GREMLIN Database
Q7LXQ9 - Uncharacterized protein
UniProt: Q7LXQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (185)
Sequences: 647 (481)
Seq/√Len: 35.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_M185_T4.9361.00
42_I47_K3.3451.00
94_I105_K3.0061.00
43_S47_K2.9111.00
140_K143_E2.8361.00
88_E91_E2.8101.00
172_R176_D2.6421.00
34_L67_I2.5831.00
34_L64_V2.5331.00
94_I124_A2.4531.00
54_L100_F2.3480.99
125_I154_L2.3360.99
185_T192_A2.2590.99
54_L58_Q2.2090.99
119_S170_G2.2080.99
42_I46_H2.1300.99
165_K172_R2.1170.99
123_D126_G2.0920.99
123_D174_K1.9670.98
133_L188_D1.9540.98
119_S123_D1.8760.97
24_R28_L1.8400.97
91_E123_D1.8260.97
15_G19_E1.7900.97
88_E126_G1.7450.96
39_G43_S1.7320.96
36_R40_E1.7090.95
97_S101_D1.6780.95
126_G181_L1.6760.95
143_E146_N1.6680.95
122_A178_I1.6510.95
161_F171_L1.6480.94
107_S111_G1.6430.94
58_Q62_S1.6320.94
88_E123_D1.6270.94
116_Y150_I1.6020.94
75_P80_G1.5950.93
41_T57_Y1.5930.93
25_E32_R1.5710.93
38_C42_I1.5180.92
62_S66_E1.4980.91
63_K66_E1.4510.90
29_M33_E1.4460.89
118_I173_Q1.3990.88
104_L121_I1.3760.87
186_N190_F1.3570.86
136_L144_A1.3570.86
30_L66_E1.3460.86
26_R70_I1.3410.86
84_T189_I1.3150.84
45_S99_Y1.3120.84
95_V131_R1.3010.84
88_E92_A1.2940.83
84_T87_Q1.2720.82
39_G42_I1.2680.82
91_E126_G1.2670.82
176_D179_R1.2570.82
14_S18_Q1.2520.81
136_L183_E1.2440.81
87_Q119_S1.2280.80
165_K176_D1.2260.80
20_R76_E1.2020.79
116_Y186_N1.1980.78
175_I178_I1.1870.78
90_A94_I1.1820.77
151_M179_R1.1810.77
42_I92_A1.1740.77
72_D75_P1.1690.77
95_V124_A1.1370.75
93_S97_S1.1220.74
118_I156_E1.1220.74
87_Q174_K1.1130.73
91_E129_R1.1000.72
59_I62_S1.0860.71
126_G174_K1.0860.71
107_S112_I1.0860.71
181_L184_E1.0810.71
108_K111_G1.0790.71
35_I39_G1.0760.70
172_R179_R1.0700.70
48_G66_E1.0690.70
142_D192_A1.0650.70
29_M123_D1.0620.69
60_A140_K1.0540.69
164_P183_E1.0480.68
35_I85_A1.0460.68
176_D187_H1.0420.68
23_N74_F1.0350.67
17_L139_N1.0300.67
104_L117_Y1.0220.66
177_T180_R1.0160.66
18_Q22_E1.0150.66
118_I166_S1.0100.65
165_K180_R1.0070.65
127_E130_R1.0050.65
96_I100_F0.9990.65
91_E124_A0.9970.64
32_R88_E0.9950.64
81_D125_I0.9850.63
84_T133_L0.9840.63
162_E166_S0.9760.63
118_I171_L0.9730.62
51_E58_Q0.9710.62
118_I165_K0.9600.61
125_I178_I0.9530.61
163_Y179_R0.9450.60
35_I42_I0.9440.60
126_G177_T0.9410.60
147_T153_E0.9180.58
190_F195_G0.9110.57
26_R73_S0.9100.57
62_S111_G0.8990.56
39_G186_N0.8940.56
38_C92_A0.8920.56
40_E43_S0.8920.56
115_I172_R0.8900.56
133_L184_E0.8890.55
88_E174_K0.8880.55
101_D135_L0.8860.55
32_R35_I0.8840.55
164_P172_R0.8800.55
134_E137_K0.8760.54
51_E55_K0.8740.54
28_L39_G0.8740.54
98_L121_I0.8680.54
15_G69_K0.8650.53
64_V86_Y0.8640.53
55_K59_I0.8620.53
52_E56_K0.8610.53
137_K186_N0.8590.53
102_V146_N0.8570.53
22_E33_E0.8500.52
132_V147_T0.8490.52
61_I89_L0.8470.52
176_D180_R0.8390.51
27_V184_E0.8360.51
164_P179_R0.8350.51
165_K183_E0.8320.51
174_K182_L0.8250.50
37_Y63_K0.8130.49
90_A122_A0.8100.49
27_V67_I0.8070.48
32_R91_E0.8070.48
48_G62_S0.8060.48
170_G173_Q0.8060.48
119_S125_I0.8060.48
180_R183_E0.8040.48
61_I65_S0.7900.47
30_L63_K0.7870.47
129_R181_L0.7800.46
136_L191_L0.7790.46
31_A35_I0.7750.46
43_S46_H0.7680.45
177_T181_L0.7650.45
87_Q188_D0.7640.45
179_R183_E0.7580.44
34_L102_V0.7560.44
97_S103_E0.7530.44
92_A126_G0.7490.43
54_L106_L0.7490.43
25_E98_L0.7470.43
39_G45_S0.7440.43
132_V186_N0.7410.43
22_E184_E0.7290.42
14_S19_E0.7270.42
18_Q106_L0.7270.42
138_K146_N0.7270.42
99_Y137_K0.7240.41
65_S103_E0.7240.41
50_K158_L0.7170.41
163_Y176_D0.7160.41
50_K53_A0.7150.41
105_K110_L0.7140.41
112_I154_L0.7130.40
42_I123_D0.7100.40
108_K115_I0.7020.40
17_L21_F0.6980.39
17_L68_Q0.6950.39
188_D191_L0.6910.39
136_L139_N0.6900.39
166_S180_R0.6890.38
36_R78_L0.6880.38
42_I88_E0.6810.38
29_M119_S0.6810.38
138_K157_L0.6810.38
28_L81_D0.6780.38
145_E149_N0.6740.37
163_Y172_R0.6740.37
18_Q113_P0.6740.37
8_G11_N0.6740.37
135_L140_K0.6700.37
120_G178_I0.6650.37
55_K69_K0.6610.36
22_E103_E0.6590.36
67_I99_Y0.6560.36
86_Y113_P0.6470.35
179_R187_H0.6420.35
166_S170_G0.6410.35
164_P191_L0.6410.35
173_Q176_D0.6390.34
56_K59_I0.6340.34
99_Y190_F0.6330.34
17_L126_G0.6320.34
133_L187_H0.6320.34
63_K89_L0.6300.34
94_I120_G0.6300.34
70_I185_T0.6290.34
43_S133_L0.6250.33
136_L162_E0.6210.33
76_E150_I0.6210.33
162_E171_L0.6170.33
161_F176_D0.6170.33
91_E127_E0.6130.32
88_E120_G0.6120.32
162_E176_D0.6120.32
189_I193_K0.6110.32
58_Q61_I0.6110.32
24_R32_R0.6100.32
162_E165_K0.6070.32
154_L161_F0.6070.32
163_Y166_S0.6050.32
26_R170_G0.6050.32
41_T60_A0.6040.32
89_L102_V0.6020.32
92_A121_I0.5920.31
12_S27_V0.5880.31
162_E172_R0.5860.30
187_H191_L0.5830.30
96_I101_D0.5820.30
12_S62_S0.5800.30
69_K153_E0.5770.30
77_L89_L0.5760.30
162_E187_H0.5750.30
45_S95_V0.5750.30
40_E173_Q0.5720.29
93_S110_L0.5710.29
106_L128_M0.5670.29
137_K166_S0.5670.29
82_V147_T0.5620.29
19_E53_A0.5610.29
87_Q123_D0.5610.29
191_L194_L0.5600.29
48_G51_E0.5550.28
162_E188_D0.5550.28
75_P78_L0.5540.28
14_S131_R0.5520.28
99_Y184_E0.5520.28
20_R74_F0.5510.28
22_E98_L0.5510.28
80_G152_E0.5470.28
115_I164_P0.5460.28
94_I106_L0.5450.28
62_S65_S0.5420.27
134_E172_R0.5420.27
52_E149_N0.5410.27
126_G184_E0.5400.27
115_I173_Q0.5400.27
46_H126_G0.5380.27
26_R85_A0.5340.27
55_K103_E0.5290.26
13_I146_N0.5270.26
119_S175_I0.5270.26
13_I97_S0.5260.26
53_A58_Q0.5240.26
98_L116_Y0.5210.26
19_E178_I0.5210.26
151_M188_D0.5170.26
11_N51_E0.5130.25
118_I131_R0.5110.25
65_S69_K0.5070.25
181_L186_N0.5070.25
39_G184_E0.5070.25
21_F25_E0.5070.25
147_T185_T0.5050.25
122_A177_T0.5040.25
45_S132_V0.5010.25
44_L105_K0.5010.25
85_A126_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3axjA 1 0.9848 100 0.066 Contact Map
3qb5K 2 0.9848 100 0.067 Contact Map
3axjB 1 0.9898 100 0.073 Contact Map
1j1jA 4 0.9645 100 0.093 Contact Map
3zc0A 5 0.9543 100 0.127 Contact Map
4nadB 2 0.3858 25.1 0.947 Contact Map
4aurA 1 0.3452 21.7 0.948 Contact Map
4flaA 2 0.3756 20 0.949 Contact Map
3wscA 2 0.9137 17.4 0.951 Contact Map
4glxA 1 0.6142 14.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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