GREMLIN Database
Q7LXR8 - Uncharacterized protein
UniProt: Q7LXR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (90)
Sequences: 152 (127)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_T49_L3.4000.99
40_P55_M3.3710.99
79_K91_L2.5410.92
17_F30_V2.3230.88
32_V43_I2.3140.88
15_F50_D2.2490.86
30_V91_L2.2150.85
52_K56_H2.1770.84
81_T93_E2.0290.80
50_D71_A2.0040.79
48_K54_V1.7980.71
80_L84_Y1.7950.71
64_N68_Y1.7780.70
85_K91_L1.7050.67
16_L29_I1.6970.66
25_T28_K1.6860.66
28_K71_A1.6330.63
44_A67_V1.6130.62
88_K91_L1.5890.61
30_V88_K1.5590.59
65_N83_F1.4830.55
12_F67_V1.4290.53
54_V89_D1.3540.49
49_L52_K1.3400.48
80_L85_K1.3350.48
84_Y91_L1.3230.47
54_V90_V1.3160.47
62_M72_D1.2940.45
16_L30_V1.2460.43
48_K73_G1.2370.42
20_S77_P1.2190.42
68_Y81_T1.1930.40
18_F27_L1.1930.40
66_I96_R1.1870.40
40_P58_L1.1400.38
32_V81_T1.1390.37
27_L33_L1.1230.37
62_M73_G1.1210.37
66_I97_E1.1000.36
50_D72_D1.0980.35
56_H60_V1.0670.34
54_V58_L1.0660.34
30_V80_L1.0650.34
46_T56_H1.0630.34
79_K85_K1.0370.33
41_N44_A1.0030.31
62_M69_R0.9890.30
32_V55_M0.9820.30
24_I65_N0.9680.29
31_R41_N0.9500.29
50_D56_H0.9500.29
25_T79_K0.9490.29
27_L95_E0.9430.28
31_R66_I0.9410.28
77_P91_L0.9390.28
33_L77_P0.9320.28
60_V77_P0.9260.28
43_I85_K0.8950.26
78_Y89_D0.8860.26
43_I68_Y0.8720.25
53_T63_E0.8670.25
46_T66_I0.8670.25
24_I50_D0.8650.25
33_L95_E0.8610.25
13_F94_L0.8590.25
54_V81_T0.8580.25
69_R76_L0.8560.25
13_F18_F0.8550.25
52_K64_N0.8320.24
30_V84_Y0.8100.23
44_A90_V0.8100.23
19_T23_G0.8090.23
33_L93_E0.8080.23
12_F82_T0.7990.23
60_V76_L0.7770.22
32_V54_V0.7720.22
45_S67_V0.7600.21
46_T82_T0.7570.21
65_N87_Y0.7310.20
41_N60_V0.7300.20
64_N79_K0.7170.20
31_R35_E0.7050.19
70_E79_K0.7040.19
31_R81_T0.7000.19
37_P74_Y0.6950.19
66_I84_Y0.6930.19
44_A97_E0.6910.19
55_M59_E0.6870.19
33_L41_N0.6860.19
22_G53_T0.6750.18
32_V67_V0.6720.18
9_V53_T0.6550.18
11_K77_P0.6550.18
14_R18_F0.6490.17
86_T95_E0.6480.17
50_D69_R0.6420.17
72_D96_R0.6390.17
14_R37_P0.6380.17
86_T89_D0.6360.17
84_Y87_Y0.6350.17
73_G96_R0.6310.17
95_E98_I0.6270.17
18_F95_E0.6240.17
16_L98_I0.6210.17
13_F19_T0.6200.17
33_L52_K0.6140.16
84_Y88_K0.6000.16
66_I85_K0.5890.16
24_I63_E0.5810.15
53_T66_I0.5780.15
28_K35_E0.5760.15
21_R69_R0.5750.15
42_Q71_A0.5630.15
64_N91_L0.5600.15
27_L94_L0.5580.15
14_R94_L0.5580.15
13_F23_G0.5570.15
17_F95_E0.5560.15
24_I42_Q0.5560.15
22_G56_H0.5550.15
60_V89_D0.5450.15
17_F72_D0.5440.14
47_L53_T0.5360.14
83_F98_I0.5350.14
66_I70_E0.5350.14
35_E48_K0.5280.14
20_S60_V0.5250.14
29_I33_L0.5240.14
15_F41_N0.5170.14
21_R88_K0.5140.14
9_V14_R0.5080.14
15_F69_R0.5060.14
69_R95_E0.5050.13
20_S96_R0.5050.13
68_Y87_Y0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u1dA 2 0.981 98.7 0.772 Contact Map
1r1tA 2 0.8952 98.6 0.774 Contact Map
2kkoA 2 0.9524 98.6 0.775 Contact Map
1r1uA 2 0.8952 98.6 0.778 Contact Map
1u2wA 2 0.8952 98.6 0.779 Contact Map
3pqkA 2 0.9524 98.5 0.781 Contact Map
1z7uA 2 0.9524 98.5 0.782 Contact Map
4k2eA 2 0.8286 98.5 0.784 Contact Map
1q1hA 1 0.7619 98.5 0.785 Contact Map
2jscA 2 0.8857 98.5 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0049 seconds.