GREMLIN Database
Q7LXP7 - Uncharacterized protein
UniProt: Q7LXP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (210)
Sequences: 1023 (736)
Seq/√Len: 50.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_D181_N8.7461.00
129_V155_V4.8711.00
123_V158_E4.2611.00
109_E203_R4.1181.00
171_V174_S3.2681.00
133_G149_K3.1341.00
18_A201_V3.0541.00
116_L175_I2.8751.00
79_S115_G2.8661.00
159_G172_L2.7841.00
63_R81_E2.6741.00
106_V203_R2.5401.00
206_D210_K2.4891.00
60_R64_D2.4471.00
127_H157_D2.3721.00
23_S181_N2.2461.00
87_L108_A2.1701.00
8_E12_R2.1481.00
126_L161_V2.1051.00
77_R85_R2.0981.00
103_G116_L1.9911.00
36_D40_N1.8980.99
195_N199_Y1.8320.99
99_V182_V1.8150.99
124_G157_D1.8130.99
43_E46_A1.8030.99
130_M152_P1.7970.99
7_S127_H1.7910.99
118_D121_K1.7890.99
16_F197_V1.7560.99
202_D206_D1.7510.99
123_V157_D1.7090.99
118_D179_V1.6980.99
154_L187_A1.6900.98
131_S147_L1.6760.98
14_G191_N1.6350.98
135_E147_L1.5740.98
71_I151_I1.5730.98
110_T200_A1.5400.97
209_E215_K1.5380.97
106_V200_A1.5370.97
125_D157_D1.5370.97
198_K202_D1.5360.97
32_D36_D1.5260.97
33_T210_K1.5140.97
44_K109_E1.4910.97
131_S153_I1.4530.96
179_V182_V1.4500.96
52_S55_N1.4490.96
35_D95_R1.4480.96
156_D159_G1.4470.96
196_L199_Y1.4350.96
164_I169_D1.4300.96
13_L130_M1.3710.95
106_V204_V1.3630.94
71_I75_K1.3400.94
194_E198_K1.3370.94
151_I167_H1.3360.94
110_T203_R1.3350.94
39_R42_E1.2950.93
5_S206_D1.2850.92
22_V208_L1.2820.92
67_W74_T1.2760.92
103_G137_F1.2400.91
64_D68_R1.2170.90
117_Y187_A1.2150.90
49_D52_S1.1930.89
151_I163_H1.1810.89
140_L169_D1.1800.89
134_N147_L1.1580.88
122_I173_T1.1540.88
147_L167_H1.1410.87
136_E146_K1.1390.87
203_R207_L1.1240.86
122_I161_V1.1220.86
21_E119_R1.1150.86
83_L107_S1.1120.86
122_I125_D1.0910.84
131_S135_E1.0880.84
121_K176_T1.0800.84
119_R122_I1.0770.84
33_T36_D1.0740.84
203_R206_D1.0710.83
147_L153_I1.0670.83
73_P85_R1.0660.83
6_I11_R1.0440.82
188_G197_V1.0280.81
31_L98_I1.0270.81
178_N206_D1.0250.81
163_H187_A1.0230.80
59_V63_R1.0110.80
104_N107_S1.0080.79
106_V207_L1.0030.79
128_L154_L1.0020.79
73_P86_R1.0000.79
103_G187_A0.9930.78
77_R169_D0.9850.78
116_L128_L0.9780.77
59_V84_R0.9720.77
117_Y166_P0.9720.77
82_A186_G0.9660.76
137_F161_V0.9640.76
207_L211_V0.9480.75
8_E32_D0.9410.75
158_E178_N0.9390.74
62_Y165_Y0.9320.74
139_G142_K0.9300.74
99_V208_L0.9200.73
83_L135_E0.9190.73
134_N146_K0.9180.73
39_R209_E0.9160.73
109_E207_L0.9150.72
62_Y187_A0.9110.72
8_E11_R0.9070.72
24_N181_N0.8910.70
62_Y166_P0.8880.70
12_R130_M0.8810.70
53_L88_A0.8790.69
117_Y154_L0.8720.69
10_V15_V0.8700.69
163_H167_H0.8680.68
79_S107_S0.8670.68
70_G75_K0.8640.68
40_N43_E0.8580.68
25_V182_V0.8550.67
14_G20_T0.8460.66
113_P165_Y0.8440.66
97_N177_L0.8420.66
22_V184_I0.8390.66
62_Y113_P0.8360.65
78_P81_E0.8340.65
63_R74_T0.8330.65
74_T80_G0.8300.65
28_K180_K0.8290.65
62_Y152_P0.8250.64
81_E183_V0.8250.64
206_D215_K0.8200.64
72_D78_P0.8090.63
44_K108_A0.8070.63
122_I183_V0.8010.62
27_A174_S0.8000.62
28_K178_N0.7980.62
137_F168_R0.7960.62
103_G166_P0.7950.62
137_F200_A0.7880.61
114_I117_Y0.7880.61
165_Y187_A0.7840.60
68_R127_H0.7810.60
100_V141_G0.7790.60
204_V208_L0.7740.59
36_D46_A0.7690.59
41_L105_I0.7660.59
42_E93_L0.7610.58
147_L165_Y0.7590.58
33_T211_V0.7590.58
64_D67_W0.7590.58
48_Q84_R0.7550.58
16_F188_G0.7530.57
131_S165_Y0.7460.57
15_V170_S0.7460.57
27_A98_I0.7450.57
69_I166_P0.7420.56
84_R108_A0.7400.56
62_Y168_R0.7390.56
166_P173_T0.7380.56
56_D111_L0.7360.56
192_I196_L0.7330.55
14_G68_R0.7320.55
66_Y166_P0.7320.55
202_D205_A0.7290.55
205_A209_E0.7260.55
79_S82_A0.7220.54
116_L131_S0.7210.54
10_V152_P0.7180.54
117_Y167_H0.7150.54
151_I168_R0.7150.54
116_L173_T0.7140.53
124_G156_D0.7140.53
138_L171_V0.7120.53
55_N132_K0.7110.53
147_L151_I0.7050.52
79_S108_A0.7040.52
38_I41_L0.7020.52
98_I212_C0.7010.52
99_V179_V0.7000.52
24_N215_K0.6990.52
53_L84_R0.6980.52
8_E132_K0.6900.51
77_R82_A0.6890.51
74_T89_R0.6870.51
72_D166_P0.6870.51
82_A137_F0.6840.50
116_L119_R0.6830.50
79_S175_I0.6820.50
31_L34_L0.6770.50
71_I135_E0.6730.49
199_Y210_K0.6720.49
112_V186_G0.6700.49
13_L68_R0.6680.49
135_E153_I0.6680.49
128_L133_G0.6640.48
139_G145_E0.6620.48
170_S185_I0.6600.48
103_G117_Y0.6580.48
80_G151_I0.6580.48
193_D196_L0.6550.47
59_V93_L0.6550.47
165_Y168_R0.6520.47
104_N115_G0.6480.47
101_D179_V0.6470.46
78_P166_P0.6470.46
65_F163_H0.6430.46
199_Y213_N0.6420.46
128_L147_L0.6420.46
56_D100_V0.6410.46
61_A197_V0.6410.46
36_D68_R0.6410.46
188_G194_E0.6400.46
80_G167_H0.6380.46
36_D195_N0.6370.45
128_L189_V0.6370.45
74_T77_R0.6360.45
166_P187_A0.6360.45
32_D35_D0.6340.45
30_P35_D0.6330.45
151_I164_I0.6300.45
101_D104_N0.6260.44
12_R43_E0.6250.44
72_D77_R0.6230.44
35_D39_R0.6160.43
168_R187_A0.6130.43
72_D75_K0.6120.43
71_I164_I0.6120.43
82_A86_R0.6100.43
70_G76_T0.6100.43
26_D180_K0.6090.43
34_L38_I0.6050.42
184_I204_V0.6050.42
101_D107_S0.6010.42
24_N180_K0.6010.42
63_R77_R0.5980.42
17_V21_E0.5960.41
12_R180_K0.5950.41
25_V121_K0.5950.41
186_G200_A0.5900.41
27_A99_V0.5900.41
86_R169_D0.5860.40
111_L187_A0.5800.40
7_S129_V0.5790.40
78_P111_L0.5790.40
122_I147_L0.5780.40
57_P111_L0.5770.39
66_Y73_P0.5740.39
12_R195_N0.5740.39
94_P145_E0.5730.39
29_R34_L0.5720.39
113_P168_R0.5660.38
151_I187_A0.5640.38
77_R111_L0.5630.38
36_D49_D0.5620.38
116_L179_V0.5590.38
178_N194_E0.5590.38
39_R45_Y0.5580.38
26_D98_I0.5570.37
199_Y209_E0.5550.37
117_Y169_D0.5550.37
32_D40_N0.5500.37
82_A115_G0.5490.37
16_F194_E0.5430.36
74_T167_H0.5430.36
126_L203_R0.5410.36
22_V43_E0.5410.36
112_V189_V0.5390.36
145_E151_I0.5380.36
135_E156_D0.5370.36
55_N209_E0.5360.35
103_G115_G0.5350.35
103_G184_I0.5310.35
161_V184_I0.5310.35
18_A197_V0.5300.35
42_E95_R0.5270.35
84_R88_A0.5260.35
132_K206_D0.5250.34
70_G85_R0.5250.34
113_P145_E0.5240.34
20_T205_A0.5240.34
117_Y164_I0.5240.34
123_V206_D0.5240.34
17_V128_L0.5210.34
85_R183_V0.5210.34
72_D165_Y0.5210.34
163_H169_D0.5200.34
92_K195_N0.5200.34
117_Y161_V0.5180.34
30_P43_E0.5170.34
34_L211_V0.5170.34
166_P169_D0.5170.34
208_L213_N0.5170.34
115_G150_G0.5160.34
173_T200_A0.5160.34
199_Y203_R0.5130.33
79_S83_L0.5120.33
89_R114_I0.5100.33
79_S86_R0.5090.33
151_I165_Y0.5090.33
112_V180_K0.5090.33
120_D180_K0.5090.33
19_M185_I0.5080.33
126_L129_V0.5070.33
76_T102_I0.5060.33
21_E34_L0.5060.33
113_P187_A0.5050.33
32_D155_V0.5030.32
24_N198_K0.5000.32
176_T179_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b7yB 2 0.8929 100 0.632 Contact Map
2rhqB 2 0.9018 99.9 0.637 Contact Map
4p72A 2 0.8973 99.9 0.645 Contact Map
3pcoB 2 0.9152 99.9 0.651 Contact Map
2cxiA 3 0.6875 99.6 0.764 Contact Map
3l4gB 2 0.8482 99.6 0.778 Contact Map
3a2kA 1 0.8482 91.6 0.925 Contact Map
3hj7A 1 0.5089 84.7 0.934 Contact Map
1z8uA 1 0.2768 17.9 0.959 Contact Map
2pftA 1 0.3795 9.8 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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