Q7LXP4 - SULSO - GREMLIN Contacts

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Q7LXP4 - Biotin--(Acetyl-CoA carboxylase) synthetase (BioR)

UniProt:	Q7LXP4	Sequences: MCGSMLVIRLNKVTSTQDFAEAISNMLFEDFLVIAEEQTKARGRLGRSWYSPKGGLWFTYVKKNFKTEEIQLSSLKVAVAVLDVLRKFVDAKIRWPNDIVVNDKKIAGILIEAKTYEEDIKLADLFIGAGIDILIKEFPSDLNATSLYLEIGKEVELNIDEVIGKIEEHLKLDNRKIIDIVNQYLSIKDREVTLKGENWEKRCKALFVDYMGRLVTECGIYEVEEIYRVEVSH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	233 (222)
Sequences:	4835 (3899)
Seq/√Len:	261.7

ECOLI - BIRA
BACSU - BIRA
HALSA - Q9HRK0
SULSO - Q7LXP4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
206_L	217_E	3.390	1.00
59_T	126_F	3.100	1.00
13_V	19_F	3.066	1.00
10_L	13_V	2.741	1.00
83_D	180_I	2.721	1.00
12_K	37_E	2.709	1.00
83_D	165_K	2.640	1.00
218_C	224_E	2.569	1.00
82_L	184_Y	2.479	1.00
19_F	22_A	2.479	1.00
209_D	213_R	2.454	1.00
51_S	57_W	2.300	1.00
92_K	186_S	2.237	1.00
87_K	165_K	2.223	1.00
182_N	207_F	2.208	1.00
14_T	18_D	2.159	1.00
20_A	61_V	2.122	1.00
193_T	202_R	2.059	1.00
86_R	184_Y	2.032	1.00
209_D	225_E	2.000	1.00
14_T	19_F	1.980	1.00
193_T	200_E	1.937	1.00
178_I	182_N	1.878	1.00
215_V	223_V	1.877	1.00
83_D	169_H	1.809	1.00
58_F	159_I	1.803	1.00
191_E	202_R	1.801	1.00
20_A	33_V	1.764	1.00
14_T	22_A	1.761	1.00
77_V	127_I	1.758	1.00
145_T	149_L	1.747	1.00
206_L	223_V	1.741	1.00
87_K	161_E	1.703	1.00
191_E	204_K	1.671	1.00
101_V	150_E	1.660	1.00
207_F	215_V	1.654	1.00
78_A	93_I	1.651	1.00
10_L	19_F	1.651	1.00
204_K	217_E	1.620	1.00
145_T	150_E	1.596	1.00
187_I	205_A	1.579	1.00
56_L	159_I	1.573	1.00
73_S	125_L	1.573	1.00
191_E	219_G	1.572	1.00
101_V	106_I	1.541	1.00
215_V	225_E	1.532	1.00
195_K	200_E	1.527	1.00
169_H	180_I	1.516	1.00
81_V	162_V	1.513	1.00
81_V	107_A	1.510	1.00
86_R	90_D	1.480	1.00
217_E	223_V	1.479	1.00
84_V	162_V	1.468	1.00
37_E	53_K	1.462	1.00
36_E	157_L	1.387	1.00
24_S	61_V	1.369	1.00
12_K	39_T	1.368	1.00
17_Q	126_F	1.343	1.00
139_P	142_L	1.340	1.00
185_L	205_A	1.337	1.00
82_L	86_R	1.326	1.00
194_L	226_I	1.321	1.00
23_I	33_V	1.310	1.00
100_V	186_S	1.309	1.00
99_I	107_A	1.305	1.00
34_I	159_I	1.282	1.00
32_L	60_Y	1.278	1.00
19_F	23_I	1.277	1.00
10_L	33_V	1.276	1.00
11_N	36_E	1.276	1.00
151_I	155_V	1.275	1.00
32_L	163_I	1.266	1.00
20_A	59_T	1.262	1.00
74_S	111_I	1.233	1.00
82_L	91_A	1.226	1.00
165_K	168_E	1.224	1.00
213_R	227_Y	1.222	1.00
8_I	31_F	1.221	1.00
8_I	23_I	1.220	1.00
169_H	172_L	1.198	1.00
213_R	225_E	1.193	1.00
80_A	169_H	1.190	1.00
91_A	101_V	1.189	1.00
136_K	148_Y	1.169	1.00
9_R	36_E	1.167	1.00
75_L	78_A	1.153	1.00
201_K	224_E	1.135	1.00
138_F	142_L	1.128	1.00
21_E	126_F	1.115	1.00
179_D	183_Q	1.114	1.00
185_L	188_K	1.107	1.00
52_P	57_W	1.097	1.00
194_L	216_T	1.092	1.00
51_S	55_G	1.089	1.00
129_A	162_V	1.086	1.00
161_E	165_K	1.077	1.00
81_V	99_I	1.075	1.00
42_R	112_E	1.074	1.00
29_E	170_L	1.074	1.00
18_D	42_R	1.062	1.00
196_G	199_W	1.055	1.00
84_V	165_K	1.054	1.00
90_D	102_N	1.051	1.00
107_A	131_I	1.046	1.00
165_K	169_H	1.042	1.00
84_V	88_F	1.040	1.00
203_C	218_C	1.038	1.00
41_A	51_S	1.038	1.00
58_F	129_A	1.037	1.00
211_M	225_E	1.028	1.00
180_I	183_Q	1.026	1.00
140_S	143_N	1.026	1.00
146_S	149_L	1.025	1.00
32_L	58_F	1.022	1.00
181_V	185_L	1.018	1.00
55_G	135_I	1.009	1.00
9_R	34_I	1.006	1.00
111_I	125_L	1.000	1.00
27_L	61_V	0.996	1.00
81_V	129_A	0.986	1.00
135_I	138_F	0.984	1.00
114_K	124_D	0.983	1.00
205_A	214_L	0.980	1.00
88_F	161_E	0.980	1.00
161_E	164_G	0.975	1.00
19_F	33_V	0.971	1.00
134_L	148_Y	0.967	1.00
58_F	162_V	0.962	1.00
21_E	112_E	0.954	1.00
18_D	40_K	0.937	1.00
103_D	190_R	0.936	1.00
17_Q	59_T	0.930	1.00
194_L	231_V	0.928	1.00
189_D	206_L	0.922	1.00
18_D	22_A	0.920	1.00
20_A	31_F	0.920	1.00
56_L	133_I	0.918	1.00
173_D	176_K	0.917	1.00
203_C	216_T	0.911	1.00
178_I	210_Y	0.909	1.00
138_F	141_D	0.901	1.00
83_D	184_Y	0.899	1.00
80_A	84_V	0.898	1.00
182_N	188_K	0.896	1.00
27_L	31_F	0.896	1.00
60_Y	166_I	0.888	1.00
162_V	166_I	0.887	1.00
166_I	170_L	0.887	1.00
91_A	99_I	0.886	1.00
21_E	114_K	0.885	1.00
28_F	31_F	0.884	1.00
148_Y	151_I	0.879	1.00
23_I	31_F	0.874	1.00
77_V	129_A	0.873	1.00
160_D	164_G	0.872	1.00
196_G	201_K	0.867	1.00
175_R	210_Y	0.863	1.00
164_G	168_E	0.860	1.00
192_V	205_A	0.857	1.00
49_W	96_P	0.850	1.00
102_N	150_E	0.848	0.99
75_L	212_G	0.848	0.99
196_G	224_E	0.844	0.99
16_T	35_A	0.843	0.99
187_I	190_R	0.837	0.99
36_E	53_K	0.834	0.99
85_L	147_L	0.831	0.99
168_E	172_L	0.831	0.99
201_K	226_I	0.827	0.99
155_V	158_N	0.825	0.99
152_G	155_V	0.818	0.99
202_R	219_G	0.818	0.99
8_I	19_F	0.818	0.99
111_I	127_I	0.815	0.99
81_V	131_I	0.813	0.99
92_K	103_D	0.813	0.99
82_L	93_I	0.809	0.99
148_Y	154_E	0.808	0.99
77_V	166_I	0.808	0.99
174_N	178_I	0.808	0.99
194_L	229_V	0.807	0.99
163_I	167_E	0.804	0.99
22_A	25_N	0.803	0.99
62_K	124_D	0.796	0.99
131_I	162_V	0.793	0.99
187_I	192_V	0.790	0.99
86_R	91_A	0.787	0.99
24_S	124_D	0.782	0.99
11_N	53_K	0.780	0.99
113_A	125_L	0.779	0.99
6_L	28_F	0.778	0.99
77_V	111_I	0.777	0.99
37_E	51_S	0.775	0.99
30_D	167_E	0.771	0.99
180_I	184_Y	0.767	0.99
37_E	57_W	0.766	0.99
201_K	218_C	0.764	0.99
61_V	124_D	0.763	0.99
47_R	230_E	0.760	0.99
69_E	72_L	0.760	0.99
199_W	224_E	0.759	0.99
76_K	79_V	0.758	0.99
81_V	85_L	0.756	0.99
72_L	174_N	0.745	0.99
151_I	154_E	0.741	0.99
13_V	35_A	0.740	0.99
79_V	181_V	0.736	0.99
36_E	54_G	0.733	0.99
31_F	61_V	0.729	0.98
34_I	58_F	0.728	0.98
133_I	157_L	0.725	0.98
13_V	33_V	0.724	0.98
195_K	198_N	0.724	0.98
27_L	30_D	0.721	0.98
35_A	57_W	0.720	0.98
6_L	31_F	0.719	0.98
79_V	180_I	0.718	0.98
182_N	185_L	0.717	0.98
181_V	208_V	0.717	0.98
82_L	99_I	0.715	0.98
206_L	215_V	0.710	0.98
100_V	187_I	0.705	0.98
85_L	91_A	0.704	0.98
6_L	27_L	0.701	0.98
79_V	177_I	0.701	0.98
17_Q	110_L	0.699	0.98
194_L	201_K	0.698	0.98
205_A	216_T	0.691	0.98
169_H	177_I	0.687	0.98
116_Y	123_A	0.686	0.98
66_K	69_E	0.686	0.98
134_L	152_G	0.683	0.98
188_K	205_A	0.680	0.98
84_V	161_E	0.680	0.98
167_E	171_K	0.679	0.98
72_L	76_K	0.675	0.97
187_I	231_V	0.665	0.97
47_R	229_V	0.665	0.97
188_K	207_F	0.665	0.97
44_R	230_E	0.661	0.97
80_A	165_K	0.658	0.97
65_F	69_E	0.655	0.97
79_V	83_D	0.653	0.97
14_T	40_K	0.648	0.97
68_E	211_M	0.647	0.97
67_T	70_I	0.646	0.97
137_E	149_L	0.645	0.97
104_K	145_T	0.645	0.97
217_E	221_Y	0.644	0.97
38_Q	41_A	0.643	0.97
29_E	63_K	0.642	0.97
101_V	145_T	0.642	0.97
85_L	131_I	0.641	0.97
18_D	21_E	0.640	0.97
29_E	61_V	0.640	0.97
30_D	61_V	0.639	0.96
37_E	50_Y	0.635	0.96
85_L	106_I	0.631	0.96
207_F	223_V	0.627	0.96
79_V	184_Y	0.625	0.96
15_S	38_Q	0.622	0.96
76_K	80_A	0.622	0.96
83_D	168_E	0.622	0.96
190_R	205_A	0.621	0.96
203_C	226_I	0.620	0.96
72_L	178_I	0.617	0.96
77_V	109_I	0.615	0.96
209_D	215_V	0.614	0.96
179_D	182_N	0.613	0.96
17_Q	112_E	0.612	0.96
79_V	169_H	0.611	0.95
85_L	88_F	0.607	0.95
103_D	186_S	0.601	0.95
60_Y	163_I	0.599	0.95
136_K	139_P	0.597	0.95
38_Q	51_S	0.595	0.95
153_K	157_L	0.594	0.95
194_L	203_C	0.591	0.95
134_L	146_S	0.591	0.95
177_I	181_V	0.590	0.95
172_L	180_I	0.590	0.95
70_I	113_A	0.581	0.94
134_L	155_V	0.578	0.94
71_Q	74_S	0.576	0.94
159_I	163_I	0.575	0.94
185_L	207_F	0.575	0.94
63_K	170_L	0.572	0.94
32_L	159_I	0.571	0.94
172_L	176_K	0.571	0.94
116_Y	119_D	0.570	0.94
8_I	13_V	0.568	0.93
104_K	150_E	0.567	0.93
176_K	179_D	0.563	0.93
160_D	167_E	0.561	0.93
133_I	155_V	0.561	0.93
10_L	14_T	0.557	0.93
52_P	135_I	0.553	0.92
87_K	164_G	0.552	0.92
217_E	220_I	0.550	0.92
106_I	145_T	0.549	0.92
135_I	146_S	0.548	0.92
13_V	16_T	0.546	0.92
58_F	163_I	0.542	0.92
83_D	86_R	0.541	0.92
192_V	229_V	0.540	0.92
218_C	221_Y	0.538	0.91
26_M	29_E	0.537	0.91
16_T	59_T	0.537	0.91
151_I	156_E	0.535	0.91
85_L	99_I	0.532	0.91
72_L	177_I	0.531	0.91
218_C	226_I	0.529	0.91
216_T	226_I	0.529	0.91
56_L	162_V	0.527	0.91
14_T	39_T	0.526	0.91
167_E	170_L	0.526	0.91
135_I	149_L	0.525	0.90
7_V	34_I	0.523	0.90
28_F	62_K	0.521	0.90
71_Q	75_L	0.519	0.90
152_G	156_E	0.519	0.90
146_S	152_G	0.517	0.90
127_I	166_I	0.517	0.90
8_I	33_V	0.514	0.89
134_L	153_K	0.512	0.89
138_F	143_N	0.512	0.89
17_Q	229_V	0.506	0.89
139_P	143_N	0.504	0.89
23_I	26_M	0.504	0.89
76_K	169_H	0.504	0.89
44_R	96_P	0.503	0.88
57_W	135_I	0.500	0.88
96_P	181_V	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ej9A	1	0.9399	100	0.155	Contact Map
4op0A	1	0.9571	100	0.164	Contact Map
3rkxA	1	0.9313	100	0.165	Contact Map
2eayA	2	0.8927	100	0.168	Contact Map
2dxuA	2	0.9185	100	0.17	Contact Map
1biaA	1	0.8884	100	0.179	Contact Map
3bfmA	2	0.9056	100	0.333	Contact Map
1vqzA	1	0.897	99.8	0.682	Contact Map
2p5iA	1	0.7897	99.7	0.725	Contact Map
2qhsA	1	0.6867	99.3	0.779	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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