GREMLIN Database
TLDD - Zinc metalloprotease TldD homolog
UniProt: Q7LXP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (401)
Sequences: 4546 (2965)
Seq/√Len: 148.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_E295_K4.4361.00
287_K290_E4.2071.00
349_E378_E4.0461.00
263_L285_E3.9711.00
252_R256_E3.7601.00
351_Y386_L3.6921.00
348_K379_N3.5501.00
347_I377_V3.3021.00
339_S342_E3.2071.00
378_E383_K3.1881.00
112_K190_N3.0551.00
102_N105_E3.0121.00
207_S384_E2.9821.00
376_R384_E2.8931.00
378_E384_E2.7811.00
349_E376_R2.7091.00
108_N112_K2.5281.00
150_A275_Y2.4851.00
164_R167_D2.4551.00
22_R137_H2.3981.00
376_R383_K2.2941.00
56_G75_I2.2771.00
259_N287_K2.2591.00
115_S119_T2.2371.00
123_S165_E2.1831.00
261_S334_K2.1631.00
261_S285_E2.1531.00
339_S407_K2.1371.00
257_F405_I2.1041.00
194_A198_K2.0901.00
252_R400_N2.0471.00
195_N198_K2.0371.00
257_F291_N2.0321.00
344_F377_V2.0161.00
345_E381_E1.9721.00
338_A342_E1.9471.00
139_E147_E1.9401.00
256_E291_N1.9191.00
254_G399_L1.9091.00
259_N291_N1.9011.00
7_K10_E1.8981.00
188_D191_Q1.8881.00
69_E73_N1.8851.00
64_T67_E1.8231.00
7_K69_E1.8141.00
124_I163_A1.8091.00
174_E195_N1.7981.00
16_A143_S1.7901.00
284_R310_P1.7561.00
299_T309_Q1.7491.00
217_I347_I1.7201.00
163_A200_I1.7191.00
198_K202_N1.6891.00
148_I276_Y1.6881.00
343_L404_M1.6811.00
366_T394_N1.6801.00
252_R293_I1.6781.00
346_G404_M1.6721.00
286_V314_N1.6691.00
163_A201_I1.6461.00
62_K67_E1.6441.00
352_Y377_V1.6421.00
8_A16_A1.6381.00
91_D94_K1.6381.00
116_Q190_N1.6341.00
105_E108_N1.6091.00
49_V75_I1.5911.00
377_V383_K1.5901.00
73_N77_G1.5901.00
106_K131_Y1.5881.00
217_I343_L1.5821.00
397_S401_A1.5791.00
286_V296_E1.5731.00
299_T303_Y1.5661.00
165_E205_K1.5651.00
285_E332_Y1.5581.00
86_L89_K1.5411.00
235_S288_I1.5341.00
340_L344_F1.5251.00
304_S310_P1.5231.00
22_R43_E1.5171.00
54_N84_V1.5091.00
163_A204_L1.5081.00
350_G377_V1.5061.00
108_N111_H1.4951.00
338_A404_M1.4851.00
86_L90_H1.4771.00
273_L283_G1.4771.00
141_Y147_E1.4661.00
273_L329_R1.4641.00
7_K11_L1.4631.00
51_Y80_R1.4561.00
45_Y60_T1.4471.00
299_T307_L1.4461.00
165_E168_V1.4431.00
70_D73_N1.4401.00
90_H94_K1.4391.00
394_N397_S1.4321.00
335_P409_F1.4281.00
375_Y382_I1.4271.00
116_Q193_L1.4221.00
111_H115_S1.4141.00
254_G258_L1.4121.00
340_L343_L1.4021.00
219_A352_Y1.4011.00
249_R396_I1.3981.00
137_H149_I1.3951.00
124_I201_I1.3891.00
281_V311_P1.3881.00
288_I298_M1.3871.00
114_A118_N1.3751.00
137_H151_D1.3651.00
233_H236_E1.3591.00
32_E126_S1.3541.00
107_I111_H1.3501.00
261_S287_K1.3471.00
117_V193_L1.3411.00
240_T297_F1.3201.00
90_H95_I1.3151.00
106_K133_D1.3141.00
8_A12_G1.3111.00
241_L307_L1.3061.00
176_L192_V1.3021.00
66_N70_D1.2941.00
236_E239_V1.2681.00
217_I377_V1.2611.00
5_I9_E1.2531.00
125_K164_R1.2521.00
193_L197_Q1.2451.00
90_H93_I1.2431.00
265_A283_G1.2421.00
243_G247_K1.2411.00
351_Y389_I1.2391.00
338_A346_G1.2281.00
110_L129_I1.2261.00
170_V387_R1.2201.00
352_Y382_I1.2171.00
250_N295_K1.2171.00
17_D142_S1.2161.00
66_N69_E1.2141.00
51_Y79_E1.2131.00
287_K295_K1.2071.00
51_Y76_Y1.2061.00
116_Q194_A1.2051.00
236_E241_L1.2011.00
291_N295_K1.1921.00
287_K291_N1.1881.00
341_N381_E1.1831.00
237_A299_T1.1791.00
135_I151_D1.1731.00
91_D95_I1.1721.00
6_K10_E1.1711.00
161_V197_Q1.1681.00
371_I374_G1.1661.00
281_V301_R1.1651.00
191_Q195_N1.1621.00
5_I143_S1.1601.00
259_N334_K1.1581.00
259_N290_E1.1551.00
341_N345_E1.1541.00
362_S366_T1.1531.00
285_E334_K1.1501.00
7_K73_N1.1501.00
158_S173_S1.1471.00
58_K71_T1.1381.00
11_L73_N1.1371.00
236_E240_T1.1260.99
163_A197_Q1.1250.99
281_V313_G1.1240.99
227_T333_M1.1210.99
104_E108_N1.1180.99
258_L405_I1.1140.99
316_R327_R1.1070.99
17_D48_R1.1060.99
332_Y409_F1.1040.99
272_S330_N1.0990.99
33_D114_A1.0920.99
217_I340_L1.0890.99
240_T243_G1.0880.99
22_R41_V1.0880.99
124_I197_Q1.0880.99
343_L406_S1.0830.99
174_E192_V1.0830.99
47_I71_T1.0820.99
92_T95_I1.0820.99
386_L389_I1.0800.99
190_N194_A1.0780.99
207_S376_R1.0770.99
296_E312_T1.0770.99
235_S239_V1.0760.99
304_S311_P1.0760.99
347_I350_G1.0720.99
117_V161_V1.0680.99
5_I16_A1.0640.99
196_L200_I1.0590.99
89_K93_I1.0590.99
344_F352_Y1.0580.99
260_I331_T1.0560.99
19_R317_A1.0490.99
231_I399_L1.0430.99
67_E71_T1.0420.99
87_P90_H1.0400.99
397_S400_N1.0370.99
142_S146_R1.0360.99
197_Q201_I1.0330.99
214_Y376_R1.0320.99
164_R169_T1.0310.99
26_N133_D1.0290.99
347_I403_E1.0280.99
344_F347_I1.0240.99
209_P214_Y1.0200.99
340_L407_K1.0200.99
60_T71_T1.0170.99
26_N106_K1.0050.99
234_L243_G1.0030.99
258_L402_I0.9970.99
4_Y68_I0.9910.99
30_I111_H0.9910.99
260_I289_I0.9900.99
15_F144_E0.9880.99
258_L333_M0.9800.99
340_L352_Y0.9770.98
131_Y157_L0.9770.98
367_F398_T0.9750.98
53_R84_V0.9710.98
87_P91_D0.9670.98
234_L239_V0.9620.98
52_N84_V0.9550.98
229_E232_G0.9540.98
254_G289_I0.9510.98
238_D242_N0.9510.98
123_S201_I0.9470.98
245_L396_I0.9460.98
299_T311_P0.9430.98
264_P273_L0.9410.98
172_V196_L0.9400.98
342_E345_E0.9360.98
70_D74_H0.9360.98
44_G57_F0.9320.98
15_F140_Y0.9250.98
218_L353_L0.9250.98
24_I41_V0.9230.98
233_H239_V0.9220.98
314_N329_R0.9190.98
113_V157_L0.9170.98
20_Y45_Y0.9130.98
234_L240_T0.9130.98
231_I331_T0.9120.98
248_L251_K0.9120.98
264_P329_R0.9110.98
46_S317_A0.9100.98
139_E149_I0.9100.98
300_D326_I0.9070.98
76_Y80_R0.9040.97
264_P283_G0.9020.97
87_P92_T0.9000.97
257_F338_A0.8960.97
255_D405_I0.8930.97
58_K75_I0.8920.97
112_K115_S0.8900.97
60_T67_E0.8860.97
72_I76_Y0.8860.97
170_V203_Q0.8830.97
210_K349_E0.8790.97
161_V200_I0.8770.97
50_I55_W0.8750.97
21_E136_F0.8740.97
101_K105_E0.8570.97
212_G349_E0.8560.96
217_I352_Y0.8550.96
18_I45_Y0.8540.96
228_H233_H0.8520.96
235_S240_T0.8510.96
350_G382_I0.8510.96
144_E301_R0.8500.96
374_G386_L0.8500.96
286_V312_T0.8480.96
338_A343_L0.8480.96
236_E243_G0.8460.96
361_T369_F0.8460.96
116_Q119_T0.8450.96
113_V189_I0.8450.96
29_T36_Y0.8390.96
57_F323_F0.8370.96
344_F382_I0.8340.96
241_L299_T0.8340.96
340_L408_D0.8310.96
237_A307_L0.8290.96
183_I186_V0.8290.96
227_T260_I0.8270.96
112_K116_Q0.8200.96
96_G135_I0.8190.95
328_M331_T0.8160.95
343_L347_I0.8160.95
237_A241_L0.8160.95
235_S243_G0.8140.95
238_D241_L0.8100.95
279_E301_R0.8100.95
206_G387_R0.8090.95
356_P360_E0.8030.95
233_H240_T0.7990.95
189_I193_L0.7980.95
11_L76_Y0.7970.95
367_F393_G0.7960.95
239_V243_G0.7960.95
266_M332_Y0.7930.95
29_T130_K0.7920.95
360_E369_F0.7910.95
298_M328_M0.7890.94
264_P286_V0.7890.94
209_P351_Y0.7870.94
300_D303_Y0.7870.94
344_F349_E0.7840.94
43_E63_I0.7830.94
24_I135_I0.7830.94
20_Y43_E0.7810.94
214_Y351_Y0.7790.94
86_L94_K0.7730.94
375_Y385_P0.7720.94
266_M269_P0.7710.94
303_Y326_I0.7710.94
351_Y376_R0.7680.94
208_T388_N0.7670.94
45_Y68_I0.7620.93
354_V375_Y0.7620.93
108_N115_S0.7610.93
222_V225_I0.7600.93
215_P349_E0.7600.93
341_N344_F0.7590.93
191_Q194_A0.7540.93
359_G369_F0.7530.93
70_D77_G0.7520.93
8_A49_V0.7510.93
315_A326_I0.7500.93
223_V333_M0.7490.93
353_L391_I0.7460.93
263_L332_Y0.7460.93
381_E384_E0.7450.93
346_G403_E0.7450.93
31_T35_K0.7430.93
235_S246_Y0.7420.92
262_D286_V0.7420.92
172_V200_I0.7390.92
96_G153_S0.7380.92
56_G79_E0.7340.92
67_E70_D0.7340.92
117_V197_Q0.7330.92
377_V382_I0.7310.92
133_D155_S0.7280.92
27_E38_S0.7280.92
233_H238_D0.7260.92
117_V196_L0.7250.92
194_A197_Q0.7240.92
235_S294_L0.7210.91
138_K150_A0.7210.91
299_T304_S0.7170.91
344_F348_K0.7160.91
48_R279_E0.7150.91
9_E143_S0.7140.91
291_N310_P0.7130.91
174_E196_L0.7120.91
105_E109_D0.7120.91
236_E242_N0.7100.91
13_A51_Y0.7100.91
232_G327_R0.7090.91
123_S204_L0.7090.91
230_A233_H0.7080.91
227_T258_L0.7080.91
116_Q197_Q0.7070.91
255_D258_L0.7060.91
96_G100_N0.7050.90
222_V356_P0.7020.90
32_E118_N0.7000.90
140_Y148_I0.6990.90
214_Y386_L0.6960.90
283_G329_R0.6950.90
4_Y11_L0.6950.90
243_G248_L0.6940.90
75_I79_E0.6930.90
264_P272_S0.6910.90
89_K92_T0.6900.90
161_V196_L0.6900.90
207_S378_E0.6890.89
176_L187_F0.6890.89
236_E328_M0.6870.89
338_A407_K0.6860.89
266_M272_S0.6860.89
370_A388_N0.6850.89
254_G402_I0.6830.89
8_A13_A0.6820.89
15_F143_S0.6800.89
136_F152_G0.6800.89
233_H241_L0.6800.89
32_E127_Y0.6790.89
25_A132_Y0.6780.89
27_E130_K0.6750.88
23_V136_F0.6750.88
109_D112_K0.6740.88
217_I344_F0.6730.88
218_L356_P0.6730.88
201_I204_L0.6720.88
241_L303_Y0.6710.88
240_T244_S0.6710.88
358_G393_G0.6700.88
13_A49_V0.6670.88
87_P95_I0.6670.88
360_E368_Q0.6660.88
230_A254_G0.6650.88
228_H327_R0.6640.88
215_P347_I0.6630.88
23_V134_E0.6610.87
96_G151_D0.6610.87
19_R138_K0.6570.87
229_E233_H0.6560.87
28_V103_E0.6540.87
356_P359_G0.6540.87
121_H201_I0.6510.87
246_Y294_L0.6500.87
117_V124_I0.6500.87
205_K385_P0.6500.87
73_N76_Y0.6480.86
302_Y306_Y0.6470.86
300_D325_L0.6460.86
222_V353_L0.6460.86
343_L382_I0.6430.86
233_H243_G0.6430.86
119_T194_A0.6390.86
56_G78_D0.6370.85
303_Y307_L0.6350.85
177_S270_Q0.6340.85
199_R219_A0.6330.85
301_R305_A0.6320.85
379_N383_K0.6290.85
234_L241_L0.6280.85
231_I328_M0.6280.85
358_G371_I0.6250.84
371_I389_I0.6240.84
284_R296_E0.6240.84
219_A354_V0.6240.84
300_D315_A0.6230.84
252_R291_N0.6220.84
226_F356_P0.6220.84
79_E82_N0.6220.84
73_N194_A0.6210.84
87_P93_I0.6210.84
240_T294_L0.6200.84
156_S177_S0.6180.84
96_G99_I0.6170.84
358_G368_Q0.6170.84
229_E369_F0.6160.84
260_I333_M0.6140.83
346_G377_V0.6140.83
101_K106_K0.6140.83
30_I110_L0.6100.83
11_L69_E0.6100.83
278_D316_R0.6080.83
209_P212_G0.6070.83
130_K158_S0.6060.83
201_I205_K0.6050.82
207_S383_K0.6040.82
355_S373_E0.6040.82
174_E199_R0.5990.82
290_E293_I0.5980.82
300_D359_G0.5970.82
110_L131_Y0.5960.81
229_E236_E0.5930.81
345_E348_K0.5920.81
119_T190_N0.5910.81
299_T326_I0.5910.81
206_G385_P0.5900.81
253_I400_N0.5890.81
187_F191_Q0.5890.81
358_G390_G0.5880.81
357_I390_G0.5870.80
228_H328_M0.5860.80
239_V242_N0.5860.80
88_S310_P0.5860.80
345_E349_E0.5850.80
113_V159_I0.5850.80
37_V111_H0.5840.80
349_E383_K0.5830.80
127_Y161_V0.5810.80
157_L189_I0.5810.80
356_P369_F0.5810.80
13_A16_A0.5800.80
336_G407_K0.5790.80
332_Y411_M0.5780.79
229_E367_F0.5770.79
124_I200_I0.5760.79
222_V370_A0.5750.79
215_P348_K0.5740.79
212_G351_Y0.5710.79
198_K201_I0.5710.79
17_D46_S0.5710.79
49_V79_E0.5680.78
370_A390_G0.5680.78
215_P403_E0.5680.78
195_N199_R0.5670.78
233_H327_R0.5670.78
218_L223_V0.5670.78
112_K189_I0.5660.78
357_I371_I0.5660.78
160_L171_E0.5650.78
40_G251_K0.5650.78
230_A253_I0.5640.78
229_E328_M0.5610.77
222_V260_I0.5590.77
232_G331_T0.5570.77
236_E327_R0.5570.77
25_A134_E0.5550.77
262_D288_I0.5550.77
261_S332_Y0.5530.76
168_V205_K0.5510.76
45_Y67_E0.5510.76
24_I137_H0.5510.76
265_A285_E0.5500.76
368_Q392_S0.5490.76
229_E359_G0.5480.76
202_N375_Y0.5480.76
231_I235_S0.5470.76
368_Q390_G0.5470.76
226_F395_T0.5470.76
19_R57_F0.5470.76
347_I352_Y0.5470.76
225_I229_E0.5460.76
217_I406_S0.5450.75
24_I39_H0.5450.75
13_A76_Y0.5450.75
228_H236_E0.5440.75
65_E68_I0.5420.75
132_Y156_S0.5420.75
86_L92_T0.5420.75
361_T395_T0.5420.75
49_V56_G0.5400.75
106_K110_L0.5400.75
190_N193_L0.5390.75
207_S381_E0.5390.75
88_S92_T0.5390.75
286_V329_R0.5390.75
207_S385_P0.5350.74
254_G260_I0.5350.74
304_S309_Q0.5350.74
376_R386_L0.5340.74
25_A42_D0.5320.74
224_G359_G0.5310.74
6_K9_E0.5300.73
251_K293_I0.5300.73
291_N334_K0.5280.73
86_L91_D0.5280.73
19_R136_F0.5260.73
97_K100_N0.5260.73
117_V159_I0.5260.73
121_H165_E0.5260.73
232_G328_M0.5240.73
287_K314_N0.5230.72
337_D407_K0.5230.72
243_G249_R0.5230.72
298_M331_T0.5230.72
269_P272_S0.5220.72
371_I391_I0.5220.72
114_A129_I0.5210.72
105_E185_D0.5210.72
228_H232_G0.5210.72
354_V382_I0.5210.72
198_K381_E0.5200.72
210_K214_Y0.5190.72
396_I400_N0.5190.72
116_Q189_I0.5180.72
230_A369_F0.5180.72
234_L396_I0.5180.72
128_S160_L0.5170.72
219_A223_V0.5170.72
228_H316_R0.5160.71
255_D291_N0.5160.71
197_Q200_I0.5140.71
272_S329_R0.5140.71
17_D57_F0.5120.71
193_L196_L0.5120.71
61_D64_T0.5120.71
254_G259_N0.5110.71
288_I331_T0.5110.71
328_M359_G0.5100.71
238_D325_L0.5080.70
225_I359_G0.5080.70
234_L242_N0.5080.70
30_I114_A0.5070.70
19_R44_G0.5070.70
88_S91_D0.5070.70
86_L93_I0.5060.70
286_V298_M0.5050.70
188_D194_A0.5040.70
25_A40_G0.5040.70
349_E379_N0.5040.70
113_V117_V0.5040.70
69_E76_Y0.5040.70
342_E346_G0.5030.70
102_N337_D0.5030.70
57_F322_N0.5030.70
365_G394_N0.5020.69
52_N80_R0.5010.69
242_N364_N0.5010.69
29_T128_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qtdA 2 0.9345 100 0.197 Contact Map
1vl4A 2 0.9187 100 0.202 Contact Map
3tv9A 2 0.921 100 0.212 Contact Map
1vpbA 2 0.9255 100 0.213 Contact Map
2znmA 3 0.1828 16.8 0.972 Contact Map
3h93A 1 0.1874 12.4 0.973 Contact Map
1vr6A 4 0.2619 11.9 0.974 Contact Map
4k2dA 1 0.1851 10.5 0.974 Contact Map
4jrrA 1 0.1783 10.4 0.974 Contact Map
2bfdA 2 0.2438 8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0125 seconds.