F0.9031.00
17_R37_M0.9031.00
115_A126_F0.8981.00
30_L41_P0.8971.00
34_A39_V0.8901.00
31_R45_H0.8711.00
72_A119_S0.8651.00
99_V102_V0.8591.00
11_L16_R0.8561.00
66_Y116_K0.8381.00
51_M56_M0.8261.00
82_D85_H0.8251.00
76_I144_V0.8161.00
26_A32_R0.8091.00
99_V113_I0.8081.00
15_D50_R0.8061.00
103_Y144_V0.8041.00
16_R20_I0.7961.00
79_A89_F0.7941.00
127_L141_T0.7881.00
103_Y147_V0.7821.00
42_A46_N0.7701.00
87_V90_E0.7671.00
92_E96_A0.7641.00
93_I102_V0.7611.00
33_L44_L0.7601.00
78_M112_V0.7581.00
26_A62_A0.7581.00
33_L48_M0.7561.00
125_S129_Q0.7561.00
86_L111_V0.7531.00
18_L47_R0.7471.00
131_L139_T0.7411.00
12_D15_D0.7401.00
88_E91_K0.7241.00
109_Y140_Y0.7221.00
18_L44_L0.7111.00
121_E124_D0.7051.00
11_L56_M0.7021.00
106_V143_I0.6951.00
21_E25_D0.6901.00
75_G123_L0.6881.00
82_D135_K0.6871.00
80_K109_Y0.6851.00
18_L28_T0.6851.00
98_N126_F0.6841.00
71_F98_N0.6821.00
71_F116_K0.6791.00
25_D28_T0.6721.00
56_M68_K0.6701.00
90_E148_V0.6681.00
78_M108_E0.6641.00
89_F111_V0.6641.00
77_I139_T0.6601.00
13_A16_R0.6601.00
104_D111_V0.6591.00
120_V143_I0.6541.00
46_N50_R0.6441.00
18_L21_E0.6421.00
77_I113_I0.6411.00
15_D51_M0.6371.00
98_N118_R0.6331.00
74_T144_V0.6301.00
19_L51_M0.6291.00
88_E135_K0.6291.00
75_G143_I0.6291.00
93_I113_I0.6271.00
121_E125_S0.6231.00
34_A41_P0.6231.00
42_A45_H0.6191.00
47_R51_M0.6191.00
46_N49_T0.6171.00
55_G58_K0.6131.00
26_A59_S0.6121.00
18_L48_M0.6081.00
65_D69_L0.6081.00
127_L139_T0.6051.00
64_L69_L0.6051.00
18_L51_M0.5941.00
30_L44_L0.5921.00
105_V109_Y0.5881.00
79_A136_I0.5881.00
122_E126_F0.5871.00
87_V132_K0.5851.00
92_E134_P0.5771.00
129_Q133_N0.5761.00
96_A133_N0.5751.00
101_A150_E0.5631.00
74_T147_V0.5631.00
74_T103_Y0.5601.00
23_T61_V0.5501.00
75_G141_T0.5501.00
85_H134_P0.5481.00
88_E134_P0.5471.00
120_V145_L0.5461.00
57_I60_F0.5431.00
126_F129_Q0.5431.00
14_I43_T0.5401.00
63_L66_Y0.5371.00
104_D110_D0.5371.00
80_K140_Y0.5341.00
79_A139_T0.5291.00
104_D124_D0.5281.00
105_V142_S0.5241.00
50_R53_Q0.5211.00
105_V144_V0.5171.00
31_R34_A0.5161.00
108_E142_S0.5111.00
102_V148_V0.5101.00
126_F130_L0.5081.00
78_M105_V0.5061.00
92_E135_K0.5031.00
121_E146_N0.5031.00
100_T114_I0.5011.00
81_V110_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9236 100 0.15 Contact Map
4un1A 1 0.9045 100 0.183 Contact Map
2e1cA 1 0.9363 100 0.198 Contact Map
4un1B 1 0.949 100 0.207 Contact Map
4pcqA 2 0.9363 100 0.209 Contact Map
2p5vA 5 0.9682 100 0.215 Contact Map
2ia0A 2 0.9172 100 0.219 Contact Map
2pn6A 5 0.9363 100 0.24 Contact Map
3i4pA 5 0.9299 100 0.244 Contact Map
2cg4A 6 0.9363 100 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.