GREMLIN Database
Q7LXQ1 - Enoyl CoA hydratase (PaaF-2)
UniProt: Q7LXQ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (243)
Sequences: 30295 (19959)
Seq/√Len: 1280.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_Q181_E3.2181.00
126_E164_I3.2001.00
178_R188_E3.1151.00
121_A176_V2.9501.00
188_E191_E2.8191.00
99_A116_C2.8051.00
14_W190_R2.6301.00
42_V94_P2.5371.00
39_R89_Y2.4891.00
23_L57_K2.3261.00
163_D195_K2.3121.00
218_P221_S2.2971.00
124_I182_P2.2441.00
169_Y172_R2.2261.00
166_K169_Y2.2131.00
157_E163_D2.1621.00
154_R173_I2.0791.00
133_N199_K2.0361.00
8_E13_E2.0171.00
123_Q168_D2.0081.00
14_W53_T2.0031.00
8_E44_N1.9811.00
159_I207_I1.9711.00
23_L58_A1.9611.00
106_L128_G1.9291.00
100_M189_V1.9251.00
29_I33_E1.8981.00
6_T13_E1.8891.00
11_P48_K1.8861.00
35_G89_Y1.8691.00
18_N55_S1.8271.00
244_N248_S1.8211.00
16_V55_S1.8161.00
100_M186_E1.8011.00
120_I180_V1.8011.00
184_S187_K1.7741.00
157_E177_N1.7501.00
156_M212_N1.7501.00
13_E41_I1.7491.00
16_V53_T1.7231.00
190_R194_L1.6931.00
123_Q182_P1.6681.00
169_Y173_I1.6661.00
50_V93_Y1.6501.00
32_R82_K1.6021.00
117_D208_K1.5841.00
13_E47_I1.5771.00
152_K156_M1.5741.00
168_D172_R1.5451.00
120_I192_L1.5451.00
40_Q44_N1.5351.00
157_E178_R1.5191.00
42_V89_Y1.5001.00
121_A127_L1.4971.00
41_I50_V1.4881.00
113_A119_R1.4671.00
119_R149_L1.4661.00
10_P194_L1.4621.00
122_S182_P1.4561.00
184_S188_E1.4541.00
156_M211_V1.4521.00
119_R153_G1.4501.00
180_V188_E1.4421.00
49_V193_A1.4361.00
15_I37_I1.4331.00
6_T41_I1.4261.00
53_T102_N1.4241.00
171_E179_V1.4161.00
9_E190_R1.4101.00
88_D220_L1.4021.00
156_M160_M1.3901.00
102_N124_I1.3641.00
91_E145_R1.3631.00
163_D169_Y1.3541.00
101_I113_A1.3451.00
90_I97_T1.3441.00
102_N122_S1.3361.00
9_E194_L1.3341.00
88_D92_R1.3291.00
101_I105_A1.3251.00
38_L93_Y1.3191.00
154_R157_E1.3181.00
28_S67_Q1.3051.00
110_L129_L1.3041.00
57_K102_N1.2881.00
9_E14_W1.2871.00
27_N30_M1.2811.00
72_D75_K1.2721.00
19_R22_K1.2711.00
158_I165_I1.2711.00
35_G39_R1.2601.00
206_L232_I1.2571.00
132_I162_G1.2481.00
128_G164_I1.2411.00
35_G85_E1.2161.00
209_T213_Y1.2141.00
17_L30_M1.1981.00
241_K248_S1.1941.00
42_V93_Y1.1881.00
239_E243_V1.1851.00
104_Y126_E1.1811.00
154_R169_Y1.1721.00
33_E37_I1.1641.00
53_T186_E1.1641.00
153_G177_N1.1531.00
185_L189_V1.1481.00
186_E190_R1.1471.00
14_W186_E1.1421.00
186_E189_V1.1391.00
122_S185_L1.1281.00
199_K204_I1.1271.00
58_A104_Y1.1231.00
217_A225_L1.1011.00
167_A179_V1.0991.00
217_A221_S1.0941.00
165_I173_I1.0911.00
17_L60_S1.0841.00
151_G154_R1.0801.00
60_S109_G1.0681.00
181_E184_S1.0671.00
22_K66_S1.0661.00
83_G140_F1.0451.00
187_K191_E1.0441.00
36_D40_Q1.0391.00
7_K16_V1.0341.00
8_E46_K1.0301.00
8_E40_Q1.0301.00
33_E36_D1.0261.00
118_L192_L1.0231.00
92_R220_L1.0211.00
213_Y225_L1.0191.00
97_T116_C1.0051.00
50_V95_K1.0031.00
19_R64_D0.9991.00
202_I238_E0.9981.00
28_S32_R0.9971.00
171_E176_V0.9731.00
111_E142_G0.9611.00
7_K14_W0.9611.00
150_I154_R0.9501.00
143_T226_E0.9471.00
56_G102_N0.9451.00
193_A197_A0.9381.00
51_I189_V0.9321.00
144_Q222_G0.9241.00
123_Q179_V0.9221.00
45_D95_K0.9201.00
47_I95_K0.9161.00
14_W51_I0.9131.00
110_L127_L0.9121.00
37_I40_Q0.9101.00
168_D171_E0.9091.00
221_S224_T0.9081.00
209_T229_G0.9021.00
201_Q205_R0.9011.00
94_P205_R0.8991.00
126_E166_K0.8991.00
102_N185_L0.8981.00
149_L153_G0.8971.00
50_V97_T0.8951.00
53_T100_M0.8951.00
101_I127_L0.8851.00
12_I49_V0.8741.00
240_K244_N0.8721.00
190_R193_A0.8601.00
132_I207_I0.8581.00
77_W81_I0.8581.00
31_I86_L0.8541.00
118_L177_N0.8541.00
101_I119_R0.8541.00
23_L61_A0.8501.00
196_L204_I0.8401.00
137_Y233_A0.8351.00
225_L228_L0.8311.00
100_M185_L0.8231.00
8_E47_I0.8221.00
38_L90_I0.8181.00
206_L229_G0.8171.00
152_K215_N0.8121.00
35_G82_K0.8091.00
122_S183_S0.8071.00
241_K245_E0.8001.00
150_I158_I0.7941.00
66_S247_L0.7931.00
188_E192_L0.7931.00
146_L150_I0.7921.00
39_R85_E0.7881.00
210_V229_G0.7831.00
187_K190_R0.7801.00
106_L164_I0.7761.00
159_I211_V0.7761.00
32_R36_D0.7731.00
111_E131_E0.7711.00
206_L233_A0.7671.00
41_I47_I0.7671.00
158_I173_I0.7581.00
171_E178_R0.7571.00
39_R43_D0.7571.00
15_I50_V0.7551.00
42_V95_K0.7521.00
107_G130_P0.7501.00
35_G86_L0.7471.00
206_L209_T0.7431.00
52_F116_C0.7331.00
28_S82_K0.7311.00
200_P238_E0.7291.00
133_N164_I0.7291.00
48_K201_Q0.7281.00
167_A176_V0.7281.00
94_P209_T0.7261.00
157_E161_L0.7251.00
178_R192_L0.7241.00
191_E194_L0.7191.00
243_V247_L0.7191.00
180_V185_L0.7181.00
101_I125_A0.7171.00
242_R245_E0.7171.00
6_T40_Q0.7151.00
195_K199_K0.7141.00
27_N67_Q0.7131.00
191_E195_K0.7121.00
93_Y97_T0.7091.00
219_I223_L0.7081.00
237_E240_K0.7071.00
19_R27_N0.7061.00
170_A175_L0.7051.00
225_L229_G0.7051.00
58_A102_N0.7041.00
189_V193_A0.7041.00
74_V78_E0.7011.00
26_I30_M0.6991.00
144_Q147_V0.6991.00
114_L175_L0.6981.00
229_G232_I0.6971.00
23_L104_Y0.6951.00
87_M115_S0.6941.00
51_I190_R0.6911.00
120_I189_V0.6801.00
151_G155_A0.6731.00
19_R25_S0.6721.00
131_E139_G0.6711.00
12_I51_I0.6681.00
224_T228_L0.6631.00
176_V179_V0.6611.00
238_E242_R0.6591.00
6_T37_I0.6581.00
41_I95_K0.6581.00
11_P46_K0.6571.00
161_L192_L0.6541.00
227_S231_G0.6541.00
93_Y96_P0.6531.00
202_I236_T0.6521.00
52_F97_T0.6501.00
120_I178_R0.6491.00
228_L232_I0.6481.00
30_M33_E0.6471.00
37_I41_I0.6441.00
102_N182_P0.6441.00
81_I85_E0.6421.00
213_Y217_A0.6411.00
138_P207_I0.6371.00
77_W228_L0.6351.00
127_L176_V0.6351.00
51_I100_M0.6311.00
29_I32_R0.6301.00
137_Y210_V0.6291.00
210_V225_L0.6281.00
220_L224_T0.6281.00
106_L130_P0.6271.00
194_L198_E0.6261.00
12_I190_R0.6231.00
152_K212_N0.6201.00
34_I86_L0.6201.00
128_G162_G0.6171.00
131_E138_P0.6171.00
8_E11_P0.6151.00
98_I193_A0.6151.00
168_D179_V0.6151.00
49_V98_I0.6121.00
131_E230_W0.6121.00
201_Q204_I0.6111.00
111_E139_G0.6091.00
81_I227_S0.6071.00
69_K244_N0.6061.00
121_A125_A0.6051.00
44_N95_K0.6021.00
152_K211_V0.5991.00
99_A119_R0.5991.00
6_T15_I0.5971.00
154_R171_E0.5971.00
161_L196_L0.5961.00
73_P232_I0.5961.00
36_D39_R0.5951.00
102_N125_A0.5911.00
39_R42_V0.5881.00
44_N47_I0.5871.00
160_M204_I0.5861.00
150_I155_A0.5851.00
12_I193_A0.5841.00
120_I188_E0.5831.00
51_I186_E0.5831.00
111_E141_G0.5781.00
63_A68_F0.5701.00
15_I38_L0.5691.00
120_I185_L0.5681.00
241_K244_N0.5681.00
207_I210_V0.5641.00
166_K172_R0.5631.00
38_L89_Y0.5611.00
167_A171_E0.5611.00
122_S125_A0.5571.00
237_E241_K0.5571.00
15_I52_F0.5551.00
165_I170_A0.5541.00
48_K197_A0.5531.00
85_E88_D0.5491.00
244_N247_L0.5491.00
147_V150_I0.5471.00
124_I167_A0.5451.00
73_P77_W0.5441.00
149_L177_N0.5431.00
157_E169_Y0.5431.00
104_Y164_I0.5401.00
129_L159_I0.5381.00
195_K198_E0.5371.00
150_I173_I0.5371.00
184_S191_E0.5371.00
161_L195_K0.5351.00
29_I67_Q0.5331.00
143_T222_G0.5301.00
136_I239_E0.5291.00
38_L50_V0.5291.00
47_I50_V0.5281.00
239_E242_R0.5261.00
110_L175_L0.5241.00
132_I199_K0.5241.00
113_A116_C0.5221.00
111_E145_R0.5211.00
129_L142_G0.5201.00
192_L195_K0.5181.00
49_V197_A0.5161.00
22_K64_D0.5161.00
144_Q148_R0.5151.00
156_M208_K0.5141.00
38_L97_T0.5111.00
77_W231_G0.5101.00
22_K25_S0.5091.00
27_N64_D0.5091.00
147_V214_G0.5081.00
154_R172_R0.5081.00
202_I233_A0.5051.00
40_Q43_D0.5051.00
91_E219_I0.5041.00
100_M193_A0.5041.00
65_I134_L0.5041.00
63_A108_G0.5031.00
85_E89_Y0.5031.00
115_S145_R0.5031.00
118_L196_L0.5031.00
78_E82_K0.5011.00
111_E129_L0.5011.00
217_A222_G0.5011.00
107_G129_L0.5001.00
147_V211_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kqfA 3 1 100 0.054 Contact Map
3qmjA 3 0.8333 100 0.055 Contact Map
4jfcA 3 0.996 100 0.057 Contact Map
4lk5A 3 0.9683 100 0.059 Contact Map
3tlfA 5 0.996 100 0.06 Contact Map
2ej5A 3 0.9722 100 0.062 Contact Map
4mi2A 3 0.996 100 0.062 Contact Map
3qxzA 3 0.996 100 0.063 Contact Map
4jcsA 6 0.9921 100 0.063 Contact Map
4kd6A 3 0.8452 100 0.063 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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