Q7LXQ8 - SULSO - GREMLIN Contacts

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Q7LXQ8 - 3-hydroxyacyl-CoA dehydrogenase (Hdb-1)

UniProt:	Q7LXQ8	Sequences: MFIHMKSINKVAVIGAGVIGVGWTTLLLAKGYKVNLYTEKKETLEKALAKVSAYLVNLKNLGMINEEPESYITNLTGITKIDDAIHNVDFVIEAIIEDYTAKKNLFKLLDTQLPQDIIIASSTSGLLMTEIQKAMIRHPERGVIAHPWNPPHLLPLVEIVPGEKTSKETVDLTREFMEKLDRVVVLLRKEVPGFIGNRLAFALFREAVNLVDEGVATVEDIDKVMTAAIGLRWAFMGPFLTYHLGGGEGGIEYFFSKGFGYGANEWMHTLAKWDKFPYTAVKKVLEQMKEYEFIKGKSFQDLSRWRDEKLVTIYKAVYKEKCNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	324 (281)
Sequences:	8907 (5295)
Seq/√Len:	315.9

ECOLI - PAAH FADB FADJ
BACSU - HBD FADN
HALSA - Q9HRI4 Q9HQ61
SULSO - Q7LXQ8 Q97UX0 Q97UK9 Q97VU5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
104_N	108_L	3.323	1.00
285_L	292_E	2.988	1.00
41_K	45_E	2.886	1.00
226_T	240_L	2.793	1.00
12_A	85_I	2.608	1.00
95_I	105_L	2.522	1.00
80_K	83_D	2.519	1.00
217_T	220_D	2.397	1.00
292_E	296_G	2.386	1.00
96_I	101_A	2.338	1.00
143_V	173_T	2.270	1.00
10_K	33_K	2.263	1.00
28_L	75_L	2.253	1.00
110_D	136_I	2.243	1.00
138_H	141_R	2.187	1.00
174_R	186_L	2.184	1.00
140_E	166_S	2.175	1.00
167_K	171_D	2.155	1.00
11_V	27_L	2.145	1.00
110_D	137_R	2.137	1.00
157_V	177_M	2.135	1.00
48_L	77_G	2.060	1.00
12_A	88_V	2.047	1.00
66_E	69_E	2.033	1.00
255_F	278_Y	2.029	1.00
89_D	114_P	1.975	1.00
211_V	221_I	1.956	1.00
95_I	101_A	1.943	1.00
99_Y	130_E	1.929	1.00
10_K	87_N	1.924	1.00
159_I	174_R	1.909	1.00
280_A	285_L	1.896	1.00
166_S	169_T	1.895	1.00
27_L	176_F	1.873	1.00
161_P	167_K	1.863	1.00
286_E	290_E	1.845	1.00
91_V	113_L	1.794	1.00
116_D	141_R	1.791	1.00
59_K	68_P	1.760	1.00
108_L	111_T	1.756	1.00
10_K	35_N	1.734	1.00
174_R	178_E	1.713	1.00
33_K	74_N	1.709	1.00
279_T	283_K	1.677	1.00
18_V	249_G	1.677	1.00
44_L	77_G	1.676	1.00
145_A	177_M	1.673	1.00
27_L	180_L	1.659	1.00
103_K	134_A	1.650	1.00
78_I	83_D	1.636	1.00
248_E	289_K	1.635	1.00
121_S	128_M	1.634	1.00
32_Y	179_K	1.623	1.00
70_S	74_N	1.618	1.00
113_L	117_I	1.617	1.00
56_V	60_N	1.607	1.00
145_A	173_T	1.564	1.00
52_S	72_I	1.560	1.00
139_P	164_K	1.551	1.00
48_L	52_S	1.536	1.00
16_A	36_L	1.529	1.00
187_L	195_I	1.510	1.00
52_S	56_V	1.496	1.00
11_V	32_Y	1.491	1.00
129_T	163_E	1.467	1.00
161_P	170_V	1.466	1.00
99_Y	126_L	1.463	1.00
216_A	221_I	1.455	1.00
100_T	103_K	1.454	1.00
106_F	119_I	1.440	1.00
90_F	173_T	1.436	1.00
242_Y	250_G	1.434	1.00
16_A	38_T	1.432	1.00
25_T	29_A	1.413	1.00
251_I	278_Y	1.412	1.00
170_V	186_L	1.406	1.00
113_L	119_I	1.404	1.00
183_V	223_K	1.404	1.00
45_E	49_A	1.401	1.00
25_T	54_Y	1.398	1.00
21_V	50_K	1.386	1.00
40_K	43_T	1.381	1.00
35_N	78_I	1.364	1.00
67_E	70_S	1.361	1.00
136_I	142_G	1.355	1.00
100_T	104_N	1.354	1.00
82_D	108_L	1.345	1.00
171_D	175_E	1.342	1.00
175_E	179_K	1.339	1.00
55_L	71_Y	1.337	1.00
104_N	107_K	1.335	1.00
37_Y	81_I	1.324	1.00
56_V	68_P	1.324	1.00
175_E	178_E	1.321	1.00
129_T	190_E	1.318	1.00
29_A	71_Y	1.317	1.00
111_T	137_R	1.300	1.00
278_Y	282_K	1.297	1.00
114_P	117_I	1.296	1.00
251_I	281_V	1.295	1.00
211_V	218_V	1.288	1.00
49_A	53_A	1.269	1.00
41_K	79_T	1.264	1.00
106_F	109_L	1.257	1.00
251_I	255_F	1.243	1.00
131_I	142_G	1.241	1.00
107_K	111_T	1.239	1.00
177_M	184_V	1.239	1.00
33_K	76_T	1.237	1.00
99_Y	103_K	1.235	1.00
130_E	133_K	1.229	1.00
69_E	73_T	1.219	1.00
90_F	176_F	1.218	1.00
162_G	165_T	1.216	1.00
59_K	64_I	1.216	1.00
24_T	36_L	1.214	1.00
103_K	107_K	1.203	1.00
87_N	114_P	1.197	1.00
275_K	279_T	1.185	1.00
68_P	72_I	1.172	1.00
128_M	144_I	1.167	1.00
46_K	50_K	1.163	1.00
44_L	79_T	1.159	1.00
120_A	143_V	1.159	1.00
82_D	112_Q	1.152	1.00
101_A	104_N	1.152	1.00
35_N	76_T	1.152	1.00
144_I	160_V	1.135	1.00
43_T	46_K	1.134	1.00
118_I	169_T	1.132	1.00
210_L	215_V	1.130	1.00
185_V	224_V	1.109	1.00
42_E	45_E	1.109	1.00
16_A	47_A	1.098	1.00
52_S	68_P	1.090	1.00
143_V	169_T	1.087	1.00
37_Y	78_I	1.081	1.00
212_D	274_D	1.075	1.00
45_E	48_L	1.056	1.00
27_L	92_I	1.053	1.00
106_F	131_I	1.051	1.00
108_L	112_Q	1.045	1.00
14_I	109_L	1.040	1.00
90_F	145_A	1.038	1.00
209_N	213_E	1.029	1.00
218_V	239_F	1.028	1.00
129_T	162_G	1.026	1.00
89_D	116_D	1.025	1.00
225_M	229_I	1.024	1.00
203_L	231_L	1.015	1.00
36_L	47_A	1.007	1.00
8_I	172_L	1.002	1.00
225_M	238_P	1.002	1.00
255_F	261_Y	1.000	1.00
81_I	112_Q	0.997	1.00
57_N	60_N	0.997	1.00
14_I	105_L	0.996	1.00
37_Y	108_L	0.983	1.00
11_V	90_F	0.968	1.00
196_G	224_V	0.962	1.00
232_R	241_T	0.962	1.00
76_T	83_D	0.961	1.00
44_L	48_L	0.947	1.00
286_E	289_K	0.944	1.00
140_E	164_K	0.937	1.00
164_K	285_L	0.937	1.00
125_G	253_Y	0.934	1.00
120_A	145_A	0.933	1.00
178_E	184_V	0.932	1.00
81_I	108_L	0.930	1.00
169_T	172_L	0.920	1.00
121_S	131_I	0.916	1.00
143_V	159_I	0.915	1.00
36_L	77_G	0.913	1.00
52_S	69_E	0.909	1.00
208_V	294_I	0.908	1.00
205_R	274_D	0.904	1.00
127_L	130_E	0.901	1.00
161_P	186_L	0.899	1.00
12_A	35_N	0.897	1.00
103_K	131_I	0.892	1.00
35_N	87_N	0.892	1.00
240_L	244_L	0.889	1.00
109_L	113_L	0.883	1.00
49_A	52_S	0.879	1.00
155_P	183_V	0.871	1.00
28_L	71_Y	0.871	1.00
8_I	11_V	0.869	1.00
90_F	120_A	0.863	1.00
99_Y	131_I	0.862	1.00
118_I	143_V	0.861	1.00
121_S	144_I	0.858	1.00
38_T	43_T	0.858	1.00
85_I	88_V	0.852	1.00
210_L	221_I	0.847	1.00
56_V	59_K	0.843	1.00
206_E	213_E	0.837	1.00
50_K	54_Y	0.836	1.00
171_D	174_R	0.830	1.00
173_T	177_M	0.829	1.00
196_G	229_I	0.827	1.00
50_K	53_A	0.827	1.00
26_L	30_K	0.825	1.00
98_D	252_E	0.818	1.00
55_L	68_P	0.813	1.00
13_V	24_T	0.804	1.00
14_I	37_Y	0.804	1.00
209_N	274_D	0.803	1.00
147_P	180_L	0.802	1.00
82_D	86_H	0.802	1.00
255_F	273_W	0.801	1.00
32_Y	176_F	0.800	1.00
10_K	88_V	0.797	1.00
9_N	89_D	0.796	1.00
54_Y	58_L	0.794	1.00
132_Q	142_G	0.794	1.00
148_W	196_G	0.790	1.00
148_W	156_L	0.788	1.00
81_I	85_I	0.787	1.00
39_E	43_T	0.786	1.00
25_T	152_H	0.784	1.00
58_L	63_M	0.780	1.00
101_A	105_L	0.779	1.00
199_L	203_L	0.779	1.00
261_Y	264_N	0.777	1.00
26_L	180_L	0.773	1.00
21_V	47_A	0.771	0.99
103_K	133_K	0.771	0.99
260_G	264_N	0.765	0.99
159_I	184_V	0.762	0.99
145_A	159_I	0.762	0.99
115_Q	138_H	0.762	0.99
126_L	130_E	0.761	0.99
107_K	134_A	0.761	0.99
204_F	242_Y	0.761	0.99
168_E	172_L	0.759	0.99
110_D	138_H	0.752	0.99
90_F	118_I	0.747	0.99
11_V	176_F	0.745	0.99
145_A	176_F	0.745	0.99
70_S	73_T	0.744	0.99
209_N	212_D	0.743	0.99
223_K	226_T	0.742	0.99
259_F	262_G	0.741	0.99
171_D	186_L	0.739	0.99
284_V	290_E	0.739	0.99
22_G	152_H	0.735	0.99
220_D	223_K	0.734	0.99
156_L	185_V	0.734	0.99
8_I	89_D	0.731	0.99
39_E	96_I	0.731	0.99
247_G	281_V	0.730	0.99
67_E	74_N	0.729	0.99
56_V	66_E	0.727	0.99
21_V	46_K	0.727	0.99
123_T	144_I	0.727	0.99
183_V	227_A	0.724	0.99
35_N	83_D	0.724	0.99
141_R	166_S	0.722	0.99
71_Y	74_N	0.719	0.99
247_G	250_G	0.718	0.99
35_N	88_V	0.717	0.99
53_A	56_V	0.717	0.99
174_R	184_V	0.716	0.99
26_L	182_R	0.716	0.99
106_F	136_I	0.711	0.99
276_F	294_I	0.707	0.99
81_I	105_L	0.707	0.99
185_V	195_I	0.706	0.99
23_W	94_A	0.704	0.99
245_G	250_G	0.703	0.99
8_I	32_Y	0.701	0.99
80_K	108_L	0.701	0.99
58_L	153_L	0.701	0.99
127_L	190_E	0.699	0.99
42_E	46_K	0.696	0.99
236_M	244_L	0.695	0.99
242_Y	247_G	0.694	0.99
207_A	239_F	0.692	0.99
58_L	64_I	0.686	0.99
201_F	250_G	0.685	0.99
14_I	85_I	0.684	0.99
249_G	253_Y	0.683	0.99
244_L	288_M	0.681	0.99
98_D	101_A	0.680	0.99
103_K	130_E	0.673	0.99
165_T	169_T	0.672	0.99
200_A	204_F	0.671	0.99
19_I	23_W	0.670	0.99
168_E	171_D	0.669	0.99
8_I	118_I	0.669	0.99
176_F	180_L	0.668	0.99
51_V	75_L	0.666	0.99
26_L	151_P	0.666	0.99
251_I	282_K	0.666	0.99
79_T	83_D	0.665	0.99
224_V	229_I	0.661	0.98
208_V	276_F	0.659	0.98
30_K	181_D	0.657	0.98
288_M	297_K	0.657	0.98
19_I	122_S	0.655	0.98
281_V	286_E	0.652	0.98
91_V	109_L	0.652	0.98
172_L	179_K	0.650	0.98
47_A	77_G	0.649	0.98
110_D	142_G	0.648	0.98
98_D	104_N	0.647	0.98
68_P	71_Y	0.646	0.98
219_E	223_K	0.643	0.98
170_V	174_R	0.642	0.98
115_Q	137_R	0.640	0.98
198_R	206_E	0.639	0.98
218_V	295_K	0.638	0.98
18_V	149_N	0.638	0.98
205_R	209_N	0.636	0.98
167_K	186_L	0.634	0.98
208_V	242_Y	0.632	0.98
60_N	63_M	0.631	0.98
279_T	282_K	0.630	0.98
128_M	190_E	0.630	0.98
132_Q	162_G	0.628	0.98
51_V	54_Y	0.626	0.98
53_A	57_N	0.626	0.98
223_K	227_A	0.626	0.98
120_A	173_T	0.625	0.98
136_I	139_P	0.625	0.98
202_A	205_R	0.625	0.98
236_M	240_L	0.621	0.98
252_E	256_S	0.621	0.98
144_I	190_E	0.620	0.98
59_K	62_G	0.619	0.98
47_A	51_V	0.618	0.98
236_M	241_T	0.613	0.97
59_K	66_E	0.613	0.97
248_E	286_E	0.612	0.97
246_G	249_G	0.611	0.97
159_I	177_M	0.609	0.97
9_N	179_K	0.605	0.97
239_F	294_I	0.604	0.97
83_D	86_H	0.602	0.97
67_E	71_Y	0.602	0.97
124_S	197_N	0.601	0.97
133_K	164_K	0.600	0.97
82_D	111_T	0.600	0.97
204_F	250_G	0.599	0.97
275_K	278_Y	0.599	0.97
197_N	202_A	0.598	0.97
285_L	290_E	0.598	0.97
12_A	37_Y	0.598	0.97
29_A	58_L	0.597	0.97
201_F	204_F	0.595	0.97
259_F	263_A	0.590	0.97
212_D	275_K	0.590	0.97
149_N	245_G	0.588	0.97
211_V	239_F	0.588	0.97
216_A	220_D	0.579	0.96
119_I	142_G	0.579	0.96
114_P	141_R	0.577	0.96
39_E	95_I	0.576	0.96
203_L	225_M	0.575	0.96
260_G	269_T	0.570	0.96
38_T	44_L	0.570	0.96
252_E	255_F	0.569	0.96
260_G	263_A	0.568	0.96
200_A	245_G	0.567	0.96
37_Y	85_I	0.566	0.96
276_F	280_A	0.566	0.96
212_D	276_F	0.563	0.96
11_V	92_I	0.563	0.96
111_T	114_P	0.561	0.96
176_F	179_K	0.560	0.96
60_N	66_E	0.560	0.96
109_L	112_Q	0.557	0.96
83_D	87_N	0.556	0.96
27_L	32_Y	0.551	0.95
130_E	282_K	0.551	0.95
287_Q	293_F	0.549	0.95
241_T	245_G	0.548	0.95
149_N	241_T	0.547	0.95
118_I	172_L	0.545	0.95
12_A	91_V	0.542	0.95
178_E	183_V	0.542	0.95
136_I	141_R	0.539	0.95
156_L	224_V	0.539	0.95
44_L	47_A	0.537	0.95
211_V	276_F	0.536	0.95
160_V	194_F	0.534	0.94
141_R	168_E	0.534	0.94
139_P	162_G	0.533	0.94
172_L	175_E	0.533	0.94
247_G	280_A	0.531	0.94
10_K	89_D	0.529	0.94
46_K	49_A	0.529	0.94
209_N	272_K	0.528	0.94
200_A	241_T	0.528	0.94
16_A	24_T	0.526	0.94
200_A	232_R	0.526	0.94
25_T	58_L	0.525	0.94
196_G	202_A	0.523	0.94
184_V	187_L	0.522	0.94
245_G	249_G	0.520	0.94
98_D	103_K	0.520	0.94
39_E	98_D	0.520	0.94
40_K	46_K	0.517	0.93
205_R	254_F	0.517	0.93
280_A	294_I	0.517	0.93
273_W	277_P	0.514	0.93
85_I	112_Q	0.513	0.93
116_D	172_L	0.512	0.93
246_G	289_K	0.512	0.93
220_D	228_A	0.511	0.93
26_L	152_H	0.510	0.93
8_I	90_F	0.508	0.93
64_I	68_P	0.505	0.93
280_A	292_E	0.503	0.93
143_V	170_V	0.503	0.93
177_M	180_L	0.502	0.92
200_A	242_Y	0.502	0.92
204_F	208_V	0.502	0.92
285_L	296_G	0.501	0.92
196_G	241_T	0.500	0.92
205_R	271_A	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wdkA	2	0.9537	100	0.303	Contact Map
2wtbA	1	0.8765	100	0.311	Contact Map
3zwcA	1	0.9722	100	0.314	Contact Map
4b3hA	1	0.9506	100	0.319	Contact Map
1zcjA	1	0.9722	100	0.324	Contact Map
3k6jA	1	0.9228	100	0.329	Contact Map
4j0eA	2	0.8858	100	0.333	Contact Map
1f0yA	2	0.8796	100	0.347	Contact Map
1zejA	2	0.8642	100	0.357	Contact Map
4r1nA	2	0.8673	100	0.363	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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