GREMLIN Database
Q7LXP8 - Homoserine dehydrogenase (ThrA/hom)
UniProt: Q7LXP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (305)
Sequences: 3861 (2375)
Seq/√Len: 136.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_N226_T6.2061.00
166_R169_E4.6651.00
83_E87_S3.8131.00
173_F194_L3.6841.00
90_I117_V3.5371.00
2_K33_E3.4121.00
178_K182_E3.0741.00
114_I125_I2.9091.00
172_S175_E2.6171.00
191_T195_N2.5711.00
171_L176_A2.5661.00
90_I113_E2.3961.00
203_L247_A2.3511.00
179_E182_E2.2731.00
64_D91_K2.2541.00
14_A295_P2.1781.00
134_G283_I2.1691.00
17_R295_P2.1361.00
86_V90_I2.1251.00
116_E120_K2.1171.00
162_Y179_E2.1161.00
76_V306_L2.1101.00
171_L179_E2.0941.00
148_E282_E2.0871.00
15_F303_L2.0721.00
93_L123_A1.9991.00
16_R34_I1.9851.00
90_I94_S1.9151.00
2_K35_A1.9001.00
274_E291_P1.8821.00
242_K263_P1.8741.00
18_L299_A1.8631.00
107_L205_I1.8601.00
150_S280_Q1.8531.00
107_L125_I1.8241.00
5_L16_R1.8181.00
185_Y273_V1.8061.00
178_K181_K1.7781.00
241_K260_I1.7761.00
140_L288_I1.7271.00
203_L254_V1.7161.00
117_V121_T1.6921.00
94_S117_V1.6721.00
151_R280_Q1.6641.00
237_K263_P1.6561.00
265_D278_E1.6541.00
98_H123_A1.6311.00
216_K219_D1.6311.00
137_S279_I1.6211.00
89_Y106_P1.6171.00
84_P87_S1.6161.00
110_K113_E1.6151.00
146_V307_V1.6091.00
94_S121_T1.6091.00
58_T61_E1.6031.00
223_K257_S1.5961.00
155_I270_I1.5831.00
239_E260_I1.5821.00
93_L117_V1.5791.00
89_Y99_V1.5611.00
17_R21_E1.5521.00
280_Q285_R1.5291.00
159_T186_A1.5181.00
172_S176_A1.5181.00
204_T220_F1.4891.00
179_E183_K1.4871.00
166_R179_E1.4841.00
112_R214_S1.4831.00
192_L201_A1.4691.00
207_S254_V1.4691.00
241_K262_G1.4571.00
16_R20_H1.4351.00
98_H309_L1.4271.00
98_H124_K1.4251.00
89_Y125_I1.4231.00
14_A296_I1.4111.00
91_K95_R1.4031.00
94_S120_K1.3931.00
171_L175_E1.3931.00
22_K26_Y1.3921.00
41_Q46_G1.3901.00
35_A71_I1.3891.00
166_R176_A1.3811.00
163_I177_L1.3771.00
236_A260_I1.3751.00
197_F222_F1.3721.00
93_L125_I1.3721.00
273_V291_P1.3401.00
200_A217_L1.3391.00
230_N234_R1.3391.00
168_Y271_D1.3381.00
8_Y16_R1.3271.00
207_S249_A1.3201.00
35_A69_D1.3021.00
236_A243_I1.3021.00
90_I114_I1.3011.00
270_I289_R1.2961.00
25_N29_L1.2951.00
248_Y257_S1.2941.00
274_E289_R1.2921.00
6_I38_I1.2921.00
166_R171_L1.2881.00
200_A222_F1.2861.00
91_K94_S1.2851.00
248_Y255_Q1.2731.00
160_T199_A1.2681.00
19_L34_I1.2601.00
153_R278_E1.2561.00
283_I286_I1.2541.00
275_N293_A1.2471.00
100_I306_L1.2441.00
173_F177_L1.2381.00
139_N308_L1.2311.00
139_N143_I1.2301.00
279_I288_I1.2281.00
126_G309_L1.2151.00
203_L249_A1.2151.00
112_R116_E1.2081.00
15_F306_L1.2081.00
61_E64_D1.1991.00
86_V110_K1.1971.00
153_R265_D1.1941.00
24_D28_I1.1891.00
13_K295_P1.1860.99
132_M135_T1.1820.99
78_N302_A1.1490.99
181_K186_A1.1480.99
248_Y259_Q1.1380.99
93_L114_I1.1290.99
96_K121_T1.1220.99
26_Y307_V1.1150.99
231_E235_R1.1140.99
105_A192_L1.1110.99
221_K257_S1.0980.99
105_A201_A1.0980.99
141_F149_V1.0940.99
132_M277_L1.0860.99
152_I206_L1.0850.99
36_G65_Y1.0850.99
68_P91_K1.0790.99
177_L186_A1.0790.99
156_L203_L1.0780.99
234_R238_S1.0770.99
170_G230_N1.0730.99
224_G245_L1.0670.99
15_F299_A1.0660.99
2_K73_D1.0610.99
150_S282_E1.0570.99
242_K271_D1.0530.99
278_E287_I1.0520.99
176_A179_E1.0500.99
93_L99_V1.0460.99
5_L34_I1.0430.99
2_K71_I1.0360.99
185_Y272_G1.0250.99
3_L32_V1.0220.98
36_G72_V1.0210.98
129_G301_G1.0190.98
41_Q47_D1.0170.98
158_G293_A1.0140.98
23_K27_P1.0120.98
6_I88_A1.0050.98
69_D72_V0.9970.98
275_N292_G0.9970.98
8_Y37_I0.9950.98
303_L306_L0.9930.98
117_V120_K0.9890.98
8_Y13_K0.9840.98
284_Q291_P0.9840.98
165_T168_Y0.9830.98
64_D68_P0.9830.98
84_P88_A0.9820.98
36_G69_D0.9790.98
3_L306_L0.9740.98
223_K227_E0.9720.98
83_E86_V0.9630.98
38_I88_A0.9610.98
124_K309_L0.9600.98
223_K255_Q0.9570.98
246_I259_Q0.9540.98
140_L144_Q0.9510.98
19_L32_V0.9510.98
207_S220_F0.9430.97
32_V310_L0.9420.97
240_G263_P0.9410.97
163_I173_F0.9300.97
234_R237_K0.9300.97
204_T217_L0.9250.97
242_K268_Y0.9220.97
72_V97_I0.9190.97
87_S91_K0.9130.97
270_I276_A0.9060.97
82_G109_L0.9030.97
221_K253_V0.9010.97
152_I203_L0.8920.96
215_L254_V0.8910.96
262_G268_Y0.8890.96
158_G292_G0.8860.96
221_K255_Q0.8860.96
207_S215_L0.8810.96
127_F209_F0.8810.96
76_V100_I0.8800.96
4_L66_I0.8770.96
147_A304_S0.8740.96
162_Y166_R0.8710.96
114_I117_V0.8690.96
225_I245_L0.8600.96
160_T245_L0.8600.96
18_L296_I0.8590.96
172_S230_N0.8580.96
27_P30_Q0.8570.96
285_R291_P0.8510.95
266_P287_I0.8500.95
109_L218_G0.8430.95
38_I63_I0.8360.95
249_A254_V0.8310.95
51_F54_D0.8300.95
93_L121_T0.8260.95
290_G293_A0.8230.94
272_G291_P0.8220.94
192_L197_F0.8200.94
153_R248_Y0.8190.94
96_K123_A0.8170.94
130_T205_I0.8110.94
74_M306_L0.8070.94
20_H23_K0.8030.94
161_N244_K0.8030.94
152_I210_I0.8030.94
173_F226_T0.7980.93
281_N286_I0.7980.93
181_K190_P0.7970.93
17_R296_I0.7950.93
4_L36_G0.7950.93
63_I92_A0.7920.93
68_P95_R0.7860.93
115_F125_I0.7840.93
143_I308_L0.7830.93
131_V138_I0.7830.93
276_A287_I0.7770.93
118_A123_A0.7720.92
22_K282_E0.7690.92
21_E296_I0.7660.92
24_D27_P0.7640.92
111_F115_F0.7630.92
52_S56_Q0.7610.92
144_Q286_I0.7590.92
166_R272_G0.7570.92
54_D57_L0.7560.92
64_D67_N0.7550.91
278_E285_R0.7510.91
228_I232_E0.7490.91
270_I287_I0.7450.91
56_Q59_V0.7450.91
197_F226_T0.7410.91
92_A99_V0.7340.90
100_I309_L0.7330.90
275_N294_G0.7310.90
16_R37_I0.7270.90
18_L303_L0.7260.90
213_R252_Y0.7240.90
133_S297_N0.7220.90
61_E65_Y0.7160.89
158_G275_N0.7150.89
204_T208_N0.7130.89
6_I66_I0.7110.89
8_Y39_T0.7110.89
50_N56_Q0.7100.89
261_I267_L0.7090.89
243_I260_I0.7080.89
275_N290_G0.7030.88
1_M310_L0.7000.88
174_N226_T0.6990.88
279_I286_I0.6940.88
70_V97_I0.6910.87
22_K25_N0.6900.87
138_I142_R0.6900.87
281_N288_I0.6880.87
231_E234_R0.6880.87
151_R250_D0.6860.87
204_T215_L0.6860.87
10_N295_P0.6840.87
158_G290_G0.6810.87
67_N91_K0.6800.87
197_F201_A0.6790.87
139_N304_S0.6770.86
50_N54_D0.6750.86
175_E178_K0.6750.86
203_L207_S0.6750.86
261_I265_D0.6750.86
92_A170_G0.6730.86
137_S277_L0.6720.86
39_T88_A0.6710.86
70_V95_R0.6700.86
13_K48_K0.6680.86
39_T42_G0.6680.86
86_V106_P0.6680.86
129_G299_A0.6670.86
263_P268_Y0.6640.85
233_I242_K0.6630.85
82_G89_Y0.6610.85
140_L286_I0.6600.85
265_D287_I0.6590.85
235_R239_E0.6590.85
265_D268_Y0.6590.85
152_I277_L0.6580.85
158_G294_G0.6580.85
66_I75_S0.6580.85
304_S308_L0.6540.84
191_T197_F0.6530.84
160_T201_A0.6510.84
235_R260_I0.6500.84
30_Q307_V0.6500.84
201_A217_L0.6490.84
2_K72_V0.6490.84
21_E282_E0.6480.84
57_L61_E0.6480.84
267_L276_A0.6470.84
188_E191_T0.6460.84
48_K52_S0.6450.84
191_T226_T0.6430.83
264_Q269_Y0.6430.83
149_V281_N0.6410.83
63_I88_A0.6410.83
160_T203_L0.6410.83
13_K17_R0.6410.83
76_V92_A0.6380.83
223_K232_E0.6340.83
53_P59_V0.6310.82
67_N88_A0.6300.82
26_Y29_L0.6290.82
26_Y34_I0.6290.82
156_L277_L0.6280.82
25_N28_I0.6260.82
93_L97_I0.6250.82
149_V152_I0.6200.81
25_N148_E0.6180.81
66_I69_D0.6180.81
181_K194_L0.6180.81
135_T288_I0.6160.81
174_N178_K0.6160.81
273_V297_N0.6160.81
162_Y165_T0.6090.80
165_T273_V0.6090.80
220_F254_V0.6060.80
185_Y293_A0.6030.79
145_P300_Y0.6030.79
137_S288_I0.5990.79
126_G308_L0.5990.79
82_G106_P0.5990.79
224_G258_P0.5970.79
15_F19_L0.5960.79
118_A121_T0.5950.78
199_A247_A0.5930.78
37_I57_L0.5930.78
263_P266_P0.5920.78
54_D58_T0.5880.78
93_L118_A0.5880.78
138_I208_N0.5870.78
102_V188_E0.5860.77
89_Y93_L0.5850.77
1_M33_E0.5850.77
175_E182_E0.5850.77
53_P56_Q0.5840.77
132_M144_Q0.5820.77
230_N233_I0.5810.77
106_P111_F0.5740.76
185_Y275_N0.5740.76
4_L63_I0.5730.76
167_I176_A0.5720.76
197_F217_L0.5720.76
282_E300_Y0.5720.76
53_P57_L0.5710.76
53_P58_T0.5700.75
60_L65_Y0.5690.75
141_F279_I0.5680.75
107_L115_F0.5670.75
48_K51_F0.5670.75
143_I304_S0.5670.75
133_S301_G0.5660.75
261_I268_Y0.5660.75
117_V123_A0.5640.75
115_F127_F0.5630.75
60_L264_Q0.5630.75
266_P278_E0.5630.75
195_N222_F0.5620.74
232_E235_R0.5610.74
4_L69_D0.5600.74
90_I110_K0.5600.74
35_A72_V0.5580.74
22_K29_L0.5580.74
155_I161_N0.5570.74
82_G110_K0.5570.74
169_E179_E0.5570.74
167_I225_I0.5560.74
165_T271_D0.5550.74
113_E117_V0.5540.73
32_V74_M0.5530.73
78_N102_V0.5520.73
16_R53_P0.5510.73
69_D97_I0.5470.72
46_G120_K0.5460.72
85_S89_Y0.5430.72
10_N299_A0.5430.72
72_V75_S0.5420.72
69_D73_D0.5410.72
144_Q147_A0.5400.71
137_S140_L0.5370.71
156_L254_V0.5370.71
292_G298_A0.5370.71
307_V311_E0.5350.71
11_V199_A0.5340.71
156_L206_L0.5340.71
86_V117_V0.5330.71
293_A298_A0.5330.71
185_Y292_G0.5320.70
134_G291_P0.5320.70
227_E230_N0.5310.70
104_K198_D0.5300.70
141_F210_I0.5280.70
40_R88_A0.5280.70
11_V188_E0.5280.70
133_S188_E0.5270.70
274_E287_I0.5260.70
232_E260_I0.5250.69
146_V311_E0.5250.69
156_L247_A0.5230.69
15_F129_G0.5210.69
306_L309_L0.5200.69
77_P80_K0.5190.69
38_I41_Q0.5190.69
106_P114_I0.5190.69
245_L258_P0.5180.68
194_L199_A0.5150.68
283_I291_P0.5140.68
134_G284_Q0.5130.68
204_T216_K0.5130.68
10_N14_A0.5130.68
66_I72_V0.5120.67
111_F114_I0.5120.67
97_I123_A0.5090.67
265_D269_Y0.5090.67
89_Y114_I0.5080.67
35_A73_D0.5080.67
147_A300_Y0.5080.67
55_K120_K0.5070.67
50_N53_P0.5060.67
40_R188_E0.5060.67
14_A17_R0.5060.67
78_N201_A0.5060.67
19_L23_K0.5050.66
163_I183_K0.5050.66
63_I67_N0.5040.66
36_G59_V0.5040.66
149_V279_I0.5030.66
111_F130_T0.5020.66
102_V129_G0.5010.66
290_G294_G0.5010.66
36_G39_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ebfA 2 0.9618 100 0.272 Contact Map
4pg7A 2 0.949 100 0.292 Contact Map
3do5A 2 0.9713 100 0.297 Contact Map
2ejwA 2 0.9554 100 0.328 Contact Map
3ingA 2 0.949 100 0.33 Contact Map
3mtjA 3 0.9841 100 0.354 Contact Map
3c8mA 2 0.9618 100 0.393 Contact Map
4xb1A 2 0.9522 100 0.397 Contact Map
3wycA 2 0.9045 99.9 0.737 Contact Map
3uplA 2 0.9363 99.9 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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