GREMLIN Database
Q7LXP1 - Glycerate kinase, putative
UniProt: Q7LXP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (370)
Sequences: 1199 (876)
Seq/√Len: 45.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_D98_R5.7581.00
119_A192_G5.7091.00
56_F112_I3.7161.00
358_R380_A3.5551.00
179_I235_N3.2281.00
305_G369_H3.1751.00
100_I168_Y3.0621.00
304_Q369_H2.9251.00
136_I218_Y2.9231.00
43_I103_L2.9001.00
142_T303_I2.7361.00
269_V272_I2.6261.00
96_G160_V2.5251.00
345_E372_Y2.5131.00
180_V239_L2.4511.00
320_F332_L2.4241.00
92_S124_E2.3471.00
17_L21_V2.3241.00
156_H199_D2.3151.00
270_G319_S2.2891.00
224_E227_K2.2531.00
146_G149_K2.1691.00
149_K213_I2.0951.00
71_K91_N2.0951.00
136_I157_L2.0921.00
256_F287_F2.0851.00
359_E374_L2.0650.99
370_N373_G2.0610.99
364_N368_T1.9920.99
149_K212_A1.9900.99
90_E94_K1.9840.99
349_C375_L1.9800.99
186_N240_D1.9760.99
48_A116_S1.9480.99
321_L355_M1.9190.99
273_I316_V1.8950.99
49_S80_V1.8870.99
259_T262_I1.8440.99
52_M116_S1.8420.99
17_L20_K1.8400.99
188_I237_I1.8230.99
265_E302_T1.8210.99
84_G89_D1.8160.99
169_V172_K1.7960.99
244_V337_T1.7900.98
110_L176_V1.7670.98
320_F324_A1.7650.98
292_Y398_R1.7390.98
137_N150_I1.7380.98
155_K199_D1.7350.98
245_L294_L1.7290.98
152_I201_S1.7230.98
177_S235_N1.7160.98
143_S150_I1.7100.98
295_V395_Y1.7060.98
53_A67_I1.7040.98
350_K382_I1.6980.98
179_I191_I1.6940.98
361_E364_N1.6640.98
42_L56_F1.6620.98
164_K167_E1.6560.97
106_E109_D1.6530.97
245_L260_S1.6510.97
70_P340_I1.6380.97
315_E369_H1.6080.97
216_E220_K1.6050.97
128_I217_K1.6010.97
156_H202_S1.5960.97
346_Y381_V1.5830.97
202_S205_D1.5690.96
66_L102_L1.5620.96
355_M380_A1.5600.96
57_R76_K1.5530.96
270_G274_A1.5470.96
376_E383_K1.5440.96
266_A319_S1.5350.96
183_V190_S1.5320.96
74_N82_E1.5320.96
98_R101_E1.5270.96
278_N327_R1.5250.96
345_E381_V1.5040.96
101_E104_A1.4820.95
124_E133_L1.4740.95
133_L161_K1.4700.95
153_V209_I1.4440.94
57_R77_E1.4330.94
131_D134_K1.4280.94
93_I97_K1.4190.94
279_S285_I1.4190.94
128_I157_L1.4180.94
346_Y372_Y1.4160.94
145_L213_I1.4030.94
70_P73_T1.4020.93
92_S96_G1.3790.93
125_Y159_K1.3790.93
44_S56_F1.3680.93
37_F108_Y1.3670.93
299_P312_R1.3550.92
244_V391_V1.3430.92
156_H201_S1.3330.92
237_I240_D1.3310.92
266_A270_G1.3260.91
149_K209_I1.3230.91
177_S233_V1.3210.91
336_A392_N1.3200.91
124_E160_V1.3190.91
66_L81_I1.2940.90
252_L292_Y1.2920.90
135_I139_V1.2910.90
92_S123_V1.2740.90
271_A323_Y1.2570.89
197_S235_N1.2560.89
343_N346_Y1.2520.89
96_G124_E1.2500.89
141_V150_I1.2470.89
249_A255_S1.2430.88
68_V95_A1.2430.88
68_V99_M1.2330.88
303_I369_H1.2290.88
309_K373_G1.2270.88
305_G368_T1.2240.88
322_K362_I1.2230.88
188_I235_N1.2190.88
103_L111_V1.2180.87
203_N224_E1.2180.87
179_I188_I1.2160.87
317_C351_V1.2160.87
90_E131_D1.2140.87
306_K368_T1.2090.87
44_S67_I1.2080.87
312_R336_A1.2070.87
335_F382_I1.2060.87
326_K353_S1.2030.87
321_L351_V1.1990.87
316_V395_Y1.1960.86
267_R369_H1.1910.86
156_H225_T1.1880.86
208_E212_A1.1870.86
74_N388_H1.1820.86
72_G82_E1.1780.86
177_S196_T1.1740.85
343_N372_Y1.1740.85
87_L134_K1.1710.85
227_K230_S1.1700.85
331_E352_S1.1670.85
273_I295_V1.1640.85
292_Y396_V1.1570.85
81_I98_R1.1560.85
259_T275_S1.1530.84
327_R330_F1.1520.84
199_D202_S1.1460.84
155_K189_S1.1450.84
317_C332_L1.1420.84
54_R58_E1.1380.84
123_V160_V1.1370.84
259_T295_V1.1350.83
316_V332_L1.1330.83
362_I374_L1.1320.83
202_S225_T1.1290.83
314_G343_N1.1270.83
325_K360_D1.1150.82
96_G125_Y1.1120.82
359_E378_H1.1110.82
75_G388_H1.1090.82
18_Q21_V1.1090.82
240_D243_E1.1080.82
86_P141_V1.1050.82
153_V206_A1.1020.82
207_L219_S1.0860.81
318_L371_S1.0760.80
287_F291_Y1.0730.80
314_G317_C1.0730.80
249_A257_I1.0670.79
372_Y381_V1.0620.79
199_D225_T1.0590.79
45_I123_V1.0540.79
39_K109_D1.0480.78
54_R75_G1.0440.78
169_V175_I1.0420.78
126_S159_K1.0360.77
344_S372_Y1.0350.77
17_L34_K1.0340.77
281_E329_R1.0280.77
174_P234_K1.0260.77
333_L382_I1.0250.77
253_V292_Y1.0240.77
66_L79_D1.0230.76
294_L396_V1.0220.76
265_E315_E1.0220.76
125_Y160_V1.0180.76
156_H227_K1.0160.76
267_R315_E1.0130.76
157_L218_Y1.0110.76
242_M279_S1.0080.75
199_D227_K1.0070.75
83_A89_D1.0040.75
128_I132_E1.0010.75
205_D209_I1.0010.75
44_S99_M0.9960.75
41_I102_L0.9930.74
284_N289_R0.9880.74
273_I395_Y0.9820.73
72_G89_D0.9820.73
145_L149_K0.9810.73
65_K78_N0.9760.73
254_N289_R0.9750.73
286_P291_Y0.9740.73
137_N184_P0.9710.73
85_H141_V0.9680.72
226_P230_S0.9670.72
313_N334_G0.9650.72
191_I237_I0.9600.72
359_E375_L0.9600.72
68_V96_G0.9580.72
66_L98_R0.9520.71
93_I124_E0.9490.71
322_K363_N0.9480.71
334_G395_Y0.9440.70
103_L168_Y0.9400.70
137_N143_S0.9370.70
259_T273_I0.9350.70
314_G344_S0.9350.70
103_L169_V0.9350.70
332_L397_L0.9340.70
242_M285_I0.9310.69
365_A377_S0.9290.69
156_H203_N0.9240.69
43_I99_M0.9210.69
270_G316_V0.9200.68
210_L214_G0.9170.68
43_I169_V0.9150.68
132_E217_K0.9140.68
258_L276_I0.9140.68
17_L22_R0.9080.67
184_P263_R0.9040.67
131_D135_I0.9030.67
320_F351_V0.8990.67
203_N223_T0.8990.67
206_A209_I0.8970.67
87_L150_I0.8970.67
71_K89_D0.8950.66
21_V34_K0.8940.66
199_D224_E0.8930.66
40_P112_I0.8920.66
309_K344_S0.8870.66
40_P110_L0.8860.66
71_K83_A0.8790.65
375_L380_A0.8780.65
21_V56_F0.8730.64
259_T395_Y0.8710.64
373_G376_E0.8710.64
269_V299_P0.8710.64
99_M123_V0.8670.64
132_E136_I0.8640.64
52_M114_A0.8640.64
44_S78_N0.8640.64
152_I206_A0.8630.63
73_T340_I0.8630.63
280_S286_P0.8610.63
349_C374_L0.8580.63
155_K190_S0.8540.63
270_G273_I0.8530.63
271_A319_S0.8520.62
376_E379_K0.8510.62
272_I286_P0.8500.62
340_I343_N0.8480.62
197_S233_V0.8470.62
270_G320_F0.8380.61
266_A320_F0.8360.61
262_I269_V0.8360.61
73_T82_E0.8350.61
277_Y330_F0.8330.61
358_R378_H0.8320.61
318_L362_I0.8280.60
156_H224_E0.8280.60
96_G123_V0.8260.60
19_E34_K0.8260.60
208_E211_K0.8250.60
178_F238_I0.8230.60
133_L158_S0.8210.60
68_V81_I0.8150.59
111_V172_K0.8140.59
203_N221_Y0.8130.59
57_R65_K0.8100.59
266_A316_V0.8070.58
293_L399_A0.8070.58
295_V316_V0.8060.58
87_L141_V0.8020.58
306_K369_H0.7990.58
100_I160_V0.7980.57
314_G372_Y0.7940.57
45_I115_I0.7890.57
203_N227_K0.7880.56
261_E278_N0.7870.56
268_D271_A0.7830.56
203_N225_T0.7830.56
104_A168_Y0.7820.56
343_N381_V0.7820.56
150_I312_R0.7810.56
314_G346_Y0.7750.55
156_H205_D0.7720.55
127_E221_Y0.7710.55
281_E327_R0.7690.55
365_A373_G0.7670.54
153_V210_L0.7670.54
140_L145_L0.7630.54
40_P60_M0.7620.54
68_V160_V0.7620.54
375_L378_H0.7620.54
224_E229_F0.7620.54
37_F110_L0.7590.54
155_K244_V0.7590.54
156_H206_A0.7580.54
275_S278_N0.7560.53
152_I157_L0.7540.53
199_D205_D0.7520.53
97_K159_K0.7520.53
359_E365_A0.7520.53
137_N141_V0.7490.53
112_I178_F0.7470.52
115_I377_S0.7440.52
21_V33_E0.7440.52
196_T235_N0.7390.52
332_L395_Y0.7380.52
115_I192_G0.7370.52
256_F276_I0.7350.51
258_L295_V0.7340.51
176_V244_V0.7340.51
148_N190_S0.7310.51
176_V236_Y0.7270.51
115_I177_S0.7270.51
155_K270_G0.7260.50
201_S227_K0.7250.50
18_Q22_R0.7240.50
275_S286_P0.7230.50
93_I130_L0.7210.50
272_I275_S0.7200.50
160_V168_Y0.7160.49
111_V175_I0.7140.49
152_I156_H0.7130.49
84_G91_N0.7120.49
277_Y397_L0.7120.49
203_N207_L0.7120.49
351_V355_M0.7100.49
100_I125_Y0.7090.49
318_L374_L0.7080.49
344_S381_V0.7080.49
183_V187_D0.7060.48
45_I78_N0.7040.48
73_T386_Y0.7040.48
245_L296_G0.7000.48
139_V143_S0.6990.48
206_A392_N0.6980.48
202_S206_A0.6970.48
94_K97_K0.6950.47
53_A78_N0.6930.47
165_I196_T0.6880.47
43_I66_L0.6870.47
115_I119_A0.6810.46
322_K356_E0.6800.46
246_R257_I0.6800.46
48_A180_V0.6790.46
359_E362_I0.6770.46
69_T73_T0.6760.46
365_A375_L0.6730.45
286_P290_P0.6720.45
284_N287_F0.6720.45
226_P232_I0.6720.45
355_M358_R0.6700.45
187_D190_S0.6690.45
156_H218_Y0.6680.45
345_E383_K0.6640.44
81_I95_A0.6640.44
365_A380_A0.6640.44
292_Y392_N0.6630.44
184_P239_L0.6630.44
321_L356_E0.6630.44
38_K108_Y0.6600.44
204_D208_E0.6590.44
248_L294_L0.6580.44
276_I286_P0.6570.44
320_F397_L0.6560.44
113_F196_T0.6560.44
47_K70_P0.6550.44
286_P289_R0.6550.44
202_S224_E0.6540.43
270_G317_C0.6520.43
155_K314_G0.6450.43
42_L78_N0.6440.42
20_K34_K0.6430.42
253_V398_R0.6420.42
374_L378_H0.6410.42
82_E89_D0.6410.42
312_R372_Y0.6410.42
96_G100_I0.6400.42
254_N291_Y0.6390.42
97_K125_Y0.6360.42
229_F232_I0.6340.42
282_S327_R0.6310.41
320_F333_L0.6300.41
73_T83_A0.6300.41
331_E353_S0.6300.41
93_I96_G0.6300.41
239_L334_G0.6280.41
49_S69_T0.6270.41
211_K219_S0.6270.41
112_I217_K0.6260.41
365_A368_T0.6250.41
237_I241_N0.6240.41
224_E230_S0.6200.40
57_R78_N0.6190.40
128_I136_I0.6170.40
336_A343_N0.6170.40
50_L70_P0.6160.40
156_H221_Y0.6150.40
319_S322_K0.6140.40
150_I176_V0.6130.40
210_L218_Y0.6120.39
50_L92_S0.6120.39
216_E219_S0.6120.39
44_S50_L0.6110.39
198_I229_F0.6110.39
190_S201_S0.6110.39
40_P346_Y0.6080.39
68_V86_P0.6040.39
51_P388_H0.6000.38
312_R317_C0.5990.38
262_I272_I0.5980.38
266_A302_T0.5970.38
245_L257_I0.5970.38
135_I138_K0.5950.38
248_L252_L0.5940.38
88_P337_T0.5940.38
209_I212_A0.5940.38
17_L33_E0.5930.38
42_L57_R0.5920.38
354_D358_R0.5920.38
265_E319_S0.5920.38
280_S289_R0.5920.38
155_K162_G0.5920.38
301_V369_H0.5920.38
155_K201_S0.5910.37
133_L157_L0.5910.37
129_P132_E0.5890.37
166_L232_I0.5870.37
166_L169_V0.5870.37
210_L215_L0.5860.37
201_S205_D0.5860.37
322_K325_K0.5850.37
201_S224_E0.5850.37
54_R198_I0.5830.37
116_S180_V0.5830.37
245_L394_I0.5820.37
350_K380_A0.5800.36
52_M312_R0.5780.36
314_G371_S0.5780.36
133_L191_I0.5760.36
49_S221_Y0.5750.36
238_I337_T0.5730.36
354_D380_A0.5710.36
113_F169_V0.5710.36
132_E218_Y0.5700.36
128_I218_Y0.5690.35
97_K101_E0.5680.35
172_K175_I0.5680.35
340_I344_S0.5660.35
49_S190_S0.5660.35
145_L209_I0.5650.35
266_A299_P0.5640.35
42_L62_L0.5640.35
43_I111_V0.5630.35
304_Q365_A0.5620.35
303_I368_T0.5620.35
190_S270_G0.5610.35
207_L211_K0.5600.35
45_I119_A0.5580.35
201_S206_A0.5580.35
41_I111_V0.5580.35
81_I96_G0.5550.34
340_I386_Y0.5530.34
137_N292_Y0.5520.34
270_G323_Y0.5520.34
40_P61_E0.5520.34
38_K41_I0.5500.34
139_V215_L0.5500.34
113_F177_S0.5500.34
256_F293_L0.5500.34
83_A114_A0.5490.34
166_L173_I0.5490.34
180_V388_H0.5480.34
70_P344_S0.5470.34
45_I50_L0.5450.33
73_T388_H0.5450.33
336_A395_Y0.5440.33
340_I346_Y0.5440.33
216_E357_I0.5440.33
77_E106_E0.5440.33
39_K63_K0.5420.33
68_V122_L0.5390.33
210_L219_S0.5380.33
58_E76_K0.5370.33
48_A52_M0.5360.33
104_A107_D0.5330.32
242_M246_R0.5320.32
256_F284_N0.5310.32
365_A374_L0.5290.32
324_A330_F0.5280.32
105_N294_L0.5280.32
70_P141_V0.5260.32
53_A80_V0.5260.32
155_K224_E0.5250.32
120_S161_K0.5230.31
262_I389_T0.5230.31
128_I294_L0.5230.31
222_L228_S0.5220.31
102_L105_N0.5210.31
71_K82_E0.5200.31
158_S161_K0.5190.31
175_I233_V0.5180.31
110_L172_K0.5180.31
312_R346_Y0.5170.31
40_P62_L0.5160.31
324_A327_R0.5150.31
130_L133_L0.5150.31
127_E218_Y0.5150.31
244_V389_T0.5150.31
110_L173_I0.5150.31
166_L233_V0.5140.31
372_Y376_E0.5140.31
50_L73_T0.5130.31
40_P343_N0.5130.31
324_A351_V0.5120.31
83_A123_V0.5120.31
281_E330_F0.5110.30
69_T82_E0.5110.30
69_T244_V0.5110.30
156_H226_P0.5090.30
112_I132_E0.5090.30
264_G269_V0.5090.30
72_G83_A0.5070.30
150_I213_I0.5070.30
317_C344_S0.5060.30
160_V235_N0.5060.30
22_R34_K0.5060.30
166_L172_K0.5060.30
317_C334_G0.5060.30
35_I234_K0.5040.30
252_L255_S0.5040.30
44_S57_R0.5040.30
256_F291_Y0.5030.30
316_V334_G0.5010.30
349_C365_A0.5010.30
121_A125_Y0.5000.30
218_Y221_Y0.5000.30
117_G120_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x3lA 1 0.9925 100 0.064 Contact Map
2b8nA 1 0.965 100 0.083 Contact Map
1aw2A 2 0.3125 55.6 0.973 Contact Map
4cpdA 2 0.485 49.3 0.974 Contact Map
4lmhA 3 0.11 40.6 0.975 Contact Map
1jeoA 4 0.4175 40.1 0.975 Contact Map
2btmA 2 0.2675 38.3 0.976 Contact Map
4mvaA 2 0.28 37.6 0.976 Contact Map
1rjwA 4 0.4975 37 0.976 Contact Map
3m6iA 4 0.505 36.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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