GREMLIN Database
Q7LXP2 - NADH dehydrogenase subunit B (NuoB)
UniProt: Q7LXP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (144)
Sequences: 1585 (617)
Seq/√Len: 51.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Y108_V5.3021.00
96_R100_D2.9701.00
37_S163_R2.8761.00
110_A116_L2.8151.00
153_R157_M2.4581.00
108_V137_V2.4461.00
49_C144_C2.4161.00
49_C114_C2.3851.00
114_C144_C2.3551.00
92_G96_R2.3111.00
139_L158_L2.2801.00
46_T51_G2.2791.00
132_D140_Y2.2201.00
87_L131_S2.2011.00
141_V154_A2.1601.00
111_L151_V2.1101.00
43_P98_V2.0191.00
83_L131_S2.0071.00
157_M160_K1.8790.99
27_P30_S1.8640.99
107_Y158_L1.8580.99
63_D66_R1.8280.99
50_C144_C1.7730.99
64_A69_M1.7300.99
82_I151_V1.7280.99
39_S66_R1.7110.99
50_C114_C1.6670.98
92_G134_G1.6530.98
65_E70_L1.6440.98
73_S78_S1.6340.98
88_S127_T1.6290.98
45_F95_A1.6200.98
69_M159_Q1.6030.98
110_A115_I1.5850.98
52_T56_A1.5690.98
87_L95_A1.5630.98
28_I32_I1.5480.97
80_I107_Y1.4770.97
54_F82_I1.4470.96
74_S77_Q1.4310.96
44_H73_S1.3330.94
83_L95_A1.3130.93
69_M155_V1.2990.93
81_L102_M1.2900.93
88_S124_S1.2470.91
89_R92_G1.2440.91
93_R97_I1.1980.90
80_I109_I1.1720.89
63_D67_Y1.1620.88
118_G130_P1.1500.88
86_T127_T1.1370.87
40_L80_I1.1360.87
160_K164_T1.1190.86
40_L162_I1.1120.86
26_K29_K1.1080.86
88_S91_M1.1070.86
39_S63_D1.0760.84
54_F71_P1.0670.84
25_R29_K1.0530.83
96_R134_G1.0510.83
22_L27_P1.0470.82
102_M106_K1.0310.81
80_I158_L1.0240.81
82_I111_L1.0200.81
99_Y106_K1.0170.80
57_F151_V1.0090.80
58_A71_P1.0080.80
122_W129_L1.0030.80
117_E120_I0.9930.79
53_E56_A0.9920.79
99_Y136_P0.9810.78
31_I80_I0.9660.77
54_F151_V0.9630.77
81_L84_E0.9510.76
44_H84_E0.9480.76
44_H71_P0.9420.75
33_D36_I0.9400.75
47_T51_G0.9340.74
51_G91_M0.9120.73
65_E71_P0.9120.73
81_L95_A0.9000.72
99_Y137_V0.8970.71
42_P71_P0.8970.71
67_Y156_L0.8950.71
95_A135_I0.8860.71
130_P134_G0.8830.70
91_M145_P0.8730.69
44_H51_G0.8730.69
107_Y126_N0.8650.69
47_T95_A0.8600.68
43_P74_S0.8550.68
57_F152_A0.8470.67
154_A159_Q0.8430.67
117_E142_P0.8390.66
48_S86_T0.8330.66
120_I123_N0.8330.66
48_S51_G0.8290.65
150_A153_R0.8280.65
40_L159_Q0.8270.65
96_R99_Y0.8250.65
22_L25_R0.8220.65
41_W70_L0.8150.64
89_R120_I0.8080.63
46_T84_E0.8050.63
88_S126_N0.8030.63
22_L26_K0.8010.63
98_V101_Q0.7970.62
47_T72_F0.7930.62
113_A150_A0.7870.61
116_L120_I0.7870.61
119_G130_P0.7840.61
29_K33_D0.7820.61
44_H54_F0.7820.61
113_A116_L0.7800.61
92_G128_V0.7730.60
107_Y129_L0.7720.60
23_I26_K0.7700.60
42_P80_I0.7690.60
52_T55_G0.7680.59
63_D106_K0.7620.59
128_V133_I0.7550.58
44_H55_G0.7550.58
64_A152_A0.7430.57
127_T130_P0.7360.56
24_N33_D0.7300.56
40_L59_A0.7240.55
28_I157_M0.7230.55
47_T54_F0.7210.55
51_G73_S0.7180.54
41_W52_T0.7150.54
125_Y132_D0.7130.54
120_I129_L0.7120.54
43_P73_S0.7120.54
153_R156_L0.7090.53
69_M124_S0.6980.52
115_I130_P0.6970.52
155_V159_Q0.6910.52
45_F159_Q0.6860.51
72_F78_S0.6770.50
81_L135_I0.6750.50
124_S129_L0.6720.50
94_A97_I0.6710.49
123_N129_L0.6710.49
46_T55_G0.6680.49
130_P140_Y0.6620.49
75_A78_S0.6540.48
47_T81_L0.6470.47
50_C145_P0.6460.47
113_A127_T0.6460.47
120_I148_P0.6410.46
158_L162_I0.6400.46
55_G58_A0.6310.45
98_V129_L0.6280.45
59_A88_S0.6250.45
45_F145_P0.6220.44
96_R135_I0.6210.44
36_I72_F0.6180.44
99_Y149_E0.6120.43
141_V155_V0.6100.43
118_G140_Y0.6090.43
76_R101_Q0.6060.43
147_R150_A0.6060.43
57_F111_L0.6010.42
54_F84_E0.5990.42
28_I152_A0.5940.42
24_N27_P0.5940.42
47_T91_M0.5930.41
47_T116_L0.5890.41
39_S76_R0.5880.41
87_L93_R0.5840.41
30_S163_R0.5770.40
51_G54_F0.5740.40
48_S144_C0.5740.40
57_F64_A0.5730.39
65_E72_F0.5730.39
118_G137_V0.5710.39
48_S114_C0.5700.39
25_R80_I0.5700.39
26_K80_I0.5670.39
90_K128_V0.5660.39
42_P54_F0.5660.39
41_W66_R0.5650.39
94_A129_L0.5620.38
84_E111_L0.5580.38
38_F159_Q0.5570.38
139_L161_K0.5560.38
78_S123_N0.5540.38
123_N133_I0.5530.37
66_R141_V0.5520.37
115_I119_G0.5520.37
45_F101_Q0.5460.37
128_V136_P0.5450.37
99_Y121_F0.5440.37
35_G95_A0.5430.36
25_R32_I0.5420.36
80_I155_V0.5410.36
23_I35_G0.5410.36
22_L60_A0.5400.36
83_L108_V0.5400.36
161_K164_T0.5370.36
131_S137_V0.5340.36
96_R131_S0.5330.36
51_G55_G0.5300.35
29_K36_I0.5230.35
48_S55_G0.5220.34
124_S127_T0.5210.34
42_P107_Y0.5200.34
118_G136_P0.5200.34
48_S88_S0.5180.34
111_L128_V0.5160.34
56_A117_E0.5140.34
56_A59_A0.5100.33
95_A98_V0.5090.33
120_I127_T0.5080.33
41_W101_Q0.5020.33
113_A120_I0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v6 1 0.8 100 0.295 Contact Map
1h2aS 1 0.8176 100 0.488 Contact Map
2wpnA 1 0.7941 100 0.5 Contact Map
4ue3S 2 0.8 100 0.502 Contact Map
3ayxB 2 0.7941 100 0.505 Contact Map
4uqlA 1 0.8 100 0.508 Contact Map
3myrA 3 0.8 100 0.518 Contact Map
4u9hS 1 0.8059 100 0.521 Contact Map
1yq9A 2 0.7941 100 0.522 Contact Map
4iucS 1 0.7941 100 0.529 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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