GREMLIN Database
Q7LXS5 - Uncharacterized protein
UniProt: Q7LXS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (189)
Sequences: 2442 (1633)
Seq/√Len: 118.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_I199_I4.0851.00
35_N38_S3.4701.00
56_T151_A3.2651.00
82_I193_I3.1521.00
59_L127_T3.0881.00
155_Y159_L2.8401.00
90_Y93_V2.8041.00
79_A190_Q2.8001.00
11_A149_L2.5581.00
49_N155_Y2.5431.00
54_A114_I2.5221.00
56_T148_L2.4951.00
78_S198_Q2.4821.00
190_Q194_D2.3651.00
58_L119_T2.2381.00
89_V192_I2.1571.00
7_I146_G2.1121.00
67_G71_A2.0841.00
169_G172_G2.0711.00
53_I57_V2.0691.00
27_L31_Y1.9641.00
11_A153_L1.9531.00
10_I146_G1.9311.00
55_V151_A1.8941.00
64_I144_I1.8501.00
7_I145_L1.8321.00
52_S151_A1.8271.00
92_G185_A1.7541.00
40_N159_L1.6841.00
163_I166_R1.6841.00
94_D99_F1.6751.00
54_A118_A1.6731.00
18_M150_A1.6721.00
60_L144_I1.6701.00
19_D22_S1.6671.00
56_T60_L1.6651.00
78_S81_E1.6481.00
82_I199_I1.6381.00
86_I89_V1.5471.00
135_S140_L1.5421.00
58_L123_V1.5371.00
86_I192_I1.5271.00
59_L123_V1.5081.00
27_L43_S1.4951.00
10_I134_L1.4841.00
14_L131_L1.4731.00
81_E194_D1.4471.00
59_L131_L1.3881.00
122_I154_V1.3581.00
89_V188_G1.3561.00
49_N159_L1.3561.00
79_A193_I1.3421.00
135_S143_L1.3421.00
7_I149_L1.3411.00
60_L148_L1.3171.00
63_S131_L1.3111.00
193_I196_I1.3001.00
27_L117_I1.3001.00
152_L156_L1.2640.99
7_I11_A1.2620.99
95_T181_A1.2500.99
41_K50_K1.2360.99
95_T180_M1.2300.99
113_I118_A1.2300.99
34_F38_S1.2260.99
18_M151_A1.2230.99
85_G192_I1.2190.99
160_L163_I1.2030.99
22_S25_P1.1930.99
39_Q162_P1.1880.99
131_L147_S1.1770.99
51_L55_V1.1770.99
52_S154_V1.1730.99
52_S155_Y1.1710.99
50_K111_E1.1610.99
63_S144_I1.1600.99
36_R39_Q1.1500.99
31_Y39_Q1.1370.99
36_R40_N1.1260.99
57_V61_F1.1230.99
65_L69_L1.1220.99
156_L160_L1.1190.99
49_N53_I1.1180.99
95_T177_G1.1100.99
82_I196_I1.1090.99
163_I167_I1.0800.98
23_I158_L1.0770.98
168_L172_G1.0670.98
184_I188_G1.0660.98
81_E198_Q1.0650.98
14_L147_S1.0640.98
34_F42_I1.0630.98
63_S135_S1.0610.98
82_I192_I1.0550.98
85_G195_G1.0520.98
76_S190_Q1.0440.98
16_A19_D1.0400.98
25_P28_I1.0190.98
58_L118_A1.0040.97
185_A188_G0.9990.97
70_L186_A0.9920.97
16_A73_L0.9870.97
127_T131_L0.9770.97
87_I185_A0.9530.96
19_D88_L0.9470.96
17_I130_G0.9420.96
89_V93_V0.9420.96
18_M127_T0.9270.96
28_I165_I0.9220.96
40_N49_N0.9170.95
59_L128_M0.9140.95
61_F65_L0.9110.95
82_I195_G0.9100.95
63_S140_L0.9100.95
89_V185_A0.9060.95
15_Y153_L0.9040.95
55_V118_A0.9030.95
86_I93_V0.9020.95
87_I91_L0.9020.95
140_L144_I0.9020.95
54_A113_I0.8990.95
17_I126_G0.8950.95
123_V147_S0.8710.94
22_S26_Y0.8580.94
141_I145_L0.8480.93
152_L163_I0.8420.93
51_L112_A0.8390.93
83_G189_V0.8370.93
128_M132_I0.8370.93
27_L161_G0.8200.92
13_K130_G0.8110.92
69_L128_M0.8100.92
100_Q103_K0.8090.91
15_Y157_S0.8070.91
142_I145_L0.7980.91
80_L129_T0.7920.91
40_N155_Y0.7840.90
22_S154_V0.7830.90
62_F132_I0.7810.90
178_R189_V0.7750.90
27_L125_P0.7680.89
23_I122_I0.7670.89
52_S55_V0.7660.89
38_S42_I0.7630.89
88_L133_T0.7620.89
100_Q105_L0.7610.89
71_A141_I0.7550.88
20_P150_A0.7520.88
65_L68_P0.7520.88
6_S138_N0.7500.88
103_K106_S0.7420.88
123_V181_A0.7420.88
80_L130_G0.7370.87
23_I121_L0.7340.87
76_S79_A0.7330.87
19_D25_P0.7280.87
68_P71_A0.7240.86
82_I189_V0.7160.86
87_I173_T0.7160.86
19_D180_M0.7130.85
141_I144_I0.7100.85
36_R162_P0.7090.85
118_A123_V0.7060.85
15_Y150_A0.7060.85
94_D97_G0.7050.85
14_L59_L0.7020.84
80_L151_A0.6990.84
24_L28_I0.6960.84
43_S176_V0.6940.84
98_G178_R0.6870.83
96_L181_A0.6860.83
19_D62_F0.6850.83
146_G150_A0.6840.83
134_L143_L0.6790.82
11_A146_G0.6770.82
27_L39_Q0.6750.82
114_I171_T0.6720.82
139_N142_I0.6590.81
58_L160_L0.6560.80
24_L158_L0.6550.80
150_A153_L0.6550.80
37_N40_N0.6510.80
41_K196_I0.6480.79
16_A78_S0.6470.79
78_S193_I0.6470.79
94_D103_K0.6460.79
20_P125_P0.6400.79
24_L157_S0.6400.79
75_I101_Q0.6400.79
63_S179_F0.6360.78
129_T132_I0.6360.78
79_A83_G0.6350.78
92_G96_L0.6350.78
16_A185_A0.6300.78
41_K156_L0.6290.77
84_G129_T0.6270.77
50_K54_A0.6270.77
171_T175_A0.6270.77
87_I131_L0.6270.77
11_A15_Y0.6250.77
179_F183_I0.6230.77
98_G181_A0.6200.76
87_I121_L0.6140.76
31_Y34_F0.6120.75
27_L76_S0.6120.75
17_I187_F0.6110.75
39_Q187_F0.6100.75
84_G95_T0.6090.75
16_A182_I0.6070.75
42_I51_L0.6050.75
79_A199_I0.6030.74
23_I87_I0.6030.74
111_E196_I0.6010.74
73_L133_T0.5990.74
13_K17_I0.5940.73
70_L132_I0.5920.73
13_K182_I0.5910.73
99_F102_L0.5890.73
84_G126_G0.5880.73
6_S142_I0.5880.73
59_L147_S0.5870.72
63_S147_S0.5870.72
96_L188_G0.5840.72
92_G174_V0.5840.72
19_D127_T0.5810.72
62_F122_I0.5800.72
101_Q104_F0.5790.71
180_M191_L0.5790.71
145_L149_L0.5780.71
112_A117_I0.5780.71
9_E12_F0.5770.71
92_G188_G0.5760.71
98_G180_M0.5750.71
70_L84_G0.5740.71
156_L159_L0.5720.71
90_Y97_G0.5710.70
17_I58_L0.5680.70
98_G184_I0.5670.70
72_F187_F0.5660.70
25_P121_L0.5640.69
119_T182_I0.5610.69
100_Q106_S0.5580.69
25_P122_I0.5570.69
170_N174_V0.5530.68
77_V92_G0.5520.68
19_D83_G0.5500.68
126_G184_I0.5470.67
13_K74_G0.5460.67
107_S110_E0.5460.67
88_L187_F0.5440.67
149_L167_I0.5440.67
98_G174_V0.5410.66
71_A166_R0.5410.66
173_T182_I0.5400.66
168_L173_T0.5400.66
11_A58_L0.5390.66
42_I117_I0.5380.66
127_T165_I0.5350.65
126_G178_R0.5340.65
61_F108_R0.5330.65
96_L150_A0.5330.65
32_E170_N0.5290.65
115_T184_I0.5290.65
102_L110_E0.5260.64
14_L18_M0.5220.64
134_L149_L0.5220.64
121_L124_G0.5220.64
16_A186_A0.5200.63
65_L133_T0.5160.63
28_I176_V0.5150.63
80_L182_I0.5150.63
21_L70_L0.5120.62
37_N57_V0.5100.62
58_L95_T0.5050.61
30_L112_A0.5040.61
54_A62_F0.5040.61
108_R152_L0.5040.61
16_A177_G0.5030.61
42_I54_A0.5030.61
75_I175_A0.5020.61
64_I131_L0.5020.61
113_I117_I0.5020.61
124_G178_R0.5010.60
21_L180_M0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4humA 1 0.8267 22 0.944 Contact Map
3mktA 1 0.8416 13.8 0.949 Contact Map
3w4tA 1 0.7921 12.8 0.949 Contact Map
4lz6A 1 0.8119 12.7 0.949 Contact Map
2cfqA 1 0.5248 8.8 0.953 Contact Map
4wgvA 2 0.401 6 0.956 Contact Map
3pr6A 2 0.2525 5.4 0.957 Contact Map
3qe7A 2 0.6733 4.7 0.958 Contact Map
1pw4A 1 0.5347 3.3 0.962 Contact Map
3ne5A 3 0.7822 2.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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