Q7LXQ2 - SULSO - GREMLIN Contacts

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Q7LXQ2 - Uncharacterized protein

UniProt:	Q7LXQ2	Sequences: MTKEAVLYKKEDGRIRCLACARKCLIGEGQVGFCGVRSVRNGKLYLDVYGKIAAAHIDPIEKKPLVHFNPGSKVFSFSTYGCNWMCMYCQNYDISQRRKAEGVELSPEEIVELAMGYDVDGMTYTYNEPAIFSEFAHDVGIVAKRYGLFNTMVSNGYWTPNLVDYVKDFLDAVTIDFKGNGEQKFLRRYTGATSAEPIIETASELSKKGIHVEITDLIIPQIGDDLQAAKQLLTKLYDQLGADIPIHFLRFHPDYKLNYIPWTPVETLERHYKLAKELGFKFVYVGNVPGHPYENTYCPNCGNLVIRRYSFDILEWHLTEDMRCKFCGYKLPIRGKLSRHAFKERFEPVFI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	351 (322)
Sequences:	1086 (882)
Seq/√Len:	49.1

SULSO - Q7LXQ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
124_Y	150_N	5.346	1.00
177_F	202_A	3.390	1.00
115_M	146_Y	3.210	1.00
22_R	33_F	3.089	1.00
272_Y	276_K	3.050	1.00
154_S	175_I	3.009	1.00
230_K	277_E	2.848	1.00
57_I	119_V	2.809	1.00
26_I	30_Q	2.806	1.00
205_L	212_V	2.767	1.00
122_M	143_A	2.721	1.00
39_V	42_G	2.714	1.00
159_T	162_L	2.607	1.00
49_Y	138_D	2.536	1.00
214_I	236_L	2.526	1.00
23_K	159_T	2.520	1.00
173_V	205_L	2.483	1.00
243_D	281_K	2.481	1.00
136_A	152_M	2.353	1.00
78_S	127_N	2.330	1.00
185_F	219_I	2.313	1.00
106_S	135_F	2.286	1.00
226_L	270_R	2.255	1.00
202_A	240_L	2.203	1.00
203_S	239_Q	2.202	1.00
222_I	260_I	2.201	1.00
264_P	267_T	2.174	1.00
28_E	41_N	2.144	1.00
9_K	18_L	2.132	1.00
174_T	215_T	2.115	1.00
295_N	304_L	2.113	1.00
77_F	110_I	2.103	1.00
206_S	212_V	2.088	1.00
182_E	194_S	2.026	1.00
280_F	283_V	2.024	1.00
196_E	200_E	2.022	1.00
66_V	294_E	2.017	1.00
230_K	278_L	1.978	0.99
196_E	199_I	1.976	0.99
144_K	171_D	1.968	0.99
205_L	210_I	1.941	0.99
160_P	200_E	1.931	0.99
225_D	228_A	1.924	0.99
307_R	314_L	1.894	0.99
55_A	75_F	1.892	0.99
111_V	143_A	1.881	0.99
16_R	25_L	1.859	0.99
246_I	275_A	1.855	0.99
317_H	325_K	1.852	0.99
299_P	331_L	1.845	0.99
206_S	241_G	1.810	0.99
143_A	148_L	1.807	0.99
164_D	204_E	1.764	0.99
233_L	278_L	1.750	0.99
235_K	239_Q	1.741	0.99
69_N	149_F	1.740	0.99
60_I	151_T	1.728	0.99
246_I	283_V	1.712	0.98
200_E	203_S	1.702	0.98
297_Y	304_L	1.689	0.98
232_L	236_L	1.644	0.98
303_N	326_F	1.634	0.98
142_V	145_R	1.616	0.98
241_G	244_I	1.605	0.98
76_S	125_T	1.605	0.98
268_L	285_V	1.590	0.97
31_V	38_S	1.554	0.97
242_A	281_K	1.549	0.97
33_F	85_M	1.548	0.97
216_D	246_I	1.527	0.97
19_A	158_W	1.500	0.96
141_I	169_F	1.486	0.96
181_G	228_A	1.485	0.96
206_S	244_I	1.481	0.96
251_F	257_L	1.479	0.96
282_F	332_P	1.475	0.96
238_D	241_G	1.470	0.96
189_Y	222_I	1.469	0.96
234_T	278_L	1.443	0.95
304_L	307_R	1.412	0.95
237_Y	280_F	1.408	0.95
65_L	172_A	1.398	0.95
273_K	277_E	1.369	0.94
202_A	244_I	1.363	0.94
295_N	307_R	1.356	0.94
111_V	122_M	1.352	0.94
233_L	280_F	1.340	0.93
282_F	331_L	1.317	0.93
243_D	332_P	1.316	0.93
316_W	325_K	1.314	0.93
216_D	232_L	1.307	0.92
173_V	210_I	1.305	0.92
204_E	207_K	1.303	0.92
67_H	284_Y	1.301	0.92
154_S	212_V	1.298	0.92
282_F	299_P	1.286	0.92
233_L	248_F	1.276	0.91
235_K	240_L	1.259	0.91
15_I	39_V	1.253	0.91
185_F	190_T	1.251	0.91
50_G	135_F	1.242	0.90
251_F	259_Y	1.238	0.90
180_N	228_A	1.236	0.90
113_L	116_G	1.230	0.90
74_V	123_T	1.228	0.90
195_A	199_I	1.211	0.89
218_I	271_H	1.207	0.89
74_V	151_T	1.206	0.89
75_F	113_L	1.206	0.89
313_I	316_W	1.205	0.89
15_I	44_L	1.204	0.89
305_V	325_K	1.198	0.89
299_P	329_Y	1.197	0.89
175_I	205_L	1.196	0.89
300_N	329_Y	1.195	0.88
211_H	333_I	1.190	0.88
53_A	78_S	1.187	0.88
221_Q	260_I	1.168	0.87
14_R	25_L	1.168	0.87
251_F	260_I	1.167	0.87
154_S	205_L	1.166	0.87
27_G	30_Q	1.166	0.87
19_A	133_S	1.164	0.87
233_L	274_L	1.156	0.87
229_A	248_F	1.152	0.87
236_L	244_I	1.152	0.87
272_Y	293_Y	1.138	0.86
229_A	271_H	1.133	0.86
123_T	151_T	1.132	0.86
203_S	207_K	1.122	0.85
112_E	146_Y	1.116	0.85
269_E	291_H	1.115	0.85
15_I	42_G	1.096	0.84
137_H	169_F	1.094	0.84
96_Q	255_Y	1.093	0.84
180_N	195_A	1.092	0.84
237_Y	244_I	1.088	0.83
179_G	228_A	1.087	0.83
95_S	154_S	1.087	0.83
18_L	161_N	1.085	0.83
154_S	173_V	1.080	0.83
9_K	16_R	1.077	0.83
233_L	246_I	1.074	0.82
238_D	244_I	1.073	0.82
58_D	62_K	1.073	0.82
106_S	109_E	1.071	0.82
74_V	121_G	1.069	0.82
158_W	162_L	1.064	0.82
317_H	326_F	1.063	0.82
137_H	141_I	1.060	0.82
111_V	148_L	1.042	0.81
214_I	237_Y	1.039	0.80
21_A	159_T	1.029	0.80
202_A	205_L	1.020	0.79
35_G	98_R	1.017	0.79
109_E	116_G	1.015	0.79
232_L	246_I	1.012	0.79
268_L	288_V	1.011	0.78
26_I	44_L	1.011	0.78
158_W	167_K	0.998	0.78
37_R	134_E	0.998	0.78
240_L	244_I	0.997	0.77
65_L	151_T	0.992	0.77
248_F	275_A	0.987	0.77
315_E	325_K	0.984	0.77
216_D	228_A	0.983	0.76
226_L	274_L	0.983	0.76
152_M	170_L	0.977	0.76
55_A	77_F	0.974	0.76
51_K	104_E	0.970	0.76
194_S	197_P	0.969	0.75
128_E	155_N	0.969	0.75
114_A	148_L	0.960	0.75
289_P	310_S	0.959	0.75
281_K	329_Y	0.956	0.74
92_Y	254_D	0.954	0.74
269_E	288_V	0.952	0.74
130_A	158_W	0.952	0.74
140_G	170_L	0.950	0.74
173_V	201_T	0.949	0.74
305_V	331_L	0.949	0.74
53_A	127_N	0.947	0.74
111_V	146_Y	0.944	0.73
26_I	39_V	0.934	0.73
21_A	162_L	0.931	0.72
202_A	214_I	0.925	0.72
187_R	194_S	0.925	0.72
230_K	274_L	0.924	0.72
84_W	155_N	0.914	0.71
21_A	158_W	0.909	0.71
246_I	280_F	0.906	0.70
130_A	155_N	0.900	0.70
72_S	120_D	0.899	0.70
267_T	270_R	0.888	0.69
281_K	299_P	0.878	0.68
124_Y	139_V	0.877	0.68
299_P	305_V	0.873	0.68
110_I	135_F	0.873	0.68
216_D	229_A	0.870	0.67
222_I	257_L	0.868	0.67
121_G	148_L	0.867	0.67
185_F	222_I	0.865	0.67
108_E	142_V	0.864	0.67
236_L	240_L	0.864	0.67
220_P	264_P	0.860	0.66
216_D	248_F	0.858	0.66
269_E	290_G	0.856	0.66
160_P	164_D	0.855	0.66
292_P	295_N	0.854	0.66
179_G	185_F	0.853	0.66
63_K	90_Q	0.851	0.66
19_A	46_L	0.850	0.65
121_G	149_F	0.849	0.65
21_A	157_Y	0.849	0.65
257_L	260_I	0.841	0.65
265_V	288_V	0.839	0.64
122_M	148_L	0.838	0.64
226_L	230_K	0.836	0.64
133_S	165_Y	0.836	0.64
79_T	127_N	0.835	0.64
136_A	166_V	0.832	0.64
111_V	142_V	0.828	0.63
53_A	94_I	0.826	0.63
322_M	333_I	0.825	0.63
229_A	233_L	0.817	0.62
57_I	117_Y	0.815	0.62
65_L	68_F	0.814	0.62
173_V	215_T	0.813	0.62
75_F	139_V	0.812	0.62
14_R	27_G	0.809	0.62
23_K	161_N	0.806	0.61
21_A	84_W	0.806	0.61
323_R	330_K	0.805	0.61
137_H	165_Y	0.803	0.61
174_T	249_L	0.802	0.61
83_N	155_N	0.801	0.61
62_K	125_T	0.800	0.61
236_L	241_G	0.792	0.60
17_C	24_C	0.791	0.60
28_E	39_V	0.790	0.60
290_G	295_N	0.788	0.60
17_C	20_C	0.787	0.59
68_F	149_F	0.783	0.59
105_L	110_I	0.780	0.59
164_D	208_K	0.777	0.58
269_E	272_Y	0.776	0.58
240_L	280_F	0.773	0.58
38_S	47_D	0.772	0.58
50_G	138_D	0.771	0.58
90_Q	217_L	0.769	0.58
133_S	137_H	0.769	0.58
307_R	315_E	0.768	0.58
109_E	112_E	0.764	0.57
218_I	229_A	0.763	0.57
270_R	273_K	0.761	0.57
21_A	197_P	0.759	0.57
216_D	233_L	0.759	0.57
158_W	201_T	0.758	0.57
87_M	257_L	0.757	0.56
69_N	120_D	0.755	0.56
63_K	153_V	0.755	0.56
320_E	325_K	0.752	0.56
20_C	24_C	0.752	0.56
226_L	267_T	0.745	0.55
182_E	197_P	0.744	0.55
215_T	249_L	0.743	0.55
248_F	285_V	0.743	0.55
149_F	171_D	0.742	0.55
314_L	317_H	0.740	0.55
250_R	265_V	0.739	0.55
69_N	121_G	0.735	0.54
88_Y	185_F	0.732	0.54
69_N	72_S	0.731	0.54
186_L	195_A	0.730	0.54
115_M	148_L	0.728	0.54
274_L	278_L	0.727	0.53
231_Q	234_T	0.726	0.53
181_G	185_F	0.726	0.53
48_V	110_I	0.725	0.53
303_N	317_H	0.725	0.53
285_V	293_Y	0.723	0.53
179_G	202_A	0.717	0.52
184_K	188_R	0.716	0.52
221_Q	259_Y	0.715	0.52
314_L	325_K	0.714	0.52
303_N	315_E	0.712	0.52
67_H	282_F	0.712	0.52
300_N	326_F	0.712	0.52
219_I	223_G	0.709	0.52
150_N	170_L	0.709	0.52
182_E	187_R	0.707	0.51
60_I	74_V	0.705	0.51
227_Q	231_Q	0.703	0.51
236_L	246_I	0.703	0.51
88_Y	189_Y	0.703	0.51
233_L	275_A	0.702	0.51
166_V	169_F	0.701	0.51
272_Y	285_V	0.701	0.51
202_A	237_Y	0.700	0.51
236_L	283_V	0.699	0.51
132_F	136_A	0.697	0.50
317_H	321_D	0.697	0.50
108_E	146_Y	0.695	0.50
63_K	76_S	0.694	0.50
62_K	126_Y	0.694	0.50
107_P	139_V	0.692	0.50
24_C	34_C	0.692	0.50
235_K	244_I	0.691	0.50
105_L	135_F	0.691	0.50
84_W	157_Y	0.690	0.50
289_P	309_Y	0.688	0.49
143_A	150_N	0.688	0.49
127_N	249_L	0.688	0.49
72_S	121_G	0.685	0.49
76_S	126_Y	0.684	0.49
136_A	170_L	0.681	0.49
40_R	45_Y	0.680	0.49
124_Y	127_N	0.678	0.48
320_E	330_K	0.675	0.48
232_L	275_A	0.672	0.48
112_E	116_G	0.672	0.48
160_P	204_E	0.668	0.47
10_K	43_K	0.667	0.47
141_I	145_R	0.667	0.47
236_L	239_Q	0.666	0.47
174_T	210_I	0.666	0.47
325_K	328_G	0.665	0.47
325_K	331_L	0.659	0.47
62_K	286_G	0.658	0.46
314_L	326_F	0.657	0.46
152_M	166_V	0.656	0.46
250_R	262_W	0.655	0.46
157_Y	197_P	0.654	0.46
133_S	162_L	0.650	0.46
46_L	79_T	0.650	0.46
17_C	34_C	0.646	0.45
36_V	131_I	0.646	0.45
195_A	198_I	0.645	0.45
21_A	123_T	0.642	0.45
66_V	249_L	0.640	0.45
196_E	203_S	0.640	0.45
239_Q	244_I	0.640	0.45
203_S	206_S	0.638	0.44
303_N	323_R	0.638	0.44
300_N	330_K	0.637	0.44
298_C	301_C	0.636	0.44
18_L	23_K	0.634	0.44
56_H	154_S	0.634	0.44
162_L	165_Y	0.634	0.44
192_A	198_I	0.633	0.44
303_N	325_K	0.630	0.44
302_G	312_D	0.627	0.43
167_K	208_K	0.627	0.43
306_I	333_I	0.626	0.43
154_S	245_P	0.624	0.43
269_E	285_V	0.622	0.43
307_R	317_H	0.618	0.42
62_K	215_T	0.616	0.42
58_D	126_Y	0.616	0.42
124_Y	132_F	0.616	0.42
305_V	317_H	0.611	0.42
90_Q	286_G	0.608	0.41
204_E	208_K	0.607	0.41
315_E	326_F	0.605	0.41
302_G	326_F	0.605	0.41
320_E	323_R	0.603	0.41
54_A	93_D	0.603	0.41
20_C	34_C	0.602	0.41
129_P	136_A	0.602	0.41
113_L	117_Y	0.601	0.41
125_T	286_G	0.601	0.41
182_E	196_E	0.598	0.40
144_K	169_F	0.597	0.40
236_L	248_F	0.597	0.40
69_N	73_K	0.595	0.40
112_E	115_M	0.595	0.40
74_V	149_F	0.590	0.40
136_A	139_V	0.590	0.40
59_P	62_K	0.589	0.40
90_Q	153_V	0.588	0.39
73_K	120_D	0.587	0.39
39_V	44_L	0.585	0.39
223_G	249_L	0.585	0.39
68_F	151_T	0.584	0.39
227_Q	320_E	0.583	0.39
269_E	273_K	0.582	0.39
111_V	133_S	0.581	0.39
143_A	147_G	0.581	0.39
103_V	113_L	0.581	0.39
52_I	135_F	0.581	0.39
36_V	48_V	0.580	0.39
87_M	191_G	0.577	0.38
307_R	316_W	0.577	0.38
229_A	246_I	0.577	0.38
63_K	286_G	0.574	0.38
67_H	70_P	0.573	0.38
123_T	135_F	0.572	0.38
105_L	113_L	0.571	0.38
161_N	164_D	0.570	0.38
249_L	311_F	0.570	0.38
140_G	169_F	0.570	0.38
139_V	142_V	0.568	0.38
61_E	64_P	0.568	0.38
53_A	74_V	0.568	0.38
324_C	327_C	0.567	0.37
123_T	311_F	0.565	0.37
44_L	109_E	0.565	0.37
60_I	121_G	0.563	0.37
19_A	36_V	0.559	0.37
123_T	174_T	0.559	0.37
152_M	210_I	0.558	0.37
136_A	141_I	0.558	0.37
85_M	191_G	0.557	0.37
170_L	210_I	0.557	0.37
26_I	45_Y	0.556	0.36
91_N	217_L	0.554	0.36
180_N	199_I	0.554	0.36
303_N	307_R	0.554	0.36
321_D	330_K	0.553	0.36
62_K	287_N	0.551	0.36
144_K	238_D	0.551	0.36
62_K	153_V	0.551	0.36
217_L	286_G	0.550	0.36
234_T	238_D	0.548	0.36
163_V	205_L	0.548	0.36
62_K	76_S	0.546	0.35
109_E	330_K	0.546	0.35
323_R	328_G	0.545	0.35
21_A	201_T	0.544	0.35
79_T	132_F	0.543	0.35
189_Y	221_Q	0.542	0.35
59_P	153_V	0.542	0.35
202_A	241_G	0.541	0.35
202_A	235_K	0.540	0.35
312_D	320_E	0.539	0.35
305_V	318_L	0.538	0.35
82_C	86_C	0.538	0.35
62_K	128_E	0.536	0.35
315_E	323_R	0.536	0.35
218_I	267_T	0.535	0.34
201_T	205_L	0.535	0.34
89_C	178_K	0.534	0.34
63_K	263_T	0.533	0.34
48_V	79_T	0.532	0.34
140_G	150_N	0.532	0.34
36_V	132_F	0.532	0.34
160_P	201_T	0.531	0.34
172_A	215_T	0.530	0.34
248_F	271_H	0.529	0.34
115_M	323_R	0.529	0.34
275_A	283_V	0.527	0.34
51_K	102_G	0.527	0.34
153_V	215_T	0.526	0.34
297_Y	326_F	0.526	0.34
51_K	264_P	0.524	0.33
234_T	237_Y	0.522	0.33
95_S	255_Y	0.522	0.33
70_P	213_E	0.520	0.33
60_I	97_R	0.520	0.33
191_G	239_Q	0.519	0.33
54_A	94_I	0.517	0.33
62_K	90_Q	0.517	0.33
303_N	330_K	0.517	0.33
307_R	328_G	0.516	0.33
86_C	89_C	0.516	0.33
12_D	27_G	0.515	0.33
58_D	76_S	0.515	0.33
144_K	170_L	0.513	0.32
84_W	159_T	0.512	0.32
298_C	327_C	0.512	0.32
104_E	135_F	0.509	0.32
304_L	317_H	0.509	0.32
82_C	89_C	0.509	0.32
298_C	324_C	0.506	0.32
71_G	84_W	0.506	0.32
58_D	63_K	0.506	0.32
62_K	65_L	0.506	0.32
188_R	277_E	0.504	0.32
166_V	170_L	0.503	0.32
58_D	125_T	0.503	0.32
304_L	313_I	0.502	0.31
167_K	205_L	0.500	0.31
181_G	225_D	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c8fA	1	0.6439	100	0.755	Contact Map
3rfaA	1	0.8006	99.9	0.802	Contact Map
3canA	2	0.4501	99.9	0.812	Contact Map
1tv8A	2	0.7749	99.9	0.817	Contact Map
2z2uA	1	0.6838	99.9	0.818	Contact Map
1r30A	2	0.7778	99.9	0.818	Contact Map
4u0oB	1	0.7208	99.9	0.82	Contact Map
2yx0A	1	0.812	99.9	0.825	Contact Map
1oltA	1	0.8519	99.9	0.832	Contact Map
4njhA	2	0.5271	99.9	0.835	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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