GREMLIN Database
Q7LXQ8 - 3-hydroxyacyl-CoA dehydrogenase (Hdb-1)
UniProt: Q7LXQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (281)
Sequences: 8907 (5295)
Seq/√Len: 315.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_N108_L3.3231.00
285_L292_E2.9881.00
41_K45_E2.8861.00
226_T240_L2.7931.00
12_A85_I2.6081.00
95_I105_L2.5221.00
80_K83_D2.5191.00
217_T220_D2.3971.00
292_E296_G2.3861.00
96_I101_A2.3381.00
143_V173_T2.2701.00
10_K33_K2.2631.00
28_L75_L2.2531.00
110_D136_I2.2431.00
138_H141_R2.1871.00
174_R186_L2.1841.00
140_E166_S2.1751.00
167_K171_D2.1551.00
11_V27_L2.1451.00
110_D137_R2.1371.00
157_V177_M2.1351.00
48_L77_G2.0601.00
12_A88_V2.0471.00
66_E69_E2.0331.00
255_F278_Y2.0291.00
89_D114_P1.9751.00
211_V221_I1.9561.00
95_I101_A1.9431.00
99_Y130_E1.9291.00
10_K87_N1.9241.00
159_I174_R1.9091.00
280_A285_L1.8961.00
166_S169_T1.8951.00
27_L176_F1.8731.00
161_P167_K1.8631.00
286_E290_E1.8451.00
91_V113_L1.7941.00
116_D141_R1.7911.00
59_K68_P1.7601.00
108_L111_T1.7561.00
10_K35_N1.7341.00
174_R178_E1.7131.00
33_K74_N1.7091.00
279_T283_K1.6771.00
18_V249_G1.6771.00
44_L77_G1.6761.00
145_A177_M1.6731.00
27_L180_L1.6591.00
103_K134_A1.6501.00
78_I83_D1.6361.00
248_E289_K1.6351.00
121_S128_M1.6341.00
32_Y179_K1.6231.00
70_S74_N1.6181.00
113_L117_I1.6171.00
56_V60_N1.6071.00
145_A173_T1.5641.00
52_S72_I1.5601.00
139_P164_K1.5511.00
48_L52_S1.5361.00
16_A36_L1.5291.00
187_L195_I1.5101.00
52_S56_V1.4961.00
11_V32_Y1.4911.00
129_T163_E1.4671.00
161_P170_V1.4661.00
99_Y126_L1.4631.00
216_A221_I1.4551.00
100_T103_K1.4541.00
106_F119_I1.4401.00
90_F173_T1.4361.00
242_Y250_G1.4341.00
16_A38_T1.4321.00
25_T29_A1.4131.00
251_I278_Y1.4121.00
170_V186_L1.4061.00
113_L119_I1.4041.00
183_V223_K1.4041.00
45_E49_A1.4011.00
25_T54_Y1.3981.00
21_V50_K1.3861.00
40_K43_T1.3811.00
35_N78_I1.3641.00
67_E70_S1.3611.00
136_I142_G1.3551.00
100_T104_N1.3541.00
82_D108_L1.3451.00
171_D175_E1.3421.00
175_E179_K1.3391.00
55_L71_Y1.3371.00
104_N107_K1.3351.00
37_Y81_I1.3241.00
56_V68_P1.3241.00
175_E178_E1.3211.00
129_T190_E1.3181.00
29_A71_Y1.3171.00
111_T137_R1.3001.00
278_Y282_K1.2971.00
114_P117_I1.2961.00
251_I281_V1.2951.00
211_V218_V1.2881.00
49_A53_A1.2691.00
41_K79_T1.2641.00
106_F109_L1.2571.00
251_I255_F1.2431.00
131_I142_G1.2411.00
107_K111_T1.2391.00
177_M184_V1.2391.00
33_K76_T1.2371.00
99_Y103_K1.2351.00
130_E133_K1.2291.00
69_E73_T1.2191.00
90_F176_F1.2181.00
162_G165_T1.2161.00
59_K64_I1.2161.00
24_T36_L1.2141.00
103_K107_K1.2031.00
87_N114_P1.1971.00
275_K279_T1.1851.00
68_P72_I1.1721.00
128_M144_I1.1671.00
46_K50_K1.1631.00
44_L79_T1.1591.00
120_A143_V1.1591.00
82_D112_Q1.1521.00
101_A104_N1.1521.00
35_N76_T1.1521.00
144_I160_V1.1351.00
43_T46_K1.1341.00
118_I169_T1.1321.00
210_L215_V1.1301.00
185_V224_V1.1091.00
42_E45_E1.1091.00
16_A47_A1.0981.00
52_S68_P1.0901.00
143_V169_T1.0871.00
37_Y78_I1.0811.00
212_D274_D1.0751.00
45_E48_L1.0561.00
27_L92_I1.0531.00
106_F131_I1.0511.00
108_L112_Q1.0451.00
14_I109_L1.0401.00
90_F145_A1.0381.00
209_N213_E1.0291.00
218_V239_F1.0281.00
129_T162_G1.0261.00
89_D116_D1.0251.00
225_M229_I1.0241.00
203_L231_L1.0151.00
36_L47_A1.0071.00
8_I172_L1.0021.00
225_M238_P1.0021.00
255_F261_Y1.0001.00
81_I112_Q0.9971.00
57_N60_N0.9971.00
14_I105_L0.9961.00
37_Y108_L0.9831.00
11_V90_F0.9681.00
196_G224_V0.9621.00
232_R241_T0.9621.00
76_T83_D0.9611.00
44_L48_L0.9471.00
286_E289_K0.9441.00
140_E164_K0.9371.00
164_K285_L0.9371.00
125_G253_Y0.9341.00
120_A145_A0.9331.00
178_E184_V0.9321.00
81_I108_L0.9301.00
169_T172_L0.9201.00
121_S131_I0.9161.00
143_V159_I0.9151.00
36_L77_G0.9131.00
52_S69_E0.9091.00
208_V294_I0.9081.00
205_R274_D0.9041.00
127_L130_E0.9011.00
161_P186_L0.8991.00
12_A35_N0.8971.00
103_K131_I0.8921.00
35_N87_N0.8921.00
240_L244_L0.8891.00
109_L113_L0.8831.00
49_A52_S0.8791.00
155_P183_V0.8711.00
28_L71_Y0.8711.00
8_I11_V0.8691.00
90_F120_A0.8631.00
99_Y131_I0.8621.00
118_I143_V0.8611.00
121_S144_I0.8581.00
38_T43_T0.8581.00
85_I88_V0.8521.00
210_L221_I0.8471.00
56_V59_K0.8431.00
206_E213_E0.8371.00
50_K54_Y0.8361.00
171_D174_R0.8301.00
173_T177_M0.8291.00
196_G229_I0.8271.00
50_K53_A0.8271.00
26_L30_K0.8251.00
98_D252_E0.8181.00
55_L68_P0.8131.00
13_V24_T0.8041.00
14_I37_Y0.8041.00
209_N274_D0.8031.00
147_P180_L0.8021.00
82_D86_H0.8021.00
255_F273_W0.8011.00
32_Y176_F0.8001.00
10_K88_V0.7971.00
9_N89_D0.7961.00
54_Y58_L0.7941.00
132_Q142_G0.7941.00
148_W196_G0.7901.00
148_W156_L0.7881.00
81_I85_I0.7871.00
39_E43_T0.7861.00
25_T152_H0.7841.00
58_L63_M0.7801.00
101_A105_L0.7791.00
199_L203_L0.7791.00
261_Y264_N0.7771.00
26_L180_L0.7731.00
21_V47_A0.7710.99
103_K133_K0.7710.99
260_G264_N0.7650.99
159_I184_V0.7620.99
145_A159_I0.7620.99
115_Q138_H0.7620.99
126_L130_E0.7610.99
107_K134_A0.7610.99
204_F242_Y0.7610.99
168_E172_L0.7590.99
110_D138_H0.7520.99
90_F118_I0.7470.99
11_V176_F0.7450.99
145_A176_F0.7450.99
70_S73_T0.7440.99
209_N212_D0.7430.99
223_K226_T0.7420.99
259_F262_G0.7410.99
171_D186_L0.7390.99
284_V290_E0.7390.99
22_G152_H0.7350.99
220_D223_K0.7340.99
156_L185_V0.7340.99
8_I89_D0.7310.99
39_E96_I0.7310.99
247_G281_V0.7300.99
67_E74_N0.7290.99
56_V66_E0.7270.99
21_V46_K0.7270.99
123_T144_I0.7270.99
183_V227_A0.7240.99
35_N83_D0.7240.99
141_R166_S0.7220.99
71_Y74_N0.7190.99
247_G250_G0.7180.99
35_N88_V0.7170.99
53_A56_V0.7170.99
174_R184_V0.7160.99
26_L182_R0.7160.99
106_F136_I0.7110.99
276_F294_I0.7070.99
81_I105_L0.7070.99
185_V195_I0.7060.99
23_W94_A0.7040.99
245_G250_G0.7030.99
8_I32_Y0.7010.99
80_K108_L0.7010.99
58_L153_L0.7010.99
127_L190_E0.6990.99
42_E46_K0.6960.99
236_M244_L0.6950.99
242_Y247_G0.6940.99
207_A239_F0.6920.99
58_L64_I0.6860.99
201_F250_G0.6850.99
14_I85_I0.6840.99
249_G253_Y0.6830.99
244_L288_M0.6810.99
98_D101_A0.6800.99
103_K130_E0.6730.99
165_T169_T0.6720.99
200_A204_F0.6710.99
19_I23_W0.6700.99
168_E171_D0.6690.99
8_I118_I0.6690.99
176_F180_L0.6680.99
51_V75_L0.6660.99
26_L151_P0.6660.99
251_I282_K0.6660.99
79_T83_D0.6650.99
224_V229_I0.6610.98
208_V276_F0.6590.98
30_K181_D0.6570.98
288_M297_K0.6570.98
19_I122_S0.6550.98
281_V286_E0.6520.98
91_V109_L0.6520.98
172_L179_K0.6500.98
47_A77_G0.6490.98
110_D142_G0.6480.98
98_D104_N0.6470.98
68_P71_Y0.6460.98
219_E223_K0.6430.98
170_V174_R0.6420.98
115_Q137_R0.6400.98
198_R206_E0.6390.98
218_V295_K0.6380.98
18_V149_N0.6380.98
205_R209_N0.6360.98
167_K186_L0.6340.98
208_V242_Y0.6320.98
60_N63_M0.6310.98
279_T282_K0.6300.98
128_M190_E0.6300.98
132_Q162_G0.6280.98
51_V54_Y0.6260.98
53_A57_N0.6260.98
223_K227_A0.6260.98
120_A173_T0.6250.98
136_I139_P0.6250.98
202_A205_R0.6250.98
236_M240_L0.6210.98
252_E256_S0.6210.98
144_I190_E0.6200.98
59_K62_G0.6190.98
47_A51_V0.6180.98
236_M241_T0.6130.97
59_K66_E0.6130.97
248_E286_E0.6120.97
246_G249_G0.6110.97
159_I177_M0.6090.97
9_N179_K0.6050.97
239_F294_I0.6040.97
83_D86_H0.6020.97
67_E71_Y0.6020.97
124_S197_N0.6010.97
133_K164_K0.6000.97
82_D111_T0.6000.97
204_F250_G0.5990.97
275_K278_Y0.5990.97
197_N202_A0.5980.97
285_L290_E0.5980.97
12_A37_Y0.5980.97
29_A58_L0.5970.97
201_F204_F0.5950.97
259_F263_A0.5900.97
212_D275_K0.5900.97
149_N245_G0.5880.97
211_V239_F0.5880.97
216_A220_D0.5790.96
119_I142_G0.5790.96
114_P141_R0.5770.96
39_E95_I0.5760.96
203_L225_M0.5750.96
260_G269_T0.5700.96
38_T44_L0.5700.96
252_E255_F0.5690.96
260_G263_A0.5680.96
200_A245_G0.5670.96
37_Y85_I0.5660.96
276_F280_A0.5660.96
212_D276_F0.5630.96
11_V92_I0.5630.96
111_T114_P0.5610.96
176_F179_K0.5600.96
60_N66_E0.5600.96
109_L112_Q0.5570.96
83_D87_N0.5560.96
27_L32_Y0.5510.95
130_E282_K0.5510.95
287_Q293_F0.5490.95
241_T245_G0.5480.95
149_N241_T0.5470.95
118_I172_L0.5450.95
12_A91_V0.5420.95
178_E183_V0.5420.95
136_I141_R0.5390.95
156_L224_V0.5390.95
44_L47_A0.5370.95
211_V276_F0.5360.95
160_V194_F0.5340.94
141_R168_E0.5340.94
139_P162_G0.5330.94
172_L175_E0.5330.94
247_G280_A0.5310.94
10_K89_D0.5290.94
46_K49_A0.5290.94
209_N272_K0.5280.94
200_A241_T0.5280.94
16_A24_T0.5260.94
200_A232_R0.5260.94
25_T58_L0.5250.94
196_G202_A0.5230.94
184_V187_L0.5220.94
245_G249_G0.5200.94
98_D103_K0.5200.94
39_E98_D0.5200.94
40_K46_K0.5170.93
205_R254_F0.5170.93
280_A294_I0.5170.93
273_W277_P0.5140.93
85_I112_Q0.5130.93
116_D172_L0.5120.93
246_G289_K0.5120.93
220_D228_A0.5110.93
26_L152_H0.5100.93
8_I90_F0.5080.93
64_I68_P0.5050.93
280_A292_E0.5030.93
143_V170_V0.5030.93
177_M180_L0.5020.92
200_A242_Y0.5020.92
204_F208_V0.5020.92
285_L296_G0.5010.92
196_G241_T0.5000.92
205_R271_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.9537 100 0.303 Contact Map
2wtbA 1 0.8765 100 0.311 Contact Map
3zwcA 1 0.9722 100 0.314 Contact Map
4b3hA 1 0.9506 100 0.319 Contact Map
1zcjA 1 0.9722 100 0.324 Contact Map
3k6jA 1 0.9228 100 0.329 Contact Map
4j0eA 2 0.8858 100 0.333 Contact Map
1f0yA 2 0.8796 100 0.347 Contact Map
1zejA 2 0.8642 100 0.357 Contact Map
4r1nA 2 0.8673 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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