GREMLIN Database
Q7LXQ4 - Uncharacterized protein
UniProt: Q7LXQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (159)
Sequences: 242 (167)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_R141_L5.7691.00
34_Y62_D3.6470.99
24_S29_T3.1660.98
155_F159_I3.0600.97
112_V118_L2.9620.97
84_V131_V2.8060.95
12_D74_E2.7110.94
59_I77_K2.6260.93
6_I132_I2.5890.93
121_I132_I2.5670.92
51_N76_A2.4880.91
37_L44_L2.3890.89
125_T135_V2.3170.88
33_L87_I2.1740.84
124_E129_R2.1230.83
80_G140_P2.0950.82
99_N102_K2.0220.79
44_L92_G2.0170.79
39_S105_E1.9960.78
57_R138_Y1.9450.76
119_Q127_Q1.8910.74
33_L101_I1.8790.74
23_Q111_F1.8660.73
45_K65_D1.8380.72
128_G135_V1.8300.72
41_S64_N1.8070.71
10_R119_Q1.7930.70
64_N92_G1.7790.70
36_T104_V1.7690.69
150_Q154_E1.7110.66
145_S148_D1.5950.61
7_D122_V1.5890.60
56_K151_E1.5750.60
125_T128_G1.5750.60
11_I19_V1.5620.59
37_L40_S1.5250.57
154_E158_K1.5110.56
13_I17_T1.4810.55
87_I101_I1.4640.54
73_I143_V1.4620.54
71_L88_Y1.4490.53
61_Y149_I1.4430.53
4_I75_N1.4330.52
13_I16_G1.4300.52
119_Q125_T1.4250.52
61_Y69_I1.4100.51
19_V88_Y1.3710.49
21_I101_I1.3610.49
21_I86_V1.3580.48
67_E90_K1.3540.48
119_Q128_G1.3410.48
130_G135_V1.3360.47
21_I120_V1.3050.46
56_K148_D1.3010.45
48_I87_I1.2820.44
11_I79_I1.2680.44
43_N64_N1.2660.44
61_Y73_I1.2620.43
21_I131_V1.2010.40
51_N130_G1.1930.40
56_K141_L1.1820.39
41_S44_L1.1640.38
37_L97_V1.1620.38
11_I86_V1.1410.37
15_E45_K1.1230.36
121_I135_V1.1000.35
40_S97_V1.0980.35
126_D139_A1.0970.35
79_I140_P1.0820.34
19_V118_L1.0740.34
22_G85_F1.0550.33
59_I93_Y1.0290.32
34_Y46_F1.0270.32
93_Y159_I1.0110.31
16_G64_N1.0100.31
59_I70_K1.0080.31
157_R162_K1.0000.31
40_S105_E0.9930.30
17_T89_L0.9890.30
51_N84_V0.9830.30
17_T71_L0.9580.29
64_N68_L0.9570.29
31_E35_E0.9560.29
112_V119_Q0.9490.28
10_R78_K0.9370.28
62_D84_V0.9230.27
98_L110_I0.9150.27
67_E103_N0.9040.26
112_V130_G0.8980.26
45_K91_N0.8660.25
12_D110_I0.8600.25
48_I66_Q0.8590.25
98_L102_K0.8570.25
35_E157_R0.8550.25
25_H35_E0.8510.24
74_E78_K0.8510.24
45_K155_F0.8400.24
18_N25_H0.8390.24
51_N149_I0.8350.24
86_V122_V0.8340.24
8_V121_I0.8340.24
80_G155_F0.8250.23
13_I71_L0.8240.23
13_I75_N0.8140.23
151_E155_F0.8090.23
73_I77_K0.8080.23
138_Y141_L0.7890.22
67_E111_F0.7780.22
122_V143_V0.7710.21
96_N129_R0.7710.21
50_F54_S0.7700.21
28_K156_L0.7680.21
111_F121_I0.7610.21
98_L108_V0.7560.21
51_N81_A0.7500.21
42_P97_V0.7460.21
11_I21_I0.7420.20
41_S92_G0.7400.20
78_K118_L0.7390.20
45_K90_K0.7390.20
12_D139_A0.7350.20
30_V62_D0.7280.20
33_L64_N0.7270.20
37_L101_I0.7240.20
124_E139_A0.7210.20
80_G145_S0.7110.19
13_I34_Y0.7090.19
35_E106_E0.7060.19
57_R140_P0.7060.19
40_S48_I0.7040.19
35_E162_K0.6900.19
57_R108_V0.6860.19
25_H106_E0.6820.18
68_L149_I0.6780.18
109_R118_L0.6770.18
24_S147_A0.6710.18
39_S143_V0.6670.18
41_S97_V0.6650.18
23_Q108_V0.6640.18
144_E152_R0.6640.18
50_F106_E0.6580.18
81_A122_V0.6580.18
107_V155_F0.6570.18
25_H50_F0.6550.18
42_P87_I0.6460.17
40_S72_A0.6450.17
39_S112_V0.6420.17
35_E50_F0.6350.17
75_N100_R0.6350.17
39_S95_I0.6310.17
61_Y126_D0.6280.17
4_I7_D0.6280.17
118_L122_V0.6280.17
4_I79_I0.6250.17
36_T129_R0.6230.17
54_S106_E0.6220.17
74_E150_Q0.6200.17
21_I64_N0.6180.16
67_E146_E0.6170.16
5_K120_V0.6160.16
88_Y143_V0.6160.16
53_A132_I0.6160.16
17_T88_Y0.6150.16
119_Q135_V0.6110.16
35_E54_S0.6070.16
5_K124_E0.6070.16
43_N111_F0.6030.16
111_F151_E0.6020.16
55_S89_L0.6000.16
101_I107_V0.5990.16
53_A56_K0.5990.16
44_L64_N0.5960.16
39_S155_F0.5920.16
9_V110_I0.5900.16
13_I88_Y0.5900.16
121_I149_I0.5890.16
62_D105_E0.5850.16
39_S100_R0.5820.15
44_L48_I0.5810.15
91_N135_V0.5800.15
43_N90_K0.5770.15
51_N101_I0.5760.15
8_V91_N0.5740.15
67_E158_K0.5720.15
9_V138_Y0.5710.15
121_I139_A0.5690.15
142_G156_L0.5670.15
122_V158_K0.5660.15
75_N88_Y0.5660.15
93_Y145_S0.5610.15
34_Y45_K0.5580.15
93_Y120_V0.5580.15
44_L155_F0.5540.15
93_Y132_I0.5510.15
30_V117_P0.5500.15
5_K45_K0.5460.14
99_N103_N0.5440.14
14_P111_F0.5420.14
148_D151_E0.5420.14
41_S59_I0.5410.14
25_H54_S0.5400.14
28_K35_E0.5400.14
123_A135_V0.5390.14
8_V119_Q0.5380.14
7_D11_I0.5370.14
42_P111_F0.5370.14
33_L100_R0.5350.14
109_R155_F0.5340.14
72_A153_K0.5340.14
12_D91_N0.5340.14
18_N106_E0.5320.14
95_I108_V0.5310.14
119_Q143_V0.5310.14
48_I84_V0.5290.14
151_E154_E0.5290.14
23_Q84_V0.5280.14
132_I135_V0.5280.14
36_T59_I0.5260.14
31_E50_F0.5260.14
37_L151_E0.5250.14
7_D74_E0.5250.14
66_Q101_I0.5220.14
106_E157_R0.5200.14
90_K120_V0.5200.14
13_I104_V0.5180.14
11_I17_T0.5170.14
88_Y104_V0.5170.14
71_L105_E0.5160.14
11_I88_Y0.5150.14
33_L48_I0.5140.14
10_R131_V0.5120.14
105_E112_V0.5110.14
28_K50_F0.5110.14
37_L41_S0.5080.13
114_T130_G0.5050.13
18_N50_F0.5020.13
18_N54_S0.5010.13
28_K54_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ekmA 3 0.9816 100 0.023 Contact Map
1wvqA 4 0.9877 100 0.034 Contact Map
1vggA 5 0.9816 100 0.041 Contact Map
1rlhA 3 0.8896 100 0.044 Contact Map
2d16A 5 0.9816 100 0.053 Contact Map
1t7lA 1 0.9141 49.9 0.958 Contact Map
1u1jA 1 0.9264 32 0.963 Contact Map
1zjcA 2 0.7178 31.1 0.963 Contact Map
3qg2A 2 0.362 26.9 0.964 Contact Map
2nq5A 1 0.8098 20.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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