GREMLIN Database
Q7LXR2 - Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (PurD)
UniProt: Q7LXR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (401)
Sequences: 17774 (9341)
Seq/√Len: 466.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_L171_L4.1561.00
6_K31_K3.4671.00
137_T140_D3.3281.00
67_E71_K3.3011.00
142_A180_R3.2921.00
170_D173_A3.2881.00
91_D109_R2.9911.00
274_K278_D2.9421.00
271_D275_R2.8141.00
91_D95_K2.8071.00
61_S64_V2.7971.00
150_G171_L2.5671.00
335_L340_H2.5501.00
299_T303_G2.4781.00
86_F112_E2.4571.00
123_K279_A2.4441.00
22_S25_R2.4421.00
70_K96_E2.4181.00
40_N57_G2.4141.00
5_M75_D2.3561.00
169_A173_A2.2941.00
121_M276_T2.2761.00
131_R206_E2.2691.00
263_N267_Q2.2601.00
267_Q271_D2.1951.00
252_S324_R2.1711.00
415_G419_E2.1621.00
92_I96_E2.1561.00
9_L20_A2.1391.00
144_F147_E2.1301.00
221_G289_V2.0891.00
169_A209_D2.0771.00
272_I304_P2.0361.00
62_P92_I2.0131.00
133_K147_E2.0011.00
326_E347_K1.9831.00
374_K400_Q1.9771.00
7_V101_F1.9481.00
116_W119_E1.9421.00
262_S265_E1.9381.00
331_E335_L1.9341.00
66_K96_E1.9341.00
119_E123_K1.9151.00
356_R424_L1.9061.00
196_K201_R1.8751.00
167_V207_K1.8701.00
332_T342_N1.8531.00
268_T303_G1.8401.00
180_R184_T1.8191.00
416_D419_E1.8191.00
267_Q270_Y1.8001.00
209_D300_E1.7621.00
326_E349_N1.7531.00
171_L180_R1.7501.00
143_K147_E1.7481.00
138_I184_T1.7431.00
63_E92_I1.7361.00
120_L279_A1.7211.00
136_Y140_D1.6941.00
142_A171_L1.6701.00
8_L35_L1.6551.00
358_V437_L1.6481.00
268_T271_D1.6371.00
138_I180_R1.6281.00
66_K70_K1.6271.00
362_G438_I1.6151.00
144_F148_Y1.6131.00
275_R278_D1.6101.00
104_S107_C1.6061.00
77_G98_I1.6021.00
64_V67_E1.5921.00
119_E122_W1.5901.00
218_L332_T1.5771.00
34_A47_V1.5621.00
109_R116_W1.5581.00
6_K54_Y1.5541.00
124_H279_A1.5531.00
25_R331_E1.5521.00
138_I142_A1.5481.00
94_R105_K1.5461.00
93_F98_I1.5351.00
218_L336_T1.5301.00
23_L32_I1.5291.00
265_E298_L1.5221.00
138_I183_L1.5101.00
270_Y274_K1.4951.00
31_K54_Y1.4871.00
92_I95_K1.4781.00
17_N50_T1.4771.00
68_V72_V1.4581.00
323_P414_I1.4571.00
265_E268_T1.4551.00
56_I68_V1.4501.00
69_I98_I1.4501.00
94_R104_S1.4481.00
368_Q373_H1.4431.00
208_V307_I1.4421.00
99_S338_T1.4301.00
218_L291_V1.4281.00
181_E185_K1.4281.00
22_S331_E1.4261.00
215_L269_T1.4141.00
120_L124_H1.4121.00
62_P66_K1.4101.00
323_P412_V1.4101.00
7_V23_L1.4031.00
391_F394_V1.4021.00
143_K146_L1.3961.00
431_I441_T1.3931.00
110_I120_L1.3931.00
142_A146_L1.3911.00
359_A406_S1.3881.00
115_A119_E1.3811.00
157_A201_R1.3721.00
43_I49_T1.3651.00
206_E305_T1.3631.00
139_E143_K1.3541.00
219_S225_I1.3541.00
355_V410_E1.3521.00
67_E70_K1.3501.00
111_E309_Y1.3461.00
217_V273_V1.3421.00
69_I77_G1.3391.00
374_K399_M1.3351.00
426_R430_Y1.3321.00
26_S328_D1.3271.00
21_Y25_R1.3251.00
313_F329_F1.3241.00
219_S277_M1.3121.00
375_I394_V1.2991.00
91_D106_K1.2821.00
56_I72_V1.2791.00
110_I116_W1.2711.00
374_K377_V1.2671.00
77_G93_F1.2581.00
145_I150_G1.2561.00
135_F144_F1.2551.00
6_K33_Y1.2411.00
117_A121_M1.2381.00
93_F100_V1.2381.00
152_V204_I1.2321.00
140_D143_K1.2311.00
222_K281_Y1.2311.00
345_S348_I1.2301.00
217_V277_M1.2281.00
340_H343_K1.2271.00
106_K110_I1.2211.00
118_R128_G1.2171.00
354_I421_A1.2161.00
133_K144_F1.2081.00
104_S289_V1.2041.00
351_K416_D1.2011.00
425_D429_Q1.1921.00
120_L123_K1.1851.00
115_A134_V1.1791.00
351_K414_I1.1781.00
341_L344_A1.1781.00
418_E422_E1.1751.00
387_C413_A1.1711.00
263_N266_Y1.1621.00
21_Y390_F1.1621.00
139_E142_A1.1621.00
181_E184_T1.1491.00
261_I265_E1.1441.00
421_A425_D1.1421.00
145_I152_V1.1421.00
300_E303_G1.1381.00
150_G170_D1.1361.00
354_I420_A1.1311.00
210_G300_E1.1261.00
166_K186_S1.1201.00
134_V201_R1.1131.00
262_S302_W1.1101.00
122_W131_R1.1081.00
395_A398_G1.1061.00
7_V30_Y1.1041.00
83_D87_N1.0981.00
415_G423_N1.0961.00
154_I202_I1.0951.00
94_R289_V1.0911.00
413_A424_L1.0841.00
35_L65_I1.0841.00
217_V294_G1.0801.00
49_T395_A1.0801.00
411_I431_I1.0791.00
138_I187_V1.0761.00
90_A100_V1.0711.00
7_V334_E1.0681.00
357_A360_T1.0621.00
122_W133_K1.0611.00
327_S332_T1.0611.00
411_I427_C1.0521.00
253_G258_L1.0391.00
89_I93_F1.0381.00
381_K431_I1.0381.00
91_D105_K1.0381.00
146_L180_R1.0341.00
419_E423_N1.0341.00
122_W128_G1.0331.00
99_S221_G1.0321.00
334_E338_T1.0251.00
172_E181_E1.0251.00
347_K350_E1.0251.00
31_K48_K1.0211.00
365_I368_Q1.0191.00
226_S343_K1.0131.00
69_I93_F1.0131.00
19_L78_V1.0121.00
131_R148_Y1.0111.00
232_D258_L1.0041.00
65_I93_F1.0031.00
215_L270_Y1.0001.00
127_P272_I0.9991.00
264_E268_T0.9971.00
121_M306_V0.9961.00
136_Y201_R0.9951.00
33_Y72_V0.9891.00
20_A32_I0.9891.00
273_V294_G0.9861.00
153_A167_V0.9861.00
264_E267_Q0.9861.00
8_L69_I0.9831.00
183_L187_V0.9801.00
358_V428_M0.9791.00
209_D299_T0.9781.00
66_K92_I0.9651.00
426_R429_Q0.9601.00
213_Y298_L0.9591.00
387_C427_C0.9581.00
30_Y338_T0.9551.00
332_T335_L0.9531.00
141_T174_Y0.9531.00
6_K75_D0.9531.00
354_I444_G0.9501.00
423_N426_R0.9481.00
140_D144_F0.9441.00
23_L334_E0.9431.00
68_V74_P0.9361.00
106_K109_R0.9331.00
23_L78_V0.9281.00
118_R205_E0.9261.00
113_S157_A0.9221.00
272_I275_R0.9211.00
9_L23_L0.9151.00
158_G196_K0.9151.00
78_V333_I0.9141.00
225_I274_K0.9091.00
422_E426_R0.9091.00
344_A347_K0.9081.00
173_A181_E0.9071.00
101_F334_E0.9051.00
358_V441_T0.9041.00
393_S396_L0.9021.00
148_Y152_V0.9011.00
260_F298_L0.8981.00
386_G389_V0.8981.00
361_L436_K0.8971.00
24_A32_I0.8961.00
276_T309_Y0.8951.00
397_E400_Q0.8881.00
378_D432_S0.8841.00
249_G356_R0.8831.00
352_P355_V0.8811.00
7_V29_G0.8811.00
183_L202_I0.8811.00
375_I378_D0.8751.00
294_G309_Y0.8751.00
428_M437_L0.8751.00
145_I183_L0.8711.00
377_V434_D0.8691.00
230_A266_Y0.8681.00
298_L304_P0.8641.00
150_G174_Y0.8631.00
42_G45_S0.8631.00
115_A157_A0.8621.00
48_K55_F0.8571.00
93_F96_E0.8561.00
88_G92_I0.8541.00
427_C430_Y0.8511.00
223_T342_N0.8501.00
343_K348_I0.8441.00
10_V89_I0.8441.00
377_V432_S0.8361.00
224_T278_D0.8361.00
20_A50_T0.8351.00
36_S55_F0.8311.00
168_I182_A0.8311.00
22_S26_S0.8301.00
63_E67_E0.8291.00
271_D274_K0.8261.00
153_A207_K0.8241.00
386_G423_N0.8191.00
227_L270_Y0.8181.00
6_K72_V0.8151.00
83_D86_F0.8131.00
66_K98_I0.8121.00
378_D396_L0.8091.00
250_S320_A0.8061.00
24_A53_E0.8061.00
172_E180_R0.8031.00
228_P252_S0.8031.00
88_G91_D0.8031.00
166_K182_A0.8031.00
6_K73_N0.8001.00
166_K185_K0.7991.00
94_R106_K0.7981.00
215_L273_V0.7981.00
26_S331_E0.7971.00
378_D434_D0.7951.00
272_I296_M0.7941.00
224_T277_M0.7931.00
258_L261_I0.7931.00
119_E132_Y0.7921.00
62_P89_I0.7921.00
206_E303_G0.7911.00
26_S335_L0.7901.00
231_Q251_I0.7831.00
268_T272_I0.7821.00
33_Y68_V0.7801.00
429_Q441_T0.7801.00
6_K30_Y0.7801.00
353_S356_R0.7771.00
413_A427_C0.7771.00
381_K430_Y0.7741.00
88_G109_R0.7721.00
111_E280_I0.7711.00
91_D94_R0.7711.00
229_L324_R0.7701.00
222_K339_G0.7681.00
138_I174_Y0.7671.00
229_L232_D0.7651.00
428_M439_Y0.7641.00
115_A201_R0.7621.00
46_I49_T0.7601.00
29_G32_I0.7601.00
345_S349_N0.7571.00
380_E432_S0.7561.00
107_C281_Y0.7551.00
17_N20_A0.7541.00
360_T373_H0.7511.00
380_E396_L0.7511.00
135_F141_T0.7511.00
218_L227_L0.7501.00
346_I349_N0.7491.00
378_D381_K0.7471.00
141_T183_L0.7471.00
145_I174_Y0.7431.00
44_N49_T0.7431.00
288_Y311_S0.7421.00
90_A94_R0.7411.00
33_Y74_P0.7401.00
46_I50_T0.7401.00
154_I183_L0.7381.00
268_T304_P0.7381.00
20_A34_A0.7381.00
107_C289_V0.7381.00
352_P417_F0.7341.00
26_S334_E0.7331.00
219_S278_D0.7331.00
333_I337_A0.7301.00
219_S224_T0.7291.00
36_S43_I0.7271.00
208_V299_T0.7271.00
273_V296_M0.7261.00
345_S350_E0.7241.00
152_V168_I0.7241.00
94_R100_V0.7231.00
142_A184_T0.7211.00
208_V305_T0.7211.00
104_S281_Y0.7191.00
248_M440_R0.7191.00
213_Y258_L0.7181.00
289_V336_T0.7171.00
228_P325_L0.7151.00
115_A203_I0.7151.00
145_I204_I0.7131.00
17_N47_V0.7111.00
261_I266_Y0.7111.00
252_S320_A0.7091.00
211_P298_L0.7081.00
266_Y270_Y0.7061.00
419_E422_E0.7061.00
141_T204_I0.7051.00
31_K53_E0.7051.00
47_V50_T0.7051.00
429_Q439_Y0.7041.00
44_N48_K0.7041.00
227_L274_K0.7021.00
378_D382_M0.7001.00
228_P324_R0.7001.00
217_V292_I0.6971.00
122_W132_Y0.6951.00
154_I182_A0.6951.00
191_G198_G0.6951.00
41_P401_L0.6921.00
187_V202_I0.6891.00
222_K278_D0.6871.00
319_S322_I0.6871.00
153_A165_V0.6871.00
125_S275_R0.6861.00
145_I149_G0.6831.00
390_F393_S0.6821.00
126_I306_V0.6811.00
211_P260_F0.6771.00
48_K51_G0.6761.00
367_K443_I0.6741.00
371_S438_I0.6741.00
418_E421_A0.6741.00
269_T304_P0.6731.00
277_M292_I0.6721.00
219_S289_V0.6721.00
145_I148_Y0.6711.00
148_Y206_E0.6711.00
395_A402_I0.6671.00
131_R147_E0.6651.00
45_S48_K0.6651.00
168_I174_Y0.6641.00
144_F204_I0.6601.00
113_S201_R0.6601.00
152_V206_E0.6581.00
34_A43_I0.6581.00
133_K140_D0.6561.00
415_G420_A0.6561.00
146_L150_G0.6531.00
343_K347_K0.6521.00
154_I204_I0.6521.00
276_T279_A0.6501.00
346_I350_E0.6501.00
57_G64_V0.6471.00
373_H434_D0.6471.00
154_I174_Y0.6461.00
58_N61_S0.6461.00
138_I141_T0.6451.00
213_Y261_I0.6441.00
275_R279_A0.6431.00
383_K387_C0.6411.00
29_G330_G0.6401.00
355_V360_T0.6401.00
154_I168_I0.6401.00
409_L431_I0.6401.00
273_V277_M0.6381.00
251_I417_F0.6371.00
185_K191_G0.6351.00
127_P303_G0.6341.00
99_S289_V0.6320.99
358_V431_I0.6310.99
355_V359_A0.6300.99
34_A51_G0.6290.99
248_M359_A0.6250.99
42_G48_K0.6240.99
7_V330_G0.6240.99
216_H291_V0.6240.99
226_S348_I0.6240.99
371_S404_K0.6230.99
165_V245_T0.6220.99
8_L74_P0.6210.99
351_K354_I0.6200.99
23_L30_Y0.6190.99
332_T346_I0.6190.99
320_A323_P0.6190.99
440_R444_G0.6180.99
433_S437_L0.6180.99
227_L232_D0.6160.99
382_M386_G0.6150.99
99_S334_E0.6120.99
67_E96_E0.6110.99
433_S439_Y0.6110.99
319_S355_V0.6110.99
428_M441_T0.6110.99
379_L431_I0.6100.99
393_S398_G0.6080.99
5_M30_Y0.6070.99
60_N87_N0.6040.99
7_V32_I0.6040.99
334_E337_A0.6040.99
10_V65_I0.6040.99
182_A186_S0.6040.99
424_L428_M0.6030.99
32_I36_S0.6030.99
265_E302_W0.6020.99
332_T343_K0.6020.99
353_S414_I0.6000.99
392_G395_A0.5970.99
23_L26_S0.5960.99
110_I311_S0.5960.99
355_V358_V0.5960.99
17_N46_I0.5950.99
101_F337_A0.5950.99
187_V191_G0.5950.99
194_Y198_G0.5950.99
113_S116_W0.5950.99
299_T302_W0.5950.99
247_G250_S0.5930.99
105_K109_R0.5930.99
62_P87_N0.5900.99
373_H436_K0.5890.99
308_E312_R0.5890.99
399_M402_I0.5870.99
110_I123_K0.5850.99
258_L262_S0.5850.99
230_A233_Y0.5850.99
23_L330_G0.5840.99
149_G171_L0.5830.99
302_W305_T0.5820.99
151_S207_K0.5820.99
262_S298_L0.5810.99
186_S202_I0.5810.99
62_P88_G0.5800.99
344_A348_I0.5800.99
229_L348_I0.5790.99
40_N43_I0.5790.99
9_L34_A0.5770.99
32_I37_S0.5750.99
184_T191_G0.5750.99
413_A420_A0.5730.99
403_T433_S0.5720.99
278_D281_Y0.5720.99
174_Y183_L0.5710.99
132_Y203_I0.5700.99
34_A37_S0.5700.99
108_A311_S0.5700.99
242_G247_G0.5680.99
220_D224_T0.5650.99
70_K98_I0.5650.99
417_F421_A0.5640.99
299_T305_T0.5630.99
69_I74_P0.5630.99
216_H230_A0.5630.99
352_P356_R0.5630.99
382_M427_C0.5620.99
329_F333_I0.5620.99
362_G365_I0.5610.99
264_E302_W0.5610.99
174_Y180_R0.5580.99
57_G68_V0.5580.99
116_W120_L0.5570.99
297_M307_I0.5560.99
322_I412_V0.5550.99
379_L382_M0.5550.99
54_Y72_V0.5530.99
20_A24_A0.5530.99
20_A51_G0.5520.99
434_D437_L0.5520.99
318_A322_I0.5490.99
77_G100_V0.5480.99
374_K378_D0.5480.99
385_R389_V0.5460.99
381_K384_E0.5460.99
68_V71_K0.5450.99
132_Y144_F0.5450.99
14_A18_V0.5450.99
396_L399_M0.5440.98
375_I379_L0.5430.98
265_E304_P0.5420.98
343_K346_I0.5420.98
135_F140_D0.5410.98
121_M126_I0.5390.98
14_A410_E0.5390.98
362_G366_S0.5380.98
380_E383_K0.5370.98
79_I100_V0.5370.98
46_I395_A0.5360.98
126_I272_I0.5350.98
65_I77_G0.5340.98
15_R313_F0.5320.98
37_S58_N0.5320.98
42_G47_V0.5310.98
398_G401_L0.5300.98
268_T275_R0.5300.98
229_L266_Y0.5280.98
40_N44_N0.5260.98
332_T336_T0.5250.98
421_A444_G0.5250.98
66_K77_G0.5250.98
117_A306_V0.5250.98
118_R122_W0.5230.98
429_Q432_S0.5230.98
75_D99_S0.5220.98
150_G167_V0.5210.98
227_L348_I0.5180.98
139_E180_R0.5170.98
319_S412_V0.5160.98
387_C423_N0.5160.98
387_C390_F0.5150.98
130_L305_T0.5140.98
361_L368_Q0.5140.98
119_E134_V0.5130.98
30_Y75_D0.5130.98
76_L337_A0.5110.98
42_G46_I0.5110.98
225_I278_D0.5110.98
33_Y50_T0.5100.98
216_H321_I0.5100.98
19_L22_S0.5080.98
80_G84_P0.5060.98
222_K289_V0.5060.98
277_M281_Y0.5060.98
135_F204_I0.5030.98
109_R113_S0.5020.97
356_R359_A0.5020.97
35_L57_G0.5000.97
118_R130_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qk4A 1 0.8675 100 0.381 Contact Map
3mjfA 1 0.8758 100 0.382 Contact Map
3lp8A 1 0.8592 100 0.383 Contact Map
2yw2A 2 0.8675 100 0.389 Contact Map
2yrxA 1 0.8551 100 0.389 Contact Map
2ip4A 1 0.8489 100 0.393 Contact Map
4qshA 4 0.8033 100 0.393 Contact Map
3n6rA 1 0.7785 100 0.395 Contact Map
3u9tA 3 0.8903 100 0.398 Contact Map
2qf7A 4 0.8282 100 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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