GREMLIN Database
Q7LXR3 - Amidophosphoribosyltransferase
UniProt: Q7LXR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (394)
Sequences: 3039 (1434)
Seq/√Len: 72.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_A155_I5.9091.00
231_L257_K4.3981.00
224_K227_E4.1331.00
365_E368_A4.0101.00
232_E383_G3.9081.00
233_Y377_H3.8921.00
228_E386_K3.5811.00
296_K300_K3.4041.00
145_I173_I3.3801.00
8_L26_G3.3501.00
147_G168_E3.2691.00
232_E380_S3.2191.00
363_N366_T3.1961.00
23_L71_G3.0971.00
303_R331_E3.0821.00
54_E83_I3.0481.00
155_I181_V2.8931.00
236_N303_R2.7581.00
41_A48_N2.7301.00
381_I399_T2.7261.00
70_A125_I2.7081.00
227_E257_K2.7011.00
145_I155_I2.6641.00
41_A50_F2.6501.00
228_E231_L2.6441.00
288_V315_T2.5831.00
103_N123_I2.5081.00
322_F326_K2.4751.00
380_S383_G2.4671.00
212_M217_E2.4671.00
228_E383_G2.4021.00
174_N190_Q2.3331.00
223_V256_K2.3211.00
239_S304_I2.3091.00
171_R188_S2.2991.00
353_D356_E2.2641.00
162_M167_A2.2601.00
395_L399_T2.2471.00
182_D187_E2.1471.00
358_I367_I2.1271.00
367_I378_W2.1151.00
144_S162_M2.1071.00
182_D185_H2.0581.00
235_I335_L2.0481.00
345_C394_C2.0481.00
333_H375_S2.0411.00
237_A305_I2.0411.00
144_S159_P2.0391.00
385_F395_L2.0171.00
37_K88_G1.9981.00
145_I179_V1.9921.00
163_F293_N1.9881.00
317_L334_V1.9171.00
227_E256_K1.9081.00
368_A376_I1.9071.00
130_Q182_D1.8971.00
133_A179_V1.8961.00
132_I180_I1.8851.00
120_I137_E1.8841.00
335_L377_H1.8541.00
12_A19_V1.8531.00
145_I181_V1.8271.00
241_I265_G1.8171.00
275_T287_G1.7741.00
219_Y249_P1.7401.00
130_Q180_I1.7401.00
230_A257_K1.6921.00
147_G151_D1.6901.00
285_I315_T1.6871.00
122_F134_Y1.6731.00
216_R221_L1.6501.00
53_L85_I1.6501.00
325_R374_D1.6421.00
220_D297_S1.6401.00
145_I186_I1.6280.99
221_L225_I1.6240.99
366_T369_R1.6210.99
200_T393_L1.6170.99
12_A152_L1.6150.99
200_T388_I1.5970.99
368_A373_A1.5950.99
334_V373_A1.5710.99
171_R177_E1.5640.99
364_D368_A1.5490.99
4_M7_I1.5470.99
113_I134_Y1.5340.99
153_A181_V1.5250.99
153_A170_K1.4990.99
51_T62_E1.4900.99
6_G75_A1.4860.99
341_L351_V1.4820.99
241_I306_L1.4730.99
334_V371_L1.4640.99
159_P169_F1.4590.99
223_V263_D1.4560.99
345_C396_G1.4400.99
365_E369_R1.4400.99
8_L23_L1.4390.99
123_I133_A1.4350.99
37_K54_E1.4220.99
347_Y396_G1.4210.99
362_L370_V1.4110.98
121_S140_L1.4070.98
234_P377_H1.4020.98
340_K359_S1.3910.98
156_S161_S1.3900.98
242_G248_L1.3850.98
394_C397_C1.3810.98
53_L60_D1.3630.98
172_E214_N1.3620.98
359_S367_I1.3380.98
303_R330_K1.3360.98
237_A260_I1.3360.98
264_L270_G1.3280.98
42_I71_G1.3270.98
248_L264_L1.3260.98
144_S169_F1.3220.98
299_V324_L1.3210.98
233_Y335_L1.3110.98
364_D376_I1.3100.98
155_I179_V1.2990.97
234_P335_L1.2950.97
154_V162_M1.2910.97
41_A101_V1.2880.97
5_A105_V1.2880.97
145_I171_R1.2750.97
128_D183_K1.2740.97
173_I179_V1.2740.97
290_L293_N1.2720.97
143_L173_I1.2570.97
245_E270_G1.2490.97
381_I395_L1.2390.97
42_I49_I1.2340.96
304_I324_L1.2320.96
343_S354_E1.2270.96
50_F92_V1.2150.96
322_F372_G1.2060.96
255_S258_L1.1980.96
383_G386_K1.1930.96
23_L73_G1.1890.96
163_F296_K1.1740.95
108_E116_I1.1740.95
109_P117_K1.1730.95
9_G131_L1.1720.95
6_G38_S1.1700.95
388_I393_L1.1670.95
132_I178_L1.1650.95
148_F152_L1.1640.95
225_I384_L1.1630.95
18_N21_R1.1630.95
199_C345_C1.1580.95
145_I153_A1.1520.95
10_I152_L1.1510.95
133_A181_V1.1510.95
340_K364_D1.1350.94
147_G170_K1.1310.94
213_I218_I1.1180.94
250_F337_G1.1120.94
10_I22_F1.1090.94
281_A285_I1.1070.94
235_I377_H1.1070.94
120_I191_V1.1060.94
79_N105_V1.1040.93
76_G81_Y1.1000.93
247_A292_L1.1000.93
113_I120_I1.0990.93
342_V400_K1.0940.93
233_Y254_Y1.0910.93
111_N114_D1.0910.93
306_L334_V1.0880.93
72_I123_I1.0880.93
22_F148_F1.0870.93
78_R83_I1.0860.93
198_Y214_N1.0800.93
36_S78_R1.0800.93
301_G330_K1.0700.92
200_T395_L1.0690.92
54_E84_T1.0680.92
180_I189_K1.0680.92
338_S398_M1.0620.92
153_A186_I1.0580.92
255_S260_I1.0570.92
76_G79_N1.0510.92
306_L324_L1.0470.91
225_I337_G1.0380.91
8_L156_S1.0370.91
9_G123_I1.0350.91
248_L262_L1.0270.91
359_S378_W1.0200.90
318_K370_V1.0150.90
38_S61_L1.0100.90
131_L181_V1.0040.90
335_L375_S0.9940.89
145_I188_S0.9910.89
343_S400_K0.9900.89
305_I335_L0.9880.89
311_M334_V0.9800.89
95_M98_D0.9690.88
8_L154_V0.9670.88
173_I186_I0.9650.88
220_D224_K0.9570.87
38_S75_A0.9550.87
299_V329_A0.9480.87
5_A79_N0.9470.87
344_Q353_D0.9300.86
138_L194_P0.9290.86
345_C397_C0.9240.85
138_L197_S0.9200.85
43_L46_Q0.9190.85
57_A61_L0.9160.85
44_N47_R0.9150.85
317_L320_T0.9140.85
72_I125_I0.9020.84
134_Y178_L0.8980.84
42_I68_G0.8930.83
177_E188_S0.8920.83
134_Y191_V0.8910.83
28_I290_L0.8910.83
216_R224_K0.8870.83
7_I123_I0.8870.83
124_A132_I0.8860.83
252_I255_S0.8850.83
55_N61_L0.8790.82
20_S66_L0.8770.82
74_Y105_V0.8750.82
331_E375_S0.8700.82
266_F298_A0.8640.81
200_T384_L0.8630.81
385_F393_L0.8540.81
341_L349_V0.8520.80
320_T323_N0.8480.80
181_V186_I0.8450.80
203_Y214_N0.8440.80
52_K55_N0.8440.80
80_S107_R0.8410.80
178_L190_Q0.8410.80
294_P299_V0.8410.80
219_Y223_V0.8380.79
11_L183_K0.8370.79
51_T61_L0.8370.79
52_K56_V0.8350.79
83_I87_N0.8350.79
232_E377_H0.8320.79
27_L73_G0.8280.79
81_Y105_V0.8280.79
224_K228_E0.8250.78
228_E387_A0.8250.78
147_G153_A0.8200.78
19_V71_G0.8170.78
299_V304_I0.8170.78
329_A332_I0.8100.77
126_S130_Q0.8090.77
286_V290_L0.8090.77
8_L165_I0.7980.76
221_L388_I0.7930.75
76_G105_V0.7910.75
282_F286_V0.7890.75
56_V59_E0.7880.75
225_I388_I0.7850.75
234_P305_I0.7840.75
79_N107_R0.7820.74
19_V42_I0.7820.74
26_G154_V0.7780.74
325_R332_I0.7750.74
382_E386_K0.7750.74
11_L70_A0.7720.74
225_I387_A0.7700.73
89_A105_V0.7680.73
243_V320_T0.7660.73
28_I58_P0.7660.73
57_A60_D0.7660.73
225_I379_L0.7660.73
5_A74_Y0.7620.73
79_N206_Q0.7610.72
48_N99_N0.7590.72
145_I170_K0.7580.72
9_G133_A0.7580.72
159_P163_F0.7550.72
159_P211_S0.7540.72
278_S287_G0.7520.72
13_F152_L0.7500.71
264_L268_R0.7490.71
22_F165_I0.7490.71
281_A315_T0.7490.71
74_Y81_Y0.7490.71
8_L152_L0.7460.71
381_I384_L0.7430.71
119_P397_C0.7410.70
21_R25_Y0.7390.70
254_Y305_I0.7350.70
5_A206_Q0.7320.69
36_S279_S0.7310.69
196_K392_D0.7280.69
300_K330_K0.7270.69
200_T204_V0.7250.69
368_A371_L0.7230.69
105_V206_Q0.7220.68
81_Y107_R0.7220.68
237_A258_L0.7210.68
113_I178_L0.7210.68
340_K397_C0.7170.68
139_G175_P0.7130.67
352_P356_E0.7120.67
328_G332_I0.7120.67
245_E248_L0.7100.67
204_V389_G0.7100.67
304_I332_I0.7060.67
10_I165_I0.7050.67
6_G30_L0.7040.66
311_M336_I0.7040.66
235_I375_S0.7020.66
340_K378_W0.7000.66
55_N59_E0.6990.66
197_S401_K0.6980.66
266_F299_V0.6960.66
203_Y213_I0.6940.65
11_L182_D0.6940.65
81_Y104_H0.6920.65
56_V61_L0.6900.65
154_V165_I0.6890.65
55_N60_D0.6860.64
175_P345_C0.6860.64
285_I288_V0.6840.64
231_L386_K0.6830.64
242_G264_L0.6830.64
339_P384_L0.6830.64
149_G152_L0.6810.64
344_Q354_E0.6790.64
154_V167_A0.6780.64
69_W183_K0.6780.64
174_N196_K0.6760.63
63_I66_L0.6760.63
43_L70_A0.6760.63
56_V60_D0.6750.63
119_P140_L0.6740.63
54_E88_G0.6730.63
319_N323_N0.6720.63
99_N127_K0.6720.63
113_I191_V0.6720.63
242_G268_R0.6710.63
249_P295_I0.6700.63
80_S83_I0.6700.63
355_K360_A0.6700.63
245_E397_C0.6690.63
200_T398_M0.6690.63
254_Y335_L0.6660.62
385_F390_H0.6660.62
342_V399_T0.6650.62
112_A116_I0.6650.62
208_R293_N0.6620.62
198_Y213_I0.6590.61
344_Q351_V0.6580.61
254_Y258_L0.6580.61
210_D293_N0.6580.61
140_L197_S0.6520.61
5_A76_G0.6520.61
10_I23_L0.6510.60
116_I120_I0.6490.60
368_A375_S0.6480.60
140_L347_Y0.6470.60
248_L270_G0.6460.60
43_L125_I0.6460.60
217_E249_P0.6440.60
243_V266_F0.6440.60
74_Y79_N0.6430.59
269_T293_N0.6430.59
321_I373_A0.6420.59
5_A81_Y0.6400.59
85_I88_G0.6400.59
10_I154_V0.6390.59
237_A303_R0.6390.59
164_V272_P0.6380.59
308_D336_I0.6370.59
195_R392_D0.6370.59
384_L387_A0.6370.59
278_S283_L0.6320.58
7_I143_L0.6310.58
235_I333_H0.6310.58
80_S204_V0.6300.58
162_M169_F0.6290.58
54_E87_N0.6290.58
182_D186_I0.6220.57
338_S341_L0.6220.57
285_I319_N0.6220.57
42_I66_L0.6210.57
148_F167_A0.6200.57
351_V357_L0.6200.57
364_D377_H0.6200.57
245_E264_L0.6190.57
139_G199_C0.6190.57
14_D69_W0.6180.56
133_A170_K0.6180.56
239_S263_D0.6150.56
198_Y242_G0.6150.56
79_N104_H0.6140.56
283_L286_V0.6140.56
148_F154_V0.6140.56
92_V109_P0.6140.56
337_G356_E0.6130.56
214_N268_R0.6110.56
273_I357_L0.6100.56
263_D298_A0.6090.55
179_V186_I0.6090.55
223_V252_I0.6080.55
289_Q326_K0.6060.55
341_L399_T0.6040.55
27_L75_A0.6030.55
23_L42_I0.6030.55
62_E65_D0.6000.54
94_G99_N0.6000.54
133_A153_A0.5990.54
190_Q194_P0.5990.54
384_L388_I0.5980.54
277_L284_K0.5970.54
369_R372_G0.5950.54
362_L366_T0.5950.54
241_I304_I0.5940.54
138_L195_R0.5930.53
245_E267_T0.5930.53
168_E296_K0.5920.53
156_S162_M0.5910.53
127_K130_Q0.5890.53
162_M165_I0.5890.53
135_R139_G0.5890.53
367_I376_I0.5890.53
40_I66_L0.5880.53
276_M284_K0.5870.53
109_P140_L0.5870.53
238_D302_K0.5850.52
225_I242_G0.5840.52
80_S352_P0.5830.52
284_K313_T0.5830.52
336_I377_H0.5820.52
180_I187_E0.5820.52
91_V99_N0.5810.52
305_I377_H0.5810.52
30_L162_M0.5810.52
14_D18_N0.5800.52
102_L185_H0.5790.52
168_E190_Q0.5780.52
61_L66_L0.5780.52
210_D269_T0.5770.51
79_N89_A0.5770.51
107_R350_E0.5760.51
198_Y393_L0.5750.51
91_V356_E0.5740.51
332_I373_A0.5740.51
214_N270_G0.5730.51
318_K369_R0.5730.51
302_K358_I0.5730.51
12_A119_P0.5720.51
239_S298_A0.5720.51
28_I378_W0.5710.51
80_S84_T0.5700.51
28_I293_N0.5700.51
26_G367_I0.5700.51
235_I305_I0.5680.50
248_L252_I0.5680.50
77_I105_V0.5670.50
81_Y206_Q0.5650.50
40_I63_I0.5650.50
174_N177_E0.5640.50
256_K322_F0.5640.50
355_K361_N0.5630.50
48_N52_K0.5630.50
383_G387_A0.5630.50
24_Y337_G0.5620.50
19_V263_D0.5620.50
131_L156_S0.5620.50
242_G262_L0.5590.49
7_I103_N0.5570.49
208_R275_T0.5570.49
367_I371_L0.5560.49
169_F172_E0.5550.49
297_S300_K0.5540.49
220_D223_V0.5540.49
328_G373_A0.5530.49
311_M379_L0.5530.49
164_V268_R0.5520.48
119_P350_E0.5510.48
306_L321_I0.5510.48
24_Y292_L0.5500.48
113_I116_I0.5490.48
36_S80_S0.5490.48
92_V99_N0.5480.48
159_P298_A0.5470.48
166_G294_P0.5470.48
385_F391_R0.5460.48
51_T65_D0.5460.48
13_F19_V0.5460.48
208_R269_T0.5460.48
53_L57_A0.5450.48
61_L68_G0.5450.48
308_D312_V0.5440.47
28_I269_T0.5440.47
114_D192_R0.5420.47
14_D19_V0.5410.47
195_R391_R0.5400.47
42_I48_N0.5390.47
302_K378_W0.5380.47
72_I167_A0.5380.47
311_M340_K0.5380.47
36_S79_N0.5370.47
280_D283_L0.5370.47
49_I53_L0.5370.47
12_A22_F0.5370.47
74_Y77_I0.5360.46
219_Y315_T0.5360.46
140_L396_G0.5350.46
52_K57_A0.5340.46
77_I277_L0.5340.46
282_F318_K0.5340.46
363_N369_R0.5330.46
341_L398_M0.5330.46
288_V292_L0.5320.46
20_S68_G0.5320.46
130_Q178_L0.5320.46
223_V227_E0.5310.46
220_D249_P0.5310.46
243_V373_A0.5300.46
204_V341_L0.5290.46
29_G165_I0.5280.45
26_G156_S0.5280.45
123_I155_I0.5270.45
130_Q371_L0.5270.45
292_L317_L0.5260.45
169_F212_M0.5260.45
110_E281_A0.5250.45
135_R172_E0.5250.45
199_C397_C0.5250.45
238_D260_I0.5240.45
24_Y290_L0.5240.45
275_T347_Y0.5230.45
308_D373_A0.5230.45
255_S286_V0.5230.45
240_V305_I0.5230.45
78_R356_E0.5220.45
41_A88_G0.5220.45
121_S397_C0.5220.45
133_A145_I0.5210.45
294_P327_L0.5200.44
246_T253_G0.5200.44
144_S214_N0.5200.44
318_K353_D0.5200.44
53_L56_V0.5190.44
81_Y89_A0.5190.44
390_H393_L0.5190.44
207_A213_I0.5190.44
84_T87_N0.5190.44
382_E385_F0.5180.44
28_I159_P0.5170.44
235_I260_I0.5170.44
212_M297_S0.5160.44
27_L31_Q0.5150.44
269_T273_I0.5130.44
135_R199_C0.5120.44
148_F166_G0.5120.44
50_F53_L0.5120.44
72_I103_N0.5120.44
14_D152_L0.5120.44
198_Y203_Y0.5110.43
219_Y323_N0.5110.43
108_E349_V0.5110.43
119_P396_G0.5110.43
241_I262_L0.5100.43
35_Y275_T0.5100.43
42_I91_V0.5090.43
18_N67_N0.5090.43
135_R201_I0.5080.43
269_T272_P0.5080.43
297_S378_W0.5060.43
134_Y298_A0.5060.43
270_G393_L0.5060.43
147_G152_L0.5050.43
12_A295_I0.5050.43
91_V97_D0.5050.43
363_N368_A0.5050.43
353_D360_A0.5040.43
263_D307_I0.5040.43
236_N257_K0.5040.43
87_N104_H0.5030.42
140_L214_N0.5020.42
58_P254_Y0.5020.42
331_E335_L0.5010.42
135_R214_N0.5010.42
178_L191_V0.5010.42
396_G402_Y0.5010.42
72_I138_L0.5010.42
233_Y305_I0.5010.42
396_G399_T0.5000.42
260_I305_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.9802 100 0.366 Contact Map
1ao0A 3 0.9678 100 0.388 Contact Map
4amvA 2 0.9208 100 0.764 Contact Map
1te5A 2 0.4356 100 0.764 Contact Map
1xffA 2 0.4653 100 0.767 Contact Map
1ct9A 2 0.8342 100 0.776 Contact Map
3mdnA 4 0.3812 100 0.782 Contact Map
1ofdA 1 0.8391 100 0.785 Contact Map
1jgtA 2 0.802 100 0.788 Contact Map
1ea0A 1 0.854 100 0.791 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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