GREMLIN Database
Q7LXR5 - Methionyl-tRNA synthetase N-term homolog (MetS-like)
UniProt: Q7LXR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (143)
Sequences: 2652 (1934)
Seq/√Len: 161.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_R98_G3.5821.00
70_Q83_L3.4361.00
77_T123_R3.3211.00
67_I110_R3.2181.00
102_T105_E3.1451.00
72_E81_K2.6961.00
63_L112_I2.5461.00
93_I113_V2.5241.00
70_Q107_L2.5151.00
57_D60_K2.4711.00
93_I129_G2.4051.00
136_C145_K2.1041.00
66_G84_I2.0871.00
83_L92_Q2.0721.00
81_K92_Q2.0621.00
69_R90_Q1.9621.00
74_I81_K1.9501.00
94_I125_F1.9411.00
94_I122_I1.9361.00
67_I157_P1.8871.00
26_N30_L1.8711.00
82_L133_A1.8671.00
92_Q125_F1.8601.00
68_V111_I1.8501.00
61_L114_I1.7231.00
62_D160_K1.6941.00
52_Q118_K1.6171.00
86_L113_V1.5681.00
64_K115_A1.5571.00
54_T57_D1.5551.00
66_G113_V1.5471.00
83_L90_Q1.5121.00
19_R22_K1.5041.00
110_R154_E1.5001.00
109_K150_T1.4701.00
121_V126_E1.4551.00
25_S28_Y1.3911.00
67_I85_D1.3691.00
28_Y32_L1.3671.00
138_E145_K1.3641.00
17_H21_K1.3531.00
82_L131_L1.3511.00
80_L103_P1.3301.00
26_N29_K1.2821.00
112_I149_L1.2731.00
85_D157_P1.2631.00
89_E128_Q1.2631.00
29_K32_L1.2341.00
81_K125_F1.2181.00
19_R23_L1.1961.00
63_L114_I1.1951.00
22_K25_S1.1391.00
86_L89_E1.1351.00
95_A133_A1.1271.00
28_Y31_L1.1211.00
94_I120_R1.1071.00
50_S160_K1.1051.00
71_A82_L1.1051.00
17_H20_Y1.1011.00
20_Y23_L1.0780.99
137_K145_K1.0710.99
69_R85_D1.0640.99
73_R103_P1.0630.99
71_A103_P1.0580.99
84_I93_I1.0560.99
13_T19_R1.0470.99
133_A148_I1.0460.99
134_A155_V1.0430.99
111_I131_L1.0290.99
80_L98_G1.0120.99
13_T18_N1.0030.99
65_V110_R0.9990.99
18_N24_A0.9900.99
74_I125_F0.9840.99
54_T118_K0.9790.99
84_I131_L0.9680.99
30_L34_Y0.9570.99
100_Y146_P0.9550.99
13_T17_H0.9490.99
110_R157_P0.9490.99
25_S29_K0.9370.99
73_R102_T0.9290.98
17_H22_K0.9280.98
72_E83_L0.9210.98
16_L19_R0.9130.98
53_I61_L0.8930.98
55_I59_A0.8890.98
109_K152_D0.8830.98
17_H23_L0.8770.98
93_I131_L0.8740.98
25_S32_L0.8710.98
82_L95_A0.8640.97
82_L106_L0.8570.97
76_G123_R0.8490.97
48_I51_N0.8470.97
30_L33_H0.8260.97
21_K24_A0.8260.97
102_T106_L0.8230.97
71_A95_A0.8200.97
84_I111_I0.8130.96
71_A80_L0.8070.96
150_T153_G0.7970.96
112_I151_V0.7940.96
86_L115_A0.7930.96
32_L35_V0.7920.96
74_I77_T0.7900.96
29_K33_H0.7850.96
85_D90_Q0.7820.95
31_L35_V0.7810.95
66_G90_Q0.7800.95
77_T98_G0.7760.95
112_I161_I0.7730.95
16_L20_Y0.7650.95
56_D59_A0.7650.95
16_L22_K0.7640.95
84_I113_V0.7550.95
117_L130_M0.7520.94
32_L36_N0.7490.94
66_G93_I0.7270.93
151_V155_V0.7240.93
149_L152_D0.7170.93
86_L90_Q0.7120.93
34_Y38_N0.7070.92
49_M62_D0.7040.92
15_I19_R0.7030.92
18_N21_K0.7010.92
147_R154_E0.6990.92
35_V38_N0.6960.92
40_Y44_P0.6960.92
20_Y24_A0.6920.92
98_G102_T0.6900.91
17_H25_S0.6870.91
41_N44_P0.6830.91
49_M88_S0.6810.91
147_R153_G0.6790.91
75_E81_K0.6720.90
27_K31_L0.6630.90
65_V161_I0.6630.90
100_Y145_K0.6580.89
49_M52_Q0.6560.89
147_R151_V0.6520.89
113_V131_L0.6520.89
65_V112_I0.6510.89
16_L21_K0.6500.89
46_L49_M0.6470.89
38_N42_S0.6470.89
131_L148_I0.6440.88
91_R128_Q0.6420.88
68_V71_A0.6370.88
147_R152_D0.6360.88
106_L148_I0.6320.87
147_R155_V0.6320.87
23_L27_K0.6320.87
96_G122_I0.6250.87
38_N41_N0.6210.87
53_I114_I0.6180.86
19_R24_A0.6160.86
74_I123_R0.6160.86
147_R150_T0.6110.86
156_P159_T0.6080.85
63_L132_L0.6080.85
20_Y25_S0.6060.85
57_D61_L0.5890.84
64_K160_K0.5860.83
50_S59_A0.5840.83
109_K148_I0.5800.83
94_I123_R0.5790.83
41_N45_M0.5780.82
110_R156_P0.5680.81
100_Y135_G0.5640.81
98_G123_R0.5640.81
103_P106_L0.5620.81
24_A29_K0.5620.81
24_A28_Y0.5620.81
49_M115_A0.5550.80
68_V148_I0.5510.79
23_L26_N0.5500.79
31_L36_N0.5490.79
111_I148_I0.5480.79
21_K25_S0.5470.79
122_I129_G0.5460.79
135_G146_P0.5430.78
48_I88_S0.5380.78
75_E123_R0.5370.78
15_I18_N0.5370.78
33_H36_N0.5350.77
97_L146_P0.5340.77
15_I23_L0.5330.77
35_V39_P0.5270.76
73_R77_T0.5250.76
155_V159_T0.5220.76
99_E138_E0.5210.75
18_N22_K0.5200.75
20_Y28_Y0.5190.75
104_E107_L0.5170.75
27_K30_L0.5150.75
39_P43_S0.5140.75
22_K26_N0.5120.74
85_D88_S0.5120.74
80_L97_L0.5120.74
24_A27_K0.5120.74
68_V131_L0.5110.74
98_G103_P0.5090.74
110_R159_T0.5070.74
132_L146_P0.5070.74
13_T23_L0.5060.73
95_A131_L0.5050.73
71_A133_A0.5040.73
76_G124_G0.5040.73
65_V151_V0.5030.73
15_I20_Y0.5030.73
15_I21_K0.5000.73
55_I120_R0.5000.73
70_Q81_K0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rqgA 2 0.2531 100 0.355 Contact Map
3ersX 2 0.6728 100 0.38 Contact Map
4r3zA 1 0.179 100 0.382 Contact Map
1pybA 2 0.6543 100 0.382 Contact Map
1mkhA 2 0.6481 100 0.385 Contact Map
2cwpA 2 0.6667 100 0.388 Contact Map
1gd7A 2 0.6543 100 0.389 Contact Map
3g48A 2 0.6605 100 0.391 Contact Map
2q2hA 2 0.7099 100 0.393 Contact Map
2q2iA 2 0.6667 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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