Q7LXR6 - SULSO - GREMLIN Contacts

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Q7LXR6 - GTP-binding protein

UniProt:	Q7LXR6	Sequences: MLNPFEKLQIPPKANQTIDTMLKRLPKIGGTTVRDREIRRLKEYYERIKKYYDFVEQFPKIDELHPFYLEATRIMTDINKLRICLSVTKKTSVISMKILKKYINQIRKSPENESNRIMRQAFGRVSSVLRKSSECIDRVIDVAKELKKIQGIDPTLPTIVVAGPPNVGKSTLVSKISTAKPEIASYPFTTKEVHVGHVILDDFRIQVIDTPGILDRPEAERNRIERKATNAIRNLNGIIVFMFDSSISSVLSVEGQIELFREVKLLKKIVIPVINKIDEKYEEYYKKIVDFLLSEGNEWHEISAEKGIGIDKLKEELFNLVKSSGTNEVSRD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (298)
Sequences:	5921 (3915)
Seq/√Len:	226.8

ECOLI - HFLX MNME DER ERA ENGB YFJP YKFA
BACSU - HFLX MNME DER ERA ENGB
HALSA - Q9HMC2 Q9HMD6 Q9HQ88 ENGB Y1111
SULSO - Q7LXR6 HFLX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
316_E	319_N	3.825	1.00
240_V	273_V	3.457	1.00
201_D	318_F	3.391	1.00
256_Q	260_F	3.361	1.00
160_V	236_N	3.050	1.00
38_I	61_I	3.010	1.00
260_F	264_K	2.925	1.00
243_F	272_P	2.755	1.00
197_H	204_R	2.679	1.00
256_Q	264_K	2.625	1.00
195_V	206_Q	2.543	1.00
33_V	41_L	2.525	1.00
175_K	310_I	2.432	1.00
256_Q	262_E	2.414	1.00
316_E	320_L	2.370	1.00
245_S	274_I	2.366	1.00
159_I	205_I	2.357	1.00
24_R	28_I	2.265	1.00
175_K	307_G	2.264	1.00
89_K	133_S	2.219	1.00
58_F	62_D	2.215	1.00
309_G	312_K	2.164	1.00
298_E	316_E	2.147	1.00
277_I	301_E	2.103	1.00
20_T	41_L	2.096	1.00
274_I	301_E	2.090	1.00
262_E	265_L	2.078	1.00
171_T	304_A	2.066	1.00
273_V	300_H	2.021	1.00
195_V	208_I	2.002	1.00
38_I	58_F	1.957	1.00
256_Q	265_L	1.945	1.00
315_E	319_N	1.902	1.00
262_E	266_L	1.891	1.00
255_G	258_E	1.870	1.00
161_V	173_V	1.855	1.00
42_K	46_E	1.853	1.00
37_E	40_R	1.846	1.00
112_N	115_N	1.830	1.00
257_I	261_R	1.828	1.00
112_N	117_I	1.827	1.00
260_F	266_L	1.824	1.00
255_G	262_E	1.821	1.00
271_I	316_E	1.816	1.00
18_I	44_Y	1.787	1.00
253_V	256_Q	1.751	1.00
260_F	265_L	1.742	1.00
255_G	259_L	1.721	1.00
275_N	304_A	1.672	1.00
254_E	258_E	1.670	1.00
256_Q	266_L	1.666	1.00
137_D	141_D	1.661	1.00
258_E	262_E	1.647	1.00
306_K	309_G	1.643	1.00
258_E	261_R	1.635	1.00
285_Y	289_V	1.596	1.00
199_I	204_R	1.580	1.00
223_R	226_R	1.576	1.00
20_T	44_Y	1.573	1.00
256_Q	259_L	1.562	1.00
174_S	183_I	1.549	1.00
181_P	194_H	1.536	1.00
182_E	186_Y	1.531	1.00
73_R	87_V	1.525	1.00
198_V	207_V	1.524	1.00
285_Y	288_I	1.509	1.00
254_E	257_I	1.503	1.00
273_V	302_I	1.480	1.00
313_L	317_L	1.459	1.00
255_G	266_L	1.437	1.00
70_E	75_M	1.415	1.00
120_Q	124_R	1.408	1.00
16_Q	82_R	1.402	1.00
114_S	117_I	1.401	1.00
173_V	181_P	1.401	1.00
255_G	265_L	1.385	1.00
113_E	117_I	1.380	1.00
255_G	260_F	1.372	1.00
131_K	135_C	1.361	1.00
31_T	34_R	1.354	1.00
298_E	320_L	1.348	1.00
71_A	75_M	1.344	1.00
39_R	43_E	1.337	1.00
42_K	61_I	1.335	1.00
170_S	181_P	1.328	1.00
238_I	317_L	1.326	1.00
273_V	313_L	1.312	1.00
43_E	46_E	1.308	1.00
242_M	275_N	1.299	1.00
82_R	86_S	1.295	1.00
92_S	96_M	1.278	1.00
182_E	189_T	1.277	1.00
261_R	264_K	1.272	1.00
200_L	205_I	1.264	1.00
216_R	225_E	1.259	1.00
162_A	232_I	1.257	1.00
84_C	88_T	1.251	1.00
137_D	140_I	1.246	1.00
24_R	39_R	1.236	1.00
45_Y	62_D	1.228	1.00
99_L	103_I	1.227	1.00
312_K	315_E	1.226	1.00
230_N	234_N	1.216	1.00
246_S	279_E	1.215	1.00
106_I	111_E	1.213	1.00
142_V	146_L	1.212	1.00
253_V	257_I	1.210	1.00
260_F	263_V	1.209	1.00
140_I	143_A	1.207	1.00
158_T	206_Q	1.199	1.00
286_K	289_V	1.193	1.00
240_V	313_L	1.187	1.00
124_R	127_S	1.182	1.00
130_R	134_E	1.182	1.00
226_R	230_N	1.176	1.00
302_I	310_I	1.167	1.00
227_K	231_A	1.158	1.00
271_I	317_L	1.152	1.00
176_I	314_K	1.152	1.00
31_T	38_I	1.148	1.00
274_I	299_W	1.147	1.00
165_P	187_P	1.146	1.00
71_A	74_I	1.137	1.00
43_E	47_R	1.137	1.00
97_K	101_K	1.135	1.00
259_L	265_L	1.135	1.00
152_I	234_N	1.134	1.00
84_C	128_V	1.128	1.00
72_T	76_T	1.123	1.00
257_I	260_F	1.121	1.00
243_F	274_I	1.119	1.00
28_I	35_D	1.117	1.00
53_D	57_Q	1.117	1.00
64_L	67_F	1.116	1.00
72_T	75_M	1.103	1.00
44_Y	48_I	1.098	1.00
257_I	270_V	1.094	1.00
70_E	74_I	1.093	1.00
127_S	130_R	1.091	1.00
101_K	135_C	1.091	1.00
272_P	299_W	1.086	1.00
103_I	107_R	1.086	1.00
219_A	222_N	1.079	1.00
259_L	262_E	1.075	1.00
185_S	219_A	1.075	1.00
78_I	81_L	1.072	1.00
38_I	62_D	1.066	1.00
119_R	123_G	1.064	1.00
74_I	81_L	1.049	1.00
238_I	271_I	1.047	1.00
93_V	97_K	1.044	1.00
159_I	238_I	1.038	1.00
172_L	313_L	1.023	1.00
277_I	308_I	1.016	1.00
175_K	304_A	1.014	1.00
112_N	116_R	1.014	1.00
69_L	75_M	1.014	1.00
59_P	62_D	1.013	1.00
253_V	272_P	1.010	1.00
87_V	91_T	0.997	1.00
94_I	135_C	0.980	1.00
65_H	68_Y	0.980	1.00
106_I	109_S	0.979	1.00
39_R	42_K	0.977	1.00
90_K	94_I	0.974	1.00
205_I	317_L	0.967	1.00
148_K	152_I	0.966	1.00
125_V	129_L	0.966	1.00
159_I	207_V	0.965	1.00
300_H	316_E	0.960	1.00
133_S	137_D	0.957	1.00
302_I	305_E	0.956	1.00
166_N	185_S	0.956	1.00
90_K	93_V	0.952	1.00
162_A	239_I	0.948	1.00
257_I	264_K	0.943	1.00
198_V	205_I	0.940	1.00
312_K	316_E	0.936	1.00
259_L	263_V	0.932	1.00
171_T	302_I	0.932	1.00
311_D	315_E	0.928	1.00
115_N	119_R	0.927	1.00
143_A	146_L	0.925	1.00
101_K	131_K	0.924	1.00
35_D	39_R	0.924	1.00
99_L	106_I	0.923	1.00
244_D	276_K	0.918	1.00
145_E	148_K	0.911	0.99
64_L	68_Y	0.911	0.99
245_S	280_K	0.909	0.99
284_Y	287_K	0.907	0.99
307_G	310_I	0.906	0.99
244_D	247_I	0.904	0.99
53_D	56_E	0.902	0.99
263_V	270_V	0.898	0.99
197_H	206_Q	0.895	0.99
175_K	305_E	0.893	0.99
134_E	138_R	0.892	0.99
97_K	100_K	0.891	0.99
172_L	242_M	0.891	0.99
177_S	198_V	0.889	0.99
140_I	226_R	0.881	0.99
255_G	264_K	0.879	0.99
99_L	102_Y	0.873	0.99
193_V	231_A	0.869	0.99
171_T	306_K	0.869	0.99
113_E	116_R	0.868	0.99
231_A	234_N	0.863	0.99
92_S	126_S	0.858	0.99
51_Y	54_F	0.856	0.99
271_I	320_L	0.856	0.99
245_S	277_I	0.852	0.99
101_K	117_I	0.852	0.99
62_D	65_H	0.852	0.99
311_D	314_K	0.851	0.99
57_Q	60_K	0.850	0.99
229_T	262_E	0.849	0.99
142_V	145_E	0.849	0.99
132_S	136_I	0.842	0.99
184_A	189_T	0.841	0.99
104_N	108_K	0.839	0.99
203_F	322_K	0.836	0.99
134_E	137_D	0.834	0.99
281_Y	284_Y	0.833	0.99
18_I	48_I	0.829	0.99
54_F	58_F	0.827	0.99
14_A	73_R	0.825	0.99
129_L	133_S	0.825	0.99
37_E	41_L	0.822	0.99
54_F	59_P	0.814	0.99
258_E	266_L	0.811	0.99
58_F	64_L	0.803	0.99
73_R	76_T	0.801	0.99
21_M	24_R	0.797	0.99
289_V	301_E	0.796	0.99
99_L	117_I	0.794	0.99
70_E	73_R	0.794	0.99
170_S	183_I	0.791	0.99
102_Y	107_R	0.790	0.99
37_E	42_K	0.783	0.98
310_I	314_K	0.779	0.98
100_K	103_I	0.778	0.98
253_V	260_F	0.775	0.98
315_E	318_F	0.771	0.98
241_F	270_V	0.764	0.98
172_L	176_I	0.762	0.98
27_K	32_T	0.758	0.98
184_A	220_E	0.757	0.98
117_I	121_A	0.757	0.98
114_S	118_M	0.755	0.98
33_V	38_I	0.753	0.98
81_L	132_S	0.753	0.98
140_I	230_N	0.749	0.98
192_E	211_P	0.745	0.98
45_Y	48_I	0.737	0.98
139_V	143_A	0.735	0.98
58_F	66_P	0.732	0.98
126_S	130_R	0.732	0.98
116_R	121_A	0.732	0.98
118_M	121_A	0.728	0.98
26_P	30_G	0.726	0.97
59_P	63_E	0.722	0.97
233_R	268_K	0.715	0.97
138_R	141_D	0.711	0.97
199_I	202_D	0.710	0.97
87_V	106_I	0.708	0.97
303_S	306_K	0.707	0.97
130_R	133_S	0.704	0.97
78_I	143_A	0.701	0.97
280_K	283_E	0.693	0.97
55_V	58_F	0.692	0.97
239_I	270_V	0.692	0.97
270_V	297_N	0.692	0.97
258_E	265_L	0.691	0.97
19_D	26_P	0.691	0.97
29_G	36_R	0.689	0.97
13_K	77_D	0.688	0.97
253_V	263_V	0.686	0.96
112_N	119_R	0.686	0.96
241_F	247_I	0.680	0.96
174_S	177_S	0.678	0.96
232_I	239_I	0.676	0.96
261_R	266_L	0.676	0.96
136_I	139_V	0.672	0.96
112_N	121_A	0.671	0.96
147_K	230_N	0.670	0.96
280_K	284_Y	0.670	0.96
101_K	128_V	0.669	0.96
241_F	272_P	0.669	0.96
118_M	122_F	0.666	0.96
314_K	318_F	0.666	0.96
228_A	231_A	0.664	0.96
186_Y	189_T	0.663	0.96
219_A	262_E	0.662	0.96
103_I	117_I	0.662	0.96
243_F	253_V	0.661	0.96
79_N	82_R	0.659	0.96
94_I	97_K	0.658	0.96
218_E	221_R	0.658	0.96
55_V	69_L	0.653	0.95
14_A	109_S	0.651	0.95
28_I	34_R	0.651	0.95
178_T	314_K	0.649	0.95
84_C	87_V	0.648	0.95
27_K	36_R	0.647	0.95
140_I	227_K	0.644	0.95
109_S	113_E	0.643	0.95
97_K	106_I	0.642	0.95
22_L	25_L	0.642	0.95
54_F	57_Q	0.641	0.95
111_E	120_Q	0.641	0.95
104_N	107_R	0.640	0.95
93_V	96_M	0.637	0.95
157_P	321_V	0.635	0.95
140_I	144_K	0.635	0.95
257_I	272_P	0.634	0.95
105_Q	111_E	0.634	0.95
54_F	66_P	0.631	0.94
280_K	285_Y	0.630	0.94
86_S	89_K	0.630	0.94
86_S	90_K	0.629	0.94
17_T	48_I	0.629	0.94
31_T	35_D	0.628	0.94
39_R	61_I	0.626	0.94
15_N	19_D	0.625	0.94
201_D	204_R	0.624	0.94
83_I	86_S	0.624	0.94
115_N	118_M	0.624	0.94
271_I	300_H	0.624	0.94
78_I	82_R	0.623	0.94
42_K	62_D	0.623	0.94
259_L	266_L	0.622	0.94
208_I	231_A	0.620	0.94
253_V	259_L	0.620	0.94
14_A	87_V	0.618	0.94
201_D	315_E	0.618	0.94
173_V	207_V	0.616	0.94
243_F	283_E	0.615	0.94
218_E	225_E	0.614	0.94
284_Y	288_I	0.613	0.93
141_D	145_E	0.612	0.93
121_A	124_R	0.610	0.93
305_E	308_I	0.606	0.93
22_L	26_P	0.602	0.93
308_I	312_K	0.602	0.93
108_K	112_N	0.601	0.93
164_P	253_V	0.600	0.93
117_I	124_R	0.598	0.93
59_P	64_L	0.598	0.93
79_N	83_I	0.597	0.93
253_V	262_E	0.595	0.92
87_V	118_M	0.592	0.92
296_G	299_W	0.586	0.92
76_T	87_V	0.586	0.92
157_P	203_F	0.585	0.92
58_F	67_F	0.581	0.92
105_Q	117_I	0.580	0.91
113_E	118_M	0.579	0.91
42_K	45_Y	0.578	0.91
115_N	121_A	0.578	0.91
65_H	77_D	0.577	0.91
112_N	118_M	0.576	0.91
203_F	318_F	0.573	0.91
164_P	247_I	0.573	0.91
100_K	104_N	0.573	0.91
222_N	226_R	0.572	0.91
55_V	59_P	0.572	0.91
58_F	68_Y	0.568	0.91
198_V	317_L	0.567	0.91
41_L	62_D	0.564	0.90
230_N	233_R	0.563	0.90
105_Q	116_R	0.562	0.90
220_E	223_R	0.560	0.90
74_I	85_L	0.560	0.90
19_D	23_K	0.559	0.90
159_I	320_L	0.558	0.90
160_V	228_A	0.558	0.90
174_S	181_P	0.558	0.90
14_A	63_E	0.557	0.90
200_L	203_F	0.556	0.90
117_I	122_F	0.556	0.90
81_L	85_L	0.555	0.90
50_K	58_F	0.554	0.90
186_Y	214_L	0.553	0.89
89_K	220_E	0.553	0.89
58_F	61_I	0.552	0.89
34_R	37_E	0.551	0.89
164_P	225_E	0.548	0.89
245_S	281_Y	0.547	0.89
225_E	229_T	0.547	0.89
164_P	259_L	0.546	0.89
157_P	205_I	0.546	0.89
138_R	142_V	0.546	0.89
30_G	33_V	0.545	0.89
144_K	152_I	0.544	0.89
28_I	31_T	0.543	0.89
253_V	258_E	0.538	0.88
57_Q	61_I	0.537	0.88
134_E	141_D	0.537	0.88
98_I	101_K	0.536	0.88
65_H	69_L	0.536	0.88
176_I	310_I	0.535	0.88
253_V	264_K	0.535	0.88
158_T	195_V	0.533	0.88
59_P	67_F	0.532	0.88
62_D	67_F	0.532	0.88
164_P	256_Q	0.532	0.88
172_L	302_I	0.532	0.88
198_V	314_K	0.530	0.87
217_P	228_A	0.526	0.87
165_P	191_K	0.526	0.87
297_N	316_E	0.526	0.87
158_T	237_G	0.525	0.87
263_V	266_L	0.525	0.87
211_P	224_I	0.524	0.87
164_P	229_T	0.524	0.87
254_E	319_N	0.523	0.87
55_V	62_D	0.521	0.87
107_R	111_E	0.521	0.87
62_D	68_Y	0.520	0.86
164_P	167_V	0.520	0.86
50_K	220_E	0.520	0.86
154_P	157_P	0.519	0.86
229_T	258_E	0.518	0.86
42_K	48_I	0.518	0.86
49_K	52_Y	0.516	0.86
163_G	168_G	0.516	0.86
256_Q	263_V	0.516	0.86
242_M	304_A	0.515	0.86
191_K	218_E	0.514	0.86
65_H	70_E	0.514	0.86
141_D	144_K	0.511	0.85
143_A	230_N	0.510	0.85
187_P	215_D	0.509	0.85
116_R	120_Q	0.508	0.85
168_G	209_D	0.507	0.85
302_I	313_L	0.506	0.85
124_R	128_V	0.505	0.85
232_I	236_N	0.505	0.85
105_Q	108_K	0.504	0.85
27_K	31_T	0.504	0.85
26_P	29_G	0.501	0.84
279_E	282_E	0.501	0.84
96_M	122_F	0.501	0.84
95_S	122_F	0.501	0.84
131_K	134_E	0.500	0.84
199_I	203_F	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qtfA	1	0.8343	100	0.383	Contact Map
2e87A	1	1	100	0.385	Contact Map
3j65o	1	0.991	100	0.393	Contact Map
3geeA	2	0.8524	100	0.437	Contact Map
3gehA	2	0.9036	100	0.447	Contact Map
1xzpA	4	0.9669	100	0.448	Contact Map
1mkyA	1	0.4789	100	0.506	Contact Map
3j8gX	1	0.4488	100	0.522	Contact Map
1egaA	2	0.5301	100	0.534	Contact Map
3ievA	1	0.5301	100	0.534	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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