GREMLIN Database
Q7LXS0 - Uncharacterized protein
UniProt: Q7LXS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (319)
Sequences: 349 (276)
Seq/√Len: 15.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_I31_L4.3381.00
223_R227_H4.2921.00
222_E226_D4.1741.00
157_D176_R4.1281.00
37_V49_I4.0401.00
154_M177_D3.9981.00
16_T20_S3.9411.00
177_D222_E3.4760.99
181_D226_D3.0460.98
155_L316_V3.0440.98
177_D226_D3.0410.98
154_M222_E2.9770.98
181_D222_E2.7010.96
319_Y325_E2.6660.96
154_M226_D2.5120.94
22_P25_W2.4850.94
158_S228_A2.4650.94
159_L168_E2.4190.93
147_A180_V2.3980.93
26_I31_L2.3780.92
179_E182_R2.3120.91
221_I275_S2.2010.89
11_L14_G2.1960.89
260_S279_N2.1500.88
157_D223_R2.0000.84
222_E325_E1.9990.84
5_I8_K1.9710.83
315_R322_D1.9690.83
93_I119_V1.9690.83
135_E186_Y1.9670.83
147_A225_G1.9230.81
8_K17_Y1.8970.80
227_H325_E1.8370.78
10_Q16_T1.8340.78
12_T15_S1.8240.78
13_G78_R1.8200.77
7_R22_P1.8180.77
226_D325_E1.8170.77
186_Y190_Q1.7970.77
13_G23_K1.7640.75
133_V219_K1.7440.74
313_L317_A1.7330.74
217_V265_F1.7300.74
177_D181_D1.7250.73
159_L289_L1.7100.73
16_T26_I1.7010.72
14_G17_Y1.7010.72
12_T223_R1.6950.72
12_T18_I1.6780.71
10_Q20_S1.6760.71
104_A146_R1.6740.71
30_S241_F1.6710.71
161_A170_A1.6660.71
212_V215_Y1.6510.70
110_V129_I1.6510.70
177_D315_R1.6460.70
7_R25_W1.6330.69
312_S319_Y1.6100.68
142_K146_R1.6060.68
32_S35_D1.5980.67
18_I223_R1.5900.67
254_I276_L1.5900.67
154_M181_D1.5800.67
223_R319_Y1.5740.66
242_S259_K1.5300.64
17_Y24_E1.5230.64
12_T17_Y1.5190.63
137_E182_R1.5130.63
13_G25_W1.5050.63
109_V114_L1.4580.60
223_R325_E1.4580.60
252_L275_S1.4440.59
201_L204_E1.4310.59
16_T130_Q1.4250.58
106_I269_K1.4190.58
315_R319_Y1.4180.58
76_I183_F1.4040.57
230_R311_E1.4010.57
10_Q15_S1.3920.56
227_H315_R1.3840.56
13_G34_G1.3810.56
12_T23_K1.3680.55
39_I47_L1.3670.55
7_R10_Q1.3440.54
289_L299_N1.3380.53
35_D150_I1.3350.53
18_I235_V1.3080.52
205_G208_L1.3040.51
93_I140_I1.3020.51
192_T213_D1.3000.51
258_Y320_S1.2950.51
14_G18_I1.2930.51
158_S170_A1.2910.51
15_S213_D1.2870.50
32_S37_V1.2790.50
81_I190_Q1.2780.50
170_A173_I1.2740.50
245_E252_L1.2600.49
49_I93_I1.2540.49
21_L25_W1.2300.47
47_L205_G1.2290.47
227_H319_Y1.2270.47
12_T122_E1.2240.47
117_A182_R1.2170.46
118_E179_E1.2130.46
117_A277_I1.2110.46
103_R157_D1.2060.46
206_Y214_I1.2050.46
95_C98_M1.1960.45
93_I217_V1.1860.45
157_D169_L1.1840.45
181_D325_E1.1740.44
224_V316_V1.1550.43
127_I178_D1.1540.43
157_D227_H1.1420.42
30_S127_I1.1360.42
12_T319_Y1.1330.42
134_D137_E1.1330.42
269_K272_I1.1320.42
82_A181_D1.1140.41
172_E176_R1.0960.40
80_F109_V1.0910.39
21_L126_T1.0860.39
221_I258_Y1.0820.39
161_A264_A1.0820.39
228_A232_A1.0790.39
314_R318_R1.0790.39
93_I268_E1.0780.39
178_D231_I1.0780.39
140_I197_A1.0770.39
84_Y116_G1.0750.39
7_R13_G1.0750.39
325_E329_D1.0690.38
7_R16_T1.0680.38
21_L46_K1.0660.38
48_L93_I1.0620.38
33_A82_A1.0590.38
121_E176_R1.0560.38
8_K15_S1.0550.38
89_S307_S1.0540.37
83_Y133_V1.0530.37
16_T46_K1.0470.37
74_E95_C1.0450.37
13_G226_D1.0410.37
140_I144_I1.0380.37
15_S72_T1.0370.37
78_R273_A1.0320.36
164_K252_L1.0310.36
13_G22_P1.0190.36
179_E246_D1.0150.35
217_V260_S1.0090.35
173_I254_I1.0070.35
6_T47_L1.0070.35
264_A273_A1.0000.35
7_R19_V0.9990.35
37_V263_N0.9870.34
191_L322_D0.9830.34
9_I17_Y0.9750.33
320_S324_A0.9710.33
183_F226_D0.9710.33
182_R218_A0.9710.33
10_Q22_P0.9670.33
114_L215_Y0.9650.33
227_H312_S0.9640.33
177_D223_R0.9600.33
181_D227_H0.9570.32
194_S265_F0.9480.32
247_L254_I0.9470.32
189_R314_R0.9410.32
160_E169_L0.9370.31
95_C122_E0.9370.31
180_V262_M0.9320.31
173_I225_G0.9320.31
34_G114_L0.9310.31
17_Y195_V0.9290.31
151_S228_A0.9290.31
194_S204_E0.9290.31
10_Q14_G0.9260.31
96_P278_S0.9220.31
174_S177_D0.9210.31
14_G20_S0.9190.31
131_F188_A0.9190.31
226_D322_D0.9160.30
157_D172_E0.9080.30
250_L310_V0.9040.30
204_E208_L0.9030.30
212_V266_L0.9030.30
311_E319_Y0.9010.30
308_M311_E0.9010.30
11_L16_T0.9010.30
39_I98_M0.8970.30
282_I317_A0.8930.29
154_M312_S0.8930.29
193_I200_V0.8920.29
147_A222_E0.8910.29
164_K264_A0.8910.29
16_T22_P0.8890.29
256_E281_E0.8890.29
14_G176_R0.8880.29
246_D292_I0.8870.29
181_D322_D0.8830.29
16_T189_R0.8830.29
31_L150_I0.8820.29
12_T325_E0.8790.29
120_I278_S0.8760.29
84_Y325_E0.8750.28
188_A215_Y0.8720.28
205_G216_S0.8670.28
110_V219_K0.8640.28
266_L289_L0.8620.28
311_E318_R0.8600.28
16_T36_E0.8540.28
222_E225_G0.8520.27
10_Q19_V0.8440.27
212_V225_G0.8380.27
120_I215_Y0.8360.27
19_V112_R0.8360.27
10_Q13_G0.8350.27
131_F137_E0.8350.27
82_A226_D0.8340.27
13_G222_E0.8330.27
29_L133_V0.8320.27
118_E181_D0.8280.26
309_T316_V0.8280.26
105_Y161_A0.8260.26
312_S328_I0.8160.26
178_D181_D0.8160.26
85_I185_F0.8150.26
11_L221_I0.8140.26
190_Q194_S0.8110.26
151_S225_G0.8100.26
35_D329_D0.8070.25
49_I271_D0.8060.25
19_V32_S0.8060.25
68_C288_E0.8040.25
187_I277_I0.8030.25
100_S144_I0.8030.25
110_V119_V0.8020.25
122_E176_R0.8000.25
176_R223_R0.7980.25
93_I284_E0.7960.25
240_K302_I0.7950.25
9_I29_L0.7840.24
162_I235_V0.7840.24
19_V22_P0.7800.24
80_F328_I0.7790.24
78_R226_D0.7760.24
23_K223_R0.7760.24
181_D223_R0.7740.24
122_E274_H0.7730.24
156_R259_K0.7720.24
175_G197_A0.7710.24
8_K158_S0.7670.24
53_S284_E0.7630.24
173_I279_N0.7620.24
124_V130_Q0.7600.23
222_E227_H0.7600.23
154_M180_V0.7580.23
47_L321_A0.7570.23
51_P143_A0.7570.23
66_I314_R0.7560.23
66_I74_E0.7550.23
21_L169_L0.7540.23
180_V225_G0.7530.23
21_L329_D0.7520.23
109_V185_F0.7520.23
14_G36_E0.7510.23
13_G181_D0.7500.23
93_I246_D0.7500.23
82_A222_E0.7460.23
36_E176_R0.7450.23
49_I206_Y0.7420.23
69_D267_N0.7420.23
95_C259_K0.7410.23
122_E325_E0.7340.22
237_D278_S0.7320.22
48_L225_G0.7300.22
14_G129_I0.7270.22
299_N302_I0.7270.22
293_A310_V0.7250.22
146_R149_T0.7250.22
286_L290_Q0.7240.22
10_Q25_W0.7240.22
312_S325_E0.7220.22
319_Y329_D0.7220.22
311_E322_D0.7210.22
118_E223_R0.7170.22
43_T179_E0.7160.22
21_L47_L0.7150.22
68_C245_E0.7150.22
156_R179_E0.7140.22
114_L185_F0.7130.22
177_D325_E0.7110.22
119_V130_Q0.7110.22
223_R315_R0.7090.21
46_K93_I0.7090.21
63_K90_S0.7070.21
159_L248_V0.7060.21
56_T167_I0.7040.21
178_D186_Y0.7010.21
15_S93_I0.7000.21
7_R20_S0.6990.21
16_T25_W0.6990.21
114_L189_R0.6960.21
177_D180_V0.6950.21
39_I185_F0.6950.21
311_E315_R0.6950.21
154_M225_G0.6940.21
20_S25_W0.6930.21
9_I154_M0.6920.21
230_R314_R0.6910.21
125_S250_L0.6880.21
306_T309_T0.6880.21
305_S309_T0.6840.20
310_V317_A0.6810.20
119_V279_N0.6790.20
154_M325_E0.6760.20
66_I257_S0.6750.20
80_F145_S0.6740.20
106_I233_S0.6720.20
95_C102_T0.6700.20
208_L214_I0.6700.20
277_I280_I0.6700.20
212_V219_K0.6650.20
159_L251_G0.6630.20
266_L313_L0.6620.20
142_K321_A0.6620.20
301_K305_S0.6610.20
99_S247_L0.6600.20
31_L39_I0.6570.19
323_I328_I0.6540.19
67_H157_D0.6530.19
177_D322_D0.6520.19
9_I325_E0.6510.19
190_Q329_D0.6480.19
215_Y326_A0.6460.19
325_E328_I0.6430.19
17_Y26_I0.6410.19
65_I70_N0.6400.19
210_Q291_E0.6400.19
174_S236_E0.6400.19
204_E219_K0.6390.19
15_S182_R0.6390.19
21_L120_I0.6380.19
13_G16_T0.6370.19
102_T171_K0.6350.19
113_R186_Y0.6350.19
50_V82_A0.6350.19
288_E292_I0.6330.19
65_I92_S0.6320.19
127_I173_I0.6320.19
31_L280_I0.6310.19
128_S263_N0.6290.19
49_I256_E0.6280.18
188_A212_V0.6260.18
115_L185_F0.6260.18
78_R182_R0.6220.18
23_K273_A0.6190.18
127_I146_R0.6180.18
179_E316_V0.6170.18
39_I49_I0.6170.18
281_E284_E0.6160.18
55_N271_D0.6100.18
35_D322_D0.6100.18
119_V267_N0.6080.18
154_M173_I0.6060.18
220_T322_D0.6060.18
33_A324_A0.6050.18
311_E325_E0.6050.18
62_I282_I0.6050.18
161_A235_V0.6050.18
282_I306_T0.6030.18
128_S285_K0.6010.18
49_I71_V0.5990.18
219_K223_R0.5990.18
31_L171_K0.5980.17
91_V248_V0.5940.17
221_I286_L0.5910.17
42_D186_Y0.5900.17
308_M319_Y0.5880.17
147_A226_D0.5880.17
92_S189_R0.5870.17
139_S182_R0.5860.17
143_A173_I0.5850.17
192_T330_I0.5850.17
193_I211_M0.5840.17
46_K259_K0.5840.17
15_S146_R0.5830.17
127_I243_N0.5820.17
21_L130_Q0.5810.17
131_F265_F0.5810.17
284_E292_I0.5800.17
80_F151_S0.5800.17
35_D217_V0.5790.17
22_P189_R0.5770.17
253_T285_K0.5770.17
17_Y224_V0.5750.17
34_G78_R0.5750.17
132_L170_A0.5720.17
68_C164_K0.5700.17
76_I247_L0.5700.17
90_S106_I0.5670.16
160_E288_E0.5660.16
222_E319_Y0.5660.16
24_E263_N0.5650.16
11_L213_D0.5650.16
107_K151_S0.5650.16
119_V122_E0.5640.16
12_T138_L0.5640.16
92_S153_N0.5620.16
31_L247_L0.5610.16
204_E313_L0.5610.16
81_I329_D0.5600.16
294_I304_T0.5600.16
107_K183_F0.5590.16
121_E131_F0.5590.16
135_E328_I0.5580.16
143_A210_Q0.5570.16
83_Y107_K0.5570.16
87_G116_G0.5550.16
191_L218_A0.5550.16
153_N242_S0.5540.16
92_S126_T0.5540.16
133_V182_R0.5530.16
311_E323_I0.5530.16
114_L147_A0.5520.16
221_I293_A0.5520.16
19_V25_W0.5510.16
205_G313_L0.5510.16
94_T163_S0.5490.16
140_I153_N0.5450.16
225_G261_A0.5440.16
160_E164_K0.5440.16
51_P76_I0.5430.16
173_I177_D0.5430.16
143_A282_I0.5420.16
39_I139_S0.5420.16
163_S245_E0.5400.16
118_E146_R0.5400.16
21_L26_I0.5400.16
115_L133_V0.5400.16
74_E163_S0.5370.16
16_T131_F0.5370.16
190_Q193_I0.5360.16
92_S172_E0.5350.15
8_K313_L0.5350.15
92_S161_A0.5340.15
41_Q191_L0.5340.15
12_T265_F0.5330.15
4_S322_D0.5330.15
26_I63_K0.5320.15
272_I288_E0.5310.15
82_A125_S0.5290.15
9_I115_L0.5260.15
43_T185_F0.5220.15
132_L150_I0.5220.15
4_S85_I0.5210.15
132_L177_D0.5210.15
13_G154_M0.5210.15
101_S292_I0.5190.15
180_V310_V0.5190.15
313_L325_E0.5180.15
156_R224_V0.5160.15
26_I150_I0.5150.15
33_A220_T0.5140.15
132_L231_I0.5140.15
15_S142_K0.5130.15
98_M310_V0.5130.15
154_M174_S0.5130.15
90_S130_Q0.5120.15
35_D78_R0.5100.15
144_I178_D0.5080.15
224_V324_A0.5070.15
112_R309_T0.5050.15
11_L28_A0.5020.15
170_A235_V0.5000.14
9_I13_G0.5000.14
19_V193_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.6071 99.9 0.744 Contact Map
1xwmA 2 0.6012 99.9 0.75 Contact Map
2i0mA 2 0.5893 99.9 0.753 Contact Map
1t72A 5 0.6161 99.9 0.756 Contact Map
4q25A 2 0.6012 99.8 0.764 Contact Map
2oltA 5 0.5744 99.7 0.804 Contact Map
2mrnA 2 0.1577 98.6 0.883 Contact Map
3l39A 3 0.5804 98.5 0.886 Contact Map
3o27A 2 0.1637 98.1 0.897 Contact Map
1mvfD 1 0.131 98.1 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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