GREMLIN Database
Q7LXR6 - GTP-binding protein
UniProt: Q7LXR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (298)
Sequences: 5921 (3915)
Seq/√Len: 226.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_E319_N3.8251.00
240_V273_V3.4571.00
201_D318_F3.3911.00
256_Q260_F3.3611.00
160_V236_N3.0501.00
38_I61_I3.0101.00
260_F264_K2.9251.00
243_F272_P2.7551.00
197_H204_R2.6791.00
256_Q264_K2.6251.00
195_V206_Q2.5431.00
33_V41_L2.5251.00
175_K310_I2.4321.00
256_Q262_E2.4141.00
316_E320_L2.3701.00
245_S274_I2.3661.00
159_I205_I2.3571.00
24_R28_I2.2651.00
175_K307_G2.2641.00
89_K133_S2.2191.00
58_F62_D2.2151.00
309_G312_K2.1641.00
298_E316_E2.1471.00
277_I301_E2.1031.00
20_T41_L2.0961.00
274_I301_E2.0901.00
262_E265_L2.0781.00
171_T304_A2.0661.00
273_V300_H2.0211.00
195_V208_I2.0021.00
38_I58_F1.9571.00
256_Q265_L1.9451.00
315_E319_N1.9021.00
262_E266_L1.8911.00
255_G258_E1.8701.00
161_V173_V1.8551.00
42_K46_E1.8531.00
37_E40_R1.8461.00
112_N115_N1.8301.00
257_I261_R1.8281.00
112_N117_I1.8271.00
260_F266_L1.8241.00
255_G262_E1.8211.00
271_I316_E1.8161.00
18_I44_Y1.7871.00
253_V256_Q1.7511.00
260_F265_L1.7421.00
255_G259_L1.7211.00
275_N304_A1.6721.00
254_E258_E1.6701.00
256_Q266_L1.6661.00
137_D141_D1.6611.00
258_E262_E1.6471.00
306_K309_G1.6431.00
258_E261_R1.6351.00
285_Y289_V1.5961.00
199_I204_R1.5801.00
223_R226_R1.5761.00
20_T44_Y1.5731.00
256_Q259_L1.5621.00
174_S183_I1.5491.00
181_P194_H1.5361.00
182_E186_Y1.5311.00
73_R87_V1.5251.00
198_V207_V1.5241.00
285_Y288_I1.5091.00
254_E257_I1.5031.00
273_V302_I1.4801.00
313_L317_L1.4591.00
255_G266_L1.4371.00
70_E75_M1.4151.00
120_Q124_R1.4081.00
16_Q82_R1.4021.00
114_S117_I1.4011.00
173_V181_P1.4011.00
255_G265_L1.3851.00
113_E117_I1.3801.00
255_G260_F1.3721.00
131_K135_C1.3611.00
31_T34_R1.3541.00
298_E320_L1.3481.00
71_A75_M1.3441.00
39_R43_E1.3371.00
42_K61_I1.3351.00
170_S181_P1.3281.00
238_I317_L1.3261.00
273_V313_L1.3121.00
43_E46_E1.3081.00
242_M275_N1.2991.00
82_R86_S1.2951.00
92_S96_M1.2781.00
182_E189_T1.2771.00
261_R264_K1.2721.00
200_L205_I1.2641.00
216_R225_E1.2591.00
162_A232_I1.2571.00
84_C88_T1.2511.00
137_D140_I1.2461.00
24_R39_R1.2361.00
45_Y62_D1.2281.00
99_L103_I1.2271.00
312_K315_E1.2261.00
230_N234_N1.2161.00
246_S279_E1.2151.00
106_I111_E1.2131.00
142_V146_L1.2121.00
253_V257_I1.2101.00
260_F263_V1.2091.00
140_I143_A1.2071.00
158_T206_Q1.1991.00
286_K289_V1.1931.00
240_V313_L1.1871.00
124_R127_S1.1821.00
130_R134_E1.1821.00
226_R230_N1.1761.00
302_I310_I1.1671.00
227_K231_A1.1581.00
271_I317_L1.1521.00
176_I314_K1.1521.00
31_T38_I1.1481.00
274_I299_W1.1471.00
165_P187_P1.1461.00
71_A74_I1.1371.00
43_E47_R1.1371.00
97_K101_K1.1351.00
259_L265_L1.1351.00
152_I234_N1.1341.00
84_C128_V1.1281.00
72_T76_T1.1231.00
257_I260_F1.1211.00
243_F274_I1.1191.00
28_I35_D1.1171.00
53_D57_Q1.1171.00
64_L67_F1.1161.00
72_T75_M1.1031.00
44_Y48_I1.0981.00
257_I270_V1.0941.00
70_E74_I1.0931.00
127_S130_R1.0911.00
101_K135_C1.0911.00
272_P299_W1.0861.00
103_I107_R1.0861.00
219_A222_N1.0791.00
259_L262_E1.0751.00
185_S219_A1.0751.00
78_I81_L1.0721.00
38_I62_D1.0661.00
119_R123_G1.0641.00
74_I81_L1.0491.00
238_I271_I1.0471.00
93_V97_K1.0441.00
159_I238_I1.0381.00
172_L313_L1.0231.00
277_I308_I1.0161.00
175_K304_A1.0141.00
112_N116_R1.0141.00
69_L75_M1.0141.00
59_P62_D1.0131.00
253_V272_P1.0101.00
87_V91_T0.9971.00
94_I135_C0.9801.00
65_H68_Y0.9801.00
106_I109_S0.9791.00
39_R42_K0.9771.00
90_K94_I0.9741.00
205_I317_L0.9671.00
148_K152_I0.9661.00
125_V129_L0.9661.00
159_I207_V0.9651.00
300_H316_E0.9601.00
133_S137_D0.9571.00
302_I305_E0.9561.00
166_N185_S0.9561.00
90_K93_V0.9521.00
162_A239_I0.9481.00
257_I264_K0.9431.00
198_V205_I0.9401.00
312_K316_E0.9361.00
259_L263_V0.9321.00
171_T302_I0.9321.00
311_D315_E0.9281.00
115_N119_R0.9271.00
143_A146_L0.9251.00
101_K131_K0.9241.00
35_D39_R0.9241.00
99_L106_I0.9231.00
244_D276_K0.9181.00
145_E148_K0.9110.99
64_L68_Y0.9110.99
245_S280_K0.9090.99
284_Y287_K0.9070.99
307_G310_I0.9060.99
244_D247_I0.9040.99
53_D56_E0.9020.99
263_V270_V0.8980.99
197_H206_Q0.8950.99
175_K305_E0.8930.99
134_E138_R0.8920.99
97_K100_K0.8910.99
172_L242_M0.8910.99
177_S198_V0.8890.99
140_I226_R0.8810.99
255_G264_K0.8790.99
99_L102_Y0.8730.99
193_V231_A0.8690.99
171_T306_K0.8690.99
113_E116_R0.8680.99
231_A234_N0.8630.99
92_S126_S0.8580.99
51_Y54_F0.8560.99
271_I320_L0.8560.99
245_S277_I0.8520.99
101_K117_I0.8520.99
62_D65_H0.8520.99
311_D314_K0.8510.99
57_Q60_K0.8500.99
229_T262_E0.8490.99
142_V145_E0.8490.99
132_S136_I0.8420.99
184_A189_T0.8410.99
104_N108_K0.8390.99
203_F322_K0.8360.99
134_E137_D0.8340.99
281_Y284_Y0.8330.99
18_I48_I0.8290.99
54_F58_F0.8270.99
14_A73_R0.8250.99
129_L133_S0.8250.99
37_E41_L0.8220.99
54_F59_P0.8140.99
258_E266_L0.8110.99
58_F64_L0.8030.99
73_R76_T0.8010.99
21_M24_R0.7970.99
289_V301_E0.7960.99
99_L117_I0.7940.99
70_E73_R0.7940.99
170_S183_I0.7910.99
102_Y107_R0.7900.99
37_E42_K0.7830.98
310_I314_K0.7790.98
100_K103_I0.7780.98
253_V260_F0.7750.98
315_E318_F0.7710.98
241_F270_V0.7640.98
172_L176_I0.7620.98
27_K32_T0.7580.98
184_A220_E0.7570.98
117_I121_A0.7570.98
114_S118_M0.7550.98
33_V38_I0.7530.98
81_L132_S0.7530.98
140_I230_N0.7490.98
192_E211_P0.7450.98
45_Y48_I0.7370.98
139_V143_A0.7350.98
58_F66_P0.7320.98
126_S130_R0.7320.98
116_R121_A0.7320.98
118_M121_A0.7280.98
26_P30_G0.7260.97
59_P63_E0.7220.97
233_R268_K0.7150.97
138_R141_D0.7110.97
199_I202_D0.7100.97
87_V106_I0.7080.97
303_S306_K0.7070.97
130_R133_S0.7040.97
78_I143_A0.7010.97
280_K283_E0.6930.97
55_V58_F0.6920.97
239_I270_V0.6920.97
270_V297_N0.6920.97
258_E265_L0.6910.97
19_D26_P0.6910.97
29_G36_R0.6890.97
13_K77_D0.6880.97
253_V263_V0.6860.96
112_N119_R0.6860.96
241_F247_I0.6800.96
174_S177_S0.6780.96
232_I239_I0.6760.96
261_R266_L0.6760.96
136_I139_V0.6720.96
112_N121_A0.6710.96
147_K230_N0.6700.96
280_K284_Y0.6700.96
101_K128_V0.6690.96
241_F272_P0.6690.96
118_M122_F0.6660.96
314_K318_F0.6660.96
228_A231_A0.6640.96
186_Y189_T0.6630.96
219_A262_E0.6620.96
103_I117_I0.6620.96
243_F253_V0.6610.96
79_N82_R0.6590.96
94_I97_K0.6580.96
218_E221_R0.6580.96
55_V69_L0.6530.95
14_A109_S0.6510.95
28_I34_R0.6510.95
178_T314_K0.6490.95
84_C87_V0.6480.95
27_K36_R0.6470.95
140_I227_K0.6440.95
109_S113_E0.6430.95
97_K106_I0.6420.95
22_L25_L0.6420.95
54_F57_Q0.6410.95
111_E120_Q0.6410.95
104_N107_R0.6400.95
93_V96_M0.6370.95
157_P321_V0.6350.95
140_I144_K0.6350.95
257_I272_P0.6340.95
105_Q111_E0.6340.95
54_F66_P0.6310.94
280_K285_Y0.6300.94
86_S89_K0.6300.94
86_S90_K0.6290.94
17_T48_I0.6290.94
31_T35_D0.6280.94
39_R61_I0.6260.94
15_N19_D0.6250.94
201_D204_R0.6240.94
83_I86_S0.6240.94
115_N118_M0.6240.94
271_I300_H0.6240.94
78_I82_R0.6230.94
42_K62_D0.6230.94
259_L266_L0.6220.94
208_I231_A0.6200.94
253_V259_L0.6200.94
14_A87_V0.6180.94
201_D315_E0.6180.94
173_V207_V0.6160.94
243_F283_E0.6150.94
218_E225_E0.6140.94
284_Y288_I0.6130.93
141_D145_E0.6120.93
121_A124_R0.6100.93
305_E308_I0.6060.93
22_L26_P0.6020.93
308_I312_K0.6020.93
108_K112_N0.6010.93
164_P253_V0.6000.93
117_I124_R0.5980.93
59_P64_L0.5980.93
79_N83_I0.5970.93
253_V262_E0.5950.92
87_V118_M0.5920.92
296_G299_W0.5860.92
76_T87_V0.5860.92
157_P203_F0.5850.92
58_F67_F0.5810.92
105_Q117_I0.5800.91
113_E118_M0.5790.91
42_K45_Y0.5780.91
115_N121_A0.5780.91
65_H77_D0.5770.91
112_N118_M0.5760.91
203_F318_F0.5730.91
164_P247_I0.5730.91
100_K104_N0.5730.91
222_N226_R0.5720.91
55_V59_P0.5720.91
58_F68_Y0.5680.91
198_V317_L0.5670.91
41_L62_D0.5640.90
230_N233_R0.5630.90
105_Q116_R0.5620.90
220_E223_R0.5600.90
74_I85_L0.5600.90
19_D23_K0.5590.90
159_I320_L0.5580.90
160_V228_A0.5580.90
174_S181_P0.5580.90
14_A63_E0.5570.90
200_L203_F0.5560.90
117_I122_F0.5560.90
81_L85_L0.5550.90
50_K58_F0.5540.90
186_Y214_L0.5530.89
89_K220_E0.5530.89
58_F61_I0.5520.89
34_R37_E0.5510.89
164_P225_E0.5480.89
245_S281_Y0.5470.89
225_E229_T0.5470.89
164_P259_L0.5460.89
157_P205_I0.5460.89
138_R142_V0.5460.89
30_G33_V0.5450.89
144_K152_I0.5440.89
28_I31_T0.5430.89
253_V258_E0.5380.88
57_Q61_I0.5370.88
134_E141_D0.5370.88
98_I101_K0.5360.88
65_H69_L0.5360.88
176_I310_I0.5350.88
253_V264_K0.5350.88
158_T195_V0.5330.88
59_P67_F0.5320.88
62_D67_F0.5320.88
164_P256_Q0.5320.88
172_L302_I0.5320.88
198_V314_K0.5300.87
217_P228_A0.5260.87
165_P191_K0.5260.87
297_N316_E0.5260.87
158_T237_G0.5250.87
263_V266_L0.5250.87
211_P224_I0.5240.87
164_P229_T0.5240.87
254_E319_N0.5230.87
55_V62_D0.5210.87
107_R111_E0.5210.87
62_D68_Y0.5200.86
164_P167_V0.5200.86
50_K220_E0.5200.86
154_P157_P0.5190.86
229_T258_E0.5180.86
42_K48_I0.5180.86
49_K52_Y0.5160.86
163_G168_G0.5160.86
256_Q263_V0.5160.86
242_M304_A0.5150.86
191_K218_E0.5140.86
65_H70_E0.5140.86
141_D144_K0.5110.85
143_A230_N0.5100.85
187_P215_D0.5090.85
116_R120_Q0.5080.85
168_G209_D0.5070.85
302_I313_L0.5060.85
124_R128_V0.5050.85
232_I236_N0.5050.85
105_Q108_K0.5040.85
27_K31_T0.5040.85
26_P29_G0.5010.84
279_E282_E0.5010.84
96_M122_F0.5010.84
95_S122_F0.5010.84
131_K134_E0.5000.84
199_I203_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtfA 1 0.8343 100 0.383 Contact Map
2e87A 1 1 100 0.385 Contact Map
3j65o 1 0.991 100 0.393 Contact Map
3geeA 2 0.8524 100 0.437 Contact Map
3gehA 2 0.9036 100 0.447 Contact Map
1xzpA 4 0.9669 100 0.448 Contact Map
1mkyA 1 0.4789 100 0.506 Contact Map
3j8gX 1 0.4488 100 0.522 Contact Map
1egaA 2 0.5301 100 0.534 Contact Map
3ievA 1 0.5301 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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