GREMLIN Database
Q7LXP5 - Zn-dependent protease, tldE protein homolog, putative (TldE)
UniProt: Q7LXP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (399)
Sequences: 4525 (2940)
Seq/√Len: 147.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
277_E282_K4.5601.00
338_N369_R4.3321.00
274_K277_E4.2981.00
251_D272_V4.0041.00
241_L244_E3.8141.00
340_V376_L3.7951.00
393_V413_R3.6941.00
202_G414_G3.6641.00
393_V411_K3.6631.00
337_E370_K3.6101.00
369_R374_I3.5961.00
237_K240_E3.1801.00
111_D179_E3.1511.00
101_N104_V3.1341.00
107_D111_D2.7491.00
338_N367_L2.7091.00
145_E262_S2.6641.00
334_N409_K2.5681.00
398_N409_K2.4611.00
367_L374_I2.4341.00
247_E274_K2.4211.00
22_K132_E2.3741.00
335_I368_N2.2591.00
249_I327_D2.2381.00
118_K158_D2.2221.00
184_S187_E2.2111.00
249_I272_V2.2091.00
92_V96_N2.1781.00
69_E73_K2.1131.00
183_A187_E2.0871.00
245_N395_T2.0671.00
247_E278_S2.0361.00
134_S142_E2.0121.00
245_N278_S2.0091.00
241_L390_K2.0031.00
336_E372_E1.9801.00
65_D69_E1.9721.00
244_E278_S1.9471.00
119_V156_A1.9081.00
177_S180_K1.8921.00
157_N160_N1.8831.00
388_L412_V1.8701.00
261_R270_S1.8461.00
271_R297_E1.8441.00
286_T296_V1.8371.00
368_N374_I1.8361.00
241_L280_L1.8181.00
8_R11_A1.7991.00
187_E191_I1.7781.00
339_S368_N1.7781.00
341_I368_N1.7771.00
143_V263_F1.7751.00
273_S301_S1.7731.00
203_Y417_L1.7701.00
167_E184_S1.7621.00
9_A16_L1.7451.00
334_N394_S1.7411.00
357_N384_N1.7371.00
104_V107_D1.7201.00
391_N414_G1.6991.00
115_L179_E1.6931.00
8_R12_M1.6801.00
156_A189_V1.6691.00
204_D411_K1.6531.00
107_D110_K1.6491.00
291_A297_E1.6411.00
272_V325_I1.6391.00
286_T290_W1.6331.00
105_V126_A1.6291.00
16_L138_T1.6281.00
86_L89_K1.6111.00
224_F275_V1.6051.00
273_S283_R1.5881.00
132_E144_S1.5871.00
44_Y60_T1.5701.00
387_Q391_N1.5631.00
119_V190_K1.5591.00
56_G75_A1.5591.00
391_N413_R1.5581.00
136_F142_E1.5441.00
110_K114_E1.5431.00
28_I33_F1.5411.00
158_D194_K1.5211.00
208_T341_I1.5161.00
115_L182_K1.5161.00
132_E146_K1.5121.00
48_L71_A1.5111.00
206_T411_K1.5081.00
331_T394_S1.5071.00
286_T294_M1.4961.00
229_F284_P1.4951.00
212_L410_L1.4931.00
9_A13_G1.4861.00
328_Y399_I1.4811.00
105_V128_A1.4721.00
22_K42_T1.4711.00
206_T334_N1.4681.00
384_N387_Q1.4651.00
204_D413_R1.4351.00
220_F324_I1.4291.00
230_Y294_M1.4141.00
275_V285_L1.4121.00
268_N298_N1.4091.00
261_R322_S1.4051.00
106_Q110_K1.3951.00
156_A190_K1.3911.00
66_N69_E1.3891.00
50_D76_K1.3861.00
249_I274_K1.3851.00
103_D107_D1.3851.00
109_I124_A1.3731.00
30_K121_L1.3691.00
206_T368_N1.3651.00
182_K186_I1.3401.00
253_L270_S1.3361.00
226_A286_T1.3341.00
332_E372_E1.3091.00
120_N157_N1.3091.00
332_E336_E1.3081.00
237_K386_K1.3061.00
239_G282_K1.2931.00
6_I138_T1.2931.00
26_Y33_F1.2881.00
8_R65_D1.2831.00
341_I373_K1.2801.00
17_E47_R1.2781.00
274_K282_K1.2741.00
56_G71_A1.2741.00
246_L395_T1.2681.00
93_K96_N1.2641.00
340_V379_L1.2631.00
396_S409_K1.2621.00
401_N406_V1.2551.00
274_K278_S1.2551.00
50_D72_L1.2531.00
278_S282_K1.2521.00
54_R80_S1.2511.00
325_I406_V1.2381.00
115_L183_A1.2321.00
325_I399_I1.2111.00
130_N146_K1.2061.00
388_L415_L1.2041.00
204_D414_G1.1991.00
158_D161_N1.1951.00
119_V186_I1.1941.00
92_V95_I1.1931.00
247_E277_E1.1881.00
352_D357_N1.1861.00
247_E327_D1.1811.00
173_D256_S1.1741.00
268_N288_T1.1691.00
87_P91_P1.1621.00
387_Q390_K1.1581.00
180_K184_S1.1551.00
198_I203_Y1.1511.00
31_D113_I1.1481.00
352_D355_S1.1471.00
395_T410_L1.1411.00
216_F326_F1.1370.99
268_N300_S1.1350.99
362_A365_S1.1340.99
17_E137_N1.1330.99
7_S11_A1.1330.99
248_I276_I1.1280.99
272_V327_D1.1240.99
283_R299_T1.1220.99
185_I189_V1.1190.99
163_P377_E1.1180.99
179_E183_A1.1180.99
303_S320_D1.1140.99
96_N130_N1.1130.99
53_Y80_S1.1020.99
51_E80_S1.1010.99
169_L181_L1.1000.99
186_I190_K1.0950.99
167_E181_L1.0940.99
246_L326_F1.0940.99
291_A298_N1.0940.99
43_G57_Y1.0910.99
238_L296_V1.0880.99
260_S323_N1.0790.99
28_I110_K1.0770.99
22_K40_E1.0760.99
376_L379_L1.0690.99
19_F304_R1.0650.99
165_I185_I1.0650.99
46_I67_V1.0640.99
246_L392_I1.0490.99
111_D114_E1.0480.99
235_P386_K1.0360.99
286_T298_N1.0340.99
335_I341_I1.0280.99
137_N141_V1.0280.99
178_L182_K1.0280.99
394_S411_K1.0260.99
334_N396_S1.0210.99
118_K190_K1.0210.99
218_S222_S1.0210.99
66_N70_E1.0200.99
207_F342_V1.0180.99
67_V71_A1.0160.99
6_I10_K1.0100.99
339_S373_K1.0070.99
202_G416_S1.0020.99
301_S322_S0.9930.99
358_F388_L0.9810.98
8_R69_E0.9790.98
252_P261_R0.9730.98
7_S10_K0.9720.98
273_S299_T0.9700.98
21_V131_Y0.9660.98
45_G304_R0.9630.98
206_T341_I0.9620.98
229_F234_S0.9620.98
20_S44_Y0.9550.98
252_P270_S0.9540.98
321_F324_I0.9530.98
6_I16_L0.9490.98
27_T35_V0.9470.98
254_N257_L0.9440.98
18_I44_Y0.9440.98
86_L90_Q0.9340.98
243_N395_T0.9260.98
332_E335_I0.9250.98
111_D115_L0.9240.98
196_E367_L0.9240.98
49_I55_I0.9220.98
116_E190_K0.9160.98
112_L178_L0.9160.98
212_L407_S0.9140.98
68_L78_G0.9110.98
331_T334_N0.9100.98
335_I338_N0.9100.98
245_N331_T0.9090.98
50_D75_A0.9070.97
201_K338_N0.9010.97
10_K13_G0.8980.97
350_T360_L0.8970.97
252_P322_S0.8970.97
29_A34_Y0.8940.97
60_T67_V0.8930.97
85_I292_T0.8920.97
366_W373_K0.8880.97
81_D85_I0.8840.97
348_I351_A0.8840.97
368_N373_K0.8800.97
287_N319_V0.8770.97
248_I324_I0.8760.97
331_T397_K0.8740.97
218_S221_P0.8680.97
58_I67_V0.8660.97
333_S336_E0.8620.97
195_K377_E0.8620.97
72_L79_E0.8610.97
343_D364_V0.8570.96
74_I78_G0.8570.96
70_E73_K0.8560.96
9_A14_I0.8540.96
358_F383_G0.8520.96
70_E74_I0.8510.96
325_I401_N0.8500.96
199_D338_N0.8500.96
196_E374_I0.8480.96
183_A186_I0.8440.96
67_V74_I0.8420.96
12_M69_E0.8410.96
134_S144_S0.8380.96
24_R40_E0.8320.96
266_E288_T0.8300.96
342_V381_I0.8280.96
9_A48_L0.8280.96
154_A189_V0.8220.96
226_A294_M0.8220.96
254_N325_I0.8190.95
107_D114_E0.8180.95
81_D84_N0.8180.95
88_S91_P0.8180.95
163_P192_M0.8160.95
399_I406_V0.8130.95
204_D338_N0.8110.95
341_I409_K0.8070.95
224_F281_V0.8070.95
67_V79_E0.8060.95
252_P273_S0.8050.95
116_E119_V0.8040.95
203_Y340_V0.8030.95
211_A214_S0.7970.95
135_I143_V0.7970.95
351_A360_L0.7960.95
216_F248_I0.7930.95
230_Y286_T0.7930.95
100_I104_V0.7920.95
156_A186_I0.7920.95
154_A186_I0.7910.94
197_R378_E0.7880.94
259_F404_K0.7870.94
286_T291_A0.7870.94
70_E78_G0.7870.94
94_R256_S0.7860.94
6_I9_A0.7860.94
348_I360_L0.7840.94
100_I105_V0.7830.94
287_N290_W0.7830.94
196_E369_R0.7810.94
250_D273_S0.7800.94
156_A193_K0.7800.94
157_N162_S0.7770.94
105_V109_I0.7760.94
216_F246_L0.7750.94
365_S376_L0.7740.94
180_K183_A0.7700.94
203_Y376_L0.7700.94
302_A319_V0.7690.94
290_W319_V0.7690.94
252_P260_S0.7640.93
257_L260_S0.7620.93
278_S297_E0.7570.93
287_N318_H0.7560.93
139_E288_T0.7550.93
190_K193_K0.7480.93
347_G362_A0.7430.92
25_E37_I0.7430.92
71_A74_I0.7410.92
226_A230_Y0.7370.92
264_D300_S0.7370.92
60_T63_L0.7350.92
219_L389_L0.7330.92
73_K114_E0.7310.92
104_V108_T0.7300.92
335_I373_K0.7270.92
47_R266_E0.7270.92
108_T111_D0.7260.92
133_V145_E0.7260.92
72_L76_K0.7250.91
87_P288_T0.7240.91
82_K85_I0.7230.91
67_V72_L0.7210.91
198_I340_V0.7200.91
230_Y290_W0.7150.91
27_T125_S0.7140.91
217_S221_P0.7120.91
236_F281_V0.7120.91
347_G383_G0.7120.91
271_R283_R0.7080.91
368_N411_K0.7080.91
103_D106_Q0.7060.90
10_K138_T0.7060.90
128_A150_L0.7040.90
351_A385_L0.7040.90
42_T63_L0.7040.90
343_D366_W0.7000.90
222_S225_S0.6970.90
211_A345_L0.6970.90
218_S360_L0.6970.90
346_E363_N0.6960.90
188_K208_T0.6960.90
243_N246_L0.6940.90
25_E125_S0.6930.90
212_L326_F0.6930.90
165_I189_V0.6920.90
118_K193_K0.6910.89
224_F236_F0.6890.89
205_V415_L0.6890.89
105_V108_T0.6870.89
254_N260_S0.6870.89
10_K14_I0.6860.89
176_I180_K0.6850.89
116_E186_I0.6830.89
115_L186_I0.6830.89
392_I410_L0.6810.89
71_A75_A0.6810.89
167_E185_I0.6810.89
251_D325_I0.6790.89
241_L278_S0.6750.88
9_A18_I0.6750.88
23_M129_I0.6750.88
347_G359_S0.6730.88
91_P297_E0.6710.88
217_S320_D0.6660.88
229_F281_V0.6660.88
238_L284_P0.6650.88
15_S51_E0.6650.88
361_V378_E0.6650.88
345_L348_I0.6630.87
68_L72_L0.6620.87
111_D178_L0.6620.87
208_T343_D0.6620.87
347_G380_L0.6620.87
27_T123_S0.6610.87
270_S322_S0.6610.87
248_I326_F0.6600.87
338_N374_I0.6560.87
216_F410_L0.6550.87
33_F106_Q0.6540.87
207_F345_L0.6530.87
24_R130_N0.6520.87
61_K64_N0.6510.86
19_F133_V0.6510.86
28_I109_I0.6490.86
234_S284_P0.6480.86
277_E280_L0.6470.86
230_Y293_R0.6470.86
242_V390_K0.6470.86
356_G384_N0.6460.86
17_E57_Y0.6450.86
20_S42_T0.6450.86
289_Y293_R0.6440.86
169_L176_I0.6430.86
8_R68_L0.6430.86
396_S408_G0.6420.86
224_F285_L0.6420.86
287_N348_I0.6410.86
345_L360_L0.6410.86
94_R255_Q0.6380.85
211_A342_V0.6380.85
240_E280_L0.6360.85
30_K122_T0.6350.85
345_L350_T0.6330.85
329_K408_G0.6320.85
131_Y147_R0.6310.85
253_L272_V0.6310.85
215_L345_L0.6310.85
330_N397_K0.6300.85
190_K194_K0.6290.85
90_Q297_E0.6290.85
370_K374_I0.6290.85
227_R231_K0.6280.84
338_N370_K0.6280.84
209_Q409_K0.6270.84
346_E380_L0.6260.84
407_S410_L0.6260.84
288_T292_T0.6250.84
346_E362_A0.6250.84
219_L360_L0.6250.84
65_D68_L0.6230.84
337_E374_I0.6230.84
184_S188_K0.6220.84
198_I201_K0.6210.84
361_V380_L0.6200.84
13_G16_L0.6200.84
115_L178_L0.6200.84
218_S351_A0.6190.84
71_A77_L0.6180.84
151_S166_Y0.6150.83
5_L12_M0.6150.83
220_F389_L0.6140.83
14_I48_L0.6140.83
218_S348_I0.6100.83
362_A379_L0.6100.83
194_K375_G0.6070.82
290_W294_M0.6070.82
334_N411_K0.6070.82
232_E237_K0.6070.82
39_V240_E0.6030.82
391_N415_L0.5980.81
69_E76_K0.5980.81
117_E183_A0.5970.81
225_S320_D0.5960.81
87_P90_Q0.5940.81
214_S218_S0.5920.81
129_I178_L0.5920.81
238_L283_R0.5910.81
364_V380_L0.5910.81
59_Y304_R0.5910.81
71_A79_E0.5900.81
334_N373_K0.5900.81
94_R173_D0.5900.81
122_T154_A0.5890.81
119_V189_V0.5880.80
45_G172_R0.5880.80
217_S321_F0.5870.80
25_E127_S0.5870.80
217_S225_S0.5850.80
225_S321_F0.5830.80
217_S222_S0.5830.80
167_E188_K0.5820.80
219_L222_S0.5820.80
222_S320_D0.5810.80
324_I407_S0.5770.79
195_K375_G0.5750.79
203_Y367_L0.5730.79
211_A361_V0.5720.79
65_D72_L0.5720.79
24_R132_E0.5720.79
350_T359_S0.5710.78
101_N107_D0.5710.78
199_D203_Y0.5710.78
69_E72_L0.5700.78
392_I396_S0.5680.78
326_F410_L0.5680.78
227_R318_H0.5680.78
359_S380_L0.5670.78
109_I126_A0.5660.78
275_V324_I0.5650.78
260_S322_S0.5650.78
73_K77_L0.5650.78
329_K397_K0.5630.77
364_V367_L0.5630.77
14_I75_A0.5620.77
196_E375_G0.5600.77
359_S382_T0.5600.77
218_S225_S0.5600.77
350_T361_V0.5590.77
66_N73_K0.5590.77
196_E372_E0.5590.77
6_I136_F0.5580.77
101_N330_N0.5570.77
243_N247_E0.5550.76
113_I124_A0.5540.76
345_L410_L0.5540.76
205_V417_L0.5520.76
201_K417_L0.5510.76
287_N298_N0.5510.76
217_S403_G0.5500.76
287_N302_A0.5500.76
170_I258_P0.5490.76
182_K185_I0.5490.76
44_Y63_L0.5490.76
114_E391_N0.5480.76
116_E158_D0.5470.75
43_G59_Y0.5460.75
218_S358_F0.5450.75
5_L65_D0.5440.75
204_D393_V0.5440.75
286_T319_V0.5420.75
154_A157_N0.5420.75
187_E190_K0.5420.75
235_P389_L0.5410.75
75_A78_G0.5410.75
215_L385_L0.5390.74
399_I408_G0.5380.74
14_I50_D0.5380.74
17_E304_R0.5360.74
45_G57_Y0.5360.74
19_F131_Y0.5350.74
266_E302_A0.5330.74
224_F276_I0.5330.74
320_D403_G0.5320.73
201_K340_V0.5320.73
51_E54_R0.5310.73
165_I192_M0.5310.73
174_S256_S0.5310.73
26_Y102_E0.5310.73
386_K390_K0.5290.73
61_K188_K0.5280.73
399_I407_S0.5280.73
286_T299_T0.5270.73
164_E363_N0.5260.73
112_L182_K0.5260.73
328_Y397_K0.5260.73
222_S321_F0.5250.72
291_A296_V0.5240.72
177_S183_A0.5240.72
362_A381_I0.5240.72
36_P110_K0.5240.72
162_S165_I0.5240.72
226_A290_W0.5230.72
231_K355_S0.5220.72
250_D275_V0.5210.72
204_D337_E0.5210.72
102_E106_Q0.5200.72
257_L404_K0.5200.72
47_R304_R0.5200.72
347_G350_T0.5200.72
17_E135_I0.5190.72
344_Q363_N0.5190.72
265_D303_S0.5180.71
48_L56_G0.5180.71
12_M72_L0.5180.71
186_I189_V0.5170.71
45_G317_P0.5170.71
389_L392_I0.5160.71
17_E45_G0.5160.71
99_Q104_V0.5160.71
8_R73_K0.5160.71
5_L8_R0.5160.71
343_D373_K0.5160.71
213_D348_I0.5150.71
66_N76_K0.5140.71
228_N353_L0.5140.71
80_S88_S0.5130.71
273_S285_L0.5120.71
227_R319_V0.5120.71
19_F43_G0.5120.71
397_K409_K0.5110.70
161_N377_E0.5100.70
194_K372_E0.5080.70
213_D400_E0.5080.70
221_P353_L0.5080.70
6_I18_I0.5050.70
113_I122_T0.5050.70
149_V258_P0.5040.69
178_L186_I0.5040.69
273_S322_S0.5040.69
15_S50_D0.5030.69
206_T409_K0.5000.69
106_Q112_L0.5000.69
240_E390_K0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl4A 2 0.9499 100 0.196 Contact Map
3tv9A 2 0.9427 100 0.212 Contact Map
3qtdA 2 0.9523 100 0.216 Contact Map
1vpbA 2 0.9427 100 0.216 Contact Map
3whrA 1 0.3222 18.7 0.969 Contact Map
2m1zA 1 0.1838 10.5 0.972 Contact Map
4tn5A 2 0.2029 8.9 0.973 Contact Map
1e2bA 1 0.1862 7.8 0.974 Contact Map
2kyrA 1 0.1885 7.3 0.974 Contact Map
2l2qA 1 0.1862 5.8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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