GREMLIN Database
Q7LXP3 - Threonylcarbamoyl-AMP synthase
UniProt: Q7LXP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (319)
Sequences: 2372 (1849)
Seq/√Len: 103.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V28_G4.8601.00
43_N46_D4.4521.00
32_F41_G4.3421.00
28_G168_D3.9501.00
44_A67_V3.6091.00
184_V229_A3.2381.00
160_I170_I3.1001.00
22_N26_A2.5161.00
71_N134_N2.4741.00
79_A102_L2.4691.00
18_K135_E2.4671.00
202_V206_E2.4161.00
41_G140_I2.4111.00
54_F61_M2.3111.00
32_F132_L2.2691.00
267_A308_L2.2621.00
178_F199_P2.2281.00
47_P109_P2.1911.00
43_N138_V2.1881.00
147_L166_K2.1851.00
132_L171_L2.1851.00
63_N148_A2.1631.00
131_A134_N2.1301.00
76_Y87_I2.1071.00
90_V100_F2.0931.00
17_I135_E2.0911.00
32_F129_A2.0881.00
70_S133_I2.0771.00
53_I141_A2.0381.00
69_I75_L2.0351.00
47_P111_E2.0171.00
204_E207_R1.9811.00
194_L202_V1.9501.00
201_S204_E1.9461.00
160_I164_Y1.9221.00
265_R314_D1.9181.00
93_V208_L1.9131.00
264_C314_D1.8951.00
157_E161_D1.8841.00
81_D103_K1.8761.00
69_I123_M1.8141.00
78_V121_V1.8131.00
155_R175_E1.8101.00
241_K309_D1.7581.00
42_A49_A1.7511.00
70_S74_Q1.7451.00
229_A232_M1.7371.00
323_E335_R1.7331.00
28_G52_K1.7331.00
147_L162_D1.7071.00
13_E16_K1.7041.00
51_K111_E1.6911.00
180_V329_A1.6901.00
27_G46_D1.6741.00
125_A130_L1.6631.00
85_K209_F1.6621.00
51_K55_I1.6601.00
156_V172_D1.6571.00
21_A135_E1.6491.00
131_A135_E1.6271.00
267_A313_V1.5911.00
87_I91_N1.5831.00
31_V167_V1.5761.00
74_Q133_I1.5661.00
21_A136_S1.5491.00
56_A163_I1.5471.00
162_D306_R1.5391.00
52_K55_I1.5341.00
24_I132_L1.5321.00
74_Q77_E1.5281.00
245_V320_S1.5281.00
23_V169_V1.5241.00
151_P306_R1.5131.00
294_L330_I1.4941.00
80_K103_K1.4911.00
272_S287_E1.4671.00
286_I304_S1.4661.00
293_N296_E1.4461.00
24_I136_S1.4361.00
67_V112_T1.4211.00
269_L304_S1.4191.00
23_V168_D1.4171.00
202_V328_L1.4101.00
186_N228_L1.4021.00
45_L138_V1.4021.00
72_I91_N1.3741.00
125_A177_F1.3731.00
79_A119_V1.3540.99
123_M130_L1.3490.99
83_P86_I1.3450.99
155_R303_D1.3440.99
24_I138_V1.3330.99
72_I87_I1.3330.99
206_E211_K1.3310.99
128_V173_S1.3310.99
45_L109_P1.3280.99
19_K22_N1.3250.99
118_T188_T1.3250.99
71_N74_Q1.3010.99
22_N25_K1.2950.99
75_L121_V1.2880.99
31_V159_V1.2840.99
286_I307_K1.2790.99
133_I136_S1.2770.99
303_D307_K1.2670.99
318_I334_T1.2550.99
123_M133_I1.2540.99
103_K117_E1.2510.99
300_N304_S1.2470.99
205_L209_F1.2410.99
187_V192_P1.2380.99
161_D310_K1.2370.99
253_R257_N1.2270.99
62_D233_K1.2230.99
72_I90_V1.2200.99
89_L98_L1.2200.99
88_N92_I1.2190.99
62_D234_Y1.2010.99
80_K106_E1.1930.99
298_S326_I1.1910.99
42_A53_I1.1880.99
78_V108_V1.1800.99
187_V209_F1.1730.98
136_S139_P1.1620.98
297_I321_I1.1500.98
269_L308_L1.1430.98
18_K22_N1.1330.98
50_V112_T1.1320.98
31_V156_V1.1310.98
89_L205_L1.1250.98
70_S134_N1.1250.98
158_H303_D1.1210.98
241_K313_V1.1210.98
100_F185_I1.1190.98
192_P210_G1.1120.98
79_A121_V1.1110.98
72_I123_M1.1040.98
180_V199_P1.1030.98
56_A166_K1.1000.98
332_N336_K1.0930.98
150_K162_D1.0640.97
297_I330_I1.0600.97
197_P332_N1.0590.97
149_T235_K1.0520.97
129_A142_A1.0510.97
186_N192_P1.0500.97
98_L185_I1.0460.97
84_K87_I1.0460.97
63_N114_G1.0450.97
259_L317_V1.0430.97
104_K110_K1.0380.97
92_I208_L1.0290.96
212_V215_P1.0260.96
273_E290_S1.0250.96
29_T56_A1.0230.96
80_K105_T1.0220.96
304_S308_L1.0150.96
133_I140_I1.0140.96
75_L82_I1.0130.96
255_V258_E1.0100.96
194_L212_V1.0090.96
77_E137_G1.0020.96
163_I166_K1.0000.96
92_I207_R0.9950.96
148_A233_K0.9900.96
273_E289_G0.9890.96
150_K240_T0.9710.95
75_L102_L0.9640.95
130_L134_N0.9620.95
180_V298_S0.9610.95
163_I167_V0.9600.95
21_A25_K0.9580.95
235_K339_G0.9530.95
294_L327_G0.9460.94
101_V120_A0.9440.94
90_V123_M0.9440.94
296_E300_N0.9380.94
88_N91_N0.9360.94
209_F212_V0.9320.94
74_Q123_M0.9310.94
76_Y82_I0.9290.94
266_I271_A0.9250.94
54_F114_G0.9250.94
227_A233_K0.9250.94
242_R315_I0.9240.94
85_K88_N0.9180.93
206_E213_V0.9180.93
203_E325_G0.9170.93
186_N189_V0.9170.93
331_M336_K0.9170.93
82_I90_V0.9110.93
53_I142_A0.9100.93
266_I315_I0.9100.93
185_I209_F0.9060.93
147_L150_K0.9060.93
245_V338_S0.9030.93
31_V41_G0.9020.93
304_S307_K0.8940.93
128_V171_L0.8910.92
300_N303_D0.8900.92
43_N136_S0.8890.92
63_N234_Y0.8880.92
94_W98_L0.8870.92
136_S140_I0.8860.92
188_T191_P0.8860.92
156_V174_G0.8850.92
241_K312_N0.8820.92
17_I132_L0.8750.92
151_P243_L0.8710.92
14_L131_A0.8710.92
93_V200_F0.8710.92
233_K332_N0.8670.91
67_V78_V0.8670.91
243_L318_I0.8630.91
321_I330_I0.8610.91
241_K308_L0.8600.91
85_K187_V0.8570.91
41_G129_A0.8560.91
86_I187_V0.8520.91
104_K113_T0.8500.91
17_I171_L0.8490.91
25_K138_V0.8460.90
45_L107_K0.8410.90
58_N166_K0.8370.90
155_R158_H0.8270.89
110_K117_E0.8260.89
331_M335_R0.8220.89
188_T192_P0.8210.89
296_E299_R0.8200.89
270_C274_V0.8180.89
199_P204_E0.8170.89
16_K169_V0.8090.88
161_D306_R0.8090.88
235_K340_F0.8090.88
156_V159_V0.8040.88
46_D49_A0.8020.88
189_V193_V0.7940.87
164_Y167_V0.7880.87
271_A297_I0.7850.87
148_A234_Y0.7820.87
113_T119_V0.7820.87
192_P209_F0.7800.86
99_T120_A0.7800.86
29_T168_D0.7760.86
320_S331_M0.7760.86
180_V330_I0.7760.86
264_C315_I0.7700.86
243_L334_T0.7680.86
42_A120_A0.7670.85
132_L136_S0.7650.85
246_V317_V0.7620.85
24_I140_I0.7610.85
243_L338_S0.7600.85
307_K311_S0.7510.84
151_P233_K0.7490.84
269_L318_I0.7480.84
77_E107_K0.7480.84
101_V195_L0.7460.84
136_S184_V0.7450.84
103_K188_T0.7450.84
151_P234_Y0.7430.84
101_V118_T0.7430.84
188_T228_L0.7420.84
240_T309_D0.7400.83
82_I87_I0.7390.83
243_L305_F0.7390.83
150_K161_D0.7370.83
148_A151_P0.7360.83
133_I137_G0.7360.83
243_L316_G0.7360.83
31_V40_L0.7350.83
58_N148_A0.7330.83
241_K316_G0.7300.83
73_D76_Y0.7280.82
201_S206_E0.7280.82
256_I268_L0.7250.82
94_W100_F0.7250.82
234_Y332_N0.7240.82
271_A321_I0.7230.82
67_V108_V0.7220.82
48_E51_K0.7220.82
160_I167_V0.7210.82
86_I100_F0.7200.82
274_V319_H0.7190.82
43_N139_P0.7180.81
244_L315_I0.7180.81
305_F334_T0.7120.81
322_S327_G0.7120.81
85_K211_K0.7080.81
321_I331_M0.7080.81
108_V119_V0.6980.80
159_V167_V0.6980.80
94_W123_M0.6960.79
255_V259_L0.6940.79
153_P158_H0.6940.79
50_V184_V0.6930.79
273_E287_E0.6920.79
40_L153_P0.6910.79
75_L90_V0.6890.79
116_L229_A0.6880.79
229_A336_K0.6880.79
69_I74_Q0.6870.79
270_C275_C0.6870.79
63_N233_K0.6850.78
85_K190_D0.6840.78
79_A105_T0.6820.78
62_D118_T0.6820.78
24_I171_L0.6800.78
318_I321_I0.6790.78
112_T141_A0.6790.78
294_L322_S0.6770.78
45_L108_V0.6770.78
163_I168_D0.6770.78
209_F213_V0.6740.77
14_L135_E0.6740.77
42_A50_V0.6710.77
308_L313_V0.6700.77
244_L317_V0.6700.77
58_N61_M0.6690.77
158_H162_D0.6690.77
274_V278_F0.6680.77
259_L262_R0.6670.77
45_L136_S0.6650.76
71_N130_L0.6640.76
50_V54_F0.6640.76
20_A130_L0.6610.76
89_L100_F0.6590.76
120_A141_A0.6550.75
186_N193_V0.6530.75
287_E290_S0.6530.75
47_P110_K0.6530.75
271_A291_E0.6510.75
86_I186_N0.6460.74
245_V330_I0.6460.74
242_R309_D0.6450.74
254_G258_E0.6430.74
151_P162_D0.6420.74
126_H173_S0.6420.74
32_F140_I0.6410.74
30_V169_V0.6410.74
241_K314_D0.6400.74
45_L139_P0.6400.74
149_T233_K0.6380.73
62_D227_A0.6380.73
156_V175_E0.6360.73
16_K171_L0.6350.73
167_V170_I0.6320.73
62_D151_P0.6310.72
238_A243_L0.6290.72
203_E328_L0.6290.72
29_T52_K0.6290.72
89_L93_V0.6280.72
291_E319_H0.6250.72
185_I213_V0.6230.72
27_G43_N0.6230.72
294_L297_I0.6220.71
206_E210_G0.6210.71
202_V215_P0.6200.71
63_N230_P0.6190.71
33_P173_S0.6180.71
204_E295_Y0.6180.71
20_A169_V0.6170.71
89_L185_I0.6150.71
86_I192_P0.6150.71
127_P131_A0.6140.70
235_K238_A0.6120.70
86_I102_L0.6100.70
87_I90_V0.6100.70
147_L163_I0.6070.70
58_N114_G0.6050.69
24_I133_I0.6050.69
175_E299_R0.6050.69
84_K88_N0.6040.69
202_V205_L0.6040.69
270_C273_E0.6020.69
221_T225_D0.6010.69
258_E261_K0.6000.69
23_V167_V0.5990.69
69_I78_V0.5980.68
70_S123_M0.5980.68
67_V119_V0.5980.68
149_T238_A0.5970.68
151_P235_K0.5970.68
274_V291_E0.5910.68
68_H184_V0.5890.67
92_I204_E0.5880.67
262_R268_L0.5880.67
162_D234_Y0.5850.67
255_V317_V0.5820.66
298_S330_I0.5810.66
69_I76_Y0.5800.66
31_V162_D0.5730.65
313_V316_G0.5730.65
292_N296_E0.5730.65
288_L297_I0.5720.65
68_H142_A0.5710.65
76_Y80_K0.5710.65
153_P159_V0.5700.65
63_N162_D0.5700.65
208_L213_V0.5700.65
308_L316_G0.5690.65
247_E335_R0.5680.64
266_I270_C0.5660.64
158_H306_R0.5650.64
42_A163_I0.5640.64
32_F142_A0.5630.64
203_E327_G0.5620.64
69_I90_V0.5620.64
160_I169_V0.5620.64
77_E80_K0.5620.64
98_L205_L0.5610.64
151_P332_N0.5590.63
56_A168_D0.5590.63
14_L18_K0.5560.63
145_A159_V0.5550.63
63_N235_K0.5540.63
111_E114_G0.5540.63
228_L336_K0.5540.63
58_N149_T0.5530.62
158_H310_K0.5520.62
88_N208_L0.5520.62
327_G331_M0.5510.62
17_I131_A0.5490.62
63_N151_P0.5480.62
194_L204_E0.5480.62
271_A319_H0.5480.62
114_G199_P0.5470.62
81_D254_G0.5450.61
42_A111_E0.5440.61
160_I165_G0.5420.61
268_L319_H0.5410.61
82_I102_L0.5410.61
121_V142_A0.5390.60
148_A180_V0.5390.60
48_E160_I0.5390.60
42_A47_P0.5380.60
200_F204_E0.5370.60
21_A24_I0.5350.60
245_V340_F0.5340.60
29_T140_I0.5330.60
199_P241_K0.5320.59
297_I300_N0.5310.59
21_A140_I0.5290.59
199_P327_G0.5290.59
90_V94_W0.5280.59
44_A50_V0.5260.59
257_N260_Q0.5260.59
193_V214_V0.5240.58
266_I317_V0.5240.58
150_K336_K0.5210.58
72_I76_Y0.5210.58
294_L326_I0.5200.58
272_S296_E0.5180.57
54_F111_E0.5180.57
270_C319_H0.5180.57
50_V141_A0.5170.57
100_F187_V0.5170.57
78_V123_M0.5160.57
116_L326_I0.5150.57
69_I94_W0.5150.57
31_V153_P0.5150.57
62_D332_N0.5150.57
19_K23_V0.5150.57
324_K327_G0.5130.57
284_E311_S0.5120.57
50_V111_E0.5120.57
156_V170_I0.5120.57
243_L337_A0.5120.57
102_L187_V0.5110.56
63_N229_A0.5110.56
206_E212_V0.5100.56
54_F229_A0.5080.56
289_G297_I0.5080.56
53_I120_A0.5040.55
70_S130_L0.5030.55
186_N195_L0.5020.55
317_V321_I0.5000.55
55_I166_K0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eqaA 1 0.9218 100 0.242 Contact Map
3l7vA 1 0.5866 100 0.541 Contact Map
1k7jA 1 0.5698 100 0.562 Contact Map
1jcuA 1 0.581 100 0.567 Contact Map
1hruA 2 0.514 100 0.6 Contact Map
3vthA 1 0.838 100 0.607 Contact Map
4g9iA 1 0.8408 100 0.641 Contact Map
3ttcA 1 0.824 100 0.65 Contact Map
2yv4A 1 0.2709 99.8 0.853 Contact Map
3r12A 2 0.6341 41.9 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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