Q7LXS0 - SULSO - GREMLIN Contacts

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Q7LXS0 - Uncharacterized protein

UniProt:	Q7LXS0	Sequences: MSKSITRKIQLTGGSTYIVSLPKEWIKALSLSAGDEVEIYQDTDMKLLIVPKSANTTDQKEIKKIIHCDNVTSEAIIREFIAYYIAGFSSVSITCPRMSSSTRAYIKDVVRRRLLGAEVIEEDVSTISIQFLVDEKELSIKKAISRAFTISYNMLRDSLEAISKADIELAKEISGRDDEVDRFFFYIARQLTISVKAINVLDSEGYNLTQMVDIYSVAKTIERVGDHANRIASLVEDVSKFSNKEDLVNLGLTILESYKSAMNAFLNEKKDIAHSLISNIEIFEKLRELQEIAIKSNDNPKIITSTSMTVESLRRVARYSADIAEATIDILAKSNK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (319)
Sequences:	349 (276)
Seq/√Len:	15.5

HALSA - Q9HRB9 Q9HS09
SULSO - Q7LXS0 Q980F5 Q97VK4 Q97ZI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_I	31_L	4.338	1.00
223_R	227_H	4.292	1.00
222_E	226_D	4.174	1.00
157_D	176_R	4.128	1.00
37_V	49_I	4.040	1.00
154_M	177_D	3.998	1.00
16_T	20_S	3.941	1.00
177_D	222_E	3.476	0.99
181_D	226_D	3.046	0.98
155_L	316_V	3.044	0.98
177_D	226_D	3.041	0.98
154_M	222_E	2.977	0.98
181_D	222_E	2.701	0.96
319_Y	325_E	2.666	0.96
154_M	226_D	2.512	0.94
22_P	25_W	2.485	0.94
158_S	228_A	2.465	0.94
159_L	168_E	2.419	0.93
147_A	180_V	2.398	0.93
26_I	31_L	2.378	0.92
179_E	182_R	2.312	0.91
221_I	275_S	2.201	0.89
11_L	14_G	2.196	0.89
260_S	279_N	2.150	0.88
157_D	223_R	2.000	0.84
222_E	325_E	1.999	0.84
5_I	8_K	1.971	0.83
315_R	322_D	1.969	0.83
93_I	119_V	1.969	0.83
135_E	186_Y	1.967	0.83
147_A	225_G	1.923	0.81
8_K	17_Y	1.897	0.80
227_H	325_E	1.837	0.78
10_Q	16_T	1.834	0.78
12_T	15_S	1.824	0.78
13_G	78_R	1.820	0.77
7_R	22_P	1.818	0.77
226_D	325_E	1.817	0.77
186_Y	190_Q	1.797	0.77
13_G	23_K	1.764	0.75
133_V	219_K	1.744	0.74
313_L	317_A	1.733	0.74
217_V	265_F	1.730	0.74
177_D	181_D	1.725	0.73
159_L	289_L	1.710	0.73
16_T	26_I	1.701	0.72
14_G	17_Y	1.701	0.72
12_T	223_R	1.695	0.72
12_T	18_I	1.678	0.71
10_Q	20_S	1.676	0.71
104_A	146_R	1.674	0.71
30_S	241_F	1.671	0.71
161_A	170_A	1.666	0.71
212_V	215_Y	1.651	0.70
110_V	129_I	1.651	0.70
177_D	315_R	1.646	0.70
7_R	25_W	1.633	0.69
312_S	319_Y	1.610	0.68
142_K	146_R	1.606	0.68
32_S	35_D	1.598	0.67
18_I	223_R	1.590	0.67
254_I	276_L	1.590	0.67
154_M	181_D	1.580	0.67
223_R	319_Y	1.574	0.66
242_S	259_K	1.530	0.64
17_Y	24_E	1.523	0.64
12_T	17_Y	1.519	0.63
137_E	182_R	1.513	0.63
13_G	25_W	1.505	0.63
109_V	114_L	1.458	0.60
223_R	325_E	1.458	0.60
252_L	275_S	1.444	0.59
201_L	204_E	1.431	0.59
16_T	130_Q	1.425	0.58
106_I	269_K	1.419	0.58
315_R	319_Y	1.418	0.58
76_I	183_F	1.404	0.57
230_R	311_E	1.401	0.57
10_Q	15_S	1.392	0.56
227_H	315_R	1.384	0.56
13_G	34_G	1.381	0.56
12_T	23_K	1.368	0.55
39_I	47_L	1.367	0.55
7_R	10_Q	1.344	0.54
289_L	299_N	1.338	0.53
35_D	150_I	1.335	0.53
18_I	235_V	1.308	0.52
205_G	208_L	1.304	0.51
93_I	140_I	1.302	0.51
192_T	213_D	1.300	0.51
258_Y	320_S	1.295	0.51
14_G	18_I	1.293	0.51
158_S	170_A	1.291	0.51
15_S	213_D	1.287	0.50
32_S	37_V	1.279	0.50
81_I	190_Q	1.278	0.50
170_A	173_I	1.274	0.50
245_E	252_L	1.260	0.49
49_I	93_I	1.254	0.49
21_L	25_W	1.230	0.47
47_L	205_G	1.229	0.47
227_H	319_Y	1.227	0.47
12_T	122_E	1.224	0.47
117_A	182_R	1.217	0.46
118_E	179_E	1.213	0.46
117_A	277_I	1.211	0.46
103_R	157_D	1.206	0.46
206_Y	214_I	1.205	0.46
95_C	98_M	1.196	0.45
93_I	217_V	1.186	0.45
157_D	169_L	1.184	0.45
181_D	325_E	1.174	0.44
224_V	316_V	1.155	0.43
127_I	178_D	1.154	0.43
157_D	227_H	1.142	0.42
30_S	127_I	1.136	0.42
12_T	319_Y	1.133	0.42
134_D	137_E	1.133	0.42
269_K	272_I	1.132	0.42
82_A	181_D	1.114	0.41
172_E	176_R	1.096	0.40
80_F	109_V	1.091	0.39
21_L	126_T	1.086	0.39
221_I	258_Y	1.082	0.39
161_A	264_A	1.082	0.39
228_A	232_A	1.079	0.39
314_R	318_R	1.079	0.39
93_I	268_E	1.078	0.39
178_D	231_I	1.078	0.39
140_I	197_A	1.077	0.39
84_Y	116_G	1.075	0.39
7_R	13_G	1.075	0.39
325_E	329_D	1.069	0.38
7_R	16_T	1.068	0.38
21_L	46_K	1.066	0.38
48_L	93_I	1.062	0.38
33_A	82_A	1.059	0.38
121_E	176_R	1.056	0.38
8_K	15_S	1.055	0.38
89_S	307_S	1.054	0.37
83_Y	133_V	1.053	0.37
16_T	46_K	1.047	0.37
74_E	95_C	1.045	0.37
13_G	226_D	1.041	0.37
140_I	144_I	1.038	0.37
15_S	72_T	1.037	0.37
78_R	273_A	1.032	0.36
164_K	252_L	1.031	0.36
13_G	22_P	1.019	0.36
179_E	246_D	1.015	0.35
217_V	260_S	1.009	0.35
173_I	254_I	1.007	0.35
6_T	47_L	1.007	0.35
264_A	273_A	1.000	0.35
7_R	19_V	0.999	0.35
37_V	263_N	0.987	0.34
191_L	322_D	0.983	0.34
9_I	17_Y	0.975	0.33
320_S	324_A	0.971	0.33
183_F	226_D	0.971	0.33
182_R	218_A	0.971	0.33
10_Q	22_P	0.967	0.33
114_L	215_Y	0.965	0.33
227_H	312_S	0.964	0.33
177_D	223_R	0.960	0.33
181_D	227_H	0.957	0.32
194_S	265_F	0.948	0.32
247_L	254_I	0.947	0.32
189_R	314_R	0.941	0.32
160_E	169_L	0.937	0.31
95_C	122_E	0.937	0.31
180_V	262_M	0.932	0.31
173_I	225_G	0.932	0.31
34_G	114_L	0.931	0.31
17_Y	195_V	0.929	0.31
151_S	228_A	0.929	0.31
194_S	204_E	0.929	0.31
10_Q	14_G	0.926	0.31
96_P	278_S	0.922	0.31
174_S	177_D	0.921	0.31
14_G	20_S	0.919	0.31
131_F	188_A	0.919	0.31
226_D	322_D	0.916	0.30
157_D	172_E	0.908	0.30
250_L	310_V	0.904	0.30
204_E	208_L	0.903	0.30
212_V	266_L	0.903	0.30
311_E	319_Y	0.901	0.30
308_M	311_E	0.901	0.30
11_L	16_T	0.901	0.30
39_I	98_M	0.897	0.30
282_I	317_A	0.893	0.29
154_M	312_S	0.893	0.29
193_I	200_V	0.892	0.29
147_A	222_E	0.891	0.29
164_K	264_A	0.891	0.29
16_T	22_P	0.889	0.29
256_E	281_E	0.889	0.29
14_G	176_R	0.888	0.29
246_D	292_I	0.887	0.29
181_D	322_D	0.883	0.29
16_T	189_R	0.883	0.29
31_L	150_I	0.882	0.29
12_T	325_E	0.879	0.29
120_I	278_S	0.876	0.29
84_Y	325_E	0.875	0.28
188_A	215_Y	0.872	0.28
205_G	216_S	0.867	0.28
110_V	219_K	0.864	0.28
266_L	289_L	0.862	0.28
311_E	318_R	0.860	0.28
16_T	36_E	0.854	0.28
222_E	225_G	0.852	0.27
10_Q	19_V	0.844	0.27
212_V	225_G	0.838	0.27
120_I	215_Y	0.836	0.27
19_V	112_R	0.836	0.27
10_Q	13_G	0.835	0.27
131_F	137_E	0.835	0.27
82_A	226_D	0.834	0.27
13_G	222_E	0.833	0.27
29_L	133_V	0.832	0.27
118_E	181_D	0.828	0.26
309_T	316_V	0.828	0.26
105_Y	161_A	0.826	0.26
312_S	328_I	0.816	0.26
178_D	181_D	0.816	0.26
85_I	185_F	0.815	0.26
11_L	221_I	0.814	0.26
190_Q	194_S	0.811	0.26
151_S	225_G	0.810	0.26
35_D	329_D	0.807	0.25
49_I	271_D	0.806	0.25
19_V	32_S	0.806	0.25
68_C	288_E	0.804	0.25
187_I	277_I	0.803	0.25
100_S	144_I	0.803	0.25
110_V	119_V	0.802	0.25
122_E	176_R	0.800	0.25
176_R	223_R	0.798	0.25
93_I	284_E	0.796	0.25
240_K	302_I	0.795	0.25
9_I	29_L	0.784	0.24
162_I	235_V	0.784	0.24
19_V	22_P	0.780	0.24
80_F	328_I	0.779	0.24
78_R	226_D	0.776	0.24
23_K	223_R	0.776	0.24
181_D	223_R	0.774	0.24
122_E	274_H	0.773	0.24
156_R	259_K	0.772	0.24
175_G	197_A	0.771	0.24
8_K	158_S	0.767	0.24
53_S	284_E	0.763	0.24
173_I	279_N	0.762	0.24
124_V	130_Q	0.760	0.23
222_E	227_H	0.760	0.23
154_M	180_V	0.758	0.23
47_L	321_A	0.757	0.23
51_P	143_A	0.757	0.23
66_I	314_R	0.756	0.23
66_I	74_E	0.755	0.23
21_L	169_L	0.754	0.23
180_V	225_G	0.753	0.23
21_L	329_D	0.752	0.23
109_V	185_F	0.752	0.23
14_G	36_E	0.751	0.23
13_G	181_D	0.750	0.23
93_I	246_D	0.750	0.23
82_A	222_E	0.746	0.23
36_E	176_R	0.745	0.23
49_I	206_Y	0.742	0.23
69_D	267_N	0.742	0.23
95_C	259_K	0.741	0.23
122_E	325_E	0.734	0.22
237_D	278_S	0.732	0.22
48_L	225_G	0.730	0.22
14_G	129_I	0.727	0.22
299_N	302_I	0.727	0.22
293_A	310_V	0.725	0.22
146_R	149_T	0.725	0.22
286_L	290_Q	0.724	0.22
10_Q	25_W	0.724	0.22
312_S	325_E	0.722	0.22
319_Y	329_D	0.722	0.22
311_E	322_D	0.721	0.22
118_E	223_R	0.717	0.22
43_T	179_E	0.716	0.22
21_L	47_L	0.715	0.22
68_C	245_E	0.715	0.22
156_R	179_E	0.714	0.22
114_L	185_F	0.713	0.22
177_D	325_E	0.711	0.22
119_V	130_Q	0.711	0.22
223_R	315_R	0.709	0.21
46_K	93_I	0.709	0.21
63_K	90_S	0.707	0.21
159_L	248_V	0.706	0.21
56_T	167_I	0.704	0.21
178_D	186_Y	0.701	0.21
15_S	93_I	0.700	0.21
7_R	20_S	0.699	0.21
16_T	25_W	0.699	0.21
114_L	189_R	0.696	0.21
177_D	180_V	0.695	0.21
39_I	185_F	0.695	0.21
311_E	315_R	0.695	0.21
154_M	225_G	0.694	0.21
20_S	25_W	0.693	0.21
9_I	154_M	0.692	0.21
230_R	314_R	0.691	0.21
125_S	250_L	0.688	0.21
306_T	309_T	0.688	0.21
305_S	309_T	0.684	0.20
310_V	317_A	0.681	0.20
119_V	279_N	0.679	0.20
154_M	325_E	0.676	0.20
66_I	257_S	0.675	0.20
80_F	145_S	0.674	0.20
106_I	233_S	0.672	0.20
95_C	102_T	0.670	0.20
208_L	214_I	0.670	0.20
277_I	280_I	0.670	0.20
212_V	219_K	0.665	0.20
159_L	251_G	0.663	0.20
266_L	313_L	0.662	0.20
142_K	321_A	0.662	0.20
301_K	305_S	0.661	0.20
99_S	247_L	0.660	0.20
31_L	39_I	0.657	0.19
323_I	328_I	0.654	0.19
67_H	157_D	0.653	0.19
177_D	322_D	0.652	0.19
9_I	325_E	0.651	0.19
190_Q	329_D	0.648	0.19
215_Y	326_A	0.646	0.19
325_E	328_I	0.643	0.19
17_Y	26_I	0.641	0.19
65_I	70_N	0.640	0.19
210_Q	291_E	0.640	0.19
174_S	236_E	0.640	0.19
204_E	219_K	0.639	0.19
15_S	182_R	0.639	0.19
21_L	120_I	0.638	0.19
13_G	16_T	0.637	0.19
102_T	171_K	0.635	0.19
113_R	186_Y	0.635	0.19
50_V	82_A	0.635	0.19
288_E	292_I	0.633	0.19
65_I	92_S	0.632	0.19
127_I	173_I	0.632	0.19
31_L	280_I	0.631	0.19
128_S	263_N	0.629	0.19
49_I	256_E	0.628	0.18
188_A	212_V	0.626	0.18
115_L	185_F	0.626	0.18
78_R	182_R	0.622	0.18
23_K	273_A	0.619	0.18
127_I	146_R	0.618	0.18
179_E	316_V	0.617	0.18
39_I	49_I	0.617	0.18
281_E	284_E	0.616	0.18
55_N	271_D	0.610	0.18
35_D	322_D	0.610	0.18
119_V	267_N	0.608	0.18
154_M	173_I	0.606	0.18
220_T	322_D	0.606	0.18
33_A	324_A	0.605	0.18
311_E	325_E	0.605	0.18
62_I	282_I	0.605	0.18
161_A	235_V	0.605	0.18
282_I	306_T	0.603	0.18
128_S	285_K	0.601	0.18
49_I	71_V	0.599	0.18
219_K	223_R	0.599	0.18
31_L	171_K	0.598	0.17
91_V	248_V	0.594	0.17
221_I	286_L	0.591	0.17
42_D	186_Y	0.590	0.17
308_M	319_Y	0.588	0.17
147_A	226_D	0.588	0.17
92_S	189_R	0.587	0.17
139_S	182_R	0.586	0.17
143_A	173_I	0.585	0.17
192_T	330_I	0.585	0.17
193_I	211_M	0.584	0.17
46_K	259_K	0.584	0.17
15_S	146_R	0.583	0.17
127_I	243_N	0.582	0.17
21_L	130_Q	0.581	0.17
131_F	265_F	0.581	0.17
284_E	292_I	0.580	0.17
80_F	151_S	0.580	0.17
35_D	217_V	0.579	0.17
22_P	189_R	0.577	0.17
253_T	285_K	0.577	0.17
17_Y	224_V	0.575	0.17
34_G	78_R	0.575	0.17
132_L	170_A	0.572	0.17
68_C	164_K	0.570	0.17
76_I	247_L	0.570	0.17
90_S	106_I	0.567	0.16
160_E	288_E	0.566	0.16
222_E	319_Y	0.566	0.16
24_E	263_N	0.565	0.16
11_L	213_D	0.565	0.16
107_K	151_S	0.565	0.16
119_V	122_E	0.564	0.16
12_T	138_L	0.564	0.16
92_S	153_N	0.562	0.16
31_L	247_L	0.561	0.16
204_E	313_L	0.561	0.16
81_I	329_D	0.560	0.16
294_I	304_T	0.560	0.16
107_K	183_F	0.559	0.16
121_E	131_F	0.559	0.16
135_E	328_I	0.558	0.16
143_A	210_Q	0.557	0.16
83_Y	107_K	0.557	0.16
87_G	116_G	0.555	0.16
191_L	218_A	0.555	0.16
153_N	242_S	0.554	0.16
92_S	126_T	0.554	0.16
133_V	182_R	0.553	0.16
311_E	323_I	0.553	0.16
114_L	147_A	0.552	0.16
221_I	293_A	0.552	0.16
19_V	25_W	0.551	0.16
205_G	313_L	0.551	0.16
94_T	163_S	0.549	0.16
140_I	153_N	0.545	0.16
225_G	261_A	0.544	0.16
160_E	164_K	0.544	0.16
51_P	76_I	0.543	0.16
173_I	177_D	0.543	0.16
143_A	282_I	0.542	0.16
39_I	139_S	0.542	0.16
163_S	245_E	0.540	0.16
118_E	146_R	0.540	0.16
21_L	26_I	0.540	0.16
115_L	133_V	0.540	0.16
74_E	163_S	0.537	0.16
16_T	131_F	0.537	0.16
190_Q	193_I	0.536	0.16
92_S	172_E	0.535	0.15
8_K	313_L	0.535	0.15
92_S	161_A	0.534	0.15
41_Q	191_L	0.534	0.15
12_T	265_F	0.533	0.15
4_S	322_D	0.533	0.15
26_I	63_K	0.532	0.15
272_I	288_E	0.531	0.15
82_A	125_S	0.529	0.15
9_I	115_L	0.526	0.15
43_T	185_F	0.522	0.15
132_L	150_I	0.522	0.15
4_S	85_I	0.521	0.15
132_L	177_D	0.521	0.15
13_G	154_M	0.521	0.15
101_S	292_I	0.519	0.15
180_V	310_V	0.519	0.15
313_L	325_E	0.518	0.15
156_R	224_V	0.516	0.15
26_I	150_I	0.515	0.15
33_A	220_T	0.514	0.15
132_L	231_I	0.514	0.15
15_S	142_K	0.513	0.15
98_M	310_V	0.513	0.15
154_M	174_S	0.513	0.15
90_S	130_Q	0.512	0.15
35_D	78_R	0.510	0.15
144_I	178_D	0.508	0.15
224_V	324_A	0.507	0.15
112_R	309_T	0.505	0.15
11_L	28_A	0.502	0.15
170_A	235_V	0.500	0.14
9_I	13_G	0.500	0.14
19_V	193_I	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sumB	2	0.6071	99.9	0.744	Contact Map
1xwmA	2	0.6012	99.9	0.75	Contact Map
2i0mA	2	0.5893	99.9	0.753	Contact Map
1t72A	5	0.6161	99.9	0.756	Contact Map
4q25A	2	0.6012	99.8	0.764	Contact Map
2oltA	5	0.5744	99.7	0.804	Contact Map
2mrnA	2	0.1577	98.6	0.883	Contact Map
3l39A	3	0.5804	98.5	0.886	Contact Map
3o27A	2	0.1637	98.1	0.897	Contact Map
1mvfD	1	0.131	98.1	0.897	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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