GREMLIN Database
Q7LXP4 - Biotin--(Acetyl-CoA carboxylase) synthetase (BioR)
UniProt: Q7LXP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (222)
Sequences: 4835 (3899)
Seq/√Len: 261.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_L217_E3.3901.00
59_T126_F3.1001.00
13_V19_F3.0661.00
10_L13_V2.7411.00
83_D180_I2.7211.00
12_K37_E2.7091.00
83_D165_K2.6401.00
218_C224_E2.5691.00
82_L184_Y2.4791.00
19_F22_A2.4791.00
209_D213_R2.4541.00
51_S57_W2.3001.00
92_K186_S2.2371.00
87_K165_K2.2231.00
182_N207_F2.2081.00
14_T18_D2.1591.00
20_A61_V2.1221.00
193_T202_R2.0591.00
86_R184_Y2.0321.00
209_D225_E2.0001.00
14_T19_F1.9801.00
193_T200_E1.9371.00
178_I182_N1.8781.00
215_V223_V1.8771.00
83_D169_H1.8091.00
58_F159_I1.8031.00
191_E202_R1.8011.00
20_A33_V1.7641.00
14_T22_A1.7611.00
77_V127_I1.7581.00
145_T149_L1.7471.00
206_L223_V1.7411.00
87_K161_E1.7031.00
191_E204_K1.6711.00
101_V150_E1.6601.00
207_F215_V1.6541.00
78_A93_I1.6511.00
10_L19_F1.6511.00
204_K217_E1.6201.00
145_T150_E1.5961.00
187_I205_A1.5791.00
56_L159_I1.5731.00
73_S125_L1.5731.00
191_E219_G1.5721.00
101_V106_I1.5411.00
215_V225_E1.5321.00
195_K200_E1.5271.00
169_H180_I1.5161.00
81_V162_V1.5131.00
81_V107_A1.5101.00
86_R90_D1.4801.00
217_E223_V1.4791.00
84_V162_V1.4681.00
37_E53_K1.4621.00
36_E157_L1.3871.00
24_S61_V1.3691.00
12_K39_T1.3681.00
17_Q126_F1.3431.00
139_P142_L1.3401.00
185_L205_A1.3371.00
82_L86_R1.3261.00
194_L226_I1.3211.00
23_I33_V1.3101.00
100_V186_S1.3091.00
99_I107_A1.3051.00
34_I159_I1.2821.00
32_L60_Y1.2781.00
19_F23_I1.2771.00
10_L33_V1.2761.00
11_N36_E1.2761.00
151_I155_V1.2751.00
32_L163_I1.2661.00
20_A59_T1.2621.00
74_S111_I1.2331.00
82_L91_A1.2261.00
165_K168_E1.2241.00
213_R227_Y1.2221.00
8_I31_F1.2211.00
8_I23_I1.2201.00
169_H172_L1.1981.00
213_R225_E1.1931.00
80_A169_H1.1901.00
91_A101_V1.1891.00
136_K148_Y1.1691.00
9_R36_E1.1671.00
75_L78_A1.1531.00
201_K224_E1.1351.00
138_F142_L1.1281.00
21_E126_F1.1151.00
179_D183_Q1.1141.00
185_L188_K1.1071.00
52_P57_W1.0971.00
194_L216_T1.0921.00
51_S55_G1.0891.00
129_A162_V1.0861.00
161_E165_K1.0771.00
81_V99_I1.0751.00
42_R112_E1.0741.00
29_E170_L1.0741.00
18_D42_R1.0621.00
196_G199_W1.0551.00
84_V165_K1.0541.00
90_D102_N1.0511.00
107_A131_I1.0461.00
165_K169_H1.0421.00
84_V88_F1.0401.00
203_C218_C1.0381.00
41_A51_S1.0381.00
58_F129_A1.0371.00
211_M225_E1.0281.00
180_I183_Q1.0261.00
140_S143_N1.0261.00
146_S149_L1.0251.00
32_L58_F1.0221.00
181_V185_L1.0181.00
55_G135_I1.0091.00
9_R34_I1.0061.00
111_I125_L1.0001.00
27_L61_V0.9961.00
81_V129_A0.9861.00
135_I138_F0.9841.00
114_K124_D0.9831.00
205_A214_L0.9801.00
88_F161_E0.9801.00
161_E164_G0.9751.00
19_F33_V0.9711.00
134_L148_Y0.9671.00
58_F162_V0.9621.00
21_E112_E0.9541.00
18_D40_K0.9371.00
103_D190_R0.9361.00
17_Q59_T0.9301.00
194_L231_V0.9281.00
189_D206_L0.9221.00
18_D22_A0.9201.00
20_A31_F0.9201.00
56_L133_I0.9181.00
173_D176_K0.9171.00
203_C216_T0.9111.00
178_I210_Y0.9091.00
138_F141_D0.9011.00
83_D184_Y0.8991.00
80_A84_V0.8981.00
182_N188_K0.8961.00
27_L31_F0.8961.00
60_Y166_I0.8881.00
162_V166_I0.8871.00
166_I170_L0.8871.00
91_A99_I0.8861.00
21_E114_K0.8851.00
28_F31_F0.8841.00
148_Y151_I0.8791.00
23_I31_F0.8741.00
77_V129_A0.8731.00
160_D164_G0.8721.00
196_G201_K0.8671.00
175_R210_Y0.8631.00
164_G168_E0.8601.00
192_V205_A0.8571.00
49_W96_P0.8501.00
102_N150_E0.8480.99
75_L212_G0.8480.99
196_G224_E0.8440.99
16_T35_A0.8430.99
187_I190_R0.8370.99
36_E53_K0.8340.99
85_L147_L0.8310.99
168_E172_L0.8310.99
201_K226_I0.8270.99
155_V158_N0.8250.99
152_G155_V0.8180.99
202_R219_G0.8180.99
8_I19_F0.8180.99
111_I127_I0.8150.99
81_V131_I0.8130.99
92_K103_D0.8130.99
82_L93_I0.8090.99
148_Y154_E0.8080.99
77_V166_I0.8080.99
174_N178_I0.8080.99
194_L229_V0.8070.99
163_I167_E0.8040.99
22_A25_N0.8030.99
62_K124_D0.7960.99
131_I162_V0.7930.99
187_I192_V0.7900.99
86_R91_A0.7870.99
24_S124_D0.7820.99
11_N53_K0.7800.99
113_A125_L0.7790.99
6_L28_F0.7780.99
77_V111_I0.7770.99
37_E51_S0.7750.99
30_D167_E0.7710.99
180_I184_Y0.7670.99
37_E57_W0.7660.99
201_K218_C0.7640.99
61_V124_D0.7630.99
47_R230_E0.7600.99
69_E72_L0.7600.99
199_W224_E0.7590.99
76_K79_V0.7580.99
81_V85_L0.7560.99
72_L174_N0.7450.99
151_I154_E0.7410.99
13_V35_A0.7400.99
79_V181_V0.7360.99
36_E54_G0.7330.99
31_F61_V0.7290.98
34_I58_F0.7280.98
133_I157_L0.7250.98
13_V33_V0.7240.98
195_K198_N0.7240.98
27_L30_D0.7210.98
35_A57_W0.7200.98
6_L31_F0.7190.98
79_V180_I0.7180.98
182_N185_L0.7170.98
181_V208_V0.7170.98
82_L99_I0.7150.98
206_L215_V0.7100.98
100_V187_I0.7050.98
85_L91_A0.7040.98
6_L27_L0.7010.98
79_V177_I0.7010.98
17_Q110_L0.6990.98
194_L201_K0.6980.98
205_A216_T0.6910.98
169_H177_I0.6870.98
116_Y123_A0.6860.98
66_K69_E0.6860.98
134_L152_G0.6830.98
188_K205_A0.6800.98
84_V161_E0.6800.98
167_E171_K0.6790.98
72_L76_K0.6750.97
187_I231_V0.6650.97
47_R229_V0.6650.97
188_K207_F0.6650.97
44_R230_E0.6610.97
80_A165_K0.6580.97
65_F69_E0.6550.97
79_V83_D0.6530.97
14_T40_K0.6480.97
68_E211_M0.6470.97
67_T70_I0.6460.97
137_E149_L0.6450.97
104_K145_T0.6450.97
217_E221_Y0.6440.97
38_Q41_A0.6430.97
29_E63_K0.6420.97
101_V145_T0.6420.97
85_L131_I0.6410.97
18_D21_E0.6400.97
29_E61_V0.6400.97
30_D61_V0.6390.96
37_E50_Y0.6350.96
85_L106_I0.6310.96
207_F223_V0.6270.96
79_V184_Y0.6250.96
15_S38_Q0.6220.96
76_K80_A0.6220.96
83_D168_E0.6220.96
190_R205_A0.6210.96
203_C226_I0.6200.96
72_L178_I0.6170.96
77_V109_I0.6150.96
209_D215_V0.6140.96
179_D182_N0.6130.96
17_Q112_E0.6120.96
79_V169_H0.6110.95
85_L88_F0.6070.95
103_D186_S0.6010.95
60_Y163_I0.5990.95
136_K139_P0.5970.95
38_Q51_S0.5950.95
153_K157_L0.5940.95
194_L203_C0.5910.95
134_L146_S0.5910.95
177_I181_V0.5900.95
172_L180_I0.5900.95
70_I113_A0.5810.94
134_L155_V0.5780.94
71_Q74_S0.5760.94
159_I163_I0.5750.94
185_L207_F0.5750.94
63_K170_L0.5720.94
32_L159_I0.5710.94
172_L176_K0.5710.94
116_Y119_D0.5700.94
8_I13_V0.5680.93
104_K150_E0.5670.93
176_K179_D0.5630.93
160_D167_E0.5610.93
133_I155_V0.5610.93
10_L14_T0.5570.93
52_P135_I0.5530.92
87_K164_G0.5520.92
217_E220_I0.5500.92
106_I145_T0.5490.92
135_I146_S0.5480.92
13_V16_T0.5460.92
58_F163_I0.5420.92
83_D86_R0.5410.92
192_V229_V0.5400.92
218_C221_Y0.5380.91
26_M29_E0.5370.91
16_T59_T0.5370.91
151_I156_E0.5350.91
85_L99_I0.5320.91
72_L177_I0.5310.91
218_C226_I0.5290.91
216_T226_I0.5290.91
56_L162_V0.5270.91
14_T39_T0.5260.91
167_E170_L0.5260.91
135_I149_L0.5250.90
7_V34_I0.5230.90
28_F62_K0.5210.90
71_Q75_L0.5190.90
152_G156_E0.5190.90
146_S152_G0.5170.90
127_I166_I0.5170.90
8_I33_V0.5140.89
134_L153_K0.5120.89
138_F143_N0.5120.89
17_Q229_V0.5060.89
139_P143_N0.5040.89
23_I26_M0.5040.89
76_K169_H0.5040.89
44_R96_P0.5030.88
57_W135_I0.5000.88
96_P181_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ej9A 1 0.9399 100 0.155 Contact Map
4op0A 1 0.9571 100 0.164 Contact Map
3rkxA 1 0.9313 100 0.165 Contact Map
2eayA 2 0.8927 100 0.168 Contact Map
2dxuA 2 0.9185 100 0.17 Contact Map
1biaA 1 0.8884 100 0.179 Contact Map
3bfmA 2 0.9056 100 0.333 Contact Map
1vqzA 1 0.897 99.8 0.682 Contact Map
2p5iA 1 0.7897 99.7 0.725 Contact Map
2qhsA 1 0.6867 99.3 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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