GREMLIN Database
Q7LXQ2 - Uncharacterized protein
UniProt: Q7LXQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (322)
Sequences: 1086 (882)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_Y150_N5.3461.00
177_F202_A3.3901.00
115_M146_Y3.2101.00
22_R33_F3.0891.00
272_Y276_K3.0501.00
154_S175_I3.0091.00
230_K277_E2.8481.00
57_I119_V2.8091.00
26_I30_Q2.8061.00
205_L212_V2.7671.00
122_M143_A2.7211.00
39_V42_G2.7141.00
159_T162_L2.6071.00
49_Y138_D2.5361.00
214_I236_L2.5261.00
23_K159_T2.5201.00
173_V205_L2.4831.00
243_D281_K2.4811.00
136_A152_M2.3531.00
78_S127_N2.3301.00
185_F219_I2.3131.00
106_S135_F2.2861.00
226_L270_R2.2551.00
202_A240_L2.2031.00
203_S239_Q2.2021.00
222_I260_I2.2011.00
264_P267_T2.1741.00
28_E41_N2.1441.00
9_K18_L2.1321.00
174_T215_T2.1151.00
295_N304_L2.1131.00
77_F110_I2.1031.00
206_S212_V2.0881.00
182_E194_S2.0261.00
280_F283_V2.0241.00
196_E200_E2.0221.00
66_V294_E2.0171.00
230_K278_L1.9780.99
196_E199_I1.9760.99
144_K171_D1.9680.99
205_L210_I1.9410.99
160_P200_E1.9310.99
225_D228_A1.9240.99
307_R314_L1.8940.99
55_A75_F1.8920.99
111_V143_A1.8810.99
16_R25_L1.8590.99
246_I275_A1.8550.99
317_H325_K1.8520.99
299_P331_L1.8450.99
206_S241_G1.8100.99
143_A148_L1.8070.99
164_D204_E1.7640.99
233_L278_L1.7500.99
235_K239_Q1.7410.99
69_N149_F1.7400.99
60_I151_T1.7280.99
246_I283_V1.7120.98
200_E203_S1.7020.98
297_Y304_L1.6890.98
232_L236_L1.6440.98
303_N326_F1.6340.98
142_V145_R1.6160.98
241_G244_I1.6050.98
76_S125_T1.6050.98
268_L285_V1.5900.97
31_V38_S1.5540.97
242_A281_K1.5490.97
33_F85_M1.5480.97
216_D246_I1.5270.97
19_A158_W1.5000.96
141_I169_F1.4860.96
181_G228_A1.4850.96
206_S244_I1.4810.96
251_F257_L1.4790.96
282_F332_P1.4750.96
238_D241_G1.4700.96
189_Y222_I1.4690.96
234_T278_L1.4430.95
304_L307_R1.4120.95
237_Y280_F1.4080.95
65_L172_A1.3980.95
273_K277_E1.3690.94
202_A244_I1.3630.94
295_N307_R1.3560.94
111_V122_M1.3520.94
233_L280_F1.3400.93
282_F331_L1.3170.93
243_D332_P1.3160.93
316_W325_K1.3140.93
216_D232_L1.3070.92
173_V210_I1.3050.92
204_E207_K1.3030.92
67_H284_Y1.3010.92
154_S212_V1.2980.92
282_F299_P1.2860.92
233_L248_F1.2760.91
235_K240_L1.2590.91
15_I39_V1.2530.91
185_F190_T1.2510.91
50_G135_F1.2420.90
251_F259_Y1.2380.90
180_N228_A1.2360.90
113_L116_G1.2300.90
74_V123_T1.2280.90
195_A199_I1.2110.89
218_I271_H1.2070.89
74_V151_T1.2060.89
75_F113_L1.2060.89
313_I316_W1.2050.89
15_I44_L1.2040.89
305_V325_K1.1980.89
299_P329_Y1.1970.89
175_I205_L1.1960.89
300_N329_Y1.1950.88
211_H333_I1.1900.88
53_A78_S1.1870.88
221_Q260_I1.1680.87
14_R25_L1.1680.87
251_F260_I1.1670.87
154_S205_L1.1660.87
27_G30_Q1.1660.87
19_A133_S1.1640.87
233_L274_L1.1560.87
229_A248_F1.1520.87
236_L244_I1.1520.87
272_Y293_Y1.1380.86
229_A271_H1.1330.86
123_T151_T1.1320.86
203_S207_K1.1220.85
112_E146_Y1.1160.85
269_E291_H1.1150.85
15_I42_G1.0960.84
137_H169_F1.0940.84
96_Q255_Y1.0930.84
180_N195_A1.0920.84
237_Y244_I1.0880.83
179_G228_A1.0870.83
95_S154_S1.0870.83
18_L161_N1.0850.83
154_S173_V1.0800.83
9_K16_R1.0770.83
233_L246_I1.0740.82
238_D244_I1.0730.82
58_D62_K1.0730.82
106_S109_E1.0710.82
74_V121_G1.0690.82
158_W162_L1.0640.82
317_H326_F1.0630.82
137_H141_I1.0600.82
111_V148_L1.0420.81
214_I237_Y1.0390.80
21_A159_T1.0290.80
202_A205_L1.0200.79
35_G98_R1.0170.79
109_E116_G1.0150.79
232_L246_I1.0120.79
268_L288_V1.0110.78
26_I44_L1.0110.78
158_W167_K0.9980.78
37_R134_E0.9980.78
240_L244_I0.9970.77
65_L151_T0.9920.77
248_F275_A0.9870.77
315_E325_K0.9840.77
216_D228_A0.9830.76
226_L274_L0.9830.76
152_M170_L0.9770.76
55_A77_F0.9740.76
51_K104_E0.9700.76
194_S197_P0.9690.75
128_E155_N0.9690.75
114_A148_L0.9600.75
289_P310_S0.9590.75
281_K329_Y0.9560.74
92_Y254_D0.9540.74
269_E288_V0.9520.74
130_A158_W0.9520.74
140_G170_L0.9500.74
173_V201_T0.9490.74
305_V331_L0.9490.74
53_A127_N0.9470.74
111_V146_Y0.9440.73
26_I39_V0.9340.73
21_A162_L0.9310.72
202_A214_I0.9250.72
187_R194_S0.9250.72
230_K274_L0.9240.72
84_W155_N0.9140.71
21_A158_W0.9090.71
246_I280_F0.9060.70
130_A155_N0.9000.70
72_S120_D0.8990.70
267_T270_R0.8880.69
281_K299_P0.8780.68
124_Y139_V0.8770.68
299_P305_V0.8730.68
110_I135_F0.8730.68
216_D229_A0.8700.67
222_I257_L0.8680.67
121_G148_L0.8670.67
185_F222_I0.8650.67
108_E142_V0.8640.67
236_L240_L0.8640.67
220_P264_P0.8600.66
216_D248_F0.8580.66
269_E290_G0.8560.66
160_P164_D0.8550.66
292_P295_N0.8540.66
179_G185_F0.8530.66
63_K90_Q0.8510.66
19_A46_L0.8500.65
121_G149_F0.8490.65
21_A157_Y0.8490.65
257_L260_I0.8410.65
265_V288_V0.8390.64
122_M148_L0.8380.64
226_L230_K0.8360.64
133_S165_Y0.8360.64
79_T127_N0.8350.64
136_A166_V0.8320.64
111_V142_V0.8280.63
53_A94_I0.8260.63
322_M333_I0.8250.63
229_A233_L0.8170.62
57_I117_Y0.8150.62
65_L68_F0.8140.62
173_V215_T0.8130.62
75_F139_V0.8120.62
14_R27_G0.8090.62
23_K161_N0.8060.61
21_A84_W0.8060.61
323_R330_K0.8050.61
137_H165_Y0.8030.61
174_T249_L0.8020.61
83_N155_N0.8010.61
62_K125_T0.8000.61
236_L241_G0.7920.60
17_C24_C0.7910.60
28_E39_V0.7900.60
290_G295_N0.7880.60
17_C20_C0.7870.59
68_F149_F0.7830.59
105_L110_I0.7800.59
164_D208_K0.7770.58
269_E272_Y0.7760.58
240_L280_F0.7730.58
38_S47_D0.7720.58
50_G138_D0.7710.58
90_Q217_L0.7690.58
133_S137_H0.7690.58
307_R315_E0.7680.58
109_E112_E0.7640.57
218_I229_A0.7630.57
270_R273_K0.7610.57
21_A197_P0.7590.57
216_D233_L0.7590.57
158_W201_T0.7580.57
87_M257_L0.7570.56
69_N120_D0.7550.56
63_K153_V0.7550.56
320_E325_K0.7520.56
20_C24_C0.7520.56
226_L267_T0.7450.55
182_E197_P0.7440.55
215_T249_L0.7430.55
248_F285_V0.7430.55
149_F171_D0.7420.55
314_L317_H0.7400.55
250_R265_V0.7390.55
69_N121_G0.7350.54
88_Y185_F0.7320.54
69_N72_S0.7310.54
186_L195_A0.7300.54
115_M148_L0.7280.54
274_L278_L0.7270.53
231_Q234_T0.7260.53
181_G185_F0.7260.53
48_V110_I0.7250.53
303_N317_H0.7250.53
285_V293_Y0.7230.53
179_G202_A0.7170.52
184_K188_R0.7160.52
221_Q259_Y0.7150.52
314_L325_K0.7140.52
303_N315_E0.7120.52
67_H282_F0.7120.52
300_N326_F0.7120.52
219_I223_G0.7090.52
150_N170_L0.7090.52
182_E187_R0.7070.51
60_I74_V0.7050.51
227_Q231_Q0.7030.51
236_L246_I0.7030.51
88_Y189_Y0.7030.51
233_L275_A0.7020.51
166_V169_F0.7010.51
272_Y285_V0.7010.51
202_A237_Y0.7000.51
236_L283_V0.6990.51
132_F136_A0.6970.50
317_H321_D0.6970.50
108_E146_Y0.6950.50
63_K76_S0.6940.50
62_K126_Y0.6940.50
107_P139_V0.6920.50
24_C34_C0.6920.50
235_K244_I0.6910.50
105_L135_F0.6910.50
84_W157_Y0.6900.50
289_P309_Y0.6880.49
143_A150_N0.6880.49
127_N249_L0.6880.49
72_S121_G0.6850.49
76_S126_Y0.6840.49
136_A170_L0.6810.49
40_R45_Y0.6800.49
124_Y127_N0.6780.48
320_E330_K0.6750.48
232_L275_A0.6720.48
112_E116_G0.6720.48
160_P204_E0.6680.47
10_K43_K0.6670.47
141_I145_R0.6670.47
236_L239_Q0.6660.47
174_T210_I0.6660.47
325_K328_G0.6650.47
325_K331_L0.6590.47
62_K286_G0.6580.46
314_L326_F0.6570.46
152_M166_V0.6560.46
250_R262_W0.6550.46
157_Y197_P0.6540.46
133_S162_L0.6500.46
46_L79_T0.6500.46
17_C34_C0.6460.45
36_V131_I0.6460.45
195_A198_I0.6450.45
21_A123_T0.6420.45
66_V249_L0.6400.45
196_E203_S0.6400.45
239_Q244_I0.6400.45
203_S206_S0.6380.44
303_N323_R0.6380.44
300_N330_K0.6370.44
298_C301_C0.6360.44
18_L23_K0.6340.44
56_H154_S0.6340.44
162_L165_Y0.6340.44
192_A198_I0.6330.44
303_N325_K0.6300.44
302_G312_D0.6270.43
167_K208_K0.6270.43
306_I333_I0.6260.43
154_S245_P0.6240.43
269_E285_V0.6220.43
307_R317_H0.6180.42
62_K215_T0.6160.42
58_D126_Y0.6160.42
124_Y132_F0.6160.42
305_V317_H0.6110.42
90_Q286_G0.6080.41
204_E208_K0.6070.41
315_E326_F0.6050.41
302_G326_F0.6050.41
320_E323_R0.6030.41
54_A93_D0.6030.41
20_C34_C0.6020.41
129_P136_A0.6020.41
113_L117_Y0.6010.41
125_T286_G0.6010.41
182_E196_E0.5980.40
144_K169_F0.5970.40
236_L248_F0.5970.40
69_N73_K0.5950.40
112_E115_M0.5950.40
74_V149_F0.5900.40
136_A139_V0.5900.40
59_P62_K0.5890.40
90_Q153_V0.5880.39
73_K120_D0.5870.39
39_V44_L0.5850.39
223_G249_L0.5850.39
68_F151_T0.5840.39
227_Q320_E0.5830.39
269_E273_K0.5820.39
111_V133_S0.5810.39
143_A147_G0.5810.39
103_V113_L0.5810.39
52_I135_F0.5810.39
36_V48_V0.5800.39
87_M191_G0.5770.38
307_R316_W0.5770.38
229_A246_I0.5770.38
63_K286_G0.5740.38
67_H70_P0.5730.38
123_T135_F0.5720.38
105_L113_L0.5710.38
161_N164_D0.5700.38
249_L311_F0.5700.38
140_G169_F0.5700.38
139_V142_V0.5680.38
61_E64_P0.5680.38
53_A74_V0.5680.38
324_C327_C0.5670.37
123_T311_F0.5650.37
44_L109_E0.5650.37
60_I121_G0.5630.37
19_A36_V0.5590.37
123_T174_T0.5590.37
152_M210_I0.5580.37
136_A141_I0.5580.37
85_M191_G0.5570.37
170_L210_I0.5570.37
26_I45_Y0.5560.36
91_N217_L0.5540.36
180_N199_I0.5540.36
303_N307_R0.5540.36
321_D330_K0.5530.36
62_K287_N0.5510.36
144_K238_D0.5510.36
62_K153_V0.5510.36
217_L286_G0.5500.36
234_T238_D0.5480.36
163_V205_L0.5480.36
62_K76_S0.5460.35
109_E330_K0.5460.35
323_R328_G0.5450.35
21_A201_T0.5440.35
79_T132_F0.5430.35
189_Y221_Q0.5420.35
59_P153_V0.5420.35
202_A241_G0.5410.35
202_A235_K0.5400.35
312_D320_E0.5390.35
305_V318_L0.5380.35
82_C86_C0.5380.35
62_K128_E0.5360.35
315_E323_R0.5360.35
218_I267_T0.5350.34
201_T205_L0.5350.34
89_C178_K0.5340.34
63_K263_T0.5330.34
48_V79_T0.5320.34
140_G150_N0.5320.34
36_V132_F0.5320.34
160_P201_T0.5310.34
172_A215_T0.5300.34
248_F271_H0.5290.34
115_M323_R0.5290.34
275_A283_V0.5270.34
51_K102_G0.5270.34
153_V215_T0.5260.34
297_Y326_F0.5260.34
51_K264_P0.5240.33
234_T237_Y0.5220.33
95_S255_Y0.5220.33
70_P213_E0.5200.33
60_I97_R0.5200.33
191_G239_Q0.5190.33
54_A94_I0.5170.33
62_K90_Q0.5170.33
303_N330_K0.5170.33
307_R328_G0.5160.33
86_C89_C0.5160.33
12_D27_G0.5150.33
58_D76_S0.5150.33
144_K170_L0.5130.32
84_W159_T0.5120.32
298_C327_C0.5120.32
104_E135_F0.5090.32
304_L317_H0.5090.32
82_C89_C0.5090.32
298_C324_C0.5060.32
71_G84_W0.5060.32
58_D63_K0.5060.32
62_K65_L0.5060.32
188_R277_E0.5040.32
166_V170_L0.5030.32
58_D125_T0.5030.32
304_L313_I0.5020.31
167_K205_L0.5000.31
181_G225_D0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8fA 1 0.6439 100 0.755 Contact Map
3rfaA 1 0.8006 99.9 0.802 Contact Map
3canA 2 0.4501 99.9 0.812 Contact Map
1tv8A 2 0.7749 99.9 0.817 Contact Map
2z2uA 1 0.6838 99.9 0.818 Contact Map
1r30A 2 0.7778 99.9 0.818 Contact Map
4u0oB 1 0.7208 99.9 0.82 Contact Map
2yx0A 1 0.812 99.9 0.825 Contact Map
1oltA 1 0.8519 99.9 0.832 Contact Map
4njhA 2 0.5271 99.9 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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