GREMLIN Database
Q7LXR4 - Amidophosphoribosyltransferase
UniProt: Q7LXR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (353)
Sequences: 6772 (3654)
Seq/√Len: 194.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_F145_V4.6621.00
163_V184_V4.3001.00
24_V73_G3.7581.00
282_A333_K3.3701.00
134_S137_D2.9791.00
219_K223_E2.8371.00
160_E209_I2.8041.00
29_R62_F2.7901.00
129_K141_E2.7771.00
139_V162_V2.7461.00
286_S296_P2.7281.00
126_F142_F2.6911.00
254_I258_E2.6411.00
163_V208_I2.5501.00
262_E288_K2.5131.00
42_A49_I2.4471.00
206_E227_Y2.3851.00
129_K145_V2.3601.00
255_R258_E2.3471.00
97_K158_D2.2891.00
42_A51_T2.2691.00
54_G87_I2.2421.00
136_P218_D2.2041.00
160_E211_K2.1811.00
122_I146_V2.1441.00
270_I273_P2.1421.00
55_S85_S2.1011.00
175_L202_I2.0871.00
197_S231_S2.0831.00
177_F197_S2.0711.00
175_L208_I2.0631.00
122_I152_V2.0031.00
177_F199_L1.9861.00
43_Y71_K1.9361.00
24_V75_G1.9011.00
282_A331_R1.8931.00
184_V210_M1.8841.00
211_K214_K1.8681.00
136_P209_I1.8551.00
42_A99_V1.8031.00
139_V154_I1.7671.00
54_G64_E1.7531.00
11_F27_G1.7481.00
330_V360_A1.7441.00
178_L181_S1.7431.00
135_I156_L1.7171.00
143_M164_F1.7091.00
59_D63_K1.7031.00
182_L215_I1.6951.00
26_E193_Q1.6831.00
94_G127_K1.6621.00
126_F154_I1.6391.00
354_M357_K1.6331.00
111_Q147_D1.6321.00
243_N248_S1.6161.00
264_H268_G1.6091.00
135_I162_V1.6031.00
162_V209_I1.6021.00
38_S90_A1.5721.00
159_E212_N1.5631.00
175_L215_I1.5601.00
175_L184_V1.5571.00
209_I216_L1.5521.00
88_E116_R1.5451.00
100_V123_Y1.5411.00
238_A241_D1.5401.00
14_S212_N1.5381.00
216_L224_E1.5271.00
268_G272_V1.5211.00
129_K142_F1.5181.00
327_A331_R1.5181.00
60_E63_K1.5081.00
126_F139_V1.5051.00
197_S229_T1.4901.00
259_L262_E1.4881.00
283_L316_N1.4861.00
258_E288_K1.4801.00
211_K216_L1.4791.00
318_V326_V1.4781.00
202_I208_I1.4771.00
15_S19_V1.4721.00
319_L346_N1.4691.00
49_I99_V1.4641.00
55_S86_S1.4551.00
137_D140_K1.4521.00
296_P338_I1.4421.00
203_L219_K1.4411.00
98_I156_L1.4391.00
353_T357_K1.4361.00
334_R362_E1.4291.00
203_L227_Y1.4161.00
153_A184_V1.4131.00
17_K181_S1.4081.00
305_R327_A1.4071.00
177_F182_L1.4061.00
364_H367_I1.3731.00
97_K157_N1.3551.00
101_A153_A1.3531.00
130_L156_L1.3531.00
43_Y73_G1.3411.00
136_P140_K1.3371.00
182_L214_K1.3341.00
45_E48_E1.3331.00
166_D205_S1.3301.00
269_D272_V1.3161.00
152_V164_F1.3131.00
174_V191_I1.3111.00
143_M146_V1.3101.00
153_A161_I1.3071.00
44_A155_L1.3051.00
367_I371_M1.3031.00
247_H252_A1.3031.00
129_K132_F1.3021.00
308_I327_A1.2981.00
141_E144_K1.2801.00
59_D62_F1.2691.00
267_N334_R1.2631.00
98_I130_L1.2621.00
53_K87_I1.2561.00
64_E87_I1.2471.00
136_P207_M1.2451.00
274_V277_S1.2421.00
7_K10_V1.2371.00
132_F141_E1.2331.00
110_Y114_S1.2321.00
303_S311_T1.2201.00
191_I196_G1.2201.00
264_H267_N1.2171.00
140_K218_D1.2121.00
185_S190_V1.2041.00
308_I329_A1.2031.00
264_H270_I1.1971.00
174_V188_D1.1931.00
136_P216_L1.1931.00
209_I218_D1.1911.00
293_L297_L1.1801.00
367_I370_P1.1771.00
98_I135_I1.1741.00
336_V360_A1.1721.00
13_V23_L1.1581.00
277_S361_K1.1541.00
100_V119_T1.1441.00
25_V41_I1.1411.00
188_D201_H1.1391.00
188_D198_V1.1391.00
234_Y239_R1.1231.00
268_G271_V1.1231.00
26_E29_R1.1081.00
12_A153_A1.1051.00
138_T142_F1.0991.00
54_G61_V1.0981.00
177_F215_I1.0891.00
43_Y69_F1.0861.00
115_F128_Q1.0791.00
323_F330_V1.0761.00
8_C103_N1.0731.00
150_Y220_V1.0681.00
109_Y113_G1.0671.00
251_L328_D1.0641.00
252_A256_L1.0591.00
285_F323_F1.0581.00
198_V201_H1.0381.00
331_R334_R1.0361.00
266_A366_R1.0341.00
265_P268_G1.0331.00
300_T316_N1.0301.00
264_H269_D1.0291.00
52_I68_K1.0261.00
11_F24_V1.0251.00
97_K127_K1.0221.00
142_F146_V1.0191.00
183_I191_I1.0171.00
182_L210_M1.0171.00
135_I139_V1.0161.00
196_G231_S1.0141.00
218_D224_E1.0121.00
270_I335_I1.0101.00
269_D273_P1.0101.00
316_N346_N1.0101.00
16_P212_N1.0091.00
130_L158_D1.0041.00
266_A270_I1.0031.00
254_I287_R1.0031.00
201_H230_C1.0021.00
265_P269_D0.9941.00
354_M358_A0.9931.00
137_D141_E0.9931.00
363_I367_I0.9911.00
124_K127_K0.9911.00
15_S181_S0.9901.00
348_M365_V0.9901.00
153_A163_V0.9891.00
13_V181_S0.9880.99
113_G121_F0.9870.99
52_I64_E0.9870.99
154_I162_V0.9820.99
175_L199_L0.9790.99
28_I75_G0.9780.99
266_A269_D0.9780.99
281_I335_I0.9780.99
13_V19_V0.9770.99
266_A272_V0.9770.99
94_G124_K0.9730.99
102_F119_T0.9720.99
23_L194_L0.9710.99
45_E50_L0.9650.99
129_K138_T0.9650.99
12_A184_V0.9650.99
9_G77_V0.9610.99
192_R324_G0.9600.99
100_V122_I0.9570.99
258_E287_R0.9560.99
125_F146_V0.9520.99
282_A332_G0.9480.99
163_V175_L0.9450.99
246_G250_Y0.9390.99
133_R141_E0.9340.99
12_A161_I0.9340.99
330_V355_L0.9320.99
255_R259_L0.9320.99
128_Q132_F0.9290.99
199_L217_Y0.9250.99
242_S246_G0.9180.99
106_I146_V0.9170.99
203_L206_E0.9160.99
150_Y166_D0.9120.99
236_Y239_R0.9110.99
127_K131_A0.9030.99
140_K207_M0.9020.99
191_I198_V0.9010.99
150_Y167_P0.8980.99
139_V164_F0.8980.99
368_G371_M0.8930.99
179_E197_S0.8930.99
165_R204_P0.8920.99
11_F185_S0.8810.99
55_S84_K0.8800.99
107_S147_D0.8780.99
365_V371_M0.8760.99
130_L134_S0.8720.99
243_N246_G0.8690.99
182_L213_G0.8690.99
81_T103_N0.8660.99
20_N43_Y0.8640.99
336_V355_L0.8620.99
48_E157_N0.8610.99
97_K156_L0.8600.99
293_L319_L0.8590.99
95_D127_K0.8580.99
38_S55_S0.8560.99
173_V202_I0.8550.99
8_C81_T0.8510.98
217_Y227_Y0.8510.98
20_N41_I0.8460.98
175_L210_M0.8420.98
275_P279_R0.8420.98
84_K116_R0.8360.98
211_K215_I0.8350.98
176_G195_G0.8300.98
140_K144_K0.8280.98
55_S87_I0.8270.98
268_G273_P0.8260.98
52_I65_N0.8230.98
25_V62_F0.8170.98
321_E324_G0.8170.98
284_G335_I0.8140.98
232_F239_R0.8130.98
15_S20_N0.8120.98
84_K88_E0.8060.98
74_I153_A0.8050.98
111_Q145_V0.8030.98
261_A288_K0.8030.98
365_V369_S0.8030.98
136_P160_E0.8000.98
30_L193_Q0.7960.98
122_I142_F0.7920.98
78_R81_T0.7910.98
53_K88_E0.7900.98
141_E145_V0.7890.98
267_N270_I0.7870.97
189_S192_R0.7850.97
334_R360_A0.7810.97
188_D192_R0.7800.97
39_A77_V0.7790.97
268_G336_V0.7790.97
199_L215_I0.7780.97
184_V208_I0.7770.97
178_L182_L0.7750.97
13_V183_I0.7740.97
233_E236_Y0.7690.97
265_P366_R0.7680.97
149_G167_P0.7660.97
272_V337_L0.7660.97
20_N71_K0.7660.97
265_P270_I0.7640.97
99_V155_L0.7630.97
124_K128_Q0.7620.97
24_V43_Y0.7610.97
37_E80_S0.7600.97
156_L162_V0.7590.97
182_L199_L0.7590.97
74_I155_L0.7560.97
18_E22_Q0.7550.97
43_Y50_L0.7540.97
22_Q26_E0.7510.97
279_R295_E0.7510.97
82_S116_R0.7490.97
250_Y280_P0.7490.97
365_V368_G0.7470.97
106_I122_I0.7430.96
281_I334_R0.7430.96
29_R59_D0.7420.96
251_L255_R0.7360.96
90_A138_T0.7350.96
348_M351_I0.7320.96
265_P271_V0.7290.96
183_I194_L0.7250.96
299_R302_S0.7240.96
80_S85_S0.7230.96
236_Y240_P0.7220.96
62_F65_N0.7210.96
130_L138_T0.7210.96
278_S281_I0.7190.96
50_L70_I0.7180.96
300_T304_V0.7140.96
364_H368_G0.7120.96
208_I215_I0.7100.95
64_E67_N0.7070.95
235_I238_A0.7060.95
9_G39_A0.7060.95
294_E297_L0.7050.95
53_K56_G0.7030.95
317_E321_E0.7030.95
178_L183_I0.7010.95
283_L331_R0.7010.95
82_S105_T0.6980.95
54_G60_E0.6980.95
9_G31_L0.6980.95
160_E163_V0.6970.95
57_L241_D0.6960.95
299_R303_S0.6950.95
177_F180_G0.6940.95
146_V150_Y0.6900.95
281_I361_K0.6900.95
18_E70_I0.6890.95
174_V198_V0.6860.95
78_R83_G0.6840.94
164_F207_M0.6840.94
93_L117_V0.6830.94
159_E211_K0.6830.94
14_S159_E0.6810.94
23_L178_L0.6810.94
277_S280_P0.6790.94
266_A271_V0.6790.94
288_K292_P0.6770.94
17_K183_I0.6760.94
58_V75_G0.6760.94
311_T317_E0.6750.94
136_P162_V0.6740.94
165_R353_T0.6740.94
280_P333_K0.6730.94
55_S60_E0.6690.94
335_I355_L0.6690.94
72_N212_N0.6670.94
303_S307_F0.6650.94
201_H245_D0.6640.94
81_T102_F0.6620.93
98_I158_D0.6600.93
126_F138_T0.6580.93
108_N112_F0.6570.93
129_K133_R0.6560.93
267_N272_V0.6540.93
355_L360_A0.6530.93
286_S311_T0.6510.93
134_S160_E0.6500.93
132_F137_D0.6500.93
10_V153_A0.6490.93
328_D354_M0.6490.93
284_G309_M0.6470.93
285_F334_R0.6460.93
153_A210_M0.6450.93
364_H369_S0.6430.92
14_S161_I0.6420.92
283_L310_P0.6400.92
175_L182_L0.6400.92
362_E367_I0.6390.92
18_E72_N0.6370.92
248_S251_L0.6370.92
362_E366_R0.6360.92
272_V296_P0.6360.92
295_E301_I0.6350.92
139_V143_M0.6340.92
147_D166_D0.6330.92
298_V301_I0.6310.92
82_S109_Y0.6310.92
352_I356_R0.6310.92
177_F229_T0.6300.92
27_G183_I0.6280.91
51_T99_V0.6260.91
65_N68_K0.6230.91
162_V207_M0.6220.91
304_V326_V0.6220.91
247_H251_L0.6190.91
76_H103_N0.6180.91
264_H271_V0.6180.91
247_H255_R0.6170.91
274_V278_S0.6160.91
207_M218_D0.6150.91
258_E262_E0.6150.91
115_F129_K0.6140.91
334_R361_K0.6120.90
235_I241_D0.6090.90
283_L334_R0.6080.90
229_T245_D0.6070.90
334_R337_L0.6070.90
87_I90_A0.6050.90
254_I294_E0.6040.90
327_A358_A0.6030.90
139_V142_F0.6030.90
29_R58_V0.6020.90
256_L259_L0.6020.90
95_D131_A0.5980.89
111_Q114_S0.5980.89
128_Q131_A0.5960.89
292_P339_D0.5940.89
306_S318_V0.5930.89
364_H370_P0.5920.89
83_G118_D0.5920.89
237_F242_S0.5910.89
143_M150_Y0.5910.89
292_P338_I0.5900.89
337_L355_L0.5890.89
285_F316_N0.5880.89
210_M215_I0.5880.89
155_L161_I0.5860.88
124_K129_K0.5860.88
330_V334_R0.5860.88
244_I249_V0.5860.88
337_L365_V0.5840.88
276_D280_P0.5830.88
63_K66_L0.5830.88
366_R369_S0.5830.88
45_E71_K0.5820.88
144_K223_E0.5820.88
281_I368_G0.5810.88
76_H83_G0.5810.88
13_V194_L0.5810.88
140_K222_Y0.5800.88
333_K337_L0.5780.88
33_H187_E0.5760.88
284_G337_L0.5760.88
166_D171_H0.5750.88
202_I215_I0.5740.87
275_P305_R0.5730.87
14_S214_K0.5700.87
276_D279_R0.5690.87
171_H348_M0.5680.87
286_S317_E0.5680.87
267_N271_V0.5670.87
8_C102_F0.5670.87
81_T118_D0.5660.87
302_S306_S0.5610.86
22_Q64_E0.5590.86
81_T119_T0.5590.86
76_H81_T0.5590.86
178_L195_G0.5580.86
139_V207_M0.5570.86
174_V351_I0.5560.86
49_I155_L0.5550.86
16_P180_G0.5550.86
83_G103_N0.5540.86
275_P281_I0.5540.86
44_A47_G0.5530.85
199_L229_T0.5520.85
96_S127_K0.5500.85
39_A61_V0.5490.85
22_Q62_F0.5470.85
8_C76_H0.5450.85
363_I366_R0.5450.85
335_I363_I0.5440.85
291_I295_E0.5440.85
207_M220_V0.5430.84
256_L368_G0.5430.84
17_K72_N0.5430.84
266_A273_P0.5420.84
94_G128_Q0.5410.84
284_G311_T0.5410.84
365_V370_P0.5400.84
332_G361_K0.5390.84
89_E116_R0.5380.84
235_I239_R0.5380.84
24_V74_I0.5380.84
286_S289_S0.5380.84
363_I368_G0.5360.84
28_I39_A0.5360.84
144_K221_I0.5320.83
28_I77_V0.5310.83
230_C275_P0.5300.83
85_S89_E0.5290.83
15_S23_L0.5260.83
325_V330_V0.5260.83
282_A334_R0.5260.83
19_V22_Q0.5260.83
52_I67_N0.5250.82
265_P273_P0.5240.82
167_P204_P0.5220.82
122_I154_I0.5210.82
364_H371_M0.5200.82
11_F183_I0.5200.82
259_L263_K0.5190.82
297_L317_E0.5180.82
52_I69_F0.5180.82
72_N159_E0.5160.81
11_F19_V0.5140.81
327_A354_M0.5140.81
14_S211_K0.5130.81
39_A56_G0.5120.81
81_T105_T0.5100.81
78_R103_N0.5090.80
352_I360_A0.5080.80
58_V62_F0.5080.80
275_P278_S0.5070.80
17_K23_L0.5060.80
264_H273_P0.5060.80
173_V184_V0.5030.80
121_F125_F0.5030.80
287_R353_T0.5020.80
268_G291_I0.5020.80
217_Y225_K0.5010.79
16_P72_N0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.9711 100 0.37 Contact Map
1ao0A 3 0.96 100 0.381 Contact Map
4amvA 2 0.9556 100 0.528 Contact Map
1xffA 2 0.4956 100 0.658 Contact Map
3mdnA 4 0.4222 100 0.691 Contact Map
1te5A 2 0.4556 100 0.693 Contact Map
1ofdA 1 0.8711 100 0.713 Contact Map
1ea0A 1 0.8711 100 0.716 Contact Map
4zflA 5 0.4511 100 0.724 Contact Map
1ct9A 2 0.8156 100 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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